Ubwino Wapamwamba Wapamwamba wa 9 wa NAC (N-Acetyl Cysteine)

Zamkati

• 1. Chofunikira Kupanga Mphamvu Antioxidant Glutathione
• 2. Amathandiza Ndi Kuwononga Mafuta Popewa kapena Kuchepetsa Kuwonongeka kwa Impso ndi Chiwindi
• 3. Atha Kukweza Mavuto Amisala ndi Khalidwe Loyeserera
• 4. Amathandiza Kuthetsa Zizindikiro Za Kupuma
• 5. Imalimbikitsa Ubongo Wathanzi Poyang'anira Glutamate ndikubwezeretsanso Glutathione
• 6. Athandize Kuchulukitsa Kuchuluka Kwa Amuna Ndi Akazi
• 7. Itha Kukhazikika Magazi A shuga Pochepetsa Kutupa M'maselo Amafuta
• 8. Mulole Kuchepetsa Matenda a Mtima Polepheretsa Kuwonongeka Kwa Oxidative
• 9. Mphamvu Zolimbikitsira Magulu a Glutathione Atha Kukweza Ntchito Zamagazi
• Mlingo
• Zotsatira zoyipa
• Mfundo Yofunika Kwambiri

Cysteine ​​ndi theka la amino acid.

Amayesedwa kuti ndi ofunikira chifukwa thupi lanu limatha kutulutsa kuchokera ku ma amino acid ena, omwe ndi methionine ndi serine. Zimakhala zofunika pokhapokha kudya kwa methionine ndi serine ndikotsika.

Cysteine ​​imapezeka mu zakudya zambiri zamapuloteni, monga nkhuku, Turkey, yogurt, tchizi, mazira, mbewu za mpendadzuwa ndi nyemba.

N-acetyl cysteine ​​(NAC) ndi mtundu wowonjezera wa cysteine.

Kugwiritsa ntchito cysteine ​​yokwanira ndi NAC ndikofunikira pazifukwa zosiyanasiyana - kuphatikiza kubwezeretsa antioxidant wamphamvu kwambiri m'thupi lanu, glutathione. Izi amino acid zimathandizanso kupuma kosalekeza, chonde komanso thanzi laubongo.

Nayi maubwino 9 apamwamba azaumoyo a NAC.

1. Chofunikira Kupanga Mphamvu Antioxidant Glutathione

NAC imayamikiridwa makamaka chifukwa cha ntchito yake pakupanga antioxidant.

Pamodzi ndi ma amino acid ena awiri - glutamine ndi glycine - NAC imafunikira kupanga ndikubwezeretsa glutathione.

Glutathione ndi imodzi mwazida zofunika kwambiri m'thupi, zomwe zimathandizira kusinthitsa zopitilira muyeso zomwe zitha kuwononga maselo ndi minyewa mthupi lanu.

Ndizofunikira pa chitetezo cha mthupi komanso polimbana ndi kuwonongeka kwama cell. Ofufuza ena amakhulupirira kuti zitha kuthandizira kukhala ndi moyo wautali ().

Katemera wa antioxidant ndiwofunikanso kuthana ndi matenda ena ambiri obwera chifukwa cha kupsinjika kwa oxidative, monga matenda amtima, kusabereka komanso matenda amisala ().

Chidule NAC imathandizira kubwerezanso glutathione, mwina antioxidant yamphamvu kwambiri mthupi lanu. Chifukwa chake, imatha kusintha zinthu zosiyanasiyana zathanzi.

2. Amathandiza Ndi Kuwononga Mafuta Popewa kapena Kuchepetsa Kuwonongeka kwa Impso ndi Chiwindi

NAC imagwira gawo lofunikira pakuwononga thupi lanu.

Itha kuthandiza kupewa zovuta zamankhwala osokoneza bongo komanso poizoni wachilengedwe ().

M'malo mwake, madokotala nthawi zonse amapereka intravenous (IV) NAC kwa anthu omwe ali ndi acetaminophen overdose kuti ateteze kapena kuchepetsa kuwonongeka kwa impso ndi chiwindi ().

