Kodi Psoriasis Ndi Matenda Odzidzimutsa?

Zamkati

• Chidule
• Kumvetsetsa matenda am'magazi
• Mikhalidwe yodziwika yokha
• Psoriasis ngati matenda omwe amadzichitira okha
• Mankhwala omwe amalimbana ndi chitetezo cha mthupi
• Mankhwala achikulire
• Zamoyo
• Otsutsa a TNF
• Zamoyo zatsopano
• Psoriasis ndi chiopsezo cha mikhalidwe ina yodzitchinjiriza
• Maganizo ake

Chidule

Psoriasis ndi khungu lotupa lomwe limadziwika ndi zigamba zofiira pakhungu lokutidwa ndi sikelo zoyera. Ndi matenda osatha. Zizindikiro zimatha kubwera ndikupita, ndipo zimatha kukhala zovuta.

Psoriasis ndichizolowezi, chomwe chimakhudza pafupifupi 3 peresenti ya anthu padziko lonse lapansi. Pafupifupi anthu 7.4 miliyoni ku United States ali ndi psoriasis.

Zomwe zimayambitsa psoriasis sizitsimikizika. Amaganiziridwa kuti ndi kuphatikiza kwa majini, zinthu zachilengedwe, komanso chitetezo chamthupi chanu.

Kutengera ndi kafukufuku wazaka zingapo zapitazi, psoriasis amadziwika kuti ndi matenda omwe amadzichotsera okha. Izi zikutanthauza kuti ma chitetezo amthupi anu, otchedwa T cell, amalakwitsa molakwika maselo anu akhungu ngati olowa kunja. Izi zimapangitsa kuti khungu lanu lichuluke msanga, zomwe zimabweretsa zotupa za khungu la psoriasis.

Osati onse ofufuza amaganiza kuti psoriasis ndimatenda amthupi okha. Ena amavomereza kuti psoriasis ndimavuto otetezedwa ndi chitetezo cha mthupi. Koma lingaliro lawo ndiloti psoriasis amachokera kuzinthu zosazolowereka zokhudzana ndi majini kubakiteriya wakhungu.

Kumvetsetsa matenda am'magazi

Nthawi zambiri chitetezo chamthupi chanu chimazindikira ma cell anu ndipo sichimawaukira. Matenda omwe amadzichotsera okha ndi pomwe chitetezo chanu chamthupi chimalowerera molakwika maselo athanzi ngati kuti anali akunja olimbana ndi thupi lanu.

Pali matenda opitilira 100 omwe amadzichotsera okha. Matenda omwe amadzichiritsira okha amakhala ndi gawo limodzi lokha la thupi lanu - monga khungu lanu mu psoriasis. Zina ndi zamachitidwe, zomwe zimakhudza thupi lanu lonse.

Zomwe zovuta zonse zama auto zimafanana ndikuti zimayambitsidwa ndi kuphatikiza kwa majini komanso zinthu zachilengedwe.

Momwemo majini ndi zochitika zachilengedwe zimayanjanirana kuti zimayambitse matenda osiyanasiyana ndiye mutu wofufuza mosalekeza.

Pakadali pano, chomwe chikudziwika ndikuti anthu omwe ali ndi vuto lobadwa nawo podzitchinjiriza atha kukhala ndi mwayi wochulukitsa matenda a autoimmune monga anthu omwe alibe chibadwa.

Gulu la majini omwe akukhudzidwa amatchedwa zovuta za histocompatibility, zotchedwa HLA. HLA ndiyosiyana ndi aliyense payekha.

Zomwe zimapangitsa kuti thupi liziyenda lokha limatha kuyenda m'mabanja, koma abale amatha kukhala ndi zovuta zosiyanasiyana. Komanso, ngati muli ndi vuto limodzi lokha, mumakhala pachiwopsezo chachikulu chotenga lina.

Pali zochepa zomwe zimadziwika pazomwe zimayambitsa zachilengedwe zomwe zimayambitsa matenda amthupi mwa munthu yemwe ali ndi chibadwa chodzipangitsa kudzitchinjiriza.

Mikhalidwe yodziwika yokha

Nazi zina mwazovuta zodziwika bwino za autoimmune:

• matenda a leliac (amachokera ku gluten)
• mtundu wa 1 shuga
• matenda otupa matumbo, kuphatikiza a Crohn's
• lupus (systemic lupus erythematosus, yomwe imakhudza khungu, impso, mafupa, ubongo, ndi ziwalo zina)
• nyamakazi (kutupa kwa mafupa)
• Matenda a Sjögren (kuuma mkamwa mwako, maso, ndi malo ena)
• vitiligo (kutayika kwa khungu, komwe kumayambitsa zigamba zoyera)

Psoriasis ngati matenda omwe amadzichitira okha

Asayansi ambiri masiku ano amakhulupirira kuti psoriasis ndimatenda amthupi okha. Zakhala zikudziwika kale kuti chitetezo cha mthupi chimakhudzidwa ndi psoriasis. Koma makina enieniwo sali otsimikiza.

M'zaka makumi awiri zapitazi, kafukufuku watsimikizira kuti majini ndi magulu amtundu wokhudzana ndi psoriasis amakhala ndi zovuta zodziwika zokha. Kafukufuku adatsimikiziranso kuti mankhwala a immunosuppressant ndi mankhwala atsopano a psoriasis. Mankhwalawa amagwira ntchito popondereza chitetezo cha mthupi chomwe chikuwononga minofu yathanzi.

