CBD ya Fibromyalgia

Zamkati

• Kafukufuku pa CBD wa fibromyalgia
• Maphunziro am'mbuyomu
• Phunziro la 2019 Dutch
• Phunziro la 2019 Israeli
• Chithandizo cha CBD
• Zotsatira zoyipa za CBD
• Chiwonetsero

Kumvetsetsa cannabidiol (CBD)

Cannabidiol (CBD) ndi mankhwala opangidwa kuchokera ku cannabis. CBD siyopanda chidwi, mosiyana ndi tetrahydrocannabinol (THC), china chotulutsa cha khansa.

CBD imaganiza kuti yambitsa ma serotonin receptors. Imagwira nawo:

• kuzindikira kupweteka
• kusunga kutentha kwa thupi
• kuchepetsa kutupa

Malinga ndi kafukufuku waposachedwa, CBD ilinso:

• Amathandiza kuchepetsa zizindikiro za kukhumudwa
• zitha kuteteza zizindikiro za psychosis

Izi ndizomwe zimapangitsa CBD kukhala yankho labwino pamankhwala opweteka monga fibromyalgia.

Kafukufuku pa CBD wa fibromyalgia

Fibromyalgia ndi matenda opweteka osatha omwe amayambitsa kupweteka kwa minofu kuphatikiza pa:

• kutopa
• kusowa tulo
• nkhani zamaganizidwe

Amakhudza kwambiri azimayi, ndipo pakadali pano palibe mankhwala odziwika a vutoli. Komabe, njira zamankhwala zilipo zomwe zimayang'ana kusamalira ululu.

CBD yakhala ikugwiritsidwa ntchito kuthana ndi zowawa zazikulu ndikuchepetsa kutupa. Ikufotokozedwa ngati njira ina m'malo moperekera mankhwala opioid omwe amatha kukhala osokoneza bongo.

Komabe, Food and Drug Administration (FDA) sinavomereze CBD ngati njira yothandizira fibromyalgia kapena zina zambiri. Mankhwala olembedwa ndi CBD Epidiolex, mankhwala a khunyu, ndiye mankhwala okhawo a CBD omwe amavomerezedwa ndikuwongoleredwa ndi FDA.

Pakadali pano palibe kafukufuku wofalitsidwa wa fibromyalgia yemwe amayang'ana zotsatira za CBD payokha. Komabe, kafukufuku wina amayang'ana zovuta za cannabis, zomwe zimatha kukhala ndi ma cannabinoids angapo, pa fibromyalgia.

Zotsatira zasakanizidwa. Maphunziro owonjezera aanthu amafunikira.

Maphunziro am'mbuyomu

Zomwe zapezeka kuti CBD itha kugwiritsidwa ntchito kuthetsa ululu wamitsempha. Ofufuzawo adazindikira kuti ma cannabinoids monga CBD atha kukhala othandizira pamankhwala ena opweteka.

Kafukufuku wa 2011 adayang'ana anthu 56 omwe ali ndi fibromyalgia. Ambiri mwa omwe adatenga nawo mbali anali azimayi.

Omwe anali nawo anali ndi magulu awiri:

• Gulu limodzi linali ndi ophunzira 28 omwe sanali ogwiritsa ntchito chamba.
• Gulu lachiwiri linali ndi ophunzira 28 omwe anali ogwiritsa ntchito mankhwala osokoneza bongo. Pafupipafupi momwe amagwiritsira ntchito mankhwalawa, kapena kuchuluka kwa mankhwala omwe amagwiritsa ntchito, amasiyana.

Patadutsa maola awiri akugwiritsa ntchito mankhwalawa, ogwiritsa ntchito mankhwalawa adapeza zabwino monga:

• kuchepetsa kupweteka ndi kuuma
• kuwonjezera kugona

Amakhalanso ndi ziwopsezo zochepa kuposa omwe sanali ogwiritsa ntchito.

