Mankhwala a Cannabidiol (CBD)

Zamkati

• Zothandiza ...
• Umboni wosakwanira woti ungagwire bwino ntchito ...
• Chenjezo lapadera & machenjezo:

Cannabidiol ndi mankhwala mu chamba cha Cannabis sativa, chotchedwanso chamba kapena hemp. Mankhwala opitilira 80, omwe amadziwika kuti cannabinoids, apezeka mu chomera cha Cannabis sativa. Ngakhale delta-9-tetrahydrocannabinol (THC) ndiye chinthu chofunikira kwambiri chamba, cannabidiol imapezekanso ku hemp, yomwe imangokhala ndi THC yochepa kwambiri.

Kuperekedwa kwa Bill Farm wa 2018 kunapangitsa kukhala kovomerezeka kugulitsa mankhwala a hemp ndi hemp ku U.S. Koma sizitanthauza kuti zinthu zonse zopangidwa ndi hemp za cannabidiol ndizovomerezeka. Popeza cannabidiol yawerengedwa ngati mankhwala atsopano, sizingaphatikizidwe mwalamulo muzakudya kapena zowonjezera zakudya. Komanso, cannabidiol sungaphatikizidwe pazogulitsidwa zomwe zanenedwa ndi zamankhwala. Cannabidiol imangophatikizidwa ndi zinthu "zodzikongoletsera" pokhapokha ngati ili ndi zosakwana 0,3% THC. Koma palinso zinthu zomwe zimatchedwa kuti zowonjezera zakudya pamsika zomwe zimakhala ndi cannabidiol. Kuchuluka kwa cannabidiol komwe kumapezeka muzinthu izi sikuti nthawi zonse kumafotokozedwa molondola pamalonda.

Cannabidiol imagwiritsidwa ntchito kwambiri pamavuto okomoka (khunyu). Amagwiritsidwanso ntchito pakakhala nkhawa, kupweteka, vuto la minofu lotchedwa dystonia, matenda a Parkinson, matenda a Crohn, ndi zina zambiri, koma palibe umboni wabwino wasayansi wotsimikizira izi.

Mankhwala Achilengedwe Pazonse mitengo yogwira ntchito potengera umboni wasayansi molingana ndi muyeso wotsatirawu: Wogwira Mtima, Wogwira Mtima, Mwinanso Wogwira Ntchito, Mwinanso Wosagwira Ntchito, Mwinanso Wosagwira Ntchito, Wosagwira Ntchito, Ndi Umboni Wosakwanira Wowerengera.

Kuchita bwino kwa CANNABIDIOL (CBD) ndi awa:

Zothandiza ...

• Matenda osokoneza bongo (khunyu). Mankhwala apadera a cannabidiol (Epidiolex, GW Pharmaceuticals) awonetsedwa kuti achepetse kugwa kwa akulu ndi ana omwe ali ndi zovuta zosiyanasiyana zomwe zimakhudzana ndi kugwidwa. Chogulitsachi ndi mankhwala omwe amachiza khunyu yoyambitsidwa ndi matenda a Dravet, Lennox-Gastaut syndrome, kapena tuberous sclerosis complex. Zikuwonekeranso kuti amachepetsa kugwidwa kwa anthu omwe ali ndi matenda a Sturge-Weber, matenda opatsirana a khunyu (FIRES), ndi zovuta zina zamatenda zomwe zimayambitsa matenda a khunyu. Koma sichivomerezedwa pochiza matenda enawa. Izi nthawi zambiri zimatengedwa limodzi ndi mankhwala ochiritsira olanda. Zinthu zina za cannabidiol zomwe zimapangidwa mu labu zikuwerengedwanso khunyu. Koma kafukufuku ali ndi malire, ndipo palibe chilichonse mwazinthuzi zomwe zimavomerezedwa ngati mankhwala akuchipatala.

Umboni wosakwanira woti ungagwire bwino ntchito ...