NAC imagwiritsanso ntchito matenda ena a chiwindi chifukwa cha ma antioxidant komanso anti-inflammatory ().

Chidule NAC imathandizira kuwononga thupi lanu ndipo imatha kuthana ndi acetaminophen overdoses.

3. Atha Kukweza Mavuto Amisala ndi Khalidwe Loyeserera

NAC imathandizira kuwongolera kuchuluka kwa glutamate - neurotransmitter yofunikira kwambiri muubongo wanu ().

Ngakhale kuti glutamate imafunika kuti ubongo ugwire bwino ntchito, kuchuluka kwa glutamate kophatikizidwa ndi kutha kwa glutathione kumatha kuwononga ubongo.

Izi zitha kupangitsa thanzi lamaganizidwe, monga matenda a bipolar, schizophrenia, obsessive-compulsive disorder (OCD) ndimakhalidwe osokoneza bongo (7,).

Kwa anthu omwe ali ndi matenda ochititsa munthu kusinthasintha zochitika komanso kupsinjika maganizo, NAC itha kuthandiza kuchepetsa zizindikilo ndikuwonjezera luso lanu logwira ntchito. Kuphatikiza apo, kafukufuku akuwonetsa kuti itha kutenga nawo mbali pochiza OCD (,).

Momwemonso, kafukufuku wazinyama amatanthauza kuti NAC itha kuchepetsa zovuta zoyipa za schizophrenia, monga kuchoka pagulu, mphwayi ndikuchepetsa chidwi ().

Zowonjezera za NAC zitha kuthandizanso kuchepetsa zizindikiritso zakulephera komanso kupewa kubwereranso ku mankhwala osokoneza bongo a cocaine (,).

Kuphatikiza apo, kafukufuku woyambirira akuwonetsa kuti NAC ichepetsa kuchepa kwa chamba ndi chikonga ndi zikhumbo (, 15).

Ambiri mwa mavutowa ali ndi njira zochepa zothandizira pakadali pano kapena zosagwira ntchito. NAC itha kukhala yothandiza kwa anthu omwe ali ndi izi ().

Chidule Poyang'anira kuchuluka kwa glutamate muubongo wanu, NAC imatha kuchepetsa zizindikilo zamavuto amisala angapo ndikuchepetsa chizolowezi chomachita.

4. Amathandiza Kuthetsa Zizindikiro Za Kupuma

NAC imatha kuthetsa zizindikilo za kupuma mwa kuchita ngati antioxidant ndi expectorant, kumasula mamina mumayendedwe anu amlengalenga.

Monga antioxidant, NAC imathandizira kubwerezanso kuchuluka kwa glutathione m'mapapu anu ndikuchepetsa kutupa m'machubu ndi m'mapapu.

Anthu omwe ali ndi matenda osokoneza bongo (COPD) amatha kuwonongeka kwa okosijeni kwakanthawi komanso kutupa kwa minyewa yam'mapapo, yomwe imapangitsa kuti mpweya uzipindika - zomwe zimapangitsa kupuma pang'ono komanso kutsokomola.

Zowonjezera za NAC zakhala zikugwiritsidwa ntchito kukonza zizindikiro za COPD, kukulitsa komanso kuchepa kwamapapo (,, 19).

Pakafukufuku wa chaka chimodzi, 600 mg ya NAC kawiri patsiku imathandizira magwiridwe antchito am'mapapo komanso zizindikiritso mwa iwo omwe ali ndi COPD yokhazikika ().

Omwe ali ndi bronchitis osachiritsika amathanso kupindula ndi NAC.

Bronchitis imachitika pomwe mamina am'mapapu anu amatuluka, kutupira ndikutseka mayendedwe ampweya m'mapapu anu (,).

Pochepetsa mamina m'matumba anu am'magazi komanso kukulitsa kuchuluka kwa glutathione, NAC itha kuthandizira kuchepa kwamphamvu komanso pafupipafupi kupuma, kutsokomola komanso kupuma (23).

