Viagra ya Akazi: Kodi imagwira ntchito bwanji, ndipo kodi ndi yotetezeka?

Zamkati

• Addyi vs. Viagra
• Cholinga ndi zopindulitsa
• Momwe flibanserin imagwirira ntchito
• Kuchita bwino
• Mwa amayi omwe atha msinkhu
• Zotsatira zoyipa
• Machenjezo a FDA: Pa matenda a chiwindi, ma enzyme inhibitors, ndi mowa
  
• Machenjezo ndi kuyanjana
• Addyi ndi mowa
• Zovuta zovomerezeka
• Kutenga

Chidule

Flibanserin (Addyi), mankhwala ofanana ndi Viagra, adavomerezedwa ndi Food and Drug Administration (FDA) ku 2015 yothandizira azimayi omwe ali ndi chidwi chogonana / matenda osokoneza bongo (FSIAD) mwa amayi omwe ali ndi premenopausal.

FSIAD imadziwikanso kuti matenda osokoneza bongo (HSDD).

Pakadali pano, Addyi imangopezeka kudzera mwa omwe amapereka mankhwala ndi mafamasi. Zimaperekedwa ndi omwe amavomereza omwe amavomereza mgwirizano pakati pa wopanga ndi FDA. Wolembetsa ayenera kutsimikiziridwa ndi wopanga kuti akwaniritse zofunikira zina za FDA.

Zimatengedwa kamodzi patsiku, nthawi yogona.

Addyi anali mankhwala oyamba a HSDD kulandira chilolezo cha FDA. Mu Juni 2019, bremelanotide (Vyleesi) adakhala wachiwiri. Addyi ndi mapiritsi a tsiku ndi tsiku, pomwe Vyleesi ndi jakisoni wodziyendetsa yekha yemwe amagwiritsidwa ntchito pakufunika.

Addyi vs. Viagra

A FDA sanavomereze Viagra (sildenafil) yokha kuti azimayi azigwiritsa ntchito. Komabe, amalembedwa kuti azichotsedwa kwa azimayi omwe ali ndi vuto lachiwerewere.

Kugwiritsa ntchito mankhwala osokoneza bongo kumatanthauza mankhwala omwe amavomerezedwa ndi FDA pacholinga chimodzi amagwiritsidwa ntchito pazinthu zina zomwe sizinavomerezedwe. Komabe, dokotala amatha kugwiritsabe ntchito mankhwalawa pazifukwa izi. Izi ndichifukwa choti a FDA amayang'anira kuyesa ndi kuvomereza mankhwala, koma osati momwe madotolo amagwiritsira ntchito mankhwala pochizira odwala awo. Chifukwa chake, adotolo amatha kukupatsani mankhwala ngakhale akuganiza kuti ndi bwino kuti musamalire.

Umboni wogwira ntchito umasakanikirana bwino kwambiri. Mayeso a Viagra mwa akazi amalingalira kuti zotsatira zabwino zimawoneka pokhudzana ndi kudzutsa thupi. Komabe, izi sizili choncho chifukwa cha zovuta kwambiri za FSIAD.

Mwachitsanzo, kuwunikiraku kunalongosola kafukufuku yemwe adapatsa Viagra kwa azimayi 202 omwe atenga msambo omwe ali ndi FSIAD yoyamba.

Ochita kafukufuku adawona kukwezedwa kwazambiri, kutsekemera kwamkazi, komanso kusangalatsa kwa omwe akuchita nawo kafukufukuyu. Komabe, azimayi omwe ali ndi matenda achiwiri omwe amakhudzidwa ndi FSIAD (monga multiple sclerosis (MS) ndi matenda ashuga) sananene chilichonse pakukonda kapena kusangalala.

Kafukufuku wachiwiri omwe wakambidwa pamwambowu adawonetsa kuti azimayi onse omwe ali ndi premenopausal komanso postmenopausal sananene chilichonse chofunikira pogwiritsa ntchito Viagra.

Cholinga ndi zopindulitsa

Pali zifukwa zingapo zomwe amayi amafunira mapiritsi ofanana ndi Viagra. Pamene akuyandikira zaka zapakati ndi kupitirira, si zachilendo kuti azimayi aziona kuchepa kwa chiwerewere chawo chonse.

Kutsika kwa kuyendetsa zogonana kumatha kuyambikanso kuzipsinjo za tsiku ndi tsiku, zochitika zazikulu m'moyo, kapena zovuta monga MS kapena matenda ashuga.

Komabe, azimayi ena amawona kuchepa kapena kupezeka pagalimoto chifukwa cha FSIAD. Malinga ndi gulu lina la akatswiri ndikuwunikanso, FSIAD ikuyenera kukhudza pafupifupi 10% ya azimayi achikulire.

