Pulayimale-Kupita Patsogolo vs. MS Yobwezeretsanso

Zamkati

• Kodi MS-patsogolo-patsogolo ndi chiyani?
• Kodi ndizizindikiro ziti za PPMS?
• Ndani amatenga PPMS?
• Nchiyani chimayambitsa PPMS?
• Kodi malingaliro a PPMS ndi otani?
• Ndi mankhwala ati omwe amapezeka ku PPMS?
• Kodi kubwereza-MS kukhululukiranji?
• Kodi ndizizindikiro ziti za RRMS?
• Ndani amalandira RRMS?
• Nchiyani chimayambitsa RRMS?
• Kodi ma RRMS ndi otani?
• Kodi mankhwala a RRMS ndi ati?
• Kodi pali kusiyana kotani pakati pa PPMS ndi RRMS?
• Zaka zoyambira
• Zoyambitsa
• Chiwonetsero
• Njira zothandizira

Chidule

Multiple sclerosis (MS) ndi matenda osachiritsika omwe amawononga mitsempha. Mitundu inayi yayikulu ya MS ndi iyi:

• matenda opatsirana (CIS)
• Kubwezeretsanso MS (RRMS)
• MS-patsogolo-patsogolo MS (PPMS)
• MS yopita patsogolo (SPMS)

Mtundu uliwonse wa MS umatsogolera kuzinthu zosiyana, milingo yolimba, ndi njira zamankhwala. Pitilizani kuwerenga kuti mupeze momwe PPMS imasiyanirana ndi RRMS.

Kodi MS-patsogolo-patsogolo ndi chiyani?

PPMS ndi amodzi mwamitundu yovuta kwambiri ya MS, yomwe imakhudza pafupifupi 15% ya aliyense amene amapezeka ndi matendawa. Ngakhale mitundu ina ya MS imadziwika ndikumenyedwa koopsa, kotchedwa kubwereranso, kutsatiridwa ndi nthawi zosachita, zotchedwa kukhululukidwa, PPMS imayambitsa kukulira kwazizindikiro pang'onopang'ono.

PPMS imatha kusintha pakapita nthawi. Nthawi yokhala ndi vutoli itha kugawidwa ngati:

• yogwira ntchito mopitilira patsogolo ngati pali zovuta zowonjezereka kapena zochitika zatsopano za MRI kapena kubwereranso
• yogwira popanda kupita patsogolo ngati zizindikiro kapena zochitika za MRI zilipo, koma zizindikilo sizinakuliretu
• osagwira ntchito popanda kupita patsogolo ngati palibe zizindikilo kapena zochitika za MRI komanso osalemala
• osagwira ntchito mopitilira muyeso ngati pali zobwereranso kapena zochitika za MRI, ndipo zizindikilozo zayamba kukulira

Kodi ndizizindikiro ziti za PPMS?

Zizindikiro za PPMS zimatha kusiyanasiyana, koma zizindikilo zake ndi izi:

• mavuto a masomphenya
• kuvuta kuyankhula
• mavuto kuyenda
• vuto ndi kulingalira
• ululu waukulu
• miyendo yolimba ndi yofooka
• vuto ndi kukumbukira
• kutopa
• vuto ndi chikhodzodzo ndi matumbo
• kukhumudwa

Ndani amatenga PPMS?

Anthu amakonda kupezeka ndi PPMS m'zaka zawo za 40 ndi 50, pomwe omwe amapezeka ndi RRMS amakhala azaka 20 kapena 30. Amuna ndi akazi amapezeka ndi PPMS pamlingo wofanana, mosiyana ndi RRMS, yomwe imakhudza azimayi ambiri.

Nchiyani chimayambitsa PPMS?

Zomwe zimayambitsa MS sizikudziwika. Chikhulupiriro chofala kwambiri chimati MS imayamba ngati njira yotupa yamatenda amomwe imawonongera mchimake wa myelin. Ichi ndiye chophimba choteteza chomwe chimazungulira mitsempha ya chapakati.

Lingaliro linanso ndiloti kuyankha mthupi kumayambitsidwa ndi matenda a ma virus. Pambuyo pake, kufooka kwa mitsempha kapena kuwonongeka kumachitika.

Umboni wina ukusonyeza kuti MS yomwe ikupita patsogolo kwambiri ndi gawo la MS ndipo siyosiyana ndi kubwereranso kwa MS.

Kodi malingaliro a PPMS ndi otani?

PPMS imakhudza aliyense mosiyanasiyana. Chifukwa PPMS ikupita patsogolo, zizindikilo zimangowonjezereka m'malo mokhala bwino. Anthu ambiri amavutika kuyenda. Anthu ena amakhalanso ndi kunjenjemera komanso mavuto amaso.

Ndi mankhwala ati omwe amapezeka ku PPMS?

Chithandizo cha PPMS ndi chovuta kwambiri kuposa RRMS. Zimaphatikizapo kugwiritsa ntchito njira zochizira matenda. Amatha kupereka thandizo kwakanthawi koma atha kugwiritsidwa ntchito mosamala kwa miyezi ingapo mpaka chaka nthawi imodzi.

Ocrelizumab (Ocevus) ndi mankhwala okhawo omwe amavomerezedwa ndi FDA kuti athetse PPMS.

Palibe mankhwala a PPMS, koma mutha kuthana ndi vutoli.

Mankhwala ena osintha matenda (DMDs) ndi ma steroids atha kuthandiza kuthana ndi zizindikilo. Kukhala ndi moyo wathanzi womwe umaphatikizapo kudya zakudya zopatsa thanzi komanso kuchita masewera olimbitsa thupi kungathandize. Kukonzanso kudzera muntchito yakuthupi ndi ntchito kungathandizenso.

