Nephropathy ya IgA

Nephropathy ya IgA ndi vuto la impso momwe ma antibodies omwe amatchedwa IgA amakhala mumisempha ya impso. Nephropathy ndi kuwonongeka, matenda, kapena mavuto ena ndi impso.

Nephropathy ya IgA imatchedwanso matenda a Berger.

IgA ndi protein, yotchedwa antibody, yomwe imathandiza thupi kulimbana ndi matenda. Nephropathy ya IgA imachitika mapuloteni ambiri akaikidwa mu impso. IgA imamanga mkati mwa mitsempha yaying'ono yamagazi ya impso. Mapangidwe a impso otchedwa glomeruli amatupa ndikuwonongeka.

Matendawa amatha kuwoneka modzidzimutsa (pachimake), kapena kuwonjezeka pang'onopang'ono pazaka zambiri (glomerulonephritis).

Zowopsa ndi izi:

• Mbiri yaumwini kapena yabanja ya IgA nephropathy kapena Henoch-Schönlein purpura, mtundu wa vasculitis womwe umakhudza ziwalo zambiri za thupi
• Mtundu wachizungu kapena waku Asia

Nephropathy ya IgA imatha kupezeka mwa anthu azaka zonse, koma nthawi zambiri imakhudza amuna azaka zapakati pa 30 mpaka 30.

Sipangakhale zizindikiro kwa zaka zambiri.

Pakakhala zizindikilo, zimatha kuphatikiza:

• Mkodzo wamagazi womwe umayamba nthawi yayitali kapenanso patangotha ​​matenda opumira
• Magawo obwereza amkodzo wamdima kapena wamagazi
• Kutupa kwa manja ndi mapazi
• Zizindikiro za matenda a impso

Nephropathy ya IgA imapezeka nthawi zambiri munthu yemwe alibe zisonyezo zina za impso ali ndi gawo limodzi kapena angapo amkodzo wamdima kapena wamagazi.

Palibe zosintha zenizeni zomwe zimawoneka pakuwunika kwakuthupi. Nthawi zina, kuthamanga kwa magazi kumatha kukhala kwakukulu kapena pangakhale kutupa kwa thupi.

Mayeso ndi awa:

• Kuyesa kwa magazi urea nitrogen (BUN) kuti muyese kugwira kwa impso
• Kuyesa magazi kwa Creatinine kuyeza ntchito ya impso
• Impso biopsy kuti zitsimikizire matenda
• Kupenda kwamadzi
• Mkodzo immunoelectrophoresis

Cholinga cha chithandizo ndikuthetsa zizindikiro ndikupewa kapena kuchedwetsa kulephera kwa impso.

Mankhwalawa atha kukhala:

• Angiotensin-converter enzyme (ACE) inhibitors ndi angiotensin receptor blockers (ARBs) kuti athetse kuthamanga kwa magazi ndi kutupa (edema)
• Corticosteroids, mankhwala ena omwe amalepheretsa chitetezo cha mthupi
• Mafuta a nsomba
• Mankhwala ochepetsa mafuta m'thupi

Mchere ndi zamadzimadzi zimatha kulepheretsa kutupa. Zakudya zochepa zomanga thupi zimatha kulimbikitsidwa nthawi zina.

Potsirizira pake, anthu ambiri amayenera kuchiritsidwa matenda a impso osatha ndipo angafunike dialysis.

Nephropathy ya IgA imakula pang'onopang'ono. Nthawi zambiri, sizimangokulirakulirabe. Mkhalidwe wanu ukhoza kukulirakulira ngati muli:

• Kuthamanga kwa magazi
• Mapuloteni ambiri mumkodzo
• Kuchuluka kwa BUN kapena milingo ya creatinine

Itanani omwe akukuthandizani ngati muli ndi mkodzo wamagazi kapena ngati mukupanga mkodzo wochepa kuposa masiku onse.

Nephropathy - IgA; Matenda a Berger

• Matenda a impso

Feehally J, Floege J. Immunoglobulin A nephropathy ndi IgA vasculitis (Henoch-Schönlein purpura). Mu: Feehally J, Floege J, Tonelli M, Johnson RJ, olemba. Chachikulu Chachipatala Nephrology. Lachisanu ndi chimodzi. Philadelphia, PA: Elsevier; 2019: chaputala 23.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ (Adasankhidwa) Matenda oyamba a glomerular. Mu: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, olemba. Brenner ndi Rector a Impso. 11th ed. Philadelphia, PA: Elsevier; 2020: chap 31.