Cholestasis

Cholestasis ndi vuto lililonse momwe kutuluka kwa bile kuchokera m'chiwindi kumachedwa kapena kutsekedwa.

Pali zifukwa zambiri za cholestasis.

Extrahepatic cholestasis imachitika kunja kwa chiwindi. Itha kuyambitsidwa ndi:

• Zotupa zotulutsa minyewa
• Ziphuphu
• Kupendekera kwamitsempha ya bile (zotupa)
• Miyala mumtambo wamba wa bile
• Pancreatitis
• Pancreatic chotupa kapena pseudocyst
• Kupanikizika pamadontho a bile chifukwa cha misa kapena chotupa chapafupi
• Pulayimale sclerosing cholangitis

Intrahepatic cholestasis imachitika mkati mwa chiwindi. Itha kuyambitsidwa ndi:

• Matenda a chiwindi
• Amyloidosis
• Bakiteriya abscess m'chiwindi
• Kudyetsedwa kokha kudzera mu mtsempha (IV)
• Lymphoma
• Mimba
• Pulayimale biliary matenda enaake
• Khansa yoyamba kapena yamatenda a chiwindi
• Pulayimale sclerosing cholangitis
• Sarcoidosis
• Matenda akulu omwe afalikira kudzera m'magazi (sepsis)
• Matenda a chifuwa chachikulu
• Matenda a chiwindi

Mankhwala ena amathanso kuyambitsa cholestasis, kuphatikiza:

• Maantibayotiki, monga ampicillin ndi ma penicillin ena
• Anabolic steroids
• Mapiritsi oletsa kubereka
• Chlorpromazine
• Cimetidine
• Estradiol
• Imipramine
• Zowonjezera
• Terbinafine
• Tolbutamide

Zizindikiro zimaphatikizapo:

• Zojambula zofiira kapena zoyera
• Mkodzo wakuda
• Kulephera kugaya zakudya zina
• Kuyabwa
• Nseru kapena kusanza
• Ululu kumtunda chakumanja kwam'mimba
• Khungu lachikaso kapena maso

Mayeso amwazi atha kuwonetsa kuti mwakwera bilirubin ndi alkaline phosphatase.

Kuyesa kuyerekezera kumagwiritsidwa ntchito kuzindikira matendawa. Mayeso ndi awa:

• CT scan pamimba
• MRI ya pamimba
• Endoscopic retrograde cholangiopancreatography (ERCP), itha kudziwa chifukwa
• Ultrasound pamimba

Zomwe zimayambitsa cholestasis ziyenera kuthandizidwa.

Momwe munthu amachitira bwino zimadalira matenda omwe amayambitsa vutoli. Miyala mumtambo wamba wa bile imatha kuchotsedwa. Izi zitha kuchiza cholestasis.

Masentimita amatha kukhazikitsidwa kuti atsegule malo amtundu wambiri wa bile womwe umachepetsa kapena kutsekedwa ndi khansa.

Ngati vutoli limayamba chifukwa chogwiritsa ntchito mankhwala ena, nthawi zambiri amatha mukasiya kumwa mankhwalawo.

Zovuta zingaphatikizepo:

• Kutsekula m'mimba
• Kulephera kwa thupi kumatha kuchitika ngati sepsis ikukula
• Mavitamini osakwanira mafuta komanso mafuta osungunuka
• Kuyabwa kwambiri
• Mafupa ofooka (osteomalacia) chifukwa chokhala ndi cholestasis kwanthawi yayitali kwambiri

Imbani wothandizira zaumoyo wanu ngati muli ndi:

• Kuyabwa komwe sikupita
• Khungu lachikaso kapena maso
• Zizindikiro zina za cholestasis

Pezani katemera wa hepatitis A ndi B ngati muli pachiwopsezo. Musagwiritse ntchito mankhwala osokoneza bongo ndikugawana singano.

Intrahepatic cholestasis; Kuchulukitsa cholestasis

• Miyala
• Chikhodzodzo
• Chikhodzodzo

Eaton JE, Lindor KD. Pulayimale biliary cholangitis. Mu: Feldman M, Friedman LS, Brandt LJ, olemba. Sleisenger ndi matenda a m'mimba ndi chiwindi a Fordtran. 11th ed. Philadelphia, PA: Elsevier; 2021: mutu 91.

Fogel EL, Sherman S. Matenda a ndulu ndi ma ducts. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 146.

Lidofsky Sd. Jaundice. Mu: Feldman M, Friedman LS, Brandt LJ, olemba. Sleisenger ndi Matenda a Mimba ndi a Fordtran Amatenda a Chiwindi. 11th ed. Philadelphia, PA: Elsevier; 2021: mutu 21.