Amadziwika ndi zizindikiro zotsatirazi:

• malingaliro ogonana ochepa kapena osakhala nawo
• kuchepetsedwa kapena kuyankha kwina kwa chikhumbo chogonana kapena kukondoweza
• kutaya chidwi kapena kulephera kukhalabe ndi chidwi chogonana
• kumva kukhumudwa, kulephera kuchita bwino, kapena kuda nkhawa posakhala ndi chidwi chogonana kapena kudzutsa chilakolako

Momwe flibanserin imagwirira ntchito

Flibanserin idapangidwa ngati mankhwala opondereza, koma idavomerezedwa ndi FDA yothandizira FSIAD mu 2015.

Zochita zake malinga ndi FSIAD sizimamveka bwino. Zimadziwika kuti kutenga flibanserin nthawi zonse kumakweza milingo ya dopamine ndi norepinephrine mthupi. Nthawi yomweyo, imachepetsa serotonin.

Dopamine ndi norepinephrine ndizofunikira pakukonda kugonana. Dopamine imathandizira pakulimbikitsa chilakolako chogonana. Norepinephrine ali ndi gawo lolimbikitsa kukakamiza kugonana.

Kuchita bwino

Kuvomerezeka kwa FDA kwa flibanserin kudachokera pazotsatira zoyesedwa zamankhwala atatu gawo lachitatu. Kuyesa kulikonse kunatenga milungu 24 ndikuwunika momwe flibanserin imagwirira ntchito poyerekeza ndi placebo mwa amayi omwe ali ndi premenopausal.

Ofufuza ndi a FDA adasanthula zotsatira zamayeso atatuwo. Atasinthidwa kuyankha kwa placebo, mwa omwe adatenga nawo gawo adanenanso za "kusintha kwambiri" kapena "kusintha kwambiri" m'masabata oyesa 8 mpaka 24. Uku ndikusintha pang'ono poyerekeza ndi Viagra.

Ndemanga yomwe idasindikizidwa patatha zaka zitatu Viagra's FDA ikuvomereza kuchiza matenda osokoneza bongo (ED) mwachidule mayankho apadziko lonse lapansi kuchipatala. Ku United States, mwachitsanzo, omwe adachita nawo kafukufukuyu adachitapo kanthu. Izi zikufaniziridwa ndi kuyankha kwabwino kwa 19 peresenti kwa iwo omwe atenga placebo.

Mwa amayi omwe atha msinkhu

Flibanserin sivomerezedwa ndi FDA kuti igwiritsidwe ntchito mwa amayi omwe atha msinkhu. Komabe, mphamvu ya flibanserin m'gulu lino idayesedwa pamayeso amodzi.

Adanenedwa kuti ndi ofanana ndi omwe adanenedwa mwa azimayi omwe amadwala asanabadwe. Izi zidzafunika kuunikidwanso m'mayeso ena kuti zivomerezedwe kwa azimayi omwe atha msambo.

Zotsatira zoyipa

Zotsatira zoyipa kwambiri za flibanserin ndizo:

• chizungulire
• kuvuta kugona kapena kukhalabe mtulo
• nseru
• pakamwa pouma
• kutopa
• kuthamanga kwa magazi, komwe kumatchedwanso hypotension
• kukomoka kapena kutaya chidziwitso

Machenjezo a FDA: Pa matenda a chiwindi, ma enzyme inhibitors, ndi mowa

• Mankhwalawa ali ndi machenjezo. Awa ndi machenjezo ovuta kwambiri ochokera ku Food and Drug Administration (FDA). Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.
• Flibanserin (Addyi) imatha kukomoka kapena kupsinjika mtima kwambiri ikatengedwa ndi anthu omwe ali ndi matenda a chiwindi kapena pafupi ndi mankhwala ena, kuphatikiza mowa.
• Musagwiritse ntchito Addyi ngati mutenga zoletsa zina zolimbitsa thupi kapena zamphamvu za CYP3A4. Gulu la ma enzyme inhibitors limaphatikizapo maantibayotiki, ma antifungals, ndi mankhwala a HIV, komanso mitundu ina ya mankhwala. Madzi amphesa amakhalanso ochepetsa CYP3A4 inhibitor.
• Pofuna kupewa zotsatirazi, muyeneranso kupewa kumwa mowa kwa maola awiri musanamwe mankhwala a Addyi usiku uliwonse. Mukamwa mankhwala, musamamwe mowa mpaka m'mawa mwake. Ngati mwamwa mowa pasanathe maola awiri nthawi yanu yogona isanakwane, muyenera kudumpha mlingo wa usiku womwewo.

