Ntchito (elotuzumab)

Zamkati

• Kodi Empliciti ndi chiyani?
• Kuchita bwino
• Empliciti generic
• Zotsatira zoyipa za Empliciti
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Mtengo wa Empliciti
• Thandizo lazachuma komanso inshuwaransi
• Mlingo wa Empliciti
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa myeloma yambiri
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Njira Zina ku Empliciti
• Ntchito (elotuzumab) vs. Darzalex (daratumumab)
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Ntchito ndi Ninlaro
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Kufunsira ma myeloma angapo
• Kuchita bwino kuchiza matenda a myeloma angapo
• Gwiritsani ntchito mankhwala osokoneza bongo
• Mankhwala angapo a myeloma omwe amagwiritsidwa ntchito ndi Empliciti
• Mankhwala oyamba kulowetsedwa omwe amagwiritsidwa ntchito ndi Empliciti
• Momwe Empliciti imagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Empliciti ndi mowa
• Kuyanjana kwa Empliciti
• Kuyesa kwa Empliciti ndi labotale
• Kuyanjana kwina kwa mankhwala
• Momwe Empliciti amaperekera
• Nthawi yoti mutenge
• Ntchito ndi pakati
• Ntchito ndi kulera
• Kulera kwa amayi
• Kulera kwa amuna
• Ntchito ndi kuyamwitsa
• Mafunso wamba okhudza Empliciti
• Kodi Empliciti chemotherapy?
• Kodi chidzachitike ndi chiyani kuchipatala changa cha Empliciti?
• Ndingadziwe bwanji ngati Empliciti ikugwira ntchito kwa ine?
• Kodi kugwiritsa ntchito Empliciti kungandipangitse kukhala ndi mitundu ina ya khansa?
• Njira zopewera
• Zambiri zamaphunziro a Empliciti
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Kodi Empliciti ndi chiyani?

Empliciti ndi mankhwala omwe amadziwika kuti ndi mankhwala. Amagwiritsidwa ntchito pochiza khansa yamagazi yotchedwa multiple myeloma mwa akulu.

Empliciti imaperekedwa kwa anthu omwe ali mgulu la mankhwalawa:

• Akuluakulu omwe adalandira chithandizo chimodzi kapena zitatu m'mbuyomu chifukwa cha myeloma angapo. Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi lenalidomide (Revlimid) ndi dexamethasone.
• Akuluakulu omwe adalandira mankhwala opatsirana a myeloma osachepera awiri omwe anali ndi lenalidomide (Revlimid) ndi proteasome inhibitor, monga bortezomib (Velcade) kapena carfilzomib (Kyprolis). Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi pomalidomide (Pomalyst) ndi dexamethasone.

Empliciti ndi m'gulu la mankhwala otchedwa monoclonal antibodies. Mankhwalawa amapangidwa mu labu kuchokera kumaselo amthupi. Empliciti imagwira ntchito poyambitsa chitetezo chanu cha mthupi ndikupangitsa kuti chitetezo chamthupi chanu chikhale cholimba. Mankhwalawa amathandizanso kuwonetsetsa chitetezo chanu chamthupi pomwe ma cell angapo a myeloma ali mthupi lanu kuti maselowa awonongeke.

Empliciti imapezeka mu mphamvu ziwiri: 300 mg ndi 400 mg. Zimabwera ngati ufa womwe wapangidwa kuti ukhale madzi amadzimadzi ndipo umapatsidwa kwa kulowetsedwa m'mitsempha (IV) (jakisoni m'mitsempha mwako kwakanthawi). Ma infusions amaperekedwa kuchipatala ndipo amakhala pafupifupi ola limodzi kapena kupitilira apo.

Kuchita bwino

Kafukufuku wamankhwala awonetsa kuti Empliciti ndiyothandiza poletsa kukula (kukulira) kwa myeloma yambiri. Zotsatira za ena mwa maphunzirowa zafotokozedwa pansipa.

Empliciti yokhala ndi lenalidomide (Revlimid) ndi dexamethasone

M'mayesero azachipatala, anthu omwe ali ndi myeloma angapo adapatsidwa Empliciti yokhala ndi lenalidomide ndi dexamethasone, kapena lenalidomide ndi dexamethasone yokha.

Kafukufukuyu akuwonetsa kuti anthu omwe akutenga kuphatikiza kwa Empliciti anali ndi chiopsezo chochepa kuti matenda awo apite patsogolo. Kwa zaka zosachepera ziwiri, iwo omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone anali ndi chiopsezo chotsika 30% kuposa anthu omwe amamwa mankhwalawo popanda Empliciti.

Mu kafukufuku wina wazaka zisanu, anthu omwe amatenga kuphatikiza kwa Empliciti anali ndi chiopsezo chotsika ndi 27% cha matenda awo kukulira kuposa anthu omwe amatenga lenalidomide ndi dexamethasone okha.

Empliciti yokhala ndi pomalidomide (Pomalyst) ndi dexamethasone

M'mayesero azachipatala, anthu omwe ali ndi myeloma angapo adapatsidwa Empliciti yokhala ndi pomalidomide ndi dexamethasone, kapena pomalidomide ndi dexamethasone yokha.

Anthu omwe amatenga kuphatikiza kwa Empliciti anali ndi chiopsezo chotsika 46% cha matenda awo kuwonjezeka pambuyo pa chithandizo cha miyezi isanu ndi inayi, poyerekeza ndi anthu omwe amatenga pomalidomide ndi dexamethasone okha.

Empliciti generic

Empliciti imapezeka kokha ngati mankhwala omwe ali ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Empliciti ili ndi mankhwala othandizira elotuzumab.

Zotsatira zoyipa za Empliciti

Empliciti imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukamatenga Empliciti. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Zotsatira zanu zimatha kusiyanasiyana kutengera ngati mukugwiritsa ntchito Empliciti ndi dexamethasone ndi lenalidomide (Revlimid) kapena pomalidomide (Pomalyst).

Kuti mumve zambiri pazomwe zingachitike ku Empliciti, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Empliciti mukamamwa ndi lenalidomide ndi dexamethasone zitha kuphatikizira izi:

• kutopa (kusowa mphamvu)
• kutsegula m'mimba
• malungo
• kudzimbidwa
• chifuwa
• matenda, monga matenda a sinus kapena chibayo
• kuchepetsa kudya kapena kuchepa thupi
• zotumphukira mitsempha matenda (kuwonongeka kwa misempha yanu)
• kupweteka m'manja kapena miyendo yanu
• mutu
• kusanza
• mathithi (mtambo m'maso mwa diso lako)
• kupweteka mkamwa ndi mmero
• kusintha kwa magawo ena pakuyesa kwanu magazi

Zotsatira zofala kwambiri za Empliciti zikagwidwa ndi pomalidomide ndi dexamethasone zitha kuphatikiza:

• kudzimbidwa
• kuchuluka kwa shuga m'magazi
• matenda, monga chibayo kapena matenda a sinus
• kutsegula m'mimba
• kupweteka kwa mafupa
• kuvuta kupuma
• kutuluka kwa minofu
• kutupa m'manja kapena miyendo yanu
• kusintha kwa magawo ena pakuyesa kwanu magazi

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zimatha kuchitika ndi Empliciti. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Mitundu ina ya khansa, monga khansa yapakhungu. Zizindikiro zimatha kuphatikiza:
  • kufooka
  • kumva kutopa
  • kusintha kwa khungu lanu ndi timadontho-timadontho
  • zotupa zam'mimba zotupa
• Mavuto a chiwindi. Zizindikiro zimatha kuphatikiza:
  • kumva kutopa
  • kufooka
  • chikasu cha azungu a maso anu kapena khungu lanu
  • kuchepa kudya
  • kutupa m'mimba mwanu
  • kumva kusokonezeka

Zotsatira zoyipa zina, zomwe zafotokozedwa mwatsatanetsatane pansipa, zitha kuphatikizira izi:

• kulowetsedwa kwamphamvu (kumatha chifukwa cha kulowetsedwa m'mitsempha yamitsempha)
• kwambiri thupi lawo siligwirizana
• matenda

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa. Nazi zina mwazomwe zingayambitse mankhwalawa.