Kodi kubwereza-MS kukhululukiranji?

RRMS ndiye mtundu wofala kwambiri wa MS. Zimakhudza pafupifupi 85 peresenti ya anthu onse omwe amapezeka ndi MS. Anthu ambiri amapezeka kuti ali ndi RRMS. Matendawa amasintha pakatha zaka makumi angapo kupita patsogolo.

Dzinalo lobwezeretsanso MS limafotokozera momwe zinthu zilili. Nthawi zambiri zimakhudza kubwereranso koopsa komanso nthawi yakukhululukidwa.

Mukayambiranso, zizindikiro zatsopano zimatha kubwera, kapena zizindikilo zomwezo zimatha kuyakira ndikukulira. Pakukhululukidwa, anthu amatha kukhala ndi zizindikilo zochepa, kapena zizindikilozo zimakhala zochepa kwa milungu, miyezi, kapena zaka.

Zizindikiro zina za RRMS zimatha kukhala zosatha. Izi zimatchedwa zizindikiro zotsalira.

RRMS amadziwika kuti:

• yogwira pakakhala kubwereranso kapena zotupa zomwe zimapezeka pa MRI
• osagwira ntchito ngati palibe zobwereranso kapena zochitika za MRI
• kukulirakulira pamene zizindikilo zimakula pang'onopang'ono mukayambiranso
• osakulirakulira pamene zizindikilo sizimangokulira pang'onopang'ono mukayambiranso

Kodi ndizizindikiro ziti za RRMS?

Zizindikiro zimasiyanasiyana kwa munthu aliyense, koma zizolowezi za RRMS zimaphatikizapo:

• mavuto ndi mgwirizano ndi kulingalira
• dzanzi
• kutopa
• kulephera kuganiza bwino
• mavuto ndi masomphenya
• kukhumudwa
• mavuto pokodza
• vuto lolekerera kutentha
• kufooka kwa minofu
• kuyenda movutikira

Ndani amalandira RRMS?

Anthu ambiri amapezeka kuti ali ndi RRMS azaka 20 mpaka 30, zomwe ndizocheperako poyerekeza ndi mitundu ina ya MS, monga PPMS. Amayi amapezeka kawiri konse kuposa amuna.

Nchiyani chimayambitsa RRMS?

Lingaliro limodzi lodziwika bwino ndiloti RRMS ndimavuto omwe amachitika thupi likayamba kudzivulaza. Chitetezo cha mthupi chimagwiritsa ntchito ulusi wapakati wamitsempha yam'mimba ndi zigawo zotetezera, zotchedwa myelin, zomwe zimateteza ulusi wamitsempha.

Kuukira kumeneku kumayambitsa kutupa ndikupanga malo ochepa owonongeka. Kuwonongeka kumeneku kumapangitsa kuti zikhale zovuta kuti mitsempha izitengera zidziwitso ku thupi. Zizindikiro za RRMS zimasiyana kutengera komwe kuwonongeka.

Zomwe zimayambitsa MS sizikudziwika, koma mwina pali zoyambitsa zamtundu komanso zachilengedwe za MS. Malingaliro ena amati kachilombo, monga Epstein-Barr, kakhoza kuyambitsa MS.

Kodi ma RRMS ndi otani?

Vutoli limakhudza aliyense mosiyanasiyana. Anthu ena amatha kukhala ndi moyo wathanzi ndikungobwereranso kawirikawiri komwe sikumayambitsa zovuta zina. Ena amatha kuzunzidwa pafupipafupi ndi zizindikilo zomwe zimadzetsa mavuto.

Kodi mankhwala a RRMS ndi ati?

Pali mankhwala angapo ovomerezeka a FDA omwe amapezeka kuti athetse RRMS. Mankhwalawa amachepetsa kuchepa kwa zotulukapo ndikukula kwa zotupa zatsopano. Amachepetsanso kukula kwa RRMS.

Kodi pali kusiyana kotani pakati pa PPMS ndi RRMS?

Ngakhale PPMS ndi RRMS ndi mitundu yonse ya MS, pali kusiyana pakati pawo, monga:

Zaka zoyambira

Matenda a PPMS amapezeka mwa anthu azaka za m'ma 40 ndi 50, pomwe RRMS imakhudza omwe ali ndi zaka 20 kapena 30.

Zoyambitsa

PPMS zonse ndi RRMS zimayambitsidwa ndi kutupa ndi chitetezo chamthupi pa myelin ndi ulusi wamitsempha. RRMS imakhala ndi kutupa kwambiri kuposa PPMS.

Omwe ali ndi PPMS ali ndi zipsera ndi zikwangwani, kapena zotupa, pamtsempha wawo, pomwe iwo omwe ali ndi RRMS ali ndi zotupa zambiri muubongo.

Chiwonetsero

PPMS ikupita patsogolo ndipo zizindikilo zikuwonjezeka pakapita nthawi, pomwe RRMS imatha kuwonetsa kuzunzika kwanthawi yayitali. RRMS itha kukhala mtundu wopita patsogolo wa MS, wotchedwa MS pang'onopang'ono, kapena SPMS, patapita nthawi.

Njira zothandizira

Ngakhale Ocrelizumab ndiye mankhwala okhawo omwe amavomerezedwa ndi FDA kuti athetse PPMS, pali zingapo zomwe zingathandize. Palinso mankhwala ena omwe akufufuzidwa. RRMS ili ndi mankhwala opitilira khumi ndi awiri ovomerezeka.

Odwala omwe ali ndi PPMS ndi RRMS atha kupindula ndi kukhazikitsa chithandizo chamankhwala komanso pantchito. Pali mankhwala ambiri omwe madotolo angagwiritse ntchito kuthandiza anthu omwe ali ndi MS kuthana ndi matenda awo.