Khansa ya chithokomiro - medullary carcinoma

Medullary carcinoma ya chithokomiro ndi khansa ya chithokomiro chomwe chimayambira m'maselo omwe amatulutsa timadzi timene timatchedwa calcitonin. Maselowa amatchedwa "C" maselo. Chithokomiro chili mkati kutsogolo kwa khosi lanu lakumunsi.

Chifukwa cha medullary carcinoma ya chithokomiro (MTC) sichidziwika. MTC ndiyosowa kwambiri. Zitha kuchitika kwa ana komanso akulu.

Mosiyana ndi mitundu ina ya khansa ya chithokomiro, MTC sichingayambitsidwe ndi mankhwala a radiation pakhosi omwe amaperekedwa kuti athetse khansa zina ali mwana.

Pali mitundu iwiri ya MTC:

• Sporadic MTC, yomwe siyiyenda m'mabanja. Ma MTC ambiri amakhala ochepa. Fomuyi imakhudza kwambiri achikulire.
• Cholowa MTC, yomwe imayendera mabanja.

Muli ndi chiopsezo chowonjezeka cha khansa yamtunduwu ngati muli:

• Mbiri ya banja ya MTC
• Mbiri ya banja la ma endocrine neoplasia angapo (MEN)
• Mbiri yakale ya pheochromocytoma, mucosal neuromas, hyperparathyroidism kapena zotupa za pancreatic endocrine

Mitundu ina ya khansa ya chithokomiro ndi iyi:

• Anaplastic carcinoma ya chithokomiro
• Chotsatira chotupa cha chithokomiro
• Papillary carcinoma ya chithokomiro
• Chithokomiro lymphoma

MTC nthawi zambiri imayamba ngati chotupa chaching'ono m'matenda a chithokomiro. Pakhoza kukhala zotupa zam'mimba pakhosi. Zotsatira zake, zizindikilo zingaphatikizepo:

• Kutupa kwa khosi
• Kuopsa
• Mavuto apuma chifukwa chakuchepera kwa mayendedwe apandege
• Tsokomola
• Tsokomola ndi magazi
• Kutsekula m'mimba chifukwa cha kuchuluka kwa calcitonin

Wothandizira zaumoyo wanu adzakuyesani ndikufunsani za zidziwitso zanu komanso mbiri yazachipatala.

Mayesero omwe angagwiritsidwe ntchito pozindikira kuti MTC ndi awa:

• Kuyesa magazi kwa Calcitonin
• Mayeso a magazi a CEA
• Kuyesedwa kwachibadwa
• Chithokomiro
• Ultrasound cha chithokomiro ndi ma lymph node a khosi
• Kujambula PET

Anthu omwe ali ndi MTC ayenera kufufuzidwa ngati ali ndi zotupa zina, makamaka pheochromocytoma ndi zotupa za parathyroid ndi zotupa za parathyroid.

Chithandizochi chimaphatikizapo kuchitidwa opaleshoni kuchotsa chithokomiro ndi ma lymph node ozungulira. Chifukwa ichi ndi chotupa chosazolowereka, opareshoni iyenera kuchitidwa ndi dokotalayo yemwe amadziwa khansa yamtunduwu ndipo amadziwa momwe opaleshoniyi amafunira.

Chithandizo china chimadalira milingo yanu ya calcitonin. Kuwonjezeka kwa milingo ya calcitonin kungatanthauzenso kukula kwa khansa.

• Chemotherapy ndi radiation sizigwira ntchito bwino kwa khansa yamtunduwu.
• Poizoniyu imagwiritsidwa ntchito mwa anthu ena atachitidwa opaleshoni.
• Njira zochiritsira zatsopano zitha kuchepetsa kukula kwa chotupa. Wothandizira anu akhoza kukuwuzani zambiri za izi, ngati zingafunike.

Pafupi ndi abale a anthu omwe amapezeka kuti ali ndi mitundu yobadwa ya MTC ali pachiwopsezo chachikulu cha khansara ndipo ayenera kukambirana ndi omwe amawapatsa chithandizo.

Mutha kuchepetsa nkhawa zamankhwala ndikulowa nawo gulu lothandizira khansa. Kugawana ndi ena omwe akumana ndi mavuto omwe akukumana nawo kungakuthandizeni kuti musamve nokha.

Anthu ambiri omwe ali ndi MTC amakhala zaka 5 atawapeza, kutengera gawo la khansa. Zaka 10 zakupulumuka ndi 65%.

Zovuta zingaphatikizepo:

• Khansa imafalikira kumadera ena a thupi
• Matenda a parathyroid amachotsedwa mwangozi pa opaleshoni

Itanani omwe akukuthandizani ngati muli ndi zizindikiro za MTC.

Kupewa sikungatheke. Koma, podziwa zomwe mungachite pachiwopsezo, makamaka mbiri ya banja lanu, zitha kuloleza kuti mupeze chithandizo chamankhwala msanga. Kwa anthu omwe ali ndi mbiri yolimba ya banja la MTC, njira yoti achotse chithokomiro ingalimbikitsidwe. Muyenera kukambirana mosamala za njirayi ndi dokotala yemwe amadziwa bwino matendawa.

Chithokomiro - medullary carcinoma; Khansa - chithokomiro (medullary carcinoma); MTC; Chithokomiro nodule - medullary

• Khansa ya chithokomiro - CT scan
• Chithokomiro

Jonklass J, Cooper DS. Chithokomiro. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 213.

Tsamba la National Cancer Institute. Chithandizo cha khansa ya chithokomiro (wamkulu) (PDQ) - mtundu wa akatswiri azaumoyo. www.cancer.gov/types/thyroid/hp/thyroid-kuchiza-pdq. Idasinthidwa pa Januware 30, 2020. Idapezeka pa Marichi 6, 2020.

Smith PW, Hanks LR, Salomone LJ, Hanks JB. Chithokomiro. Mu: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Buku Lopanga Opaleshoni. Wolemba 20th. Philadelphia, PA: Elsevier Saunders; 2017: mutu 36.

Viola D, Elisei R. Kuwongolera khansa ya chithokomiro ya medullary. Chipatala cha Endocrinol Metab North Am. 2019; 48 (1): 285-301. (Adasankhidwa) PMID: 30717909 adatulutsidwa.ncbi.nlm.nih.gov/30717909/.

Wells SA Jr, Asa SL, Dralle H. Revised American Thyroid Association malangizo othandizira kasamalidwe ka matenda a chithokomiro a khansa. Chithokomiro. 2015; 25 (6): 567-610. PMID: 25810047 adasankhidwa.ncbi.nlm.nih.gov/25810047/.