Matupi awo sagwirizana

Monga momwe zimakhalira ndi mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Empliciti. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro za kuyanjana kwambiri ndi izi:

• kutupa pansi pa khungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma

Itanani dokotala wanu nthawi yomweyo ngati muli ndi vuto lalikulu ku Empliciti. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Kulowetsedwa zochita

Mutha kukhala ndi vuto lolowetsedwa mutalandira Empliciti. Izi ndizomwe zimatha kuchitika mpaka maola 24 mutalandira mankhwala kudzera mu kulowetsedwa kwa intravenous (IV).

M'mayesero azachipatala, 10% ya anthu omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone adalowetsedwa. Ambiri mwa anthuwa adalowetsedwa mkati mwa kulowetsedwa kwawo koyamba kwa Empliciti. Komabe, ndi 1% yokha mwa anthu omwe amamwa mankhwalawa omwe amayenera kusiya mankhwala chifukwa chakulowetsedwa kwakukulu.

Komanso m'mayesero azachipatala, 3.3% ya anthu omwe amatenga Empliciti ndi pomalidomide ndi dexamethasone adalowetsedwa. Chizindikiro chokha cha kulowetsedwa kwawo chinali kupweteka pachifuwa.

Zizindikiro zakulowetsedwa zimatha kukhala:

• malungo
• kuzizira
• kuchulukitsa kapena kutsika kwa magazi
• kuchepa kwa mtima
• kuvuta kupuma
• chizungulire
• zotupa pakhungu
• kupweteka pachifuwa

Musanalowetsedwe IV ya Empliciti, dokotala kapena namwino wanu adzakupatsani mankhwala kuti athandize kupewa kulowetsedwa.

Ngati muli ndi zizindikiro zakulowetsedwa mukalandira Empliciti, kapena mpaka maola 24 mutalowetsedwa, uzani dokotala nthawi yomweyo. Pazovuta zazikulu, dokotala wanu angakulimbikitseni kuti musiye chithandizo cha Empliciti.

Nthawi zina, chithandizo cha Empliciti chimatha kuyambiranso pambuyo polowetsedwa. Koma nthawi zina, kusankha mankhwala osiyanasiyana kungakhale njira yabwinoko kwa inu.

Matenda

Mutha kukhala ndi chiopsezo chowonjezeka cha matenda pamene mukugwiritsa ntchito Empliciti. Izi zimaphatikizapo matenda a bakiteriya, mavairasi, ndi mafangasi. Nthawi zina, matendawa amatha kukhala ovuta kwambiri ngati sakuchiritsidwa. Nthawi zina, amatha kudwala kapena kufa kumene.

M'mayesero azachipatala, matenda amapezeka mwa anthu 81% omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone. Mwa anthu omwe amatenga lenalidomide ndi dexamethasone okha, 74% anali ndi matenda.

Komanso m'mayesero azachipatala, matenda amapezeka mwa anthu 65% omwe amatenga Empliciti ndi pomalidomide ndi dexamethasone. Matendawa amapezeka mwa anthu omwewo amatenga pomalidomide ndi dexamethasone okha.

Zizindikiro za matenda zimasiyana kutengera mtundu wamatenda omwe muli nawo. Zitsanzo za zomwe zingachitike ndi izi:

• malungo
• kuvuta kupuma
• Zizindikiro zonga chimfine, monga kupweteka kwa thupi komanso kuzizira
• chifuwa
• zotupa pakhungu
• kutentha pamene mukukodza

Ngati muli ndi zizindikiro zilizonse zodwala, lankhulani ndi dokotala nthawi yomweyo. Angakulimbikitseni kuti musiye kugwiritsa ntchito Empliciti mpaka matenda anu atatha. Akulimbikitsanso ngati matenda anu akuyenera kuthandizidwa.

Matenda aumphawi

Mutha kuwonongeka ndi mitsempha ngati mutenga Empliciti. Kuwonongeka kwa mitsempha kumatha kutchedwanso matenda a zotumphukira. Vutoli limatha kuyambitsa kufooka komanso kupweteka komwe kumachitika m'manja kapena m'mapazi anu. Matenda a mitsempha yotumphuka nthawi zambiri samatha, koma amatha kuthandizidwa ndi mankhwala ena.

M'mayesero azachipatala, matenda amitsempha am'mimba amachitika mwa 27% mwa anthu omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone. Vutoli lidachitika mwa 21% ya anthu omwe amatenga lenalidomide ndi dexamethasone okha.

Lankhulani ndi dokotala wanu ngati muli ndi zizindikiro za matenda a mitsempha. Akhoza kukupatsani chithandizo chamankhwala ngati mukufuna.

Kutopa

Mutha kukhala ndi kutopa (kusowa mphamvu) mukamagwiritsa ntchito Empliciti. Izi zinali zoyipa zomwe zimawoneka panthawi yophunzira mwa anthu omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone.

M'maphunziro, kutopa kunachitika mwa 62% ya anthu omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone. Mwa anthu omwe amatenga lenalidomide ndi dexamethasone okha, 52% adatopa.

Lankhulani ndi dokotala ngati mukumva wotopa mukamalandira chithandizo cha Empliciti. Atha kulangiza chithandizo chamankhwala ngati mungafune chilichonse ndikufotokozerani njira zochepetsera matenda anu.

Kutsekula m'mimba

Mutha kukhala ndi kutsekula m'mimba mukamamwa Empliciti. M'mayesero azachipatala, kutsekula m'mimba kunachitika mwa 47% ya anthu omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone. Mwa anthu omwe amatenga lenalidomide ndi dexamethasone okha, 36% adatsegula m'mimba.

Kutsekula m'mimba kunayambanso kuwonetsa anthu omwe amatenga Empliciti ndi pomalidomide ndi dexamethasone. M'mayesero azachipatala, kutsekula m'mimba kunachitika mwa 18% mwa anthu omwe amamwa mankhwalawa. Mwa anthu omwe amatenga pomalidomide ndi dexamethasone okha, 9% adatsegula m'mimba.

Lankhulani ndi dokotala ngati muli ndi matenda otsekula m'mimba mukamamwa mankhwala a Empliciti. Atha kulangiza chithandizo chamankhwala ngati mungafune chilichonse ndikufotokozerani njira zochepetsera matenda anu.

