Kusowa kwa Factor VII

Kuperewera kwa factor VII (zisanu ndi ziwiri) ndimatenda omwe amabwera chifukwa chosowa kwa protein yotchedwa factor VII m'magazi. Zimadzetsa mavuto ndi magazi oundana (coagulation).

Mukamatuluka magazi, zochitika zingapo zimachitika mthupi zomwe zimathandiza kuundana kwamagazi. Izi zimatchedwa coagulation cascade. Zimaphatikizapo mapuloteni apadera otchedwa coagulation, kapena clotting factor. Mutha kukhala ndi mwayi wambiri wokhetsa magazi ngati chimodzi kapena zingapo mwazimene zikusowa kapena sizikugwira ntchito moyenera.

Factor VII ndichimodzi mwazinthu zoterezi. Kuperewera kwa factor VII kumayambira m'mabanja (obadwa nawo) ndipo ndi osowa kwambiri. Makolo onse ayenera kukhala ndi jini yopatsira ana awo vutoli. Mbiri yabanja yokhudzana ndi kutaya magazi imatha kukhala pachiwopsezo.

Kuperewera kwa factor VII kumathanso chifukwa cha vuto lina kapena kugwiritsa ntchito mankhwala ena. Izi zimatchedwa kusowa kwa VII. Itha kuyambitsidwa ndi:

• Vitamini K wotsika (ana ena amabadwa ndi kuchepa kwa vitamini K)
• Matenda owopsa a chiwindi
• Kugwiritsa ntchito mankhwala omwe amateteza kuundana (maanticoagulants monga warfarin)

Zizindikiro zimatha kuphatikizira izi:

• Kutuluka magazi kuchokera kumatope
• Magazi m'magazi
• Kutuluka magazi mu minofu
• Kulalata mosavuta
• Kutaya magazi kwambiri
• Kutulutsa magazi m'mphuno komwe sikumatha mosavuta
• Umbilical chingwe kutuluka magazi atabadwa

Mayeso omwe angachitike ndi awa:

• Nthawi yapadera ya thromboplastin (PTT)
• Ntchito ya Plasma factor VII
• Nthawi ya Prothrombin (PT)
• Kusakaniza kuphunzira, kuyesa kwapadera kwa PTT kutsimikizira kusowa kwa factor VII

Kutulutsa magazi kumatha kuyang'aniridwa ndikulowetsedwa m'mitsempha yamitsempha yamagazi (IV) ya plasma yabwinobwino, kuphatikiza kwa VII, kapena chinthu cha VII chopanga chibadwa.

Mudzafunika kulandira chithandizo pafupipafupi mukamatuluka magazi chifukwa chinthu VII sichikhala kwakanthawi m'thupi. Fomu ya VII yotchedwa NovoSeven itha kugwiritsidwanso ntchito.

Ngati muli ndi vuto la VII chifukwa chakusowa kwa vitamini K, mutha kumwa vitamini mukamwa, kudzera muma jakisoni pakhungu, kapena kudzera mumitsempha (kudzera m'mitsempha).

Ngati muli ndi vuto lotaya magazi, onetsetsani kuti:

• Uzani omwe amakupatsani chithandizo chamankhwala musanachite chilichonse, kuphatikiza opaleshoni ndi ntchito ya mano.
• Uzani achibale anu chifukwa atha kukhala ndi vuto lofananalo koma sakudziwa panobe.

Izi zitha kukupatsirani zambiri zakusowa kwa Factor VII:

• National Hemophilia Foundation: Zofooka Zina Zowonjezera - www.hemophilia.org/Bleeding-Disorders/Types-of-Beeding-Disorders/Other-Factor-Deficiencies
• National Organisation for Rare Disways - rarediseases.org/rare-diseases/factor-vii-deficiency
• Buku Lofotokozera za NLM Genetics - ghr.nlm.nih.gov/condition/factor-vii-deficiency

Mutha kuyembekezera zotsatira zabwino ndi chithandizo choyenera.

Choloŵa cha chinthu cha VII chotengera ndichikhalidwe cha moyo wonse.

Kuwona kwakusowa kwa chinthu VII kutengera chifukwa. Ngati imayambitsidwa ndi matenda a chiwindi, zotsatira zake zimadalira momwe matenda anu a chiwindi angachiritsiridwe. Kutenga zowonjezera mavitamini K kumathandiza kuchepa kwa vitamini K.

Zovuta zingaphatikizepo:

• Kutaya magazi kwambiri (kukha magazi)
• Sitiroko kapena mavuto ena amanjenje ochokera ku mitsempha yayikulu yotulutsa magazi
• Mavuto olowa pamavuto akulu mukamatuluka magazi nthawi zambiri

Pezani chithandizo chadzidzidzi nthawi yomweyo ngati muli ndi magazi owopsa, osadziwika.

Palibe choletsa kudziwika chifukwa chakusowa kwa VII. Ngati kusowa kwa vitamini K ndiye chifukwa, kugwiritsa ntchito vitamini K kumatha kuthandizira.

Kulephera kwa Proconvertin; Kuperewera kwa zinthu zakunja; Seramu prothrombin kutembenuka accelerator akusowa; Matenda a Alexander

• Mapangidwe a magazi
• Kuundana kwamagazi

Gailani D, Wheeler AP, Neff AT. Zofooka zambiri zomwe zimachitika nthawi zambiri. Mu: Hoffman R, Benz EJ, Silberstein LE, et al, olemba. Hematology: Mfundo Zoyambira ndi Zochita. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2018: mutu 137.

Hall JE. Hemostasis ndi magazi coagulation. Mu Hall JE, mkonzi. Guyton ndi Hall Textbook of Medical Physiology. Wolemba 13. Philadelphia, PA: Elsevier; 2016: chap 37.

Ragni MV. Matenda a hemorrhagic: coagulation factor deficience. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 174.