Funsani Katswiri: Kumvetsetsa Malo Amankhwala a Ankylosing Spondylitis

Zamkati

• Kodi ankylosing spondylitis ingachiritsidwe?
• Kodi ndi mankhwala ati odalirika kwambiri m'mayesero azachipatala?
• Ndingadziwe bwanji ngati ndili woyenera kukayezetsa matenda anga?
• Kodi njira zamankhwala zatsopano kwambiri za ankylosing spondylitis ndi ziti?
• Kodi ndi njira ziti zochiritsira zomwe mungalimbikitse? Ndi njira ziti zomwe mumalimbikitsa?
• Kodi kuchitira opaleshoni njira yothandizira ankylosing spondylitis?
• Kodi mukuwona bwanji chithandizo cha ankylosing spondylitis chikusintha pazaka 10 zikubwerazi?
• Mukuganiza kuti njira yotsatira yothandizira ankylosing spondylitis idzakhala iti?
• Kodi ukadaulo wamakono umathandizira bwanji chithandizo chamankhwala?

Kodi ankylosing spondylitis ingachiritsidwe?

Pakadali pano, palibe mankhwala a ankylosing spondylitis (AS). Komabe, odwala ambiri omwe ali ndi AS amatha kukhala ndi moyo wautali, wopindulitsa.

Chifukwa cha nthawi yapakati pazizindikiro komanso kutsimikizika kwa matendawa, kuzindikira koyambirira ndikofunikira.

Kuyang'anira zamankhwala, othandizira othandizira, komanso zochita zolimbitsa thupi zitha kupatsa odwala moyo wabwino. Zotsatira zabwino zimaphatikizapo kupumula kwa ululu, kuchuluka kwa mayendedwe, ndikuwonjezera magwiridwe antchito.

Kodi ndi mankhwala ati odalirika kwambiri m'mayesero azachipatala?

Mayesero odalirika kwambiri azachipatala ndi omwe amafufuza mphamvu ndi chitetezo cha bimekizumab. Ndi mankhwala omwe amaletsa onse interleukin (IL) -17A ndi IL-17F - mapuloteni ang'onoang'ono omwe amathandizira kuzizindikiro za AS.

Filgotinib (FIL) ndi inhibitor yosankha ya Janus kinase 1 (JAK1), puloteni ina yovuta. FIL pakadali pano ikupanga chithandizo cha psoriasis, psoriatic nyamakazi, ndi AS. Zimatengedwa pakamwa ndipo zimakhala zamphamvu kwambiri.

Ndingadziwe bwanji ngati ndili woyenera kukayezetsa matenda anga?

Kuyenerera kwanu kutenga nawo mbali pakuyesa kwachipatala kwa AS kumadalira cholinga cha mlanduwo.

Mayesero atha kuphunzira za mphamvu ndi chitetezo cha mankhwala ofufuzira, kukula kwa mafupa, kapena matenda achilengedwe. Kuwunikanso njira zodziwira za AS kumathandizira pakupanga kwamankhwala azachipatala mtsogolo.

Kodi njira zamankhwala zatsopano kwambiri za ankylosing spondylitis ndi ziti?

Mankhwala atsopano a FDA omwe amachiritsidwa ndi AS ndi awa:

• ustekinumab (Stelara), choletsa IL12 / 23
• tofacitinib (Xeljanz), choletsa JAK
• secukinumab (Cosentyx), IL-17 inhibitor komanso anti-monoclonal antibody
• ixekizumab (Taltz), choletsa IL-17

Kodi ndi njira ziti zochiritsira zomwe mungalimbikitse? Ndi njira ziti zomwe mumalimbikitsa?

Mankhwala othandizira omwe ndimalimbikitsa pafupipafupi ndi awa:

• kutikita
• kutema mphini
• acupressure
• machitidwe a hydrotherapy

Zochita zolimbitsa thupi ndizo:

• kutambasula
• atakhala khoma
• matabwa
• chibwano m'malo obwerera
• mchiuno kutambasula
• kupuma kozama komanso kuyenda

Kugwiritsidwanso ntchito kwa njira za yoga komanso mayunitsi amagetsi opitilira muyeso (TENS) amalimbikitsidwanso.

Kodi kuchitira opaleshoni njira yothandizira ankylosing spondylitis?

Opaleshoni siyodziwika mu AS. Nthawi zina, matendawa amapitilira mpaka kusokoneza zochitika za tsiku ndi tsiku chifukwa cha kupweteka, kulephera kuyenda, ndi kufooka. Pazochitikazi, opaleshoni ingalimbikitsidwe.

Pali njira zingapo zomwe zingachepetse kupweteka, kukhazikika msana, kukonza magwiridwe antchito, komanso kupewa kupsinjika kwa mitsempha. Kuphatikizika kwa msana, mafupa, ndi ma lamine opangidwa ndi akatswiri odziwa opaleshoni atha kukhala othandiza kwa odwala ena.

Kodi mukuwona bwanji chithandizo cha ankylosing spondylitis chikusintha pazaka 10 zikubwerazi?

Ndikulingalira kwanga kuti chithandizo chamankhwala chidzakonzedwa kutengera zomwe zapezedwa pachipatala, njira zowonetsera bwino, komanso malingaliro aliwonse okhudzana ndi matendawa.

AS imagwera pansi pa ambulera yamatenda ambiri otchedwa spondyloarthropathies. Izi zimaphatikizapo psoriasis, nyamakazi ya psoriatic, matenda am'matumbo, komanso spondyloarthropathy.

Pakhoza kukhala ziwonetsero za crossover za ma subsets awa ndipo anthu adzapindula ndi njira yolandirira chithandizo.

Mukuganiza kuti njira yotsatira yothandizira ankylosing spondylitis idzakhala iti?

Mitundu iwiri yapadera, HLA-B27 ndi ERAP1, itha kutenga nawo mbali pofotokoza AS. Ndikuganiza kuti chithandizo chotsatira cha AS chiziwitsidwa pomvetsetsa momwe amalumikizirana komanso momwe amathandizira ndi matenda opatsirana am'mimba.

Kodi ukadaulo wamakono umathandizira bwanji chithandizo chamankhwala?

Kupita patsogolo kwakukulu kuli mu nanomedicine. Njira imeneyi yagwiritsidwa ntchito pochiza bwino matenda ena otupa monga osteoarthritis ndi nyamakazi. Kupanga makina opangira njira za nanotechnology kumatha kukhala kosangalatsa kuwonjezera pa kasamalidwe ka AS.

Brenda B. Spriggs, MD, FACP, MPH, ndi Pulofesa Wachipatala Emerita, UCSF, Rheumatology, mlangizi m'mabungwe angapo azachipatala, komanso wolemba. Zokonda zake zimaphatikizapo kuleza mtima kwa odwala komanso chidwi chofuna kupereka upangiri kwa akatswiri a zamankhwala kwa asing'anga komanso anthu omwe sanatetezedwe. Ndiwothandizirana nawo kuti "Yang'anani pa Thanzi Lanu Labwino Kwambiri: Upangiri Wanzeru ku Chithandizo Chamoyo Chomwe Mukuyenera."