Zochitika Zachipatala Zatsopano Zisanu Zomwe Zitha Kuchepetsa Kugwiritsa Ntchito Opioid

Zamkati

• Mano lasers
• Pang'onopang'ono Kumasula Anesthetics Akuderalo
• Chatsopano C-Section Tech
• Kuyeza kwa DNA
• Regenerative Medicine
• Onaninso za

Amereka ali pakati pamavuto a opioid. Ngakhale kuti sizingawoneke ngati chinthu chomwe muyenera kuda nkhawa nacho, ndikofunika kuzindikira kuti amayi akhoza kukhala ndi chiopsezo chachikulu chogwiritsa ntchito mankhwala opha ululu, omwe nthawi zambiri amalembedwa pambuyo pa maopaleshoni achizolowezi. Ndipo ngakhale amagwiritsidwanso ntchito kuthana ndi ululu wosatha, kafukufuku akuwonetsa kuti ma opioid sangathandizire kupumula kwakanthawi. Zowonjezera, ngakhale kuti si anthu onse omwe amagwiritsa ntchito ma opioid amakhala osokoneza bongo, ambiri amachita, ndipo chiyembekezo chokhala ndi moyo ku US chatsika pomwe anthu ambiri amafa ndi opioid overdoses.

Gawo lalikulu la kuyesayesa kulimbana ndi mliriwu ndikuzindikira nthawi yomwe ma opioid safunika ndikupeza mankhwala ena. Komabe, madokotala ambiri amaumirira kuti ma opioid ndi ofunika pazochitika zina zowawa-zosatha komanso zowawa. "Chifukwa kupweteka kwakanthawi ndichinthu chovuta kudziwa kuti chimakhudza zochitika zachilengedwe, zamaganizidwe, komanso chikhalidwe-ndizapadera ndipo zimakhudza aliyense mosiyanasiyana," akufotokoza Shai Gozani, MD, Ph.D., Purezidenti ndi CEO ku NeuroMetrix. Ma opioid amafunikanso nthawi zina ngati wina ali ndi ululu wopweteka, monga atangochitidwa opaleshoni kapena atavulala. "Popeza kuti ululu umakhala wotere, njira zamankhwala zimayenera kusinthidwa mwakukonda kwawo." Nthawi zina, izi zimaphatikizapo kugwiritsa ntchito opioid, ndipo nthawi zina sizitero.

Akatswiri amavomereza kuti palinso njira zina zambiri zothandizirana zopwetekera zomwe sizikhala ndi chiopsezo chochepa chomwa mankhwala osokoneza bongo. Ndizosamveka kunena kuti chithandizo chamankhwala, chithandizo chamankhwala china monga kutema mphini, komanso ngakhale psychotherapy ingathandize kuchepetsa kugwiritsa ntchito opioid, koma njira ina yodzitetezera ku mliri wa opioid ndi matekinoloje omwe akubwera omwe akukhala angwiro ndikukhala ovomerezeka kwambiri. Nazi zisanu zomwe zingathandize kuchepetsa kugwiritsa ntchito opioid.

Mano lasers

Kafukufuku akuwonetsa kuti anthu nthawi zambiri amakhala ndi mankhwala opweteka omwe amatsalira pambuyo pa opaleshoni ya m'kamwa, monga kuchotsa dzino lanzeru, zomwe zimasiya khomo lotseguka kuti ligwiritsidwe ntchito molakwika. Mukaganizira kuti oposa 90 peresenti ya odwala omwe ali ndi opaleshoni ya m'kamwa (ganizirani: kuchotsa dzino, opaleshoni ya chingamu yomwe imaphatikizapo stitches) amapatsidwa mankhwala opioid, malinga ndi Robert H. Gregg, DDS, woyambitsa nawo Millennium Dental Technologies ndi Institute for Advanced. Laser Dentistry, ndizochita zazikulu.

Ndicho chifukwa chake anatulukira laser ya LANAP, yomwe ingagwiritsidwe ntchito popanga opaleshoni ya mano ndi kuchepetsa ululu, kutaya magazi, ndi nthawi yochira. Dr.Gregg akuti odwala omwe amasankha njira ya laser amangopatsidwa ma opioid 0,5 peresenti ya nthawiyo - kusiyana kwakukulu.

Pakalipano, ma lasers akugwiritsidwa ntchito m'maofesi a mano a 2,200 osiyanasiyana m'dziko lonselo, ndipo Dr. Gregg akunena kuti akuyembekeza kuti chiwerengerocho chidzakula pang'onopang'ono pamene anthu amaphunzira zambiri za laser dentistry ndikumvetsetsa zochepetsera za kulembera opioids pa opaleshoni yapakamwa.

