Kodi Chimayambitsa Narcolepsy Ndi Chiyani?

Zamkati

• Kodi matenda osokoneza bongo amakhudza bwanji kugona mokwanira?
• Matenda osokoneza bongo
• Kusagwirizana kwa mankhwala
• Chibadwa ndi mbiri ya banja
• Kuvulala kwa ubongo
• Matenda ena
• Kutenga

Narcolepsy ndi mtundu wamatenda amisala omwe amakhudza magwiridwe anu ogona.

Zomwe zimayambitsa matendawa sizidziwika, koma akatswiri amakhulupirira kuti pali zinthu zingapo zomwe zingathandize.

Izi zimaphatikizaponso matenda am'thupi, kusagwirizana kwamankhwala am'magazi, chibadwa, komanso nthawi zina kuvulala kwaubongo.

Pemphani kuti mudziwe zambiri pazomwe zingayambitse komanso zomwe zingayambitse matenda osokoneza bongo.

Kodi matenda osokoneza bongo amakhudza bwanji kugona mokwanira?

Usiku wamba tulo timakhala ndimayendedwe angapo oyenda mofulumira (REM) komanso osakhala a REM. Mukamazungulira REM, thupi lanu limakhala lopuwala komanso kumasuka kwambiri.

Zimatenga pafupifupi mphindi 90 osagona REM kuti alowe mu REM - koma mukakhala ndi narcolepsy, kugona kwa REM komanso REM sikumayenda moyenera. Mutha kulowa mu REM mphindi zochepa ngati 15, ngakhale nthawi yamasana pomwe simukuyesera kugona.

Kusokonezeka koteroko kumapangitsa kugona kwanu kukhala kotsitsimula kuposa momwe ziyenera kukhalira ndipo kumatha kukudzutsani pafupipafupi usiku wonse. Zitha kuchititsanso mavuto masana, kuphatikiza kugona tulo masana komanso zizindikilo zina za matendawa.

Ngakhale zomwe zimayambitsa kusokonezeka kumeneku sizikudziwika, ofufuza apeza zinthu zingapo zomwe zingayambitse.

Matenda osokoneza bongo

Umboni wina ukusonyeza kuti matenda omwe amadzichitira okhaokha atha kutengapo gawo pakukula kwa matenda osokoneza bongo.

Mu chitetezo chamthupi chokwanira, ma cell amthupi amalimbana ndi adani monga mabakiteriya oyambitsa matenda komanso ma virus. Chitetezo chamthupi chikalakwitsa molakwika maselo amthupi ndi minyewa yathanzi, izi zimatanthauzidwa kuti ndimatenda amthupi okha.

Mu mtundu woyamba wa narcolepsy, maselo amthupi amthupi amatha kuwononga maselo ena aubongo omwe amatulutsa mahomoni otchedwa hypocretin. Imathandizira pakukhazikitsa magonedwe.

N'zotheka kuti matenda omwe amadzimadzimadzimadzimodzi amathandizanso kuti azigwiritsa ntchito mankhwala osokoneza bongo amtundu wa 2. Kafukufuku wina wofalitsidwa mu nyuzipepala ya Neurology adapeza kuti anthu omwe ali ndi vuto lodana ndi matenda achiwiri anali othekera kwambiri kuposa anthu omwe alibe narcolepsy kukhala ndi mitundu ina yamatenda amthupi.

Kusagwirizana kwa mankhwala

Hypocretin ndi hormone yomwe imapangidwa ndi ubongo wanu. Amadziwikanso kuti orexin. Zimathandiza kulimbikitsa kudzuka pamene kupondereza kugona kwa REM.

Hypocretin yocheperako kuposa yachibadwa imatha kuyambitsa chizindikiro chotchedwa cataplexy mwa anthu omwe ali ndi mtundu woyamba wa narcolepsy. Cataplexy ndikutaya mwadzidzidzi, kwakanthawi kochepa kwa minofu mukadzuka.

Anthu ena omwe ali ndi mtundu wachiwiri wa narcolepsy amakhalanso ndi hypocretin yochepa. Komabe, anthu ambiri omwe ali ndi vuto lodana ndi matenda achiwiri amakhala ndi mahomoni oterewa.

Pakati pa anthu omwe ali ndi mtundu wachiwiri wamankhwala osokoneza bongo omwe ali ndi vuto lochepa kwambiri la hypocretin, ena pamapeto pake amatha kudwala matendawa ndikulemba narcolepsy yoyamba.

Chibadwa ndi mbiri ya banja

Malinga ndi National Organisation for Rare Disways, kafukufuku wapeza kuti anthu omwe ali ndi vuto lodana ndi matendawa amasintha mtundu wa T cell receptor. Narcolepsy yakhala ikugwirizanitsidwa ndi mitundu ina ya majini m'gulu la majini otchedwa human leukocyte antigen complex.

Mitundu imeneyi imakhudza momwe chitetezo cha mthupi lanu chimagwirira ntchito. Kafukufuku wowonjezereka amafunikira kuti aphunzire momwe angathandizire kunyoza.

Kukhala ndi mikhalidwe yamtunduwu sikutanthauza kuti mudzayamba kudwala matendawa, koma kumakuikani pachiwopsezo chachikulu cha vutoli.

Ngati muli ndi mbiri yoti makolo anu amadwaladwala, zimakulitsa mwayi wanu wopeza vutoli. Komabe, makolo omwe ali ndi matenda osokoneza bongo amangopatsira ana awo pafupifupi 1% ya milandu.

Kuvulala kwa ubongo

Narcolepsy yachiwiri ndi mtundu wosowa kwambiri wamankhwala osokoneza bongo, womwe ndiofala kwambiri kuposa mtundu 1 kapena mtundu wachiwiri wamankhwala osokoneza bongo.

M'malo moyambitsidwa ndi matenda omwe amadzichiritsira okha kapena ma genetics, narcolepsy yachiwiri imayambitsidwa ndi kuvulala kwaubongo.

Ngati mukuvulala kumutu komwe kumawononga gawo lina laubongo wanu wotchedwa hypothalamus, mutha kukhala ndi zizindikilo zachiwiri za narcolepsy. Zotupa zamaubongo zitha kuchititsanso izi.

Anthu omwe ali ndi vuto lodana ndi matenda achiwerewere amakumananso ndi mavuto ena amitsempha. Izi zitha kuphatikizira kukhumudwa kapena zovuta zina zam'maganizo, kukumbukira kukumbukira, ndi hypotonia (kuchepa kwamphamvu ya minofu).

Matenda ena

Malipoti angapo akuti kuwonetsa matenda ena kumatha kuyambitsa matenda osokoneza bongo mwa anthu ena. Koma palibe umboni wotsimikizika wasayansi kuti matenda aliwonse kapena chithandizo chilichonse chimayambitsa vutoli.

Kutenga

Zinthu zingapo zitha kupangitsa kuti pakhale matenda osokoneza bongo, monga matenda amthupi, kusamvana kwamankhwala, komanso majini.

Asayansi akupitilizabe kufufuza zomwe zingayambitse komanso zomwe zimawopseza matenda opatsirana pogonana, kuphatikizapo autoimmune ndi majini.

Kuphunzira zambiri pazomwe zimayambitsa vutoli kungathandize kukhazikitsa njira zothandiza zothandizira.