Zifukwa za 6 Zoyesera Biologics Yanu Matenda A Crohn's

Zamkati

• 1. Simukuyankha kuchipatala cha Crohn's matenda
• 2. Muli ndi matenda atsopano
• 3. Mumakumana ndi vuto lotchedwa fistula
• 4. Mukufuna kusunga chikhululukiro
• 5. Mlingo ukhoza kukhala kamodzi pamwezi
• 6. Biologics ikhoza kukhala ndi zovuta zochepa kuposa ma steroids
• Kuthetsa kukayikira kwanu
• Kusankha biologic

Monga munthu wokhala ndi matenda a Crohn, mwina mwamvapo za biologics ndipo mwina mungaganizire zogwiritsa ntchito nokha. Ngati chinachake chikukulepheretsani, mwafika pamalo abwino.

Nazi zifukwa zisanu ndi chimodzi zomwe mungafune kuganiziranso za chithandizo chamtunduwu, ndi malingaliro amomwe mungachitire izi.

1. Simukuyankha kuchipatala cha Crohn's matenda

Mwina mwakhala mukumwa mankhwala osiyanasiyana a Crohn's disease, monga ma steroids ndi ma immunomodulators, kwakanthawi tsopano. Komabe, mukukumanabe ndi zovuta kangapo pachaka.

Malangizo a American College of Gastroenterology (ACG) amalimbikitsa mwamphamvu kutenga mankhwala a biologic ngati muli ndi matenda a Crohn's wastani omwe amalimbana ndi ma steroids kapena ma immunomodulators. Dokotala wanu angaganizirenso kuphatikiza biologic ndi immunomodulator, ngakhale simunayese mankhwalawa mosiyana.

2. Muli ndi matenda atsopano

Pachikhalidwe, mapulani azachiritso a matenda a Crohn amaphatikizapo njira yowonjezerera. Mankhwala osakwera mtengo, monga steroids, adayesedwa kaye, pomwe ma biologics okwera mtengo adayesedwa komaliza.

Posachedwapa, malangizo amalimbikitsa njira zoperekera kuchipatala, monga umboni wasonyeza zotsatira zabwino ndi mankhwala a biologic mwa odwala omwe angopeza kumene.

Mwachitsanzo, kafukufuku wina wamkulu wazidziwitso zakuchipatala adapeza kuti kuyambira biologics koyambirira kwamankhwala a Crohn's matenda kumathandizira kuyankha mankhwala.

Gulu lowerengera lomwe linayamba anti-TNF biologics koyambirira linali ndi mitengo yotsika kwambiri yofunikira ma steroids pochiza zovuta kuposa magulu ena ophunzira. Anachitanso maopaleshoni ochepa chifukwa cha matenda a Crohn.

3. Mumakumana ndi vuto lotchedwa fistula

Fistula ndizolumikizana modabwitsa pakati pa ziwalo zamthupi. Mu matenda a Crohn, fistula imatha kupezeka pamene chilonda chimadutsa mumtambo wanu wam'mimba, womwe umalumikiza matumbo anu ndi khungu, kapena matumbo anu ndi chiwalo china.

Fistula itenga kachilomboka, imatha kukhala pangozi. Biologics yotchedwa TNF inhibitors itha kuperekedwa ndi dokotala ngati muli ndi fistula chifukwa ndi yothandiza kwambiri.

A FDA adavomereza biologics makamaka kuti ichiritse fistulism ya matenda a Crohn ndikusungabe kutsekemera kwa fistula.

4. Mukufuna kusunga chikhululukiro

Corticosteroids amadziwika kuti amabweretsa chikhululukiro koma sangathe kusunga chikhululukocho. Ngati mwakhala mukumwa mankhwalawa kwa miyezi itatu kapena kupitilira apo, dokotala wanu akhoza kukuyambitsani pa biologic m'malo mwake. Kafukufuku wamankhwala akuwonetsa kuti anti-TNF biologics imatha kukhalabe ndi chikhululukiro mwa odwala omwe ali ndi matenda oopsa a Crohn.

ACG yatsimikiza kuti maubwino amankhwalawa kuti akhalebe ndi chikhululukiro amaposa zovuta zonse kwa odwala ambiri.

5. Mlingo ukhoza kukhala kamodzi pamwezi

Lingaliro la jakisoni lingawopsyeze, koma pambuyo pochepetsa pang'ono, biologics ambiri amaperekedwa kamodzi pamwezi. Pamwamba pa izi, singano ndi yaying'ono kwambiri, ndipo mankhwalawo amabayidwa pansi pa khungu lanu.

Ma biologics ambiri amaperekedwanso ngati auto-injector - izi zikutanthauza kuti mutha kupeza jakisoni osawona singanoyo. Mutha kudzipatsa nokha biologics kunyumba mukaphunzitsidwa bwino momwe mungachitire izi.

6. Biologics ikhoza kukhala ndi zovuta zochepa kuposa ma steroids

Corticosteroids omwe amagwiritsidwa ntchito pochiza matenda a Crohn, monga prednisone kapena budesonide, amagwira ntchito popondereza chitetezo chonse cha mthupi.

Biologics, komano, imagwira ntchito mwanjira yosankha kwambiri polunjika mapuloteni ena m'thupi lanu omwe atsimikiziridwa kale kuti ali ndi chotupa cha Crohn. Pachifukwa ichi, ali ndi zovuta zochepa kuposa corticosteroids.

Pafupifupi mankhwala onse amakhala pachiwopsezo chazovuta. Kwa biologics, zotsatira zoyipa kwambiri zimakhudzana ndi momwe amaperekera. Mutha kukhala ndi mkwiyo pang'ono, kufiyira, kupweteka, kapena kuyankha patsamba la jakisoni.

Palinso chiopsezo chachikulu chotenga kachirombo, koma chiwopsezo sichikhala chachikulu monga mankhwala ena, monga corticosteroids.

Kuthetsa kukayikira kwanu

Biologic yoyamba yamatenda a Crohn idavomerezedwa mu 1998, chifukwa chake biologics ili ndi chidziwitso chambiri komanso kuyesa kwa chitetezo kuti adziwonetse okha. Mutha kukhala mukukayesa kuyesa mankhwala a biologic chifukwa mudamva kuti ndi "mankhwala osokoneza bongo" kapena mukuwopa mtengo wake.

Ngakhale zili zowona kuti biologics imawerengedwa ngati njira yankhanza kwambiri, biologics imakhalanso mankhwala osokoneza bongo, ndipo imagwira ntchito bwino kwambiri.

Mosiyana ndi mankhwala ena akale a matenda a Crohn omwe amafooketsa chitetezo chonse cha mthupi, mankhwala a biologic amalimbana ndi mapuloteni otupa omwe amadziwika kuti ali ndi matenda a Crohn. Mosiyana ndi izi, mankhwala a corticosteroid amapondereza chitetezo chanu chonse chamthupi.

Kusankha biologic

Pamaso pa biologics, panali njira zochiritsira zochepa kupatula kuchitira opaleshoni anthu omwe ali ndi matenda oopsa a Crohn. Tsopano pali njira zingapo:

• adalimumab (Humira, Exemptia)
• chitsimikizo cha pegol (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)
• natalizumab (Tysabri)
• ustekinumab (Stelara)
• vedolizumab (Entyvio)

Muyenera kugwira ntchito ndi kampani yanu ya inshuwaransi kuti mudziwe ngati biologic inayake yapangidwa ndi pulani yanu.

Zikuwonekeratu kuti mankhwala a biologic asintha malo azotheka kuthana ndi matenda a Crohn ndi mavuto ena amthupi okha. Kafukufuku akupitilizabe kukula pa biologics, zomwe zimapangitsa kuti mwina njira zina zamankhwala zitha kupezeka mtsogolo.

Pamapeto pake, dongosolo lanu la chithandizo ndi chisankho chabwino kwambiri chomwe mungapange ndi dokotala wanu.