Zosintha pamiyeso yamalabu kapena mayeso

Mutha kukhala ndi kusintha pamayeso ena a magazi mukamamwa Empliciti. Zitsanzo zikuphatikiza kusintha kwa:

• kuchuluka kwa maselo amwazi
• Kuyesa kwa chiwindi kapena impso
• kuchuluka kwa shuga, calcium, potaziyamu, kapena sodium

Dokotala wanu amatha kuyesa kuyezetsa magazi nthawi zambiri kuposa nthawi zonse mukamamwa mankhwala a Empliciti. Izi zimalola dokotala wanu kuwona ngati pali zosintha zilizonse m'magazi anu. Ngati zoterezi zikuchitika, dokotala akhoza kuyang'anitsitsa kuyesa kwanu magazi mobwerezabwereza kapena akulimbikitseni kuti musiye mankhwala a Empliciti.

Mtengo wa Empliciti

Monga mankhwala onse, mtengo wa Empliciti umasiyana. Mankhwalawa amaperekedwa ndikulowetsedwa kwa intravenous (IV) kuzipatala zamankhwala.

Mtengo weniweni womwe mudzalipira umadalira dongosolo la inshuwaransi yanu, komwe mumakhala, ndi malo azachipatala omwe mumalandila chithandizo chanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Empliciti, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Bristol-Myers Squibb, wopanga Empliciti, amapereka pulogalamu yotchedwa BMS Access Support. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 800-861-0048 kapena pitani patsamba lino.

Mlingo wa Empliciti

Mlingo wa Empliciti womwe dokotala akukulemberani umadalira pazifukwa zingapo. Izi zikuphatikiza:

• mankhwala omwe mumamwa ndi Empliciti
• thupi lanu

Mlingo wanu ukhoza kusinthidwa pakapita nthawi kuti mufike pamlingo woyenera kwa inu. Dokotala wanu pomaliza adzakupatsani mlingo wochepa kwambiri womwe umafunikira.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Empliciti imabwera ngati ufa womwe umasakanikirana ndi madzi osabala ndikupanga yankho. Amapatsidwa ngati kulowetsedwa m'mitsempha (IV) (jakisoni m'mitsempha yanu kwakanthawi). Yankho lake limapangidwa ndipo kulowetsedwa kwa IV kumaperekedwa kwa inu kuchipatala.

Empliciti imapezeka mu mphamvu ziwiri: 300 mg ndi 400 mg.

Mlingo wa myeloma yambiri

Mlingo wa Empliciti womwe mumalandira umadalira kulemera kwanu komanso mankhwala omwe mumamwa ndi Empliciti.

Ngati mukumwa Empliciti ndi lenalidomide (Revlimid) ndi dexamethasone:

• mulingo woyenera ndi 10 mg wa Empliciti pa kilogalamu iliyonse (pafupifupi mapaundi 2.2) a kulemera kwanu
• mudzalandira mankhwala a mlungu ndi mlungu a Empliciti kwa milungu isanu ndi itatu yoyambirira, yomwe imawerengedwa kuti ndi njira ziwiri
• mutalandira chithandizo chamankhwala awiri oyamba, Empliciti imaperekedwa kamodzi pamasabata awiri

Ngati mukumwa Empliciti ndi pomalidomide (Pomalyst) ndi dexamethasone:

• mulingo woyenera ndi 10 mg wa Empliciti pa kilogalamu iliyonse (pafupifupi mapaundi 2.2) a kulemera kwanu
• mudzalandira mankhwala a mlungu ndi mlungu a Empliciti kwa milungu isanu ndi itatu yoyambirira, yomwe imawerengedwa kuti ndi njira ziwiri
• mutalandira chithandizo chamankhwala awiri oyamba, mlingowo umakulanso mpaka 20 mg ya Empliciti pa kilogalamu iliyonse yolemera thupi lanu, yomwe imaperekedwa kamodzi pakatha milungu inayi

Monga chitsanzo cha kuwerengera kwa mlingo, munthu wamkulu yemwe amalemera makilogalamu 70 (pafupifupi mapaundi 154) alandila Empliciti. Izi zimawerengedwa ngati ma kilogalamu 70 ochulukitsidwa ndi 10 mg ya mankhwala, omwe ndi 700 mg ya Empliciti.

Ndi njira iliyonse yamankhwala, nthawi zambiri mupitiliza kutenga Empliciti mpaka myeloma yanu ingowonjezeka kapena mutakhala ndi zovuta kuchokera ku Empliciti.

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya nthawi yokumana ndi kulowetsedwa kwanu kwa Empliciti, konzani nthawi ina posachedwa. Lankhulani ndi dokotala wanu za njira yabwino kwambiri yokonzekera mlingo wanu wamtsogolo kuti muthe kukwanitsa kupita ku infusions anu.

Onetsetsani kuti mwamwa mankhwala anu dexamethasone monga mwa malangizo a dokotala. Ngati mwaphonya mlingo wa dexamethasone, uzani dokotala kuti mwaiwala kumwa. Kuyiwala kuchuluka kwa mankhwalawa kumatha kukupangitsani kuyankha ku Empliciti. Izi nthawi zina zimakhala zovuta kwambiri.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Nthawi zina kugwiritsa ntchito mankhwala kumathandiza kuti myeloma yanu ikhale yolimba (osakula) kwanthawi yayitali. Ngati mukugwiritsa ntchito Empliciti ndipo myeloma yanu yambiri sikuipiraipira, adokotala angakulimbikitseni kuti mukhalebe pa chithandizo cha Empliciti nthawi yayitali.

M'mayesero azachipatala, opitilira theka la anthu omwe amatenga Empliciti sanakhale ndi vuto la myeloma yawo yambiri kwa miyezi yopitilira 10. Kutalika kwa nthawi yomwe mutenge Empliciti kumadalira momwe thupi lanu limayankhira mankhwala.

Njira Zina ku Empliciti

Mankhwala ena kapena mankhwala alipo omwe angachiritse myeloma angapo. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Empliciti, lankhulani ndi dokotala wanu. Amatha kukuwuzani zamankhwala ena kapena mankhwala omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochiza angapo a myeloma ndi awa:

• bortezomib (Velcade)
• carfilzomib (Kyprolis)
• ixazomib (Ninlaro)
• daratumumab (Darzalex)
• thalidomide (Thalomid)
• lenalidomide (Wowonjezera)
• pomalidomide (Pomalyst)
• ma steroids ena, monga prednisone kapena dexamethasone

Mankhwala ena omwe angagwiritsidwe ntchito pochiza matenda a myeloma angapo ndi awa:

• radiation (imagwiritsa ntchito mphamvu za kupha ma cell a khansa)
• tsinde lothandizira

Ntchito (elotuzumab) vs. Darzalex (daratumumab)

Mutha kudabwa momwe Empliciti amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa tikuwona momwe Empliciti ndi Darzalex alili ofanana komanso osiyana.

Ntchito

Onse a Empliciti ndi Darzalex amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse ma myeloma angapo mwa akulu omwe:

• adayesapo kale mankhwala awiri am'mbuyomu omwe amaphatikizapo lenalidomide (Revlimid) ndi proteasome inhibitor, monga bortezomib (Velcade) kapena carfilzomib (Kyprolis). Kwa anthuwa, mwina Empliciti kapena Darzalex imagwiritsidwa ntchito ndi pomalidomide (Pomalyst) ndi dexamethasone.

Empliciti imaperekedwanso kwa akulu omwe:

• akhala akuchiritsidwa kamodzi kapena katatu m'mbuyomu chifukwa cha myeloma yawo yambiri. Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi lenalidomide (Revlimid) ndi dexamethasone.