Kuphatikiza pakuthandizira COPD ndi bronchitis, NAC itha kusintha zina zam'mapapo ndi njira zopumira monga cystic fibrosis, asthma ndi pulmonary fibrosis, komanso zizindikilo za mphuno ndi sinus chifukwa cha chifuwa kapena matenda ().

Chidule Mphamvu ya NAC ya antioxidant ndi expectorant imatha kukonza magwiridwe antchito a mapapo pochepetsa kutupa komanso kuswa ntchofu.

5. Imalimbikitsa Ubongo Wathanzi Poyang'anira Glutamate ndikubwezeretsanso Glutathione

Kukhoza kwa NAC kudzaza glutathione ndikuwongolera kuchuluka kwa ma glutamate muubongo kumatha kukulitsa thanzi laubongo.

Ubongo wa neurotransmitter glutamate umakhudzidwa ndimaphunziro osiyanasiyana, machitidwe ndi kukumbukira, pomwe antioxidant glutathione imathandizira kuchepetsa kuwonongeka kwa okosijeni m'maselo aubongo okhudzana ndi ukalamba ().

Chifukwa NAC imathandizira kuwongolera kuchuluka kwa glutamate ndikubwezeretsanso glutathione, itha kupindulitsa iwo omwe ali ndi matenda am'magazi komanso kukumbukira ().

Matenda aubongo Matenda a Alzheimer amachepetsa kuphunzira kwa munthu komanso kukumbukira kwake. Kafukufuku wa zinyama akuwonetsa kuti NAC ichepetsa kuchepa kwa kuthekera kwazindikiritso mwa anthu omwe ali ndi Alzheimer's (,).

Matenda ena aubongo, matenda a Parkinson, amadziwika ndi kuwonongeka kwa maselo omwe amapanga neurotransmitter dopamine. Kuwonongeka kwa okosijeni m'maselo ndi kuchepa kwa mphamvu ya antioxidant kumayambitsa matendawa.

Zowonjezera za NAC zimawoneka kuti zikuthandizira kugwira ntchito kwa dopamine komanso zizindikilo zamatenda monga kunjenjemera ().

Ngakhale NAC itha kusintha thanzi laubongo, kafukufuku wowonjezera wa anthu amafunikira kuti apange ziganizo zomveka.

Chidule Pothandiza kubwezeretsanso antioxidant glutathione ndikuwongolera glutamate, NAC imatha kuthana ndi matenda monga Alzheimer's and Parkinson.

6. Athandize Kuchulukitsa Kuchuluka Kwa Amuna Ndi Akazi

Pafupifupi 15% mwa mabanja onse omwe akuyesera kutenga pakati amakhudzidwa ndi kusabereka. Pafupifupi theka la milanduyi, kusabereka kwa amuna ndiye chinthu chofunikira kwambiri ().

Amuna ambiri omwe amabereka osabereka amachulukirachulukira pomwe ma antioxidant osakwanira kuthana ndi mapangidwe aulere muubereki wanu. Kupsinjika kwa oxidative kumatha kuyambitsa kufa kwa cell ndikuchepetsa kubereka ().

Nthawi zina, NAC yawonetsedwa kuti ikuthandizira kubereka.

Vuto lina lomwe limapangitsa kuti abambo azikhala osabereka ndi varicocele - pomwe mitsempha mkati mwa scrotum imakulitsidwa chifukwa cha kuwonongeka kwakukulu kwaulere. Opaleshoni ndiyo mankhwala oyamba.

Pakafukufuku wina, amuna 35 omwe ali ndi varicocele adapatsidwa 600 mg ya NAC patsiku kwa miyezi itatu atachitidwa opaleshoni. Kuphatikiza kwa opareshoni ndi othandizira a NAC kumathandizira kukhulupirika kwa umuna komanso kuchuluka kwa pakati pa 22% poyerekeza ndi gulu lolamulira ().

