Cerebral amyloid angiopathy

Cerebral amyloid angiopathy (CAA) ndi momwe mapuloteni otchedwa amyloid amakhala pamakoma a mitsempha muubongo. CAA imawonjezera chiopsezo cha sitiroko yoyambitsidwa ndi kutaya magazi ndi matenda amisala.

Anthu omwe ali ndi CAA amakhala ndi mapuloteni amyloid m'makoma amitsempha yamagazi muubongo. Puloteniyo samayikidwa kwina kulikonse mthupi.

Choopsa chachikulu ndikukula kwa msinkhu. CAA imawonekera kwambiri mwa anthu okalamba kuposa 55. Nthawi zina, imafalikira kudzera m'mabanja.

CAA imatha kuyambitsa magazi muubongo. Kutuluka magazi nthawi zambiri kumachitika kunja kwa ubongo, kotchedwa kotekisi, osati malo akuya. Zizindikiro zimachitika chifukwa kutuluka magazi mu ubongo kumawononga minofu yaubongo. Anthu ena amakhala ndi mavuto okumbukira pang'onopang'ono. CT scan ikachitika, pamakhala zizindikiro zosonyeza kuti akhala akutuluka magazi muubongo omwe mwina sanazindikire.

Ngati pali magazi ambiri, nthawi yomweyo zimachitika ndipo zimafanana ndi sitiroko. Zizindikirozi ndi monga:

• Kusinza
• Mutu (nthawi zambiri mbali ina yamutu)
• Kusintha kwamanjenje komwe kumatha kuyamba mwadzidzidzi, kuphatikiza kusokonezeka, kusokonekera, kuwona kawiri, kuchepa kwa masomphenya, kusintha kwamphamvu, mavuto olankhula, kufooka, kapena kufooka
• Kugwidwa
• Stupor kapena coma (kawirikawiri)
• Kusanza

Ngati kutuluka magazi sikofala kapena kufalikira, zizindikilo zimatha kuphatikizira izi:

• Magawo achisokonezo
• Kupweteka komwe kumabwera ndikupita
• Kutaya ntchito kwamaganizidwe (dementia)
• Kufooka kapena zachilendo zomwe zimabwera ndikupita, ndikuphatikizira magawo ang'onoang'ono
• Kugwidwa

CAA ndizovuta kuzizindikira motsimikiza popanda zitsanzo za minofu yaubongo. Izi zimachitika pambuyo poti munthu wamwalira kapena pomwe mitsempha yamaubongo imachitika.

Kuyezetsa thupi kumatha kukhala kwachilendo ngati magazi amatuluka pang'ono. Pakhoza kukhala kusintha kwa magwiridwe antchito aubongo. Ndikofunikira kuti adokotala afunse mafunso mwatsatanetsatane wazizindikiro komanso mbiri yazachipatala. Zizindikiro ndi zotsatira za kuyezetsa thupi ndi mayeso aliwonse amalingaliro angapangitse dokotala kukaikira CAA.

Kuyerekeza mayeso amutu omwe atha kukhala monga:

• CT scan kapena MRI scan kuti muwone ngati magazi akutuluka magazi muubongo
• MRA amayesa kuti aone ngati akutuluka magazi ambiri ndikuwunika zina zomwe zimayambitsa magazi
• PET kusanthula kuti muwone momwe amyloid amasungidwira muubongo

Palibe mankhwala odziwika othandiza. Cholinga cha chithandizo ndikuthetsa zizindikiro. Nthawi zina, kukonzanso kumafunika chifukwa cha kufooka kapena kuwuma. Izi zitha kuphatikizira kulimbitsa thupi, ntchito, kapena kulankhula.

Nthawi zina, mankhwala omwe amathandiza kukonza kukumbukira, monga a matenda a Alzheimer, amagwiritsidwa ntchito.

Kugwidwa, komwe kumatchedwanso kuti amyloid, kumatha kuthandizidwa ndi mankhwala oletsa kulanda.

Vutoli limakula pang'onopang'ono.

Zovuta za CAA zitha kuphatikiza:

• Kusokonezeka maganizo
• Hydrocephalus (kawirikawiri)
• Kugwidwa
• Nkhani zobwerezabwereza zamagazi muubongo

Pitani kuchipinda chodzidzimutsa kapena itanani nambala yadzidzidzi yakomweko (monga 911) ngati mwangotaya mwendo, kumva, masomphenya, kapena kulankhula.

Amyloidosis - ubongo; CAA; Angiopathy yachisokonezo

• Amyloidosis wa zala
• Mitsempha ya ubongo

Charidimou A, Boulouis G, Gurol ME, ndi al. Maganizo omwe akubwera mu ubongo wa amyloid angiopathy. Ubongo. 2017; 140 (7): 1829-1850. PMID: 28334869 pubed.ncbi.nlm.nih.gov/28334869/.

Greenberg SM, Charidimou A. Kuzindikira kwa angiopathy yamaubongo am'mimba: kusinthika kwamachitidwe a Boston. Sitiroko. 2018; 49 (2): 491-497. (Adasankhidwa) PMID: 29335334 pubed.ncbi.nlm.nih.gov/29335334/.

Kase CS, Shoamanesh A. Kutaya magazi kwamkati. Mu: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, olemba. Neurology ya Bradley mu Kuchita Zachipatala. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2016: chap 66.