Darzalex imavomerezedwanso ndi FDA kuti ichiritse myeloma angapo mwa akulu omwe adalandira mankhwala amodzi kapena angapo m'mbuyomu. Zimalimbikitsidwa kuti zizigwiritsidwa ntchito zokha komanso kuphatikiza mankhwala ena, kutengera mbiri ya chithandizo cha munthu aliyense.

Mafomu azamankhwala ndi makonzedwe

Empliciti imabwera ngati ufa. Amapangidwa kukhala yankho ndipo amakupatsani ngati kulowetsedwa kwa mtsempha (IV) (jakisoni mumitsempha yanu kwakanthawi). Empliciti imapezeka mu mphamvu ziwiri: 300 mg ndi 400 mg.

Mlingo wanu wa Empliciti umasiyanasiyana kutengera kulemera kwanu komanso mankhwala ena omwe mukugwiritsa ntchito ndi Empliciti. Kuti mumve zambiri zamankhwala, onani gawo la "Empliciti dosage" pamwambapa.

Empliciti nthawi zambiri amapatsidwa sabata pamankhwala awiri oyambira (milungu isanu ndi itatu yonse) ya chithandizo. Pambuyo pake, mupeza Empliciti milungu iwiri kapena inayi iliyonse, kutengera mankhwala omwe mukugwiritsa ntchito ndi Empliciti. Kuti mumve zambiri, chonde onani gawo "Mlingo wa Empliciti" pamwambapa.

Darzalex imabwera ngati yankho lamadzi. Amaperekedwanso ngati kulowetsedwa m'mitsempha (IV). Darzalex imapezeka mu mphamvu ziwiri: 100 mg / 5 mL ndi 400 mg / 20 mL.

Mlingo wanu wa Darzalex umadaliranso thupi lanu. Komabe, dongosolo la mlingo lidzasiyana malinga ndi mankhwala omwe mukugwiritsa ntchito ndi Darzalex.

Darzalex nthawi zambiri imaperekedwa mlungu uliwonse kwa milungu isanu ndi umodzi kapena isanu ndi inayi. Pambuyo pake, mupeza Darzalex kamodzi pamasabata awiri kapena anayi, kutengera kuti mwakhala mukugwiritsa ntchito nthawi yayitali bwanji.

Zotsatira zoyipa ndi zoopsa

Empliciti ndi Darzalex onse ali ndi mankhwala omwe amalimbana ndi myeloma yambiri. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zanu zimatha kusiyanasiyana kutengera mankhwala omwe mumamwa ndi Empliciti kapena Darzalex. Dokotala wanu akhoza kufotokoza zovuta zomwe mungakumane nazo kutengera mankhwala omwe mumamwa.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Empliciti, ndi Darzalex, kapena ndi mankhwala onse awiri (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Empliciti:
  • mathithi (mtambo m'maso mwa diso lako)
  • kupweteka pakamwa panu kapena pakhosi
  • kupweteka kwa mafupa
• Zitha kuchitika ndi Darzalex:
  • kufooka
  • nseru
  • kupweteka kwa msana
  • chizungulire
  • kusowa tulo (kuvuta kugona)
  • kuthamanga kwa magazi
  • kupweteka pamodzi
• Zitha kuchitika ndi Empliciti ndi Darzalex:
  • kutopa (kusowa mphamvu)
  • kutsegula m'mimba
  • kudzimbidwa
  • kuchepa kudya
  • malungo
  • chifuwa
  • kusanza
  • kuvuta kupuma
  • kutuluka kwa minofu
  • kutupa m'manja kapena miyendo yanu
  • kuchuluka kwa shuga m'magazi
  • mutu

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Empliciti, ndi Darzalex, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Empliciti:
  • mavuto a chiwindi
  • kupanga mitundu ina ya khansa, monga khansa yapakhungu
• Zitha kuchitika ndi Darzalex:
  • neutropenia (mulingo woyela wamagazi oyera)
  • thrombocytopenia (mlingo wotsika wamagazi)
• Zitha kuchitika ndi Empliciti ndi Darzalex:
  • kulowetsedwa zochita
  • zotumphukira mitsempha matenda (kuwonongeka kwa misempha yanu)
  • matenda, monga chibayo

Kuchita bwino

Empliciti ndi Darzalex onse amavomerezedwa kuti athetse matenda a myeloma akuluakulu.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Koma maphunziro osiyana apeza kuti Empliciti ndi Darzalex ndizothandiza kuthana ndi ma myeloma angapo.

Mtengo

Empliciti ndi Darzalex onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Onse a Empliciti ndi Darzalex amapatsidwa ma infravenous (IV) infusions kuchipatala. Ndalama zomwe mumalipira ngati mutadwala zimadalira inshuwaransi yanu, komwe mumakhala, ndi chipatala kapena chipatala komwe mumalandira chithandizo.

Ntchito ndi Ninlaro

Mutha kudabwa momwe Empliciti amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa tikuwona momwe Empliciti ndi Ninlaro alili ofanana komanso osiyana.

Ntchito

Onse a Empliciti ndi Ninlaro amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse ma myeloma angapo.

Empliciti imaperekedwa kwa anthu omwe ali mgulu la mankhwalawa:

• Akuluakulu omwe adalandira chithandizo chimodzi kapena zitatu m'mbuyomu chifukwa cha myeloma angapo. Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi lenalidomide (Revlimid) ndi dexamethasone.
• Akuluakulu omwe adalandira mankhwala opatsirana a myeloma osachepera awiri omwe anali ndi lenalidomide (Revlimid) ndi proteasome inhibitor, monga bortezomib (Velcade) kapena carfilzomib (Kyprolis). Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi pomalidomide (Pomalyst) ndi dexamethasone.

Ninlaro wavomerezedwa kuti azichiza matenda a myeloma angapo mwa achikulire omwe adayesapo chithandizo china chimodzi m'mbuyomu. Ninlaro imavomerezedwa kuti igwiritsidwe ntchito limodzi ndi lenalidomide (Revlimid) ndi dexamethasone.

Mafomu azamankhwala ndi makonzedwe

Empliciti imabwera ngati ufa. Amapangidwa kukhala yankho ndipo amakupatsani ngati kulowetsedwa kwa mtsempha (IV) (jakisoni mumitsempha yanu kwakanthawi). Empliciti imapezeka mu mphamvu ziwiri: 300 mg ndi 400 mg.

Mlingo wanu wa Empliciti umasiyanasiyana kutengera kulemera kwanu komanso mankhwala ena omwe mukugwiritsa ntchito ndi Empliciti. Kuti mumve zambiri zamankhwala, onani gawo la "Empliciti dosage" pamwambapa.

Empliciti nthawi zambiri amapatsidwa sabata pamankhwala awiri oyambira (milungu isanu ndi itatu yonse) ya chithandizo. Pambuyo pake, mupeza Empliciti milungu iwiri kapena inayi iliyonse, kutengera mankhwala omwe mukugwiritsa ntchito ndi Empliciti. Kuti mumve zambiri, chonde onani gawo "Mlingo wa Empliciti" pamwambapa.

Ninlaro amabwera ngati makapisozi omwe amatengedwa pakamwa kamodzi sabata iliyonse. Ninlaro amapezeka mwamphamvu zitatu:

• 2.3 mg
• 3 mg
• 4 mg

Zotsatira zoyipa ndi zoopsa

Empliciti ndi Ninlaro onse ali ndi mankhwala omwe amathandizira kuthetsa ma cell angapo a myeloma. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Ninlaro imavomerezedwa kuti igwiritsidwe ntchito ndi lenalidomide (Revlimid) ndi dexamethasone. M'chigawo chino, tikufanizira zoyipa zamankhwala ophatikizana a Ninlaro ndi zovuta za Empliciti komanso kuphatikiza lenalidomide (Revlimid) ndi dexamethasone.