Machenjezo ndi kuyanjana

Flibanserin sayenera kugwiritsidwa ntchito kwa anthu omwe ali ndi vuto la chiwindi.

Lankhulani ndi dokotala wanu za mankhwala ndi zowonjezera zomwe mumamwa musanayambe flibanserin. Muyeneranso kumwa flibanserin ngati mukumwa mankhwala aliwonse otsatirawa:

• mankhwala ena omwe amachiza matenda amtima, monga diltiazem (Cardizem CD) ndi verapamil (Verelan)
• maantibayotiki ena, monga ciprofloxacin (Cipro) ndi erythromycin (Ery-Tab)
• mankhwala ochizira matenda opatsirana, monga fluconazole (Diflucan) ndi itraconazole (Sporanox)
• Mankhwala a HIV, monga ritonavir (Norvir) ndi indinavir (Crixivan)
• nefazodone, wopanikizika
• zowonjezera monga wort St.

Ambiri mwa mankhwalawa ndi a gulu la ma enzyme inhibitors omwe amadziwika kuti CYP3A4 inhibitors.

Pomaliza, simuyenera kumwa madzi amphesa mukamamwa flibanserin. Komanso ndi CYP3A4 inhibitor.

Addyi ndi mowa

Addyi atavomerezedwa koyamba ndi FDA, a FDA adachenjeza omwe amagwiritsa ntchito mankhwalawa kuti asamamwe mowa chifukwa chowopsa kukomoka komanso kupsinjika mtima. Komabe, a FDA mu Epulo 2019.

Ngati mwalamulidwa Addyi, simufunikiranso kupewa kumwa mowa kwathunthu. Komabe, mutamwa mowa usiku uliwonse, muyenera kupewa kumwa mowa mpaka m'mawa mwake.

Muyeneranso kupewa kumwa mowa kwa maola awiri kale kutenga mlingo wanu usiku. Ngati mwamwa mowa pasanathe maola awiri nthawi yanu yogona isanakwane, muyenera kudumpha mlingo wa usiku wa Addyi m'malo mwake.

Ngati mwaphonya mlingo wa Addyi pazifukwa zilizonse, musamwe mankhwala kuti mupange m'mawa mwake. Dikirani mpaka usiku wotsatira ndikuyambiranso dongosolo lanu lokhazikika.

Zovuta zovomerezeka

Flibanserin anali ndi njira yovuta yovomerezera FDA.

A FDA adawunikiranso mankhwalawa katatu asanavomereze. Panali nkhawa zakufunika kwake poyerekeza ndi zovuta zoyipa. Mavutowa anali zifukwa zazikulu zomwe a FDA adalangizira kuti asavomerezedwe pambuyo pakuwunika koyambirira.

Panalinso mafunso okhalabe okhudzana ndi momwe akazi ayenera kugwirira ntchito molakwika. Kuyendetsa kugonana ndizovuta kwambiri. Pali mbali zonse zakuthupi komanso zamaganizidwe.

Flibanserin ndi sildenafil amagwira ntchito m'njira zosiyanasiyana. Sildenafil, mwachitsanzo, sichikulitsa chiwerewere mwa amuna. Kumbali inayi, flibanserin imagwira ntchito yolimbikitsa milingo ya dopamine ndi norepinephrine kuti ilimbikitse chikhumbo ndi kudzutsa.

Chifukwa chake, mapiritsi amodzi amalimbana ndi vuto lakugonana. Wina amawunikira kukhudzidwa ndi kukhumba, nkhani yovuta kwambiri.

Kutsatira kuwunikanso kwachitatu, a FDA adavomereza mankhwalawo chifukwa cha zosowa zamankhwala zosakwaniritsidwa. Komabe, nkhawa zimatsalirabe pazovuta zake. Chodetsa nkhaŵa chachikulu ndi hypotension yomwe imawonedwa pamene flibanserin imamwa ndi mowa.

Kutenga

Pali zifukwa zambiri zoyendetsera kugonana kotsika, kuyambira kupsinjika kwa tsiku ndi tsiku mpaka FSIAD.

Viagra yawona zotsatira zosakanikirana mwa azimayi ambiri, ndipo sizinapezeke zothandiza kwa azimayi omwe ali ndi FSIAD. Amayi omwe ali ndi premenopausal omwe ali ndi FSIAD atha kuwona kusintha pang'ono pakukhumba ndikudzuka atatenga Addyi.

Lankhulani ndi dokotala wanu ngati mukufuna kutenga Addyi. Onetsetsani kuti mukukambirana za mankhwala anu kapena zowonjezera musanagwiritse ntchito Addyi.