Matenda a Sjögren

Matenda a Sjögren ndimatenda amomwe mthupi mwake mumatulutsa misozi ndi malovu. Izi zimayambitsa pakamwa pouma ndi maso owuma. Vutoli limatha kukhudza ziwalo zina za thupi, kuphatikizapo impso ndi mapapo.

Zomwe zimayambitsa matenda a Sjögren sizikudziwika. Ndi matenda omwe amadzichitira okhaokha. Izi zikutanthauza kuti thupi limagunda minofu yathanzi molakwika. Matendawa amapezeka nthawi zambiri mwa amayi azaka 40 mpaka 50. Ndiosowa kwa ana.

Matenda a Sjögren amafotokozedwa ngati maso owuma ndi pakamwa pouma popanda vuto linanso lodziyimira palokha.

Matenda a Sekondale a Sjögren amapezeka ndimatenda ena amthupi okha, monga:

• Matenda a nyamakazi (RA)
• Njira lupus erythematosus
• Scleroderma
• Polymyositis
• Hepatitis C imatha kukhudza ma gland amate ndipo imawoneka ngati Sjögren syndrome
• Matenda a IgG4 amatha kuwoneka ngati Sjogren syndrome ndipo ayenera kuganiziridwa

Maso owuma ndi pakamwa pouma ndizizindikiro zofala kwambiri za matendawa.

Zizindikiro za diso:

• Maso oyabwa
• Ndikumverera kuti china chake chili m'diso

Pakamwa ndi pakhosi zizindikiro:

• Zovuta kumeza kapena kudya zakudya zowuma
• Kutaya kwakumva kukoma
• Mavuto kulankhula
• Malovu kapena olimba
• Zilonda za pakamwa kapena zowawa
• Kuwonongeka kwa mano ndi chingamu kutupa
• Kuopsa

Zizindikiro zina zitha kuphatikiza:

• Kutopa
• Malungo
• Sinthani mtundu wa manja kapena mapazi ndikutentha kozizira (Raynaud phenomenon)
• Ululu wophatikizana kapena kutupa palimodzi
• Zotupa zotupa
• Ziphuphu pakhungu
• Kunjenjemera ndi kupweteka chifukwa cha matenda a ubongo
• Chifuwa ndi kupuma pang'ono chifukwa cha matenda am'mapapo
• Kugunda kwamtima kosasintha
• Nsautso ndi kutentha pa chifuwa
• Kuuma kwa nyini kapena kukodza kopweteka

Kuyezetsa kwathunthu kumachitika. Mayesowa akuwonetsa maso owuma ndi pakamwa pouma. Pakhoza kukhala zilonda zam'kamwa, mano owola kapena kutupa kwa chingamu. Izi zimachitika chifukwa cha kuuma pakamwa. Wothandizira zaumoyo wanu adzayang'ana mkamwa mwanu matenda a bowa (candida). Khungu limatha kuwonetsa zotupa, mayeso am'mapapo atha kukhala osazolowereka, m'mimba mudzagundika chifukwa chokulitsa chiwindi. Malumikizowo adzafufuzidwa ngati ali ndi nyamakazi. Kuyesa kwa neuro kuyang'ana zoperewera.

Mutha kukhala ndi mayeso otsatirawa:

• Mankhwala athunthu am'magazi ndi michere ya chiwindi
• Kuwerengera kwathunthu kwa magazi ndikusiyanitsa
• Kupenda kwamadzi
• Mayeso a Antinuclear antibodies (ANA)
• Anti-Ro / SSA ndi anti-La / SSB antibodies
• Chifuwa cha nyamakazi
• Yesani ma cryoglobulins
• Malizitsani milingo
• Mapuloteni electrophoresis
• Kuyesa kwa hepatitis C ndi HIV (ngati kuli pachiwopsezo)
• Mayeso a chithokomiro
• Kuyesa kwa Schirmer kopanga misozi
• Kujambula kwa salivary gland: ndi ultrasound kapena MRI
• Matenda a salivary gland
• Khungu lachikopa ngati ziphuphu zilipo
• Kupenda kwa maso ndi ophthalmologist
• X-ray pachifuwa

Cholinga ndikuchepetsa zizindikiritso.