Zotsatira zanu zimatha kusiyanasiyana kutengera mankhwala omwe mumamwa ndi Empliciti kapena Ninlaro. Dokotala wanu akhoza kufotokoza zovuta zomwe mungakumane nazo kutengera mankhwala omwe mumamwa.

Zotsatira zofala kwambiri

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Empliciti, ndi Ninlaro, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi kuphatikiza mankhwala a Empliciti:
  • kutopa (kusowa mphamvu)
  • malungo
  • chifuwa
  • kuchepa kudya
  • mutu
  • mathithi (mtambo m'maso mwa diso lako)
  • kupweteka mkamwa mwako
• Zitha kuchitika ndi kuphatikiza kwa mankhwala a Ninlaro:
  • nseru
  • kusungira madzimadzi, komwe kungayambitse kutupa
  • kupweteka kwa msana
• Zitha kuchitika ndi kuphatikiza kwa mankhwala a Empliciti ndi Ninlaro:
  • kutsegula m'mimba
  • kudzimbidwa
  • kusanza

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Empliciti, ndi Ninlaro, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi kuphatikiza mankhwala a Empliciti:
  • kulowetsedwa zochita
  • matenda akulu
  • akupanga mitundu ina ya khansa
• Zitha kuchitika ndi kuphatikiza kwa mankhwala a Ninlaro:
  • thrombocytopenia (mlingo wotsika wamagazi)
  • zotupa kwambiri pakhungu
• Zitha kuchitika ndi kuphatikiza kwa mankhwala a Empliciti ndi Ninlaro:
  • zotumphukira mitsempha matenda (kuwonongeka kwa misempha yanu)
  • mavuto a chiwindi

Kuchita bwino

Empliciti ndi Ninlaro onse ndi ovomerezeka kuchiza matenda a myeloma akuluakulu.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Koma maphunziro osiyana apeza kuti Empliciti ndi Ninlaro ndi othandiza pochiza matenda a myeloma angapo.

Mtengo

Empliciti ndi Ninlaro onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Empliciti imaperekedwa ngati kulowetsedwa m'mitsempha (IV) kuchipatala. Makapisozi a Ninlaro amaperekedwa ndi ma pharmacies apadera. Ndalama zomwe mumalipira ngati mutadwala zimadalira inshuwaransi yanu, komwe mumakhala, komanso ngati mumalandira chithandizo kuchipatala kapena kuchipatala.

Kufunsira ma myeloma angapo

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Empliciti kuti athetse ma myeloma angapo. Matendawa ndi mtundu wa khansa womwe umakhudza ma plasma. Maselowa ndi mtundu wa selo loyera lomwe limathandiza thupi lanu kulimbana ndi majeremusi ndi matenda.

Ndi ma myeloma angapo, thupi lanu limapanga maselo osadziwika am'magazi. Maselo achilengedwe a plasma, otchedwa maselo a myeloma, amadzaza maselo anu athanzi a m'magazi. Izi zikutanthauza kuti muli ndi maselo ochepa am'magazi omwe amatha kulimbana ndi majeremusi. Maselo a Myeloma amapanganso mapuloteni otchedwa M protein. Puloteni iyi imatha kukhala mthupi lanu ndikuwononga ziwalo zina.

Empliciti imaperekedwa kwa anthu omwe ali mgulu la mankhwalawa:

• Akuluakulu omwe adalandira chithandizo chimodzi kapena zitatu m'mbuyomu chifukwa cha myeloma angapo. Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi lenalidomide (Revlimid) ndi dexamethasone.
• Akuluakulu omwe adalandira mankhwala opatsirana a myeloma osachepera awiri omwe anali ndi lenalidomide (Revlimid) ndi proteasome inhibitor, monga bortezomib (Velcade) kapena carfilzomib (Kyprolis). Kwa anthuwa, Empliciti imagwiritsidwa ntchito limodzi ndi pomalidomide (Pomalyst) ndi dexamethasone.

Kuchita bwino kuchiza matenda a myeloma angapo

Kafukufuku wamankhwala awonetsa kuti Empliciti ndiyothandiza poletsa kukula (kukulira) kwa myeloma yambiri. Zotsatira za ena mwa maphunzirowa zafotokozedwa pansipa.

Empliciti yokhala ndi lenalidomide (Revlimid) ndi dexamethasone

M'mayesero azachipatala, anthu omwe ali ndi myeloma angapo adapatsidwa Empliciti yokhala ndi lenalidomide ndi dexamethasone, kapena lenalidomide ndi dexamethasone yokha.

Kafukufukuyu akuwonetsa kuti anthu omwe akutenga kuphatikiza kwa Empliciti anali ndi chiopsezo chochepa kuti matenda awo apite patsogolo. Kwa zaka zosachepera ziwiri, iwo omwe amatenga Empliciti ndi lenalidomide ndi dexamethasone anali ndi chiopsezo chotsika 30% kuposa anthu omwe amamwa mankhwalawo popanda Empliciti.

Mu kafukufuku wina wazaka zisanu, anthu omwe amatenga kuphatikiza kwa Empliciti anali ndi chiopsezo chotsika ndi 27% cha matenda awo kukulira kuposa anthu omwe amatenga lenalidomide ndi dexamethasone okha.

Empliciti yokhala ndi pomalidomide (Pomalyst) ndi dexamethasone

M'mayesero azachipatala, anthu omwe ali ndi myeloma angapo adapatsidwa Empliciti yokhala ndi pomalidomide ndi dexamethasone, kapena pomalidomide ndi dexamethasone yokha.

Anthu omwe amatenga kuphatikiza kwa Empliciti anali ndi chiopsezo chotsika 46% cha matenda awo kuwonjezeka pambuyo pa chithandizo cha miyezi isanu ndi inayi, poyerekeza ndi anthu omwe amatenga pomalidomide ndi dexamethasone okha.

Gwiritsani ntchito mankhwala osokoneza bongo

Empliciti imaperekedwa ndi mankhwala ena ikagwiritsidwa ntchito pochiza myeloma yambiri.

Mankhwala angapo a myeloma omwe amagwiritsidwa ntchito ndi Empliciti

Empliciti imagwiritsidwa ntchito nthawi zonse kuphatikiza ndi steroid yotchedwa dexamethasone. Amagwiritsidwanso ntchito nthawi zonse kuphatikiza ndi lenalidomide (Revlimid) kapena pomalidomide (Pomalyst). Kugwiritsa ntchito mankhwalawa ndi Empliciti kumathandiza mankhwalawa kukhala othandiza kwambiri pochiza matenda a myeloma angapo.

Mankhwala oyamba kulowetsedwa omwe amagwiritsidwa ntchito ndi Empliciti

Musanayambe kulowetsedwa mu mtsempha (IV) wa Empliciti, mutenga mankhwala ena omwe amatchedwa pre-infusion mankhwala. Mankhwalawa amagwiritsidwa ntchito kuthana ndi zovuta (kuphatikiza kulowetsedwa) chifukwa cha mankhwala a Empliciti.