Kafukufuku akupitilirabe pantchito yama cell a chitetezo cha mthupi mu psoriasis. Maselo a T ndi "asilikali" a chitetezo cha mthupi omwe nthawi zambiri amalimbana ndi matenda. Maselo a T akamayaka moto m'malo mwake amenyana ndi khungu labwino, amatulutsa mapuloteni apadera otchedwa cytokines. Izi zimapangitsa khungu kuti lichuluke ndikukula pakhungu lanu, zomwe zimabweretsa zilonda zam'mimba.

Nkhani ya 2017 inanena za kafukufuku watsopano yemwe wazindikira kuyanjana kwamaselo ena a T ndi ma interleukin omwe amadziwika kale kuti akuchita nawo psoriasis. Monga momwe zadziwika bwino, zitha kukhala zotheka kupanga njira zatsopano zamankhwala.

Mankhwala omwe amalimbana ndi chitetezo cha mthupi

Chithandizo cha psoriasis chimatengera mtundu ndi kuopsa kwa vutoli, thanzi lanu, ndi zina.

Nawa mankhwala osiyanasiyana omwe amakhudzana ndi chitetezo cha mthupi chomwe chimayambitsa kutupa. Izi zimagwiritsidwa ntchito ngati zizindikiro zanu za psoriasis zimakhala zochepa kwambiri. Dziwani kuti mankhwala atsopano ndiokwera mtengo.

Mankhwala achikulire

Mankhwala awiri achikulire omwe amapondereza chitetezo cha mthupi komanso kuwonekera kwa psoriasis ndi methotrexate ndi cyclosporine. Zonsezi ndizothandiza, koma zimakhala ndi zotsatirapo zoyipa zikagwiritsidwa ntchito kwakanthawi.

Zamoyo

Otsutsa a TNF

Mankhwala aposachedwa kwambiri amayang'ana chinthu chomwe chimayambitsa kutupa kotchedwa tumor necrosis factor (TNF). TNF ndi cytokine yopangidwa ndi chitetezo chamthupi monga ma T cell. Mankhwala atsopanowa amatchedwa antagonists a TNF.

Mankhwala a anti-TNF ndi othandiza, koma ocheperako kuposa ma biologics atsopano. Mankhwala osokoneza bongo a TNF ndi awa:

• adalimumab (Humira)
• etanercept (Enbrel)
• infliximab (Kutulutsa)
• chitsimikizo cha pegol (Cimzia)

Zamoyo zatsopano

Ma biologics aposachedwa kwambiri amalola ndikuletsa njira zina za T ndi ma interleukin omwe amapezeka mu psoriasis. Ma biologics atatu omwe amayang'ana IL-17 avomerezedwa kuyambira 2015:

• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)

Mankhwala ena amayesetsa kutsekereza njira ina ya interleukin (I-23 ndi IL-12):

• ustekinuman (Stelara) (IL-23 ndi IL-12)
• guselkumab (Tremfya) (IL-23)
• tildrakizumab-asmn (Ilumya) (IL-23)
• risankizumab-rzaa (Skyrizi) (IL-23)

Izi biologics zatsimikizira kukhala zotetezeka komanso zothandiza.

Psoriasis ndi chiopsezo cha mikhalidwe ina yodzitchinjiriza

Kukhala ndi matenda amodzi mthupi monga psoriasis kumakuyikani kuti mupange matenda ena amthupi okha. Chiwopsezo chikuwonjezeka ngati psoriasis yanu ili yayikulu.

Magulu amtundu womwe amakukonzekeretsani kuti mukhale ndi vuto lodziyimira palokha ndi ofanana pamitundu yosiyanasiyana yamatenda amthupi. Zina mwazotupa ndi zochitika zachilengedwe ndizofanananso.

Mavuto akulu omwe amabwera chifukwa cha psoriasis ndi awa:

• psoriatic arthritis, yomwe imakhudza 30 mpaka 33 peresenti ya anthu omwe ali ndi nyamakazi
• nyamakazi
• matenda a celiac
• Matenda a Crohn ndi matenda ena amatumbo
• matenda ofoola ziwalo
• lupus (systemic lupus erythematosus kapena SLE)
• matenda a chithokomiro
• Matenda a Sjögren
• kutayika kwa tsitsi lanu (alopecia areata)
• oopsa pemphigoid

The psoriasis ili ndi nyamakazi ya nyamakazi.

Ubwenzi wa psoriasis ndi matenda ena am'thupi ndi mutu wakupitiliza kuphunzira. Komanso kuphunzira ndi kuyanjana kwa psoriasis ndikumwalira kwamatenda amenewo.

Maganizo ake

Maganizo a anthu omwe ali ndi psoriasis ndiabwino kwambiri. Matendawa sangachiritsidwe, koma chithandizo chamakono chimatha kuchepetsa zizindikilo.

Kafukufuku wamankhwala akupitilizabe kupeza zambiri zazomwe zimayambitsa psoriasis ndi zovuta zina za autoimmune. Kupeza kwatsopano kumeneku kumathandizira pakupanga mankhwala atsopano omwe amayang'anitsitsa ndikuletsa matenda.

Mwachitsanzo, mankhwala ena atsopano okhudzana ndi interleukin-23 tsopano ali m'mayesero azachipatala. Njira zina zatsopano zitha kutuluka pakufufuza komwe kumachitika pazovuta zama auto.

Lankhulani ndi dokotala wanu za kutenga nawo mbali pazoyeserera zamankhwala zomwe zikuchitika komanso za zatsopano. Mwinanso mungafune kulowa nawo gulu lothandizira pa psoriasis / PsA lapaintaneti.