Kodi mastocytosis ndi chiyani, mitundu, zizindikiro ndi chithandizo

Zamkati

• Mitundu ya mastocytosis
• Zizindikiro za mastocytosis
• Kodi chithandizo

Mastocytosis ndi matenda osowa omwe amadziwika ndi kuwonjezeka ndi kuchuluka kwa maselo amtundu pakhungu ndi ziwalo zina za thupi, zomwe zimapangitsa mawanga ndi mawanga ang'ono ofiira ofiira pakhungu lomwe limayabwa kwambiri, makamaka pakasintha kutentha ndi khungu likakhudzana ndi zovala, mwachitsanzo.

Maselo akulu ndi maselo omwe amapangidwa m'mafupa, omwe amapezeka m'matumba osiyanasiyana mthupi ndipo amathanso kulumikizana ndi chitetezo cha mthupi, makamaka poyankha. Komabe, mosiyana ndi chifuwa, zizindikilo za mastocytosis ndizanthawi yayitali ndipo sizogwirizana ndi zomwe zimayambitsa.

Ndikofunika kuti mastocytosis izindikiridwe ndikuchiritsidwa malinga ndi malangizo a dokotala, chifukwa nthawi zina imathanso kukhudzana ndi zovuta zina zamagazi, monga leukemia, lymphoma, neutropenia yanthawi yayitali komanso kusintha kwa myeloproliferative.

Mitundu ya mastocytosis

Mastocytosis imachitika m'maselo amtunduwu akamachulukirachulukira ndikuchulukirachulukira m'thupi ndipo, kutengera komwe maselowa amapezeka, mastocytosis amatha kugawidwa kukhala:

• Matenda a mastocytosis, momwe ma cell am'madzi amadziunjikira pakhungu, zomwe zimapangitsa kuti ziwonekere zizikhala zazizindikiro, kukhala pafupipafupi mwa ana;
• Mastocytosis yokhazikika, momwe ma cell am'madzi amadzipezera m'matumba ena amthupi, makamaka m'mafupa, zomwe zimasokoneza kupanga maselo amwazi. Kuphatikiza apo, pamtundu wa mastocytosis, ma cell amtundu amatha kudziunjikira pachiwindi, ndulu, ma lymph node ndi m'mimba, ndipo amatha kusokoneza, nthawi zina, pakugwira ntchito kwa limba.

Kuyambira pomwe pamakhala ma cell ochulukirapo pamalopo, zizindikilo ndi zisonyezo zosonyeza matenda zikuwoneka, ndipo ndikofunikira kukaonana ndi adotolo kuti mayeso athe kuchitidwa kuti athe kumaliza matendawa ndikuyamba chithandizo choyenera.

Zizindikiro za mastocytosis

Zizindikiro za mastocytosis zimatha kusiyanasiyana kutengera mtunduwo ndipo ndizokhudzana ndi kufalikira kwa histamine. Izi ndichifukwa choti ma mast cell amapangidwa ndi ma granules omwe amatulutsa histamine. Chifukwa chake, kukwera kwa ma cell am'magazi, kuchuluka kwa histamine kumadzetsa zizindikilo za mastocytosis, zazikuluzikulu ndizo:

• Urticaria ya nkhumba, yomwe ndi mawanga ang'onoang'ono ofiira ofiira pakhungu lomwe limatha kuyabwa;
• Chilonda chachikulu;
• Mutu;
• Kupindika;
• Kusanza;
• Matenda otsekula m'mimba;
• Kupweteka m'mimba;
• Kumva chizungulire podzuka;
• Mimbulu ndi zala dzanzi.

Nthawi zina, zizindikiro za mastocytosis zimatha kukulira pakasintha kutentha, mutadya zakudya zotentha kapena zokometsera kapena zakumwa, mutatha kuchita masewera olimbitsa thupi, mutayanjana ndi zovala kapena chifukwa chogwiritsa ntchito mankhwala.

Kuzindikira kwa mastocytosis kumachitika pogwiritsa ntchito mayeso amwazi omwe cholinga chake ndi kuzindikira milingo ya histamine ndi prostaglandin D2 m'magazi, omwe amayenera kusonkhanitsidwa nthawi yovutayi itatha, kapena mkodzo wa maola 24.

Kuphatikiza apo, pakafunika mastocytosis yochepetsetsa, kuyesanso kwa histological kumatha kuchitidwanso, momwe zitsanzo zazing'onoting'ono zimasonkhanitsidwa ndikutumizidwa ku labotale kuti zikaunikidwe ndikuwunika ngati pali kuchuluka kwa ma mast cell mu mnofu .

Kodi chithandizo

Chithandizo cha mastocytosis chikuyenera kutsogozedwa ndi immunoallergologist kapena dokotala wamba malinga ndi kuchuluka kwa histamine, mbiri yaumoyo wa munthu ndi zizindikiritso zake.

Nthawi zambiri, adokotala amalimbikitsa kugwiritsa ntchito mankhwala ochepetsa zizindikilo, makamaka antihistamines ndi mafuta a corticosteroid ndi mafuta. Komabe, pamene zizindikilo zikuwonjezeka kwambiri, makamaka zikafika ku systemic mastocytosis, chithandizo chitha kukhala chovuta kwambiri, ndipo nthawi zina kuchitidwa opaleshoni kumafunika.