Mukalandira mankhwala otsatirawa asanalowetsedwe pafupi mphindi 45 mpaka 90 musanalandire chithandizo cha Empliciti:

• Dexamethasone. Mudzalandira 8 mg wa dexamethasone ndi jakisoni wa IV.
• Diphenhydramine (Benadryl). Mutenga 25 mg mpaka 50 mg wa diphenhydramine pamaso pa kulowetsedwa kwanu kwa Empliciti. Diphenhydramine itha kuperekedwa ndi jakisoni (IV) kapena piritsi lomwe limatengedwa pakamwa.
• Acetaminophen (Tylenol). Mutenganso 650 mg mpaka 1,000 mg wa acetaminophen pakamwa.

Momwe Empliciti imagwirira ntchito

Multiple myeloma ndi mtundu wa khansa yomwe imakhudza ma cell oyera amtundu wina otchedwa ma plasma. Maselowa amathandiza thupi lanu kulimbana ndi majeremusi ndi matenda. Maselo a plasma omwe amakhudzidwa ndi ma myeloma angapo amakhala ndi khansa ndipo amatchedwa maselo a myeloma.

Empliciti imagwira ntchito pamtundu wina wamagazi oyera wotchedwa cell killer (NK) cell. Maselo a NK amagwira ntchito mthupi lanu kupha ma cell osazolowereka, monga ma cell a khansa kapena ma cell omwe ali ndi ma virus.

Empliciti imagwira ntchito poyambitsa (kuyatsa) ma cell anu a NK. Izi zimathandiza ma cell anu a NK kuti apeze maselo am'magazi omwe amakhudzidwa ndi ma myeloma angapo. Maselo a NK amawononga maselo osadziwikawo. Empliciti imagwiranso ntchito pakupeza ma cell a myeloma am'maselo anu a NK.

Empliciti amatchedwa mankhwala a immunotherapy. Mankhwalawa amagwira ntchito ndi chitetezo cha mthupi lanu kuti muthandize thupi lanu kulimbana ndi zovuta zina.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Empliciti imayamba kugwira ntchito mthupi lanu mutalandira kulowetsedwa kwanu koyamba. Komabe, mwina simukuzindikira pomwe Empliciti iyamba kugwira ntchito. Dokotala wanu azitha kuwona ngati zikugwira ntchito popanga mayeso ena. Ngati muli ndi mafunso okhudza momwe Empliciti amagwirira ntchito kwa inu, lankhulani ndi dokotala wanu.

Empliciti ndi mowa

Palibe kulumikizana kulikonse komwe kumadziwika pakati pa Empliciti ndi mowa. Komabe, Empliciti itha kuyambitsa mavuto a chiwindi. Kumwa mowa kumathandizanso kuti chiwindi chanu chiwonjezeke.

Lankhulani ndi dokotala musanamwe mowa mukamwa Empliciti. Amatha kukulangizani ngati zili bwino kuti muzimwa mowa mukamamwa mankhwalawa.

Kuyanjana kwa Empliciti

Empliciti sikuti nthawi zambiri imagwirizana ndi mankhwala ena. Komabe, mankhwala omwe amagwiritsidwa ntchito ndi Empliciti amadziwika kuti amalumikizana ndi mankhwala ena.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito. Kuyanjana kwina kumatha kukulitsa zovuta zina kapena kuwapangitsa kukhala owopsa.

Chithandizo cha Empliciti chingakhudzenso zotsatira za mayeso ena a labu.

Kuyesa kwa Empliciti ndi labotale

Empliciti imatha kukhudza zotsatira za mayeso ena omwe amagwiritsidwa ntchito poyang'ana mapuloteni a M mthupi lanu. Mapuloteni a M amapangidwa ndi maselo angapo a myeloma. Mapuloteni apamwamba a M amatanthauza kuti khansa yanu ndiyotsogola kwambiri.

Dokotala wanu adzaitanitsa mayesero kuti aone ngati M protein m'thupi lanu panthawi yamankhwala a Empliciti. Izi zimapangitsa dokotala wanu kuwona momwe thupi lanu limayankhira ndi mankhwalawa.

Komabe, Empliciti ikhoza kusintha zotsatira za mayeso anu am'magazi a M protein. Izi zitha kukhala zovuta kuti dokotala wanu adziwe ngati myeloma yanu yambiri ikuyenda bwino kapena ayi. Empliciti itha kupangitsa kuti ziwoneke ngati muli ndi mapuloteni ambiri a M kuposa momwe mumachitira. Pofuna kuthana ndi izi, dokotala wanu atha kuyitanitsa mayeso a labu omwe sakukhudzidwa ndi Empliciti kuti muwunikire mankhwala anu.

Kuyanjana kwina kwa mankhwala

Empliciti nthawi zonse amatengedwa ndi dexamethasone ndipo mwina pomalidomide (Pomalyst) kapena lenalidomide (Revlimid). Ngakhale palibe zochitika zilizonse zodziwika ndi mankhwala ndi Empliciti, pali zochitika zodziwika bwino za mankhwala omwe amagwiritsidwa ntchito.

Onetsetsani kuti mukukambirana ndi dokotala kapena wamankhwala zomwe mungachite pophatikizana ndi mankhwala omwe mumamwa.

Momwe Empliciti amaperekera

Muyenera kutenga Empliciti malinga ndi malangizo a dokotala kapena wothandizira zaumoyo. Empliciti imaperekedwa ndikulowetsedwa kwamitsempha (IV), nthawi zambiri kudzera mumitsempha m'manja mwanu. Mankhwala omwe amaperekedwa ndi kulowetsedwa kwa IV amaperekedwa pang'onopang'ono kwakanthawi. Zitha kutenga ola limodzi kapena kupitilira apo kuti mulandire kuchuluka kwa Empliciti.

Empliciti imangoperekedwa kuofesi ya dokotala kapena kuchipatala. Mukamakulowetsani, mudzayang'aniridwa kuti musavutike kapena kulowetsedwa.

Nthawi yoti mutenge

Empliciti imaperekedwa pamasiku 28 azithandizo. Nthawi zingati mumamwa mankhwalawa zimadalira mankhwala ena omwe mukumwa ndi Empliciti. Ndandanda yamomwe mudzatengere Empliciti ndi iyi:

• Ngati mukumwa Empliciti ndi lenalidomide (Revlimid) ndi dexamethasone, mudzalandira Empliciti kamodzi pamlungu kwa magawo awiri oyambilira (milungu isanu ndi itatu yonse). Pambuyo pake, mudzalandira Empliciti kamodzi sabata iliyonse.
• Ngati mukumwa Empliciti ndi pomalidomide (Pomalyst) ndi dexamethasone, mudzalandiranso Empliciti kamodzi sabata iliyonse pamayendedwe awiri oyamba (milungu isanu ndi itatu yonse). Pambuyo pake, mudzalandira Empliciti kamodzi kuzungulira kulikonse, komwe kumayesedwa kamodzi pamilungu inayi iliyonse.

Dokotala wanu adzawunika chithandizo chanu ndikudziwitsani kuchuluka kwa kuchuluka kwa Empliciti komwe mungafune.

Ntchito ndi pakati

Sipanakhalepo maphunziro aliwonse a Empliciti mwa amayi apakati. Maphunziro a zinyama ali ndi pakati nawonso sanachitikebe chifukwa cha mankhwalawa.