Phunziro la 2019 Dutch

Kafukufuku waku 2019 waku Dutch adayang'ana momwe azimayi 20 omwe ali ndi fibromyalgia amakhudzidwira ndi khansa. Pakati pa kafukufukuyu, aliyense amene adatenga nawo gawo adalandira mitundu inayi ya khansa:

• kuchuluka kosanenedwa kwamitundu yosiyanasiyana ya placebo, komwe kunalibe CBD kapena THC
• Ma 200 milligrams (mg) osiyanasiyana osiyanasiyana CBD ndi THC (Bediol)
• 200 mg ya mitundu yosiyanasiyana yokhala ndi CBD yambiri komanso yotsika kwambiri ya THC (Bedrolite)
• 100 mg yazosiyanasiyana ndi kuchepa kwa CBD komanso kuchuluka kwa THC (Bedrocan)

Ofufuzawo adapeza kuti zopweteka zomwe zimachitika anthu omwe amagwiritsa ntchito mitundu ya placebo anali ofanana ndi zopweteka zomwe zimachitika anthu omwe amagwiritsa ntchito mitundu ina ya placebo.

Komabe, Bediol, yomwe ili ndi CBD yayikulu komanso THC, idabweretsa mpumulo kwa anthu ambiri kuposa omwe placebo adachita. Zinapangitsa kuti 30 peresenti ichepetse zowawa zadzidzidzi mwa ophunzira 18 mwa 20. Malowa adachepetsa kuchepa kwadzidzidzi kwa 30% mwa omwe akuchita nawo 11.

Kugwiritsa ntchito kwa Bediol kapena Bedrocan, mitundu yonse yayikulu-THC, kumathandizira kwambiri kupsinjika kwakanthawi kocheperako poyerekeza ndi placebo.

Bedrolite, yomwe ili ndi CBD yayikulu komanso yotsika mu THC, sinawonetse umboni uliwonse wokhoza kuthana ndi zodzidzimutsa kapena zopweteketsa.

Phunziro la 2019 Israeli

Pakafukufuku waku Israeli waku 2019, mazana a anthu omwe ali ndi fibromyalgia adawonedwa kwa miyezi yosachepera 6. Mwa omwe atenga nawo mbali, 82% anali akazi.

Ophunzirawo adalandira chitsogozo kuchokera kwa anamwino asanadye mankhwala osokoneza bongo. Anamwino adapereka upangiri pa:

• mitundu 14 ya ma cannabis yomwe idalipo
• njira zoperekera
• Mlingo

Onse omwe adatenga nawo gawo adayamba ndi mankhwala ochepa, ndipo miyezo idakulitsidwa pang'onopang'ono pamaphunziro. Mlingo wovomerezeka wa pakati pa cannabis umayamba pa 670 mg patsiku.

Pakadutsa miyezi 6, mulingo wovomerezeka wa apakati anali 1,000 mg patsiku. Mlingo wovomerezeka wapakatikati wa THC unali 140 mg, ndipo mulingo woyambira wa CBD unali 39 mg patsiku.

Ofufuzawo adavomereza kuti kafukufukuyu anali ndi malire. Mwachitsanzo, adangotsatira ndi 70% ya omwe akutenga nawo mbali. Kugwiritsa ntchito mitundu yambiri yosiyanasiyana kunapangitsanso kuti zikhale zovuta kuyerekezera zovuta za CBD zolemera ndi THC zolemera.

Komabe, adapitilizabe kunena kuti mankhwala osokoneza bongo azachipatala anali otetezeka komanso othandiza kuchipatala cha fibromyalgia.

Kumayambiriro kwa kafukufukuyu, 52.5% ya omwe akutenga nawo mbali, kapena anthu 193, adanenanso kuti ululu wawo ndiwokwera. Pakutsatira kwa miyezi isanu ndi umodzi, 7.9 peresenti yokha ya omwe adayankha, kapena anthu 19, adamva zowawa zambiri.

Chithandizo cha CBD

Ngati mukufuna kupewa zovuta za psychoactive za chamba, mutha kupeza zinthu za CBD zomwe zili ndi zotsalira za THC zokha. Ngati mumakhala kumalo osuta kapena osuta chamba ndizovomerezeka, mutha kupeza zinthu za CBD zomwe zimakhala ndi kuchuluka kwa THC.

