C1 esterase inhibitor

C1 esterase inhibitor (C1-INH) ndi puloteni yomwe imapezeka m'magazi amwazi wanu. Imayang'anira puloteni yotchedwa C1, yomwe ndi gawo la makina othandizira.

Njira yothandizirayi ndi gulu la mapuloteni pafupifupi 60 am'magazi am'magazi kapena pamaselo ena. Mapuloteni oyenerana amagwira ntchito ndi chitetezo chanu cha mthupi kuteteza thupi ku matenda. Amathandizanso kuchotsa maselo akufa ndi zinthu zakunja. Pali mapuloteni asanu ndi anayi akulu othandizira. Amatchedwa C1 kudzera C9. Nthawi zambiri, anthu amatha kulandira kuchepa kwa mapuloteni ena othandizira. Anthuwa amatha kudwala matenda ena kapena matenda omwe amadzichitira okha.

Nkhaniyi ikufotokoza za kuyesa komwe kumachitika kuti muyeza kuchuluka kwa C1-INH m'magazi anu.

Muyenera kuyesa magazi. Izi nthawi zambiri zimatengedwa kudzera mumtsempha. Njirayi imatchedwa venipuncture.

Palibe kukonzekera kwapadera komwe kumafunikira.

Pamene singano imayikidwa kuti ikoke magazi, anthu ena amamva kupweteka pang'ono. Ena amangomva kuti amangobaya kapena kuluma. Pambuyo pake, pakhoza kukhala kupindika.

Mungafunike mayesowa ngati muli ndi zizindikilo zakubadwa kapena angioedema. Mitundu yonse ya angioedema imayamba chifukwa cha kuchepa kwa C1-INH.

Zowonjezeranso zingakhale zofunikira pakuyesa matenda amthupi mokha, monga systemic lupus erythematosus.

Mitengo yamtengo wapatali imatha kusiyanasiyana pakati pa ma labotore osiyanasiyana. Wothandizira zaumoyo wanu adzayesanso magwiridwe antchito a C1 esterase inhibitor yanu. Lankhulani ndi omwe akukuthandizani za tanthauzo la zotsatira zanu zoyeserera.

Magawo otsika a C1-INH atha kuyambitsa mitundu ina ya angioedema. Angioedema imabweretsa kutupa kwadzidzidzi kwaminyewa ya nkhope, khosi lakumtunda ndi lilime. Zingayambitsenso kupuma movutikira. Kutupa m'matumbo ndi m'mimba kumayambanso. Pali mitundu iwiri ya angioedema yomwe imachokera kutsika kwa C1-INH. Hereditary angioedema imakhudza ana ndi achikulire ochepera zaka 20. Angioedema yopezeka imawoneka mwa achikulire omwe ali ndi zaka zoposa 40. Akuluakulu omwe ali ndi angioedema amakhala ndi zovuta zina monga khansa kapena matenda amthupi.

Zowopsa zomwe zimakhudza kukoka magazi ndizochepa, koma zimatha kuphatikiza:

• Kutaya magazi kwambiri
• Kukomoka kapena kumva mopepuka
• Hematoma (magazi akuchuluka pansi pa khungu)
• Kutenga (chiopsezo chochepa nthawi iliyonse khungu likasweka)

C1 choletsa chinthu; C1-INH

• Kuyezetsa magazi

Cicardi M, Aberer W, Banerji A, ndi al. Gulu, kuzindikira, ndi njira yothandizira angioedema: lipoti logwirizana lochokera ku Hereditary Angioedema International Working Group. Ziwengo. 2014; 69 (5): 602-616. PMID: 24673465 www.ncbi.nlm.nih.gov/pubmed/24673465. (Adasankhidwa)

Leslie TA, Greaves MW. Cholowa cholowa angioedema. Mu: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, olemba. Kuchiza kwa Matenda a Khungu: Njira Zambiri Zakuchiritsira. 5th ed. Philadelphia, PA: Elsevier; 2018: mutu 101.

Zanichelli A, Azin GM, Wu MA, ndi al. Kuzindikira, kumene, ndikuwongolera angioedema mwa odwala omwe ali ndi vuto la C1-inhibitor. J Allergy Clin Immunol Pract. 2017; 5 (5): 1307-1313. PMID: 28284781 www.ncbi.nlm.nih.gov/pubmed/28284781. (Adasankhidwa)