Komabe, lenalidomide (Revlimid) ndi pomalidomide (Pomalyst), zomwe zimagwiritsidwa ntchito ndi Empliciti, zitha kuvulaza mwana yemwe akukula. Mankhwalawa sayenera kugwiritsidwa ntchito panthawi yapakati. Kugwiritsa ntchito mankhwalawa panthawi yoyembekezera kumatha kubweretsa zopinga zazikulu kapena padera.

Chifukwa Empliciti imavomerezedwa kugwiritsidwa ntchito ndi lenalidomide (Revlimid) kapena pomalidomide (Pomalyst), Empliciti iyeneranso kupeŵedwa panthawi yapakati. Anthu omwe amatenga Empliciti ayenera kugwiritsa ntchito njira zakulera zikafunika. Onani gawo lotsatirali, "Empliciti ndi kulera," kuti mumve zambiri.

Ngati muli ndi mafunso okhudza kugwiritsa ntchito Empliciti panthawi yoyembekezera, lankhulani ndi dokotala wanu.

Ntchito ndi kulera

Sizikudziwika ngati Empliciti ndiotetezeka kutenga nthawi yapakati.

Komabe, lenalidomide (Revlimid) ndi pomalidomide (Pomalyst), zomwe zimagwiritsidwa ntchito ndi Empliciti, zitha kuvulaza mwana yemwe akukula. Mankhwalawa sayenera kugwiritsidwa ntchito panthawi yapakati. Chifukwa Empliciti imavomerezedwa kugwiritsidwa ntchito ndi lenalidomide kapena pomalidomide, Empliciti iyeneranso kupeŵedwa panthawi yapakati.

Chifukwa cha ichi, pulogalamu yapadera yapangidwa yothandiza kupewa mimba kwa anthu omwe amagwiritsa ntchito mankhwalawa. Pulogalamuyi imatchedwa pulogalamu ya Risk Evaluation and Mitigation Strategy (REMS).

Amuna ndi akazi omwe amagwiritsa ntchito Empliciti ayenera kuvomereza ndikutsatira malangizo a Revlimid REMS kapena Pomalyst REMS. Mudzatsata pulogalamu ya REMS pamankhwala aliwonse omwe mukugwiritsa ntchito ndi Empliciti. Pulogalamu iliyonse ili ndi zofunika zina zomwe ziyenera kutsatidwa kuti mupitilize kutenga lenalidomide kapena pomalidomide.

Kuphatikiza pakufunira anthu omwe akutenga Empliciti kuti agwiritse ntchito njira zakulera, pulogalamu ya REMS ikufunikanso kuti:

• muyesedwe pafupipafupi ngati muli ndi pakati, ngati ndinu mkazi wogwiritsa ntchito mankhwalawa
• vomerezani kuti musapereke magazi kapena mbeu iliyonse mukamagwiritsa ntchito mankhwalawa

Kulera kwa amayi

Ngati ndinu azimayi omwe amatha kutenga pakati, muyenera kukhala ndi mayeso awiri olakwika okhudzana ndi pakati musanayambe kugwiritsa ntchito lenalidomide kapena pomalidomide.

Mukamamwa mankhwalawa, muyenera kugwiritsa ntchito njira ziwiri zakulera kapena kupewa kugonana mukamalandira chithandizo. Muyenera kupitiliza kugwiritsa ntchito njira zakulera kapena kupewa kugonana kwa milungu ingapo mutasiya mankhwala.

Kulera kwa amuna

Ngati ndinu bambo amene mumamwa Empliciti ndi lenalidomide kapena pomalidomide, ndipo mukugonana ndi amayi omwe amatha kutenga pakati, muyenera kugwiritsa ntchito njira zakulera (monga makondomu) mukamamwa mankhwala. Izi ndizofunikira kutero ngakhale mnzanu akugwiritsa ntchito njira zakulera. Muyenera kupitiliza kugwiritsa ntchito njira zakulera kwa milungu ingapo mwatha kumwa mankhwala.

Ntchito ndi kuyamwitsa

Palibe maphunziro omwe akuwonetsa ngati Empliciti imadutsa mkaka wa m'mawere kapena ngati zingayambitse mwana woyamwitsa.

Sikudziwikanso ngati lenalidomide (Revlimid) ndi pomalidomide (Pomalyst) zingayambitse mavuto aliwonse mwa ana. Komabe, chifukwa cha kuopsa kwa zovuta zoyipa mwa ana, kuyamwitsa kuyenera kupewedwa mukamamwa Empliciti.

Mafunso wamba okhudza Empliciti

Nawa mayankho pamafunso omwe amafunsidwa zambiri za Empliciti.

Kodi Empliciti chemotherapy?

Ayi, Empliciti samaganiziridwa kuti chemotherapy (mankhwala achikhalidwe omwe amagwiritsidwa ntchito pochiza khansa). Chemotherapy imagwira ntchito popha maselo mthupi lanu omwe akuchulukirachulukira (ndikupanga ma cell ambiri). Ngakhale izi zimapha ma cell a khansa, amathanso kupha ma cell ena athanzi.

Mosiyana ndi chemotherapy wamba, Empliciti ndi mankhwala omwe amatsata. Mankhwala amtunduwu amagwira ntchito pamaselo ena (otchedwa maselo achilengedwe), kuti athe kulunjika maselo a khansa. Chifukwa Empliciti imayang'ana gulu lapadera la ma cell, sizimakhudza ma cell anu athanzi kwambiri. Izi zikutanthauza kuti zimatha kuyambitsa zovuta zochepa kuposa chemotherapy.

Kodi chidzachitike ndi chiyani kuchipatala changa cha Empliciti?

Empliciti imaperekedwa ngati kulowetsedwa kwamitsempha (IV) (jakisoni mumitsempha yanu kwakanthawi). IV nthawi zambiri imayikidwa m'manja mwanu.

Nthawi zambiri mumalandira mulingo umodzi wa Empliciti sabata iliyonse pazithandizo ziwiri zoyambirira. (Kuzungulira kulikonse ndi masiku 28.) Kenako, mutha kulowetsedwa kamodzi pamasabata awiri kapena kamodzi pakadutsa milungu inayi. Gawo ili lanu la dosing limatengera mankhwala omwe mumamwa ndi Empliciti.

Kutalika kwa kulowetsedwa kulikonse kumatengera kulemera kwanu komanso kuchuluka kwa kuchuluka kwa mankhwala omwe mudalandira kale.

Pambuyo pa mlingo wanu wachiwiri wa Empliciti, kulowetsedwa kwanu sikuyenera kutenga nthawi yopitilira ola limodzi. Kungakhale kothandiza kubweretsa china choti muchite mukamakulowetsani kuti nthawi idutse mwachangu. Mwachitsanzo, mutha kubweretsa buku kapena magazini kuti muwerenge kapena nyimbo zoti mumvetsere.

Musanalandire kulowetsedwa kwanu kwa Empliciti, mupeza mankhwala ena othandizira kupewa zovuta zina, kuphatikiza kulowetsedwa. Mankhwalawa amatchedwa mankhwala asanalowetsedwe.

Mankhwala omwe adzalandilidwe musanalowetsedwe ku Empliciti ndi awa:

• diphenhydramine (Benadryl)
• dexamethasone
• acetaminophen (Tylenol)

Ndingadziwe bwanji ngati Empliciti ikugwira ntchito kwa ine?

