Biologics ya AS: Kodi Mungasankhe Chiyani?

Zamkati

• Kodi biologics ndi AS ndi chiyani?
• 1. Zoletsa zotupa za necrosis factor (TNF)
• 2. Interleukin 17 (IL-17) zoletsa
• Kodi biologics ya AS imaperekedwa motani?
• Mtengo wa biologics wa AS
• Zotsatira zoyipa za biologics ya AS
• Momwe mungapezere chithandizo choyenera cha biologic cha AS
• Tengera kwina

Ankylosing spondylitis (AS) ndi matenda osachiritsika omwe amakhudza kwambiri msana wam'mimba, koma mafupa akulu, monga chiuno ndi mapewa, amathanso kutenga nawo mbali.

Kutupa, komwe kumachitika chifukwa cha chitetezo cha mthupi, kumayambitsa kusakanikirana molumikizana m'magulu a msana, komwe kumabweretsa ululu, kutupa, ndi kuuma.

Izi zitha kuchepetsa kuyenda, zomwe zimapangitsa kuti zikhale zovuta kumaliza ntchito za tsiku ndi tsiku.

Palibe mankhwala a matendawa, koma mitundu ingapo yamankhwala ingachedwetse kukula ndikukuthandizani kuti mukhale moyo wachangu. Wothandizira zaumoyo wanu amakupangirani dongosolo lamankhwala mukadzazindikira.

Chifukwa chakuti zizindikiro za AS zimatha kukhala zofewa mpaka zovuta, anthu ena amatha kuthana ndi matendawa ndi ma nonsteroidal anti-inflammatory (NSAIDs), monga ibuprofen (Motrin, Advil) ndi naproxen sodium (Aleve).

Ngati zizindikiro zanu sizikugwirizana ndi mankhwalawa, mankhwala akuchipatala ndiye njira yotsatira yodzitetezera.

Mankhwala omwe amagwiritsidwa ntchito ku AS amaphatikizapo mankhwala osinthira rheumatic (DMARDs) kuti achepetse kutupa kwa chitetezo cha mthupi.

Ngakhale kuti sangathe kuthana ndi chifukwa chenichenicho, ma NSAID ndi ma DMARD onse adapangidwa kuti athetse kutupa.

Nthawi zina kupweteka ndi kuuma AS kumabweretsa sikumayankha mankhwalawa. Pofuna kukuthandizani kuthana ndi zizindikilo, adotolo angakulimbikitseni mtundu wina wa mankhwala otchedwa biologics.

Kodi biologics ndi AS ndi chiyani?

Biologics ndi mapuloteni omwe amapangidwa kuchokera ku zamoyo zomwe zimatsanzira ntchito zachilengedwe.

Amayang'aniridwa ndi chithandizo chamankhwala omwe amalimbana ndi mapuloteni amtundu wa chitetezo omwe amatulutsa kutupa, omwe ndi:

• chotupa necrosis factor (TNF)
• interleukin 17 (IL-17)

Food and Drug Administration (FDA) idavomereza biologic yoyamba mu 1988 kuchiza nyamakazi ya nyamakazi. Kuyambira pamenepo, ma biology ena angapo apangidwa.

Pakadali pano, mitundu isanu ndi iwiri ya biologics imavomerezedwa kuchiza AS. Izi zikuphatikiza:

1. Zoletsa zotupa za necrosis factor (TNF)

• adalimumab (Humira)
• chitsimikizo cha pegol (Cimzia)
• etanercept (Enbrel)
• golimumab (Simponi, Simponi Aria)
• infliximab (Kutulutsa)

2. Interleukin 17 (IL-17) zoletsa

• secukinumab (Cosentyx)
• ixekizumab (Taltz)

Kodi biologics ya AS imaperekedwa motani?

Biologics iyenera kuperekedwa munyama pansi pa khungu kapena mkati mwaminyewa. Sizimapezeka pamapiritsi kapena mawonekedwe apakamwa. Mumawalandira kudzera mu jakisoni kapena infusions.

Kuchuluka kwa jakisoni kapena infusions kofunikira kumasiyana kutengera mtundu wa biologic Therapy.

Mutha kulandira kulowetsedwa miyezi ingapo. Kapena, mungafune jakisoni zingapo zoyambira kenako majekeseni otsatira chaka chonse.

Mwachitsanzo, biology ya Simponi imafunikira jakisoni atatu oyambira:

• jakisoni awiri patsiku loyamba la chithandizo
• jakisoni mmodzi Patatha milungu iwiri

Pambuyo pake, mudzadzipatsa jekeseni kamodzi pamasabata 4 aliwonse.

Kumbali inayi, ngati mutenga Humira, mudzadzichitira jekeseni kamodzi sabata iliyonse mukatha kumwa magawo anayi oyambira.

Dokotala wanu angakuuzeni kangati mukafunika mankhwala a biologic, ndipo akupatsani malangizo amomwe mungapangire jakisoni wanu.