Pang'onopang'ono Kumasula Anesthetics Akuderalo

Mankhwala amtunduwu akhalapo kwa zaka zingapo, koma akuperekedwa mochulukira m'mitundu yambiri ya opaleshoni. Chofala kwambiri chimatchedwa Exparel, yomwe ndi njira yotulutsira pang'onopang'ono mankhwala oletsa ululu otchedwa bupivacaine. "Ndi mankhwala okhalitsa a nthawi yayitali obayidwa panthawi yochita opaleshoni omwe amatha kuletsa kupweteka kwamasiku oyamba atachitidwa opareshoni, pomwe odwala amafunikira kwambiri," akufotokoza a Joe Smith, M.D., katswiri wodziletsa pa Chipatala cha Inova Loudon ku Leesburg, Virginia. "Izi zimachepetsa, kapena nthawi zina kumachotsa kufunikira kwa ma opioid. Sikuti izi zimangothandiza odwala kupewa chiopsezo chodziwikiratu, komanso zoyipa zamankhwala osokoneza bongo monga kupuma, kupwetekedwa mtima ndi kusanza, kudzimbidwa, chizungulire ndi kusokonezeka, kutchula ochepa."

Chimodzi mwazinthu zabwino kwambiri pazothetsera vutoli ndikuti chitha kugwiritsidwa ntchito pamitundu ingapo ya maopaleshoni, kuphatikiza maopaleshoni monga mafupa, kukonza ACL, ndi ena ambiri, akutero Dr. Smith. Amagwiritsidwanso ntchito pochita maopazi, ma c-magawo, opaleshoni ya pulasitiki, opaleshoni yamlomo, ndi zina zambiri. Anthu ambiri ndioyenera kutero, kupatula omwe sagwirizana ndi mankhwala opha ululu m'deralo komanso omwe ali ndi matenda a chiwindi, malinga ndi Dr. Smith.

Chokhacho chokha? "Ngakhale kuti kwa nthawi yayitali mankhwala opatsirana m'deralo monga Exparel atha kuthandiza kuchepetsa kufunika kwa ma opioid atatha kugwira ntchito, awa ndiokwera mtengo ndipo odwala ambiri amasankha chuma cha opioid," atero a Adam Lowenstein, MD, dokotala wa opaleshoni wa pulasitiki ndi migraine. Mapulani ena a inshuwaransi amatha kubisala kapena kubisala pang'ono, koma sizomwe zimachitika. Komabe, imapereka njira yothandiza kwa iwo omwe akutsimikiza kuti sakufuna ma opioid post-op.

Chatsopano C-Section Tech

"C-sections ndi opaleshoni yaikulu, kotero pafupifupi amayi onse amalandira opioids pambuyo popanga opaleshoni," akutero Robert Phillips Heine, MD, ob-gyn ku Duke University Medical Center. "Popeza kuti kubereka kwa cesarean ndi njira yopangira opaleshoni yomwe imachitika kawirikawiri ku United States, zingakhale zopindulitsa kuchepetsa kuchuluka kwa mankhwala osokoneza bongo, chifukwa opaleshoni yaikulu ndi njira yodziwika yodalira opioid," akuwonjezera. (Zogwirizana: Kodi Opioids Amafunikiradi Pambuyo C-Gawo?)

Kuphatikiza pa zosankha zodzikongoletsa monga Exparel, palinso china chomwe chimatchedwa kutsekeka kosavomerezeka komwe kumatha kuchepetsa kufunikira kwa ma opioid pambuyo pa gawo la c. Dr. Heine akutero: "Ndikumavala kosavala komwe kumagwiritsidwa ntchito popanga opaleshoni ndikumangirizidwa pampu yomwe imapitilizabe kukakamira ndipo imakhala m'malo mwa masiku asanu kapena asanu ndi awiri." Izi zidakhazikitsidwa poyambirira pofuna kupewa matenda atatha opaleshoni, koma madokotala adapeza kuti zidachepetsanso kuchuluka kwa mankhwala opweteka omwe amayi omwe adadwala amafunikira. Pakadali pano, njirayi imagwiritsidwa ntchito makamaka kwa odwala omwe ali ndi chiopsezo chachikulu chotenga matenda, monga omwe ali ndi BMI yoposa 40, popeza amenewo ndi omwe amafufuza odwala akuwonetsa phindu, Dr. Heine akuti. "Ngati pakupezeka zambiri zomwe zikusonyeza kuti zimalepheretsa matenda opatsirana komanso / kapena kuchepetsa kugwiritsa ntchito mankhwala osokoneza bongo mwa odwala omwe ali ndi chiopsezo chochepa, atha kugwiritsidwanso ntchito m'derali."

Kuyeza kwa DNA

Tikudziwa kuti kuledzera sikungobadwa kumene, ndipo ofufuza amakhulupirira kuti apatula zina mwa majini zomwe zitha kuneneratu ngati wina angamwe mankhwala a opioid kapena ayi. Tsopano, pali mayeso anyumba omwe mungatenge kuti muwone kuwopsa kwanu. Chimodzi mwazodziwika kwambiri chimatchedwa LifeKit Predict, chomwe chimapangidwa ndi Prescient Medicine. Malinga ndi kafukufuku wofalitsidwa mu Annals of Clinical Laboratory Science, Njira zatsopano zoyeserera zomwe a Prescient amatha kuneneratu ndi 97% zowona ngati wina ali pachiwopsezo chochepa cha opioid. Ngakhale kafukufukuyu anali wocheperako ndipo madotolo ena omwe adagwira nawo ntchito pakampaniyi anali gawo la kafukufukuyu, zikuwoneka kuti zikuwonetsa kuti kuyezetsako kungakhale kothandiza kwa wina yemwe akukhudzidwa ndi chiwopsezo chawo chotengera chizolowezi choledzeretsa.