Kafukufuku wina mwa amuna 468 omwe ali osabereka adapeza kuti kuwonjezera ndi 600 mg ya NAC ndi 200 mcg wa selenium kwa masabata 26 kwapangitsa kuti umuna ukhale wabwino ().

Ofufuzawo akuti kuphatikiza kophatikizaku kuyenera kuchitidwa ngati njira yothandizira osabereka.

Kuphatikiza apo, NAC itha kupititsa patsogolo chonde kwa amayi omwe ali ndi polycystic ovary syndrome (PCOS) potulutsa kapena kuwonjezera kuzungulira kwa ovulation ().

Chidule NAC itha kuthandiza kukonza kubala mwa amuna pochepetsa kupsinjika kwa oxidative komwe kumawononga kapena kupha maselo oberekera. Zitha kuthandizanso kubereka mwa amayi omwe ali ndi PCOS.

7. Itha Kukhazikika Magazi A shuga Pochepetsa Kutupa M'maselo Amafuta

Shuga wamagazi ambiri ndi kunenepa kwambiri kumathandizira kutupa kwamafuta.

Izi zitha kubweretsa kuwonongeka kapena kuwonongeka kwa ma insulin receptors ndikukuyikani pachiwopsezo chachikulu cha matenda amtundu wa 2 ().

Kafukufuku wazinyama akuwonetsa kuti NAC itha kukhazikika shuga wamagazi pochepetsa kutupa m'maselo amafuta motero kutulutsa kukana kwa insulin (,).

Ma insulin receptors atakhala olimba komanso athanzi, amachotsa shuga m'magazi anu moyenera, osasunthika.

Komabe, kumbukirani kuti kafukufuku wa anthu pa NAC amafunikira kuti atsimikizire izi pakulamulira shuga.

Chidule Pochepetsa kutupa kwamafuta, NAC imatha kuchepetsa kukana kwa insulin ndikusintha kayendedwe ka shuga wamagazi, koma kafukufuku wofufuza za anthu akusowa.

8. Mulole Kuchepetsa Matenda a Mtima Polepheretsa Kuwonongeka Kwa Oxidative

Kuwonjezeka kwa okosijeni pamatenda amtima nthawi zambiri kumayambitsa matenda amtima, kuyambitsa zilonda, matenda amtima ndi zina zovuta.

NAC ikhoza kuchepetsa chiwopsezo cha matenda amtima pochepetsa kuwonongeka kwa okosijeni m'matenda mumtima mwanu ().

Zikuwonetsanso kuti zikuwonjezera kupanga kwa nitric oxide, komwe kumathandiza mitsempha kutulutsa ndikusintha magazi. Izi zimafulumizitsa kupititsa magazi kubwerera mumtima mwanu ndipo kumachepetsa chiopsezo chanu cha mtima ().

Chosangalatsa ndichakuti kafukufuku wofufuza adawonetsa kuti - ikaphatikizidwa ndi tiyi wobiriwira - NAC ikuwoneka kuti ichepetsa kuwonongeka kuchokera ku cholesterol "choyipa" cha LDL, chomwe chimathandizira matenda amtima ().

Chidule NAC imatha kuchepetsa kuwonongeka kwa okosijeni pamtima panu, zomwe zingachepetse chiopsezo cha matenda amtima.

9. Mphamvu Zolimbikitsira Magulu a Glutathione Atha Kukweza Ntchito Zamagazi

NAC ndi glutathione zimalimbikitsanso chitetezo chamthupi.

Kafukufuku wokhudzana ndi matenda ena omwe amadza chifukwa cha kuchepa kwa NAC komanso kusowa kwa glutathione akuwonetsa kuti chitetezo chamthupi chitha kusintha - ndikubwezeretsanso - powonjezera NAC ().

Izi zawerengedwa kwambiri mwa anthu omwe ali ndi kachilombo ka HIV.

M'maphunziro awiri, kuphatikiza ndi NAC kudapangitsa kuwonjezeka kwakukulu kwa chitetezo chamthupi - ndikubwezeretsa kwathunthu kwa ma cell omwe amapha achilengedwe (,,).

Magulu apamwamba a NAC mthupi lanu amathanso kupondereza kubereka kwa HIV-1 ().

Kafukufuku woyeserera adawonetsa kuti munthawi zina zomwe zimafooka mthupi, monga chimfine, NAC itha kulepheretsa kuti kachilombo kangobwereza. Izi zitha kuchepetsa zizindikilo ndi utali wamatenda ().

Mofananamo, maphunziro ena oyeserera adalumikiza NAC ndi kufa kwa ma cell a khansa ndikuletsa kubwereza kwa cell ya khansa (,).

Ponseponse, maphunziro owonjezera aumunthu amafunikira. Chifukwa chake, onetsetsani kuti mwalankhula ndi dokotala musanatenge NAC mukamalandira khansa ().

Chidule Kukhoza kwa NAC kukulitsa milingo ya glutathione kumatha kupititsa patsogolo chitetezo cha mthupi m'matenda osiyanasiyana.

Mlingo

Palibe malingaliro azakudya za cysteine ​​chifukwa thupi lanu limatha kupanga zochepa.

Kuti thupi lanu lipange amino acid cysteine, muyenera kuchuluka kwa mavitamini, vitamini B6 ndi vitamini B12. Zakudya izi zimapezeka mu nyemba, mphodza, sipinachi, nthochi, nsomba ndi nsomba.

Ngakhale zakudya zambiri zamapuloteni, monga nkhuku, Turkey, yogurt, tchizi, mazira, mbewu za mpendadzuwa ndi nyemba, zimakhala ndi cysteine, anthu ena amasankha kuwonjezera ndi NAC kuti iwonjezere cysteine.

NAC ili ndi bioavailability yotsika monga chowonjezera pakamwa, kutanthauza kuti siyabwino. Malangizo olandiridwa tsiku ndi tsiku ndi 600-1,800 mg wa NAC (,).

NAC itha kuperekedwa ngati IV kapena kumamwedwa pakamwa, ngati kutsitsi la aerosol kapena mawonekedwe amadzi kapena a ufa.

Chidule Kudya zakudya zamapuloteni kwambiri kumatha kupatsa thupi lanu amino acid cysteine, koma NAC itha kumwedwa ngati chowonjezera chothandizira kuthana ndi mavuto ena.

Zotsatira zoyipa

NAC ndiyotheka kukhala yotetezeka kwa akulu ngati iperekedwa ngati mankhwala akuchipatala.

Komabe, kuchuluka kwambiri kumatha kuyambitsa nseru, kusanza, kutsegula m'mimba ndi kudzimbidwa ().

Mukapuma, imatha kutupa pakamwa, kutuluka m'mphuno, kuwodzera komanso kukhazikika pachifuwa.

Anthu omwe ali ndi vuto lakukha magazi kapena kumwa mankhwala ochepetsa magazi sayenera kumwa NAC, chifukwa imachedwetsa magazi kuundana ().

NAC ili ndi fungo losasangalatsa lomwe limapangitsa kukhala kovuta kudya. Ngati mwasankha kumwa mankhwalawo, kambiranani ndi dokotala poyamba.

Chidule Ngakhale kuti NAC imaonedwa ngati yotetezeka ngati mankhwala akuchipatala, imatha kuyambitsa nseru, kusanza, kusokonezeka m'mimba, komanso mavuto am'kamwa ngati mutapuma.

Mfundo Yofunika Kwambiri

NAC imagwira ntchito zingapo zofunika pamoyo wamunthu.

Wotchuka chifukwa chokhoza kubwezeretsanso kuchuluka kwa antioxidant glutathione, imayendetsanso ubongo wofunikira wa neurotransmitter glutamate. Kuphatikiza apo, NAC imathandizira machitidwe amthupi owononga.

Ntchitoyi imapangitsa kuti NAC iwonjezere chithandizo chofunikira pamavuto angapo azaumoyo.

Funsani dokotala wanu kuti muwone ngati NAC ikhoza kukulitsa thanzi lanu.