Biologics siyikulitsa zizindikiro za AS usiku umodzi, koma muyenera kuyamba kumva bwino pafupifupi 4 mpaka 12 milungu, nthawi zina posachedwa.

Cholinga cha chithandizo ndikubisa zizindikiro zanu kuti vutoli lisasokoneze moyo wanu. Ndikofunika kuzindikira kuti biologics sichitha AS.

Mtengo wa biologics wa AS

Biologics nthawi zambiri imakhala yothandiza, koma ndiokwera mtengo kwambiri ku United States. Pafupifupi, mtengo wa biologics ndi womwe ndipo nthawi zina umakhala wokwera mtengo kwambiri kwa othandizira okwera mtengo kwambiri.

Inshuwaransi itha kulipira mbali zina za ndalamazo, ngakhale zitengera momwe mungalipirire.

Lankhulani ndi dokotala wanu za zomwe mungachite pamagulu a zamoyo (zofanana ndi za biologics) ndi mapulogalamu aliwonse othandizira odwala kudzera mwa opanga mankhwala.

Zotsatira zoyipa za biologics ya AS

Pali chiopsezo cha zotsatirapo kapena zosavomerezeka ndi mitundu yambiri ya mankhwala, ndipo biologics ndizosiyana.

Zotsatira zoyipa za mankhwala a biologic atha kukhala:

• kupweteka, kufiira, kuthamanga, kapena kuvulala pamalo obayira
• mutu
• ming'oma kapena zidzolo
• kupweteka m'mimba
• kupweteka kwa msana
• nseru
• chifuwa kapena zilonda zapakhosi
• malungo kapena kuzizira
• kuvuta kupuma
• kuthamanga kwa magazi

Zotsatirazi nthawi zambiri zimakhala zofewa ndipo nthawi zambiri zimatha kenako zimatha.

Komabe, muyenera kuyimbira dokotala ngati muli ndi zizindikiro monga ming'oma, kutupa, kapena kupuma movutikira. Izi zitha kukhala zizindikilo zosavomerezeka.

Chifukwa biologics imalepheretsa chitetezo chanu chamthupi, zitha kukulitsa chiopsezo chotenga matenda komanso khansa.

Dokotala wanu akhoza kuyitanitsa mayeso a labu musanalandire jakisoni woyamba kapena kulowetsedwa kuti muwone:

• chifuwa chachikulu
• chiwindi B ndi C
• matenda ena

Onani dokotala ngati mutakhala ndi zizindikiro za matenda mutayamba mankhwala, monga:

• malungo
• kuzizira
• kupuma movutikira
• kukhosomola

Komanso, dziwitsani dokotala ngati simunafotokoze:

• kuvulaza
• kuonda
• kutopa kwachilendo

Biologics imatha kuwonjezera chiopsezo chokhala ndi khansa yamagazi monga lymphoma.

Momwe mungapezere chithandizo choyenera cha biologic cha AS

Ngakhale ma biologics onse a AS amafunikira kuti achepetse matendawa ndikusiya kutupa, ma biologics sagwira ntchito chimodzimodzi kwa aliyense.

Mukayamba mankhwala a biologic, dokotala wanu akhoza kukuyambitsani ndi mtundu umodzi ndikuwunika momwe zinthu zilili m'miyezi itatu yotsatira kuti muwone ngati pali kusintha kulikonse.

Osataya mtima ngati zizindikilo zanu sizichepera pambuyo poti munalandira infusions kapena jakisoni. Ngati AS yanu isasinthe, dokotala wanu atha kunena kuti musinthe kupita ku biologic ina yovomerezeka ya AS.

Chithandizo cha biologic chokha sindicho njira yokhayo.

Simuyenera kutenga biologic yopitilira imodzi nthawi imodzi chifukwa chakuwopsa kwa matenda, koma mutha kumwa biologics ndi mankhwala ena a AS. Kupeza mpumulo ku AS nthawi zina kumakhala kuyesa.

Khazikani mtima pansi. Zitha kutenga nthawi kuti mupeze mankhwala oyenera.

Mwachitsanzo, ngakhale zizindikiro zanu sizinasinthe mukamamwa ma NSAID kapena ma DMARD, kuphatikiza biologic ndi mankhwalawa kungakhale kothandiza.

Tengera kwina

Popanda chithandizo choyenera, AS imatha kupita patsogolo pang'onopang'ono ndikupangitsa kupweteka, kuuma, komanso kuchepa kwa mayendedwe.

Lankhulani ndi dokotala ngati mukumva kuti chithandizo chanu chamakono sichikugwira ntchito. Mutha kukhala woyenera pa biologics.

Koma musanayambe mankhwala a biologic (monga chithandizo chilichonse), onetsetsani kuti mukudziwa zomwe mungasankhe ndikufunsa mafunso.