Empliciti imagwira ntchito pothandizira chitetezo cha mthupi kuti chiteteze ma cell angapo a myeloma. Dokotala wanu amatha kuwona momwe chitetezo chanu chamthupi chimayankhira kuchipatala polamula mayeso kuti aone ngati ali ndi mapuloteni a M.

Mapuloteni a M amapangidwa ndimaselo angapo a myeloma. Mapuloteniwa amatha kumangirira mthupi lanu ndikuwononga ziwalo zina. Mapuloteni apamwamba a M amawoneka mwa anthu omwe ali ndi myeloma yambiri.

Dokotala wanu amatha kuwona kuchuluka kwanu kwamapuloteni a M kuti awone momwe mukuyankhira kuchipatala. M protein itha kuyesedwa poyang'ana magazi kapena mkodzo.

Dokotala wanu amathanso kuwunika momwe mungayankhire mwa kulamula mapangidwe amafupa. Zithunzi izi ziwonetsa ngati mungasinthe mafupa chifukwa cha myeloma yambiri.

Kodi kugwiritsa ntchito Empliciti kungandipangitse kukhala ndi mitundu ina ya khansa?

Zitha kutero. Kugwiritsa ntchito Empliciti kuchiza ma myeloma angapo kumatha kukulitsa chiopsezo chokhala ndi mitundu ina ya khansa.

M'mayesero azachipatala, 9% ya anthu omwe amatenga Empliciti ndi lenalidomide (Revlimid) ndi dexamethasone adapanga khansa yamtundu wina. Mwa anthu omwe amangotenga lenalidomide ndi dexamethasone, 6% idakhala ndi zotsatira zofananira. Mitundu ya khansa yomwe idayamba inali khansa yapakhungu ndi zotupa zolimba, monga khansa ya m'mawere kapena ya prostate.

Komanso m'mayesero azachipatala, 1.8% ya anthu omwe amatenga Empliciti ndi pomalidomide (Pomalyst) ndi dexamethasone adapanga khansa yamtundu wina. Mwa anthu omwe amatenga pomalidomide ndi dexamethasone okha, palibe amene adayambitsa khansa yamtundu wina.

Mukamalandira chithandizo ndi Empliciti, dokotala wanu atha kuyitanitsa zoyezetsa magazi kapena zowunikira kuti zikuwunikireni za khansa yatsopano yomwe ikukula.

Njira zopewera

Musanatenge Empliciti, lankhulani ndi dokotala za mbiri yanu. Empliciti sangakhale oyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Mimba. Sidziwika ngati Empliciti ndi yovulaza kwa mwana yemwe akutukuka kumene. Komabe, Empliciti imagwiritsidwa ntchito ndi lenalidomide (Revlimid) kapena pomalidomide (Pomalyst). Mankhwala onsewa amadziwika kuti amayambitsa zolakwika kubadwa. Chifukwa cha ichi, anthu omwe amatenga lenalidomide kapena pomalidomide ayenera kugwiritsa ntchito njira zolerera popewa kutenga pakati pomwe akugwiritsa ntchito mankhwalawa. Kuti mudziwe zambiri, chonde onani gawo "Empliciti ndi mimba" pamwambapa.
• Kuyamwitsa. Sizikudziwika ngati Empliciti imadutsa mkaka wa m'mawere wa anthu. Komabe, chifukwa cha chiwopsezo cha zovuta zoyipa mwa ana, kuyamwitsa kuyenera kupewedwa mukamamwa Empliciti. Kuti mumve zambiri, onani gawo "Empliciti ndi kuyamwitsa" pamwambapa.
• Matenda apano. Simuyenera kuyamba kumwa Empliciti ngati muli ndi kachilombo koyambitsa matenda. Izi zimaphatikizapo chimfine, fuluwenza, kapena matenda ena a bakiteriya ndi ma virus. Dokotala wanu angakulimbikitseni kuti muyambe Empliciti mutalandira chithandizo cha matenda aliwonse. Izi ndichifukwa choti Empliciti imatha kufooketsa chitetezo cha mthupi lanu, zomwe zimapangitsa kuti zikhale zovuta kulimbana ndi matendawa.

Zindikirani: Kuti mumve zambiri paza zotsatira zoyipa za Empliciti, onani gawo la "Zotsatira za Empliciti" pamwambapa.

Zambiri zamaphunziro a Empliciti

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Empliciti imawonetsedwa kuti imachiza matenda a myeloma angapo mwa anthu omwe ali mgulu la mankhwalawa:

• Akuluakulu omwe adalandirapo chithandizo chimodzi kapena zitatu. Mwa anthuwa, Empliciti imagwiritsidwa ntchito ndi lenalidomide (Revlimid) ndi dexamethasone.
• Akuluakulu omwe alandila kale mankhwala osachepera awiri omwe amaphatikizapo lenalidomide (Revlimid) ndi proteasome inhibitor iliyonse. Mwa anthuwa, Empliciti imagwiritsidwa ntchito ndi pomalidomide (Pomalyst) ndi dexamethasone.

Empliciti sichiwonetsedwa kuti ingagwiritsidwe ntchito kwa anthu ochepera zaka 18.

Njira yogwirira ntchito

Empliciti ndi anti-IgG1 monoclonal anti-immunostimulatory. Empliciti imagwira ntchito yolimbana ndi Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7).

SLAMF7 imafotokozedwa osati kokha pa maselo achilengedwe (NK) ndi ma plasma m'magazi, komanso pama cell angapo a myeloma. Empliciti imagwira ntchito poyambitsa kuwonongedwa kwa maselo a myeloma kudzera mu cytotoxicity (ADCC) ya anti-anti-cellular. Njirayi imagwira ntchito chifukwa cholumikizana pakati pa maselo a NK ndi maselo omwe ali ndi matenda a myeloma. Kafukufuku wina akuwonetsa kuti Empliciti itha kuthandizanso kuyambitsa ma cell a NK, omwe amafufuza ndikuwononga ma cell a myeloma.

Pharmacokinetics ndi metabolism

Chilolezo cha Empliciti chimawonjezeka ndikukula kwa thupi. Empliciti idawonetsa pharmacokinetics yopanda malire, pomwe kuwonjezeka kwa mlingo kunayambitsa kukhudzana ndi mankhwalawa kuposa momwe zidanenedweratu.

Zotsutsana

Empliciti ilibe zotsutsana zenizeni. Komabe, ziyenera kupewedwa mwa amayi apakati akamamwedwa monga akuwonetsera, zomwe zimaphatikizapo kugwiritsa ntchito pomalidomide kapena lenalidomide.

Yosungirako

Empliciti imapezeka ngati 300 mg kapena 400 mg ya lyophilized powder mu botolo limodzi. Ufawo uyenera kupangidwanso ndi kusungunuka usanaperekedwe.

Empliciti ufa uyenera kusungidwa mufiriji (kutentha kwa 36 ° F mpaka 46 ° F / 2 ° C mpaka 8 ° C) ndikutetezedwa ku kuwala. Osazizira kapena kugwedeza mbale.

Ufa ukakhazikitsidwanso, yankho liyenera kulowetsedwa mkati mwa maola 24. Mukasakaniza, ngati kulowetsedwa sikugwiritsidwe ntchito nthawi yomweyo, kuyeneranso kukhala ndi firiji yotetezedwa ku kuwala. Yankho la Empliciti liyenera kusungidwa kwa maola opitilira 8 (a maola 24) kutentha ndi kuwunika kwapakati.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.