• Mtundu wamatenda otupa (matenda a Crohn). Kafukufuku woyambirira akuwonetsa kuti kutenga cannabidiol sikuchepetsa kuchepa kwa matenda kwa akulu omwe ali ndi matenda a Crohn.
• Matenda a shuga. Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito cannabidiol sikuthandizira kuwongolera magazi m'magazi achikulire omwe ali ndi matenda amtundu wa 2.
• Matenda oyenda omwe amadziwika ndi kutsekeka kwa minofu (dystonia). Sizikudziwika ngati cannabidiol ndiyopindulitsa kwa dystonia.
• Chikhalidwe chobadwa nacho chodziwika ndi kulephera kuphunzira (chosalimba- X matenda). Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito gelidiol gel kungachepetse nkhawa ndikuwongolera machitidwe kwa ana omwe ali ndi matenda a X osalimba.
• Mkhalidwe womwe kumuika kumawononga thupi (matenda olandirira-motsutsana-nawo kapena GVHD). Matenda olimbana ndi omwe amakhala nawo ndi zovuta zomwe zimatha kuchitika pakangolowa mafuta m'mafupa. Kafukufuku woyambirira apeza kuti kutenga cannabidiol tsiku lililonse kuyambira masiku 7 asanalowe m'mafupa ndikupitilira masiku 30 mutangowonjezera kumatha kuwonjezera nthawi yomwe munthu amatenga GVHD.
• Vuto lobadwa nalo lomwe limakhudza mayendedwe, malingaliro, ndi kuganiza (Matenda a Huntington). Kafukufuku woyambirira akuwonetsa kuti kutenga cannabidiol tsiku lililonse sikuthandizira kusintha kwa matenda a Huntington.
• Multiple sclerosis (MS). Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito mankhwala osokoneza bongo a cannabidiol pansi pa lilime kumatha kupweteka komanso kulimba kwa anthu omwe ali ndi MS.
• Kusiya heroin, morphine, ndi mankhwala ena opioid. Kafukufuku woyambirira akuwonetsa kuti kutenga cannabidiol masiku atatu kumatha kuchepetsa zikhumbo ndi nkhawa mwa anthu omwe ali ndi vuto la kugwiritsa ntchito heroin.
• Matenda a Parkinson. Kafukufuku woyambirira akuwonetsa kuti cannabidiol imatha kuchepetsa nkhawa komanso zizindikiritso zama psychotic mwa anthu omwe ali ndi matenda a Parkinson.
• Matenda achizungu. Kafukufuku woyambirira akuwonetsa kuti kumwa cannabidiol kumathandizira kusintha zizindikiritso komanso kukhala ndi thanzi labwino mwa anthu omwe ali ndi schizophrenia.
• Kusiya kusuta. Kafukufuku woyambirira akuwonetsa kuti kupumira cannabidiol ndi inhaler sabata limodzi kumachepetsa kuchuluka kwa ndudu zosuta ndi omwe amasuta omwe akufuna kusiya.
• Mtundu wamavuto omwe amadziwika ndi mantha m'malo ena kapena m'malo ena onse (matenda amisala). Kafukufuku woyambirira akuwonetsa kuti cannabidiol itha kuchepetsa nkhawa mwa anthu omwe ali ndi vutoli. Koma sizikudziwika ngati zimathandiza kuchepetsa nkhawa pakulankhula pagulu.
• Gulu la zowawa zomwe zimakhudza nsagwada ndi minofu (matenda a temporomandibular kapena TMD). Kafukufuku woyambirira akuwonetsa kuti kupaka mafuta okhala ndi cannabidiol pakhungu kumatha kuchepetsa kupweteka kwa anthu omwe ali ndi TMD.
• Mitsempha yawonongeka m'manja ndi m'mapazi (zotumphukira za m'mitsempha).
• Matenda osokoneza bongo.
• Kusowa tulo.
• Zochitika zina.

Umboni wina umafunikira kuti tiwone momwe cannabidiol imagwirira ntchito.

Cannabidiol imakhudza ubongo. Zomwe zimayambitsa izi sizikudziwika. Komabe, cannabidiol ikuwoneka kuti imalepheretsa kuwonongeka kwa mankhwala muubongo omwe amakhudza kuwawa, malingaliro, ndi magwiridwe antchito. Kupewa kuwonongeka kwa mankhwalawa ndikuwonjezera kuchuluka kwake m'magazi kumawoneka kuti kumachepetsa zizindikiritso zama psychotic zokhudzana ndi mikhalidwe monga schizophrenia. Cannabidiol amathanso kuletsa zina mwazomwe zimachitika chifukwa cha delta-9-tetrahydrocannabinol (THC). Komanso, cannabidiol ikuwoneka kuti imachepetsa kupweteka komanso nkhawa.

Mukamamwa: Cannabidiol ndi WOTSATIRA BWINO akamwedwa pakamwa kapena kuthiridwa mankhwala pansi pa lilime moyenerera. Cannabidiol muyezo wa 300 mg tsiku lililonse amatengedwa pakamwa mosamala kwa miyezi isanu ndi umodzi. Mlingo wapamwamba wa 1200-1500 mg tsiku lililonse watengedwa pakamwa mosamala kwa milungu inayi. Mankhwala a cannabidiol product (Epidiolex) amavomerezedwa kuti amwe pakamwa mpaka 25 mg / kg tsiku lililonse. Mankhwala a Cannabidiol omwe amagwiritsidwa ntchito pansi pa lilime agwiritsidwa ntchito muyezo wa 2.5 mg mpaka milungu iwiri.

Zotsatira zina zoyipa za cannabidiol zimaphatikizira pakamwa pouma, kuthamanga kwa magazi, kupepuka, komanso kugona. Zizindikiro zovulala pachiwindi zanenedwa mwa odwala ena, koma izi sizachilendo.

Mukagwiritsidwa ntchito pakhungu: Palibe chidziwitso chodalirika chokwanira chodziwira ngati cannabidiol ili bwino kapena zotsatirapo zake.

Chenjezo lapadera & machenjezo:

Mimba ndi kuyamwitsa: Cannabidiol ndi ZOTSATIRA ZOSATETEZEKA kugwiritsa ntchito ngati muli ndi pakati kapena mukuