Histiocytosis: ndi chiyani, zizindikiro ndi chithandizo

Zamkati

• Zizindikiro zazikulu
• Momwe matendawa amapangidwira
• Momwe muyenera kuchitira

Histiocytosis imafanana ndi gulu la matenda omwe amatha kudziwika ndi kutulutsa kwakukulu komanso kupezeka kwa ma histiocyte omwe amayenda m'magazi, omwe, ngakhale samapezeka, amapezeka pafupipafupi mwa amuna ndipo matenda ake amapangidwa mzaka zoyambirira za moyo, ngakhale zizindikiro zowonetsa Matenda amathanso kuonekera msinkhu uliwonse.

Ma Histiocyte ndi maselo omwe amachokera ku monocyte, omwe ndi maselo a chitetezo cha mthupi, motero amateteza chitetezo cha thupi. Pambuyo pochita masiyanidwe ndi kusasitsa, ma monocyte amadziwika kuti macrophages, omwe amapatsidwa dzina lenileni kutengera komwe amawonekera mthupi, amatchedwa maselo a Langerhans akapezeka mu epidermis.

Ngakhale histiocytosis imakhudzana kwambiri ndi kusintha kwa kupuma, ma histiocyte amatha kupezeka m'ziwalo zina, monga khungu, mafupa, chiwindi ndi dongosolo lamanjenje, zomwe zimabweretsa zizindikilo zosiyanasiyana kutengera komwe kuchuluka kwa ma histiocyte kukufalikira.

Zizindikiro zazikulu

Histiocytosis imatha kukhala yopanda tanthauzo kapena kupita patsogolo mpaka kuyamba kwa zizindikilo mwachangu. Zizindikiro zosonyeza kuti histiocytosis imatha kusiyanasiyana kutengera komwe kuli kupezeka kwa ma histiocyte. Chifukwa chake, zizindikilo zazikulu ndi izi:

• Chifuwa;
• Malungo;
• Kuchepetsa thupi popanda chifukwa chomveka;
• Kupuma kovuta;
• Kutopa kwambiri;
• Kusowa magazi;
• Chiwopsezo chachikulu cha matenda;
• Mavuto a coagulation;
• Zotupa pakhungu;
• Kupweteka m'mimba;
• Kupweteka;
• Kuchedwa msinkhu;
• Chizungulire.

Kuchuluka kwa ma histiocyte kumatha kubweretsa kupangika kwambiri kwa ma cytokines, kuyambitsa njira yotupa ndikulimbikitsa mapangidwe am'mimba, kuphatikiza pakuwononga ziwalo zomwe kutsimikizika kwa maselowa kumatsimikizika. Ndizofala kwambiri kuti histiocytosis imakhudza mafupa, khungu, chiwindi ndi mapapo, makamaka ngati pali mbiri yakusuta. Pafupipafupi, histiocytosis imatha kuphatikizira dongosolo lamanjenje, ma lymph node, m'mimba komanso chithokomiro.

Chifukwa chakuti chitetezo cha ana sichinakule bwino, ndizotheka kuti ziwalo zingapo zimakhudzidwa mosavuta, zomwe zimapangitsa kuzindikira koyambirira komanso kuyamba kwa chithandizo ndikofunikira nthawi yomweyo.

Momwe matendawa amapangidwira

Kuzindikira kwa histiocytosis kumapangidwa makamaka ndi biopsy ya tsamba lomwe lakhudzidwa, pomwe limatha kuwunikiridwa kudzera pakuwunika kwa labotale pansi pa microscope, kupezeka kwa kulowerera ndikuchulukirachulukira kwa ma histiocyte mu mnofu womwe kale unali wathanzi.

Kuphatikiza apo, mayesero ena otsimikizira kuti ali ndi matendawa, monga computed tomography, kafukufuku wosintha komwe kumakhudzana ndi matendawa, monga BRAF, mwachitsanzo, kuphatikiza mayeso a immunohistochemical ndi kuchuluka kwa magazi, komwe kungasinthe kuchuluka kwa ma neutrophils , ma lymphocyte ndi ma eosinophil.

Momwe muyenera kuchitira

Chithandizo cha histiocytosis chimadalira kukula kwa matendawa ndi tsamba lomwe lakhudzidwa, ndipo chemotherapy, radiotherapy, kugwiritsa ntchito mankhwala osokoneza bongo kapena opaleshoni ndikulimbikitsidwa, makamaka pankhani ya mafupa. Ngati histiocytosis imayamba chifukwa cha kusuta, mwachitsanzo, kusiya kusuta kumalimbikitsidwa, zomwe zimapangitsa kuti wodwalayo akhale wolimba.

Nthawi zambiri, matendawa amatha kuchira okha kapena kutha chifukwa chothandizidwa, komabe amathanso kuwonekeranso. Chifukwa chake, ndikofunikira kuti munthuyo aziyang'aniridwa pafupipafupi kuti adotolo athe kuwona ngati pali chiwopsezo chotenga matendawa, motero, kukhazikitsa chithandizo kumayambiriro.