• Maso owuma amatha kuthandizidwa ndi misozi yokumba, mafuta odzola m'maso, kapena madzi a cyclosporine.
• Ngati Candida alipo, atha kuthandizidwa ndi miconazole yopanda shuga kapena kukonzekera kwa nystatin.
• Mapulagi ang'onoang'ono amatha kuikidwa m'mayenje osungunula misozi kuti misozi ikhale pamtunda.

Mankhwala osokoneza bongo (DMARDs) ofanana ndi omwe amagwiritsidwa ntchito pa RA amatha kusintha zizindikiritso za Sjögren syndrome. Izi zikuphatikiza chotupa cha necrosis factor (TNF) choletsa mankhwala monga Enbrel, Humira kapena Remicaide.

Zinthu zina zomwe mungachite kuti muchepetse zizindikilo ndi izi:

• Sip madzi tsiku lonse
• Kutafuna chingamu chopanda shuga
• Pewani mankhwala omwe angayambitse mkamwa, monga antihistamines ndi mankhwala opangira mankhwala
• Pewani mowa

Lankhulani ndi dokotala wa mano za:

• Kutsuka mkamwa kuti mutenge mchere m'mano anu
• Olowa m'malo mwa malovu
• Mankhwala omwe amathandiza kuti ma gland anu amate apange mate ambiri

Kupewa kuwola kwamano koyambitsa mkamwa:

• Sambani ndi kutsuka mano anu nthawi zambiri
• Pitani kwa dokotala wa mano kuti mukapimidwe pafupipafupi komanso kuyeretsa

Matendawa nthawi zambiri sawopsa. Zotsatira zake zimatengera matenda ena omwe muli nawo.

Pali chiopsezo chachikulu cha lymphoma ndi kufa msanga pomwe matenda a Sjögren akhala akugwira ntchito kwanthawi yayitali, komanso anthu omwe ali ndi vasculitis, low complements, ndi cryoglobulins.

Zovuta zingaphatikizepo:

• Kuwonongeka kwa diso
• Meno a mano
• Impso kulephera (kawirikawiri)
• Lymphoma
• Matenda am'mapapo
• Vasculitis (osowa)
• Matenda a ubongo
• Kutupa kwa chikhodzodzo

Itanani omwe akukuthandizani ngati mukukula ndi matenda a Sjögren.

Xerostomia - matenda a Sjögren; Keratoconjunctivitis sicca - Sjögren; Matenda a Sicca

• Ma antibodies

Baer AN, Alevizos I. Sjögren matenda. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, olemba. Zamatsenga. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2019: mutu 147.

Matenda a Mariette X. Sjögren. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 268.

Seror R, Bootsma H, Saraux A, ndi al. Kutanthauzira zochitika zamatenda ndikuwongolera kwakatikati mwa matenda a Sjögren's syndrome omwe ali ndi matenda a EULAR oyambira matenda a Sjögren's (ESSDAI) ndi ma index omwe amalembedwa ndi odwala (ESSPRI). Ann Rheum Dis. 2016; 75 (2): 382-389. PMID: 25480887 www.ncbi.nlm.nih.gov/pubmed/25480887.

Singh AG, Singh S, Matteson EL. Mlingo, zoopsa zomwe zimayambitsa kufa kwa odwala omwe ali ndi Sjögren's syndrome: kuwunika mwatsatanetsatane ndikuwunika meta kwamaphunziro a gulu. Rheumatology (Oxford). 2016; 55 (3): 450-460. PMID: 26412810 www.ncbi.nlm.nih.gov/pubmed/26412810. (Adasankhidwa)

Turner MD. Mawonedwe apakamwa a matenda amachitidwe. Mu: Flint PW, Haughey BH, Lund V, et al, olemba. Cummings Otolaryngology. Lachisanu ndi chimodzi. Philadelphia, PA: Elsevier Saunders; 2015: mutu 14.