Kuyezetsa magazi kwa Cortisol

Kuyezetsa magazi kwa cortisol kumayeza kuchuluka kwa cortisol m'magazi. Cortisol ndi steroid (glucocorticoid kapena corticosteroid) hormone yopangidwa ndi adrenal gland.

Cortisol imatha kuyezedwanso pogwiritsa ntchito mayeso a mkodzo kapena malovu.

Muyenera kuyesa magazi.

Dokotala wanu adzakuyesani m'mawa kwambiri. Izi ndizofunikira, chifukwa kuchuluka kwa cortisol kumasiyanasiyana tsiku lonse.

Mutha kupemphedwa kuti musachite masewera olimbitsa thupi mwamphamvu tsiku lisanafike mayeso.

Muthanso kuuzidwa kuti musiye kumwa mankhwala omwe angakhudze mayeso, kuphatikiza:

• Mankhwala oletsa kulanda
• Estrogen
• Zopangidwa ndi anthu (zopanga) glucocorticoids, monga hydrocortisone, prednisone ndi prednisolone
• Androgens

Pamene singano imayikidwa kuti ikoke magazi, anthu ena amamva kupweteka pang'ono. Ena amangomva kubaya kapena kuluma. Pambuyo pake, pakhoza kukhala kupunduka kapena kuvulala pang'ono. Izi posachedwa zichoka.

Kuyesaku kumachitika kuti muwone kuchuluka kwa cortisol yowonjezera kapena yotsika. Cortisol ndi hormone ya glucocorticoid (steroid) yotulutsidwa mu adrenal gland poyankha adrenocorticotropic hormone (ACTH). ACTH ndi timadzi tomwe timatuluka mu ubongo wa pituitary.

Cortisol imakhudza machitidwe amthupi osiyanasiyana. Imagwira nawo:

• Kukula kwa mafupa
• Kuthamanga kwa magazi
• Chitetezo cha mthupi
• Kagayidwe ka mafuta, chakudya, ndi mapuloteni
• Mchitidwe wamanjenje umagwira
• Kupsinjika

Matenda osiyanasiyana, monga Cushing syndrome ndi matenda a Addison, amatha kuyambitsa cortisol yochulukirapo kapena yochepa. Kuyeza kuchuluka kwa magazi a cortisol kumatha kuthandizira kuzindikira izi. Amayesedwanso kuti awunikire momwe matenda a pituitary ndi adrenal amagwirira ntchito.

Kuyesaku kumachitika nthawi zambiri isanakwane ndi ola limodzi mutabayidwa mankhwala otchedwa ACTH (cosyntropin). Gawo ili la mayeso limatchedwa mayeso okondoweza a ACTH. Ndi mayeso ofunikira omwe amathandizira kuwunika momwe ntchito ya pituitary ndi adrenal gland imagwirira ntchito.

Zina mwazomwe mayeso angayitanitsidwe ndi monga:

• Vuto lalikulu la adrenal, vuto lowopsa lomwe limachitika pakakhala kuti pali cortisol yokwanira
• Sepsis, matenda omwe thupi limayankha kwambiri mabakiteriya kapena majeremusi ena
• Kuthamanga kwa magazi

Makhalidwe abwinobwino oyesa magazi omwe amatengedwa nthawi ya 8 m'mawa ndi 5 mpaka 25 mcg / dL kapena 140 mpaka 690 nmol / L.

Makhalidwe abwinobwino amatengera nthawi yamasana komanso momwe zinthu ziliri. Mitundu yodziwika imatha kusiyanasiyana pang'ono pakati pa ma laboratories osiyanasiyana. Ma lab ena amagwiritsa ntchito miyeso yosiyana kapena amatha kuyesa mitundu yosiyanasiyana. Lankhulani ndi dokotala wanu tanthauzo la zotsatira zanu zoyesa.

Mulingo woposa wabwinobwino ungasonyeze:

• Cushing matenda, momwe chifuwa cha pituitary chimapanga ACTH yochulukirapo chifukwa chokula kwambiri kwa matenda am'mimbamo kapena chotupa m'matumbo
• Ectopic Cushing syndrome, momwe chotupa kunja kwa ma pituitary kapena adrenal glands chimapanga ACTH yochulukirapo
• Chotupa cha adrenal gland chomwe chimatulutsa cortisol wambiri
• Kupsinjika
• Matenda oopsa

Mlingo wotsika kuposa wamba ungasonyeze:

• Matenda a Addison, momwe ma adrenal gland samatulutsa cortisol yokwanira
• Hypopituitarism, momwe chifuwa cha pituitary sichimatanthauza kuti adrenal gland imatulutsa cortisol yokwanira
• Kuchepetsa kugwira ntchito kwa pituitary kapena adrenal ndi mankhwala a glucocorticoid kuphatikiza mapiritsi, mafuta apakhungu, eyedrops, inhalers, jakisoni wamagulu, chemotherapy

Pali chiopsezo chochepa chotenga magazi anu. Mitsempha ndi mitsempha imasiyana mosiyanasiyana kuchokera pa munthu wina kupita kwina komanso kuchokera mbali imodzi ya thupi kupita mbali inayo. Kutenga magazi kuchokera kwa anthu ena kumatha kukhala kovuta kuposa ena.

Zowopsa zina zomwe zimakoka magazi ndi zochepa, koma mwina ndi izi:

• Kutaya magazi kwambiri
• Kukomoka kapena kumva mopepuka
• Ma punctures angapo kuti mupeze mitsempha
• Hematoma (magazi akuchuluka pansi pa khungu)
• Kutenga (chiopsezo chochepa nthawi iliyonse khungu likasweka)

Seramu cortisol

Chernecky CC, Berger BJ. Cortisol - plasma kapena seramu. Mu: Chernecky CC, Berger BJ, olemba., Eds. Kuyesa Kwantchito ndi Njira Zakuzindikira. Lachisanu ndi chimodzi. St Louis, MO: Elsevier Saunders; 2013: 388-389.

Stewart PM, Newell-Price JDC. Kachilombo kotchedwa adrenal cortex. Mu: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, olemba. Buku la Williams la Endocrinology. Wolemba 13. Philadelphia, PA: Elsevier; 2016: chap 15.