Ngakhale onse ali ndi maubwino padera, CBD ndi TCH mwina zimagwira ntchito bwino zikaphatikizidwa. Akatswiri amatchula za mgwirizano, kapena kulumikizana, monga "gawo logulitsira."

CBD imagwiranso ntchito polimbana ndi zolandila za THC kuti muchepetse zovuta za chamba, monga paranoia ndi nkhawa.

Mutha kudya CBD m'njira zingapo, kuphatikiza:

• Kusuta kapena kutulutsa mpweya. Ngati mukufuna kuthetsa ululu wapompo, kusuta chamba chokhala ndi CBD ndiye njira yachangu kwambiri yochepetsera zizindikilo. Zotsatira zimatha mpaka maola atatu. Kusuta kapena kutulutsa mpweya kumakupatsani mwayi wopumira mwachindunji CBD kuchokera ku chomera cha cannabis, kuyamwa mankhwalawo m'magazi anu ndi m'mapapu.
• Zowonongeka. Zakudya ndi zakudya zophikidwa ndi chomera cha cannabis, kapena mafuta kapena batala wambiri. Zitenga nthawi yayitali kuti mukhale ndi kupumula kwa zizindikilo, koma zovuta zoyipa zimatha mpaka maola 6.
• Akupanga mafuta. Mafuta amatha kupaka pamutu, kutengedwa pakamwa, kapena kusungunuka pansi pa lilime ndikulowetsedwa m'matumba am'kamwa.
• Mitu. Mafuta a CBD atha kulowetsedwa mumtambo kapena mafuta azitsamba ndikugwiritsidwa ntchito pakhungu. Izi zogulitsa za CBD zitha kukhala njira yothandiza yochepetsera kutupa ndikuthandizira kupweteka kwakunja.

Pakhoza kukhala ziwopsezo za kupuma kusuta kapena kutulutsa chamba. Anthu omwe ali ndi vuto la mphumu kapena m'mapapo sayenera kugwiritsa ntchito njirayi.

Muyeneranso kutsatira malangizo a mlingo mosamala, makamaka ndi zakudya, kuti mupewe zovuta zoyipa zakumwa mopitirira muyeso.

Zotsatira zoyipa za CBD

Cannabidiol amaganiza kuti ndiwotetezeka komanso amakhala ndi zotsatirapo zochepa. Komabe, anthu ena adakumana ndi zotsatirazi atagwiritsa ntchito CBD:

• kutopa
• kutsegula m'mimba
• chilakolako kusintha
• kulemera kumasintha

Kafukufuku wokhudzana ndi mbewa zomwe zimalumikizidwa ndi CBD ndikuwopsa kwa chiwindi. Komabe, mbewa zina zomwe zidafufuzidwazo zidakakamizidwa kudyetsa CBD yambiri ngati mtundu wa cannabis wokhala ndi CBD.

Kuyanjana kwa mankhwala ndizotheka ndi CBD. Dziwani za iwo ngati mukumwa mankhwala ena owonjezera kapena mankhwala.

CBD, monga zipatso zamphesa, imasokonezanso ma cytochromes P450 (CYPs). Gulu la michere ili lofunikira pakupanga mankhwala.

Chiwonetsero

Ofufuzawa akufufuzabe ngati CBD ingathe kuthana ndi zovuta zopweteka. Maphunziro owonjezera amafunikira. Pali nkhani zina zopambana, koma CBD siyovomerezeka ndi FDA ku fibromyalgia. Komanso, kafukufuku sanatiwonetse zotsatira zakanthawi yayitali za CBD m'thupi.

Mpaka zambiri zidziwike, mankhwala achikhalidwe a fibromyalgia amalimbikitsidwa.

Ngati mwasankha kugwiritsa ntchito mankhwala a CBD pakuthana ndi ululu, onetsetsani kuti mwaonana ndi dokotala poyamba. Amatha kukuthandizani kupewa zovuta zoyipa kapena kulumikizana kovulaza ndi mankhwala ndi chithandizo chamakono.