Ndikofunika kudziwa kuti mayeserowa sangatsimikizire kuti wina sangamwe mankhwala osokoneza bongo, koma atha kupereka chidziwitso chofunikira kwa iwo omwe akupanga chisankho chodzigwiritsa ntchito. Mayesowa amaphimbidwa ndi mapulani ena a inshuwaransi, ndipo ngakhale simufunikira mankhwala kuti mumwe, Prescient amalimbikitsa kukaonana ndi dokotala za kuyezetsa komanso zotsatira zake mukangolandira. (Zogwirizana: Kodi Kuyesedwa Kwachipatala Panyumba Kukuthandizani kapena Kukupwetekani?)

Regenerative Medicine

Ngati mudangomvapo za maselo am'maso potengera cloning, mungadabwe kudziwa kuti akugwiritsidwa ntchito kwambiri ngati mankhwala ngati njira yolimbana ndi ululu. Stem cell therapy ndi gawo la mchitidwe waukulu wotchedwa regenerative mankhwala. Kristin Comella, Ph.D., Chief Science Officer wa American Stem Cell Centers of Excellence akufotokoza kuti: "Ikukula mosalekeza, ndipo imaphatikizapo njira zosiyanasiyana, monga stem cell therapy, kuti mugwiritse ntchito machiritso achilengedwe a thupi lanu." Pamene mankhwala a opioid amathetsa zizindikiro zowawa, chithandizo cha maselo a stem chimapangidwira kuthetsa chomwe chimayambitsa ululu. "Mwanjira iyi, stem cell therapy imatha kuthana ndi ululu ndipo imatha kuchepetsa kufunikira kwa kupumula kwa ma opioid," akutero Comella.

Ndiye kodi chithandizocho chimaphatikizapo chiyani? "Masisitimu amakhalapo mu mnofu uliwonse wamatupi athu ndipo ntchito yawo yayikulu ndikusamalira ndikukonzanso minofu yowonongeka," akutero Comella. "Amatha kukhala kutali ndi malo amodzi mthupi lanu ndikusamukira ku gawo lina lomwe likufunika kuchiritsidwa, kuthana ndi zowawa m'malo osiyanasiyana." Chofunika kwambiri, maselo am'madzi amangogwiritsidwa ntchito kuchokera ku zake thupi mu mankhwalawa, omwe amachotsa zina mwamakhalidwe abwino omwe amabwera ndi mawu akuti "stem cell."

Nthawi zina, stem cell therapy imaphatikizidwa ndi platelet-rich plasma therapy (PRP), yomwe Comella akuti imagwira ngati feteleza wama cell cell. "PRP ndi chiwerengero cha anthu olemera omwe amakula ndi mapuloteni omwe amapezeka m'magazi a munthu. Imawonjezera machiritso a machiritso omwe amapangidwa ndi maselo oletsa kutupa omwe amapezeka mwachibadwa," akufotokoza. "PRP ndi yopambana kwambiri pochiza ululu chifukwa cha kuvulala kwatsopano chifukwa imapangitsa kuti machiritso a machiritso apangidwe omwe akukula kale chifukwa akupita kumalo ovulala." Ndipo, chithandizochi chitha kugwiritsidwanso ntchito kuthamangitsa kupumula kwa ululu wa zotupa pazovuta zina monga osteoarthritis, Comella akuti.

Ndibwino kuti muzindikire kuti mankhwala am'madzi am'magazi siili ndendende ambiri, komanso sivomerezedwa ndi FDA. Ngakhale a FDA (ndi ofufuza ambiri azachipatala, pankhaniyi) amavomereza kuti chithandizo cha stem cell chikulonjeza, sakhulupirira kuti pali kafukufuku wokwanira woti avomereze ngati chithandizo. Nkhani yayitali: Sikuti a FDA saganiza kuti chithandizo cha stem cell ndi chothandiza, ndikokwanira kuti tilibe chidziwitso chokwanira kuti tigwiritse ntchito mosamala kapena modalirika.Pongochita zakunja, njira zopanda opaleshoni zomwe zimayendetsedwa ndi madokotala pogwiritsa ntchito maselo a odwala, komabe, zipatala za stem cell zimatha kugwira ntchito motsatira malangizo a FDA.

Ngakhale mankhwala obwezeretsanso mwina sangakulimbikitseni ndi dokotala-ndipo sangayang'anitsidwe ndi inshuwaransi yanu - ndikuwonetserabe chidwi chamankhwala omwe angakhale ngati zaka makumi angapo kuchokera pano.

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