Kodi SVR imatanthauza chiyani kwa anthu omwe ali ndi chiwindi cha C?

Zamkati

• Mayankho ena a virologic
• Momwe mungakwaniritsire SVR
• Kodi ma genotypes amakhudzana bwanji ndi SVR?
• Mankhwala amakono a HCV
• Bwanji ngati simukwaniritsa SVR?
• Chiwonetsero
• Pangani netiweki yothandizira

SVR ndi chiyani?

Cholinga cha mankhwala a hepatitis C ndikutsuka magazi anu a hepatitis C virus (HCV).Mukamalandira chithandizo, dokotala wanu amayang'anira kuchuluka kwa kachilombo ka HIV m'magazi anu (kuchuluka kwa ma virus). Matendawa atapanda kupezeka, amatchedwa virologic response, zomwe zikutanthauza kuti mankhwala anu akugwira ntchito.

Mupitilizabe kumayezetsa magazi pafupipafupi kuti muwone ngati pali RNA iliyonse, majini a kachilombo ka hepatitis C. Kuyankha kwa virologic reaction (SVR) kumachitika mukamayesa magazi anu osapezekanso mu RNA m'masabata 12 kapena kupitilira mankhwala.

Chifukwa chiyani SVR ndiyofunika? Chifukwa 99% ya anthu omwe amakwaniritsa SVR amakhalabe opanda kachilombo kwa moyo wawo wonse ndipo atha kuwawona ngati akuchiritsidwa.

Mukakwaniritsa SVR, mulibenso kachilomboka m'dongosolo lanu, chifukwa chake simuyenera kuda nkhawa kuti mungafalitse kachilomboka kwa wina aliyense. Pambuyo pa SVR, chiwindi chanu sichikuvutikanso. Koma ngati mwakhala mukuwonongeka kale pachiwindi, mungafunikire chithandizo china.

Magazi anu adzakhala ndi ma antibodies a hepatitis C. kosatha. Izi sizikutanthauza kuti simungathenso kuyambiranso. Muyenera kuchitabe zinthu zodzitetezera kuti musapewe zovuta za HCV.

Mayankho ena a virologic

Kuyesedwa kwamagazi kwakanthawi kumawunika momwe mankhwala angathandizire. Mawu omwe amagwiritsidwa ntchito pofotokozera mayankho a virologic atha kukhala osokoneza pang'ono.

Nayi mndandanda wamawu wamba ndi tanthauzo lake:

• SVR12. Apa ndipamene mayeso anu amwazi amawonetsa kuyankha kwa virologic (SVR), kapena kuchuluka kwa HCV, patatha milungu 12. Pakadali pano, mumawerengedwa kuti mwachiritsidwa matenda a chiwindi a C. Chizindikiro cha mankhwala omwe kale anali SVR24, kapena mulibe kuchuluka kwa HCV m'magazi anu pambuyo pa masabata 24 akuchipatala. Koma ndi mankhwala amakono, SVR12 tsopano imadziwika kuti ndi machiritso.
• SVR24. Apa ndipamene mayeso anu amawonetsa kuyankha kwakanthawi kwa virologic (SVR), kapena mulibe kuchuluka kwa HCV m'magazi anu, mutatha milungu 24. Umu ndi momwe zimakhalira machiritso, koma ndimankhwala atsopano amakono, SVR12 tsopano imadziwika kuti ndi machiritso.
• Kuyankha pang'ono. Magulu anu a HCV atsika mukamalandira chithandizo, koma kachilomboka kamaonekabe m'magazi anu.
• Kusayankha kapena kuyankha mwachabe. Palibe kusintha pang'ono kapena kusintha kwa kuchuluka kwa ma virus anu a HCV chifukwa chamankhwala.
• Kubwereranso. Kachilomboko kanali kosaoneka m'magazi anu kwakanthawi, koma kanapezekanso. Kubweranso kwake kumatha kuchitika panthawi yomwe mwalandira kapena mutalandira chithandizo. Dokotala wanu adzakuthandizani kusankha njira zina zamankhwala.

Momwe mungakwaniritsire SVR

Pali njira zingapo zopezera chithandizo. Zitha kuphatikizira mankhwala osakanikirana, ambiri mwa iwo omwe tsopano akuphatikizidwa kukhala mapiritsi amodzi. Chifukwa chake mumayenera kumwa mapiritsi amodzi patsiku.

Dokotala wanu amalangiza regimen kutengera:

• msinkhu komanso thanzi lathunthu
• mtundu wa hepatitis genotype
• kuwonongeka kwa chiwindi, ngati chilipo
• kutha kutsatira malangizo amankhwala
• zotsatira zoyipa

Kukhazikitsidwa kwa mankhwala ochepetsa mphamvu ya ma virus (DAAs) mu 2011 kunasinthiratu chithandizo cha matenda otupa chiwindi a C.

Zisanachitike, chithandizo chimakhala makamaka ndi jakisoni wa mankhwala otchedwa interferon ndi ribavirin, kuphatikiza mankhwala ena amtundu wa mapiritsi. Chithandizo nthawi zambiri sichimagwira, ndipo zotsatirapo, kuphatikiza kukhumudwa, nseru, ndi kuchepa kwa magazi m'thupi, zinali zazikulu.

Mu 2014, funde lachiwiri la ma DAA othandiza kwambiri adayambitsidwa. Mankhwala atsopano otetezera mavairasi akhala akuthandizira kwambiri masiku ano ku hepatitis C ku United States. Amalimbana ndi kachilomboka ndipo amakhala othandiza kwambiri kuposa mankhwala am'mbuyomu.

Ma DAA atsopano amatha kumwa pakamwa, nthawi zambiri pamapiritsi amodzi tsiku lililonse. Amakhala ndi zovuta zochepa, amachulukitsa kuchiritsa, komanso amachepetsa nthawi yamankhwala pazaka zisanu zokha zapitazo.

Ma DAA achiwiri amathandizanso kuthana ndi mitundu isanu ndi iwiri yodziwika bwino ya hepatitis C genotypes, kapena mitundu ya majini. Ena mwa ma DAA atsopano amatha kuthana ndi ma genotypes onse pophatikiza mankhwala osiyanasiyana m'mapiritsi kuti akwaniritse mitundu yosiyanasiyana.

Ma DAA ena oyamba kugwiritsidwa ntchito amagwiritsidwabe ntchito mophatikizana ndi interferon ndi roburin, koma ma DAA ambiri achiwiri amagwiritsidwa ntchito paokha.

Kuchuluka kwa machiritso, kapena SVR, amachitidwe amakono a DAA tsopano ali pafupifupi 95 peresenti yonse. Mlingowu nthawi zambiri umakhala waukulu kwa anthu omwe alibe chiwindi, kapena zipsera, m'chiwindi ndipo sanalandire chithandizo cha hepatitis C m'mbuyomu.

Chiyambire kuwonjezera kwa ma DAA ogwira ntchito kuyambira 2014, ena a ma DAA oyambilira adatha ntchito, ndipo opanga awo adawachotsa pamsika.

Izi zikuphatikiza mankhwala Olysio (simeprevir), omwe adatha mu Meyi 2018, ndi mankhwala a Technivie (ombitasvir / paritaprevir / ritonavir) ndi Viekira Pak (ombitasvir / paritaprevir / ritonavir kuphatikiza dasabuvir), omwe adatha pa Januware 1, 2019.

Ma DAA onse ndi kuphatikiza kwa mankhwala. Asayansi apeza kuti kuphatikiza mankhwala omwe amalimbana ndi kachilombo mosiyanasiyana kumawonjezera mwayi wochiritsidwa. Anthu omwe amamwa mankhwala nthawi zambiri amatenga mapiritsi osiyanasiyana, ngakhale mankhwala ambiri tsopano ali ndi piritsi limodzi lophatikiza mankhwala osiyanasiyana. Nthawi zambiri amamwa mankhwalawa kwa milungu 12 mpaka 24, kapena kupitilira apo.

Dokotala wanu adzakuthandizani kusankha pazomwe mungapangire mankhwala, kutengera mbiri yanu yamankhwala komanso mtundu wa hepatitis C womwe muli nawo. Palibe katemera wa hepatitis C monga momwe zilili ndi hepatitis A ndi B.

Kodi ma genotypes amakhudzana bwanji ndi SVR?

Mankhwala a hepatitis C nthawi zambiri amadziwika ndi mtundu wa kachilombo ka HIV komwe amapangidwa kuti azitha kuchiza. Genotype ndi mtundu winawake wamtundu wa kachilombo kamene kamapangidwa pamene kachilomboka kamasinthira.

Pali mitundu isanu ndi iwiri yodziwika bwino ya HCV, kuphatikiza ma subtypes omwe amadziwika.

Genotype 1 ndi yofala kwambiri ku United States, yomwe imakhudza pafupifupi 75 peresenti ya anthu aku America omwe ali ndi HCV. Genotype 2 ndiye wachiwiri kwambiri, womwe umakhudza anthu 20 mpaka 25% aku America omwe ali ndi HCV. Anthu omwe amatenga genotypes 3 mpaka 7 nthawi zambiri amakhala kunja kwa United States.

Mankhwala ena amachiza mitundu yonse yambiri kapena yambiri ya HCV, koma mankhwala ena amangotengera mtundu umodzi wokha. Kuganizira mosamala mankhwala anu ndi mtundu wa matenda anu a HCV kungakuthandizeni kukwaniritsa SVR.

Dokotala wanu adzakuyesani kuti adziwe mtundu wa HCV, womwe umatchedwa genotyping. Njira zamankhwala ndi magawo amtundu wa mankhwala ndizosiyana siyana pamitundu yosiyanasiyana.

Mankhwala amakono a HCV

Otsatirawa ndi mndandanda wa mankhwala amakono antivirusi omwe amagwiritsidwa ntchito kwambiri pochizira matenda a chiwindi a C, okonzedwa motsatira zilembo. Mutha kudziwa zambiri zamankhwala a HCV pano.

Zambiri pamndandanda pansipa zatengedwa kuchokera ku mankhwala ovomerezeka a hepatitis C. Dzinalo la mankhwala aliwonse amatsatiridwa ndi mayina achibadwa a zosakaniza zake.

Opanga mankhwalawa nthawi zambiri amapereka chidziwitso chambiri komanso zodzinenera zothandizila ma genotypes owonjezera patsamba lawo. Dokotala wanu akhoza kukuthandizani kuti muwone izi. Zina zitha kukhala zomveka, pomwe zina mwina ndizokokomeza kapena zosagwirizana ndi inu.

Onetsetsani kuti mukambirane ndi dokotala kuti ndi mankhwala ati omwe angakuthandizeni kupita ku SVR.

• Daklinza (daclatasvir). Nthawi zambiri amaphatikizidwa ndi sofosbuvir (Sovaldi). Idavomerezedwa mu 2015 kuchiza genotype 3. Chithandizo nthawi zambiri chimakhala milungu 12.

• Bwanji ngati simukwaniritsa SVR?

  Sikuti aliyense amafikira SVR. Zotsatira zoyipa zimatha kukupangitsani kusiya kumwa mankhwala koyambirira. Koma anthu ena samangoyankha, ndipo sizidziwika bwinobwino chifukwa chake. Dokotala wanu angakulimbikitseni kuti muyesere mankhwala osiyanasiyana.

  Ngakhale simukufika ku SVR, mankhwalawa atha kuthandiza kuchepetsa vutoli komanso kukhala opindulitsa pachiwindi.

  Ngati simudzayesere mankhwala ena ochepetsa mphamvu ya kachilombo ka HIV pazifukwa zilizonse, simufunikira kuyezetsa magazi ambiri. Koma muli ndi matenda omwe amafunikira chisamaliro. Izi zikutanthauza kuyezetsa magazi pafupipafupi ndi kuyesa kwa chiwindi. Pogwira ntchito limodzi ndi dokotala, mutha kuthetsa mavuto aliwonse omwe angabuke mwachangu.

  Ngati mwayesapo mankhwala angapo osapambana, mungafune kulingalira zofunsira kuyesa kuchipatala. Mayeserowa nthawi zina amakulolani kuyesa mankhwala atsopano omwe akadali pachiyeso. Mayesero azachipatala amakhala ndi zofunikira kwambiri, koma dokotala ayenera kupereka zambiri.

  Chiwonetsero

  Ngakhale mulibe zizindikiro zambiri pakadali pano, matenda a chiwindi a C ndi matenda osachiritsika. Chifukwa chake ndikofunikira kusamalira thanzi lanu lonse, kusamalira chiwindi chanu. Pangani thanzi lanu kukhala patsogolo.

  Muyenera:

  • Khalani ndi ubale wabwino ndi dokotala wanu. Nenani zisonyezo zatsopano nthawi yomweyo, kuphatikiza nkhawa ndi kukhumudwa. Funsani dokotala musanamwe mankhwala atsopano kapena zowonjezera, chifukwa zina zitha kuvulaza chiwindi chanu. Dokotala wanu amathanso kukudziwitsani za kupita patsogolo kwamankhwala.
  • Idyani chakudya choyenera. Ngati mukukumana ndi mavuto ndi izi, pemphani dokotala wanu kuti akalangize wazakudya kuti akutsogolereni koyenera.
  • Muzichita masewera olimbitsa thupi nthawi zonse. Ngati masewera olimbitsa thupi sali anu, ngakhale kuyenda tsiku ndi tsiku kumathandiza. Kungakhale kosavuta ngati mupeza bwenzi lochita masewera olimbitsa thupi.
  • Gonani mokwanira usiku. Kuwotcha kandulo kumapeto onse awiri kumawononga thupi lanu.
  • Osamwa. Mowa umawononga chiwindi, choncho ndibwino kuti uzipewe.
  • Osasuta. Pewani mankhwala a fodya chifukwa amawononga thanzi lanu lonse.

  Pangani netiweki yothandizira

  Kukhala ndi matenda osatha kungakhale kovuta nthawi zina. Ngakhale achibale ndi anzanu apamtima sangadziwe nkhawa zanu. Kapenanso sangadziwe choti anene. Chifukwa chake dziwani kuti mutsegule njira zolankhulirana. Pemphani kuti mulimbikitsidwe komanso kuthandizidwa pakafunika kutero.

  Ndipo kumbukirani, simuli nokha. Anthu opitilira 3 miliyoni ku United States ali ndi matenda a hepatitis C.

  Ganizirani zolowa nawo gulu lothandizira pa intaneti kapena mwa anthu kuti muthe kulumikizana ndi ena omwe akumvetsetsa zomwe mukukumana nazo. Magulu othandizira angakuthandizeni kugwiritsa ntchito zidziwitso ndi zinthu zomwe zingasinthe kwambiri pamoyo wanu.

  Zitha kupanganso ubale wosatha, wopindulitsa. Mutha kuyamba kufunafuna chithandizo ndipo posakhalitsa mutha kupeza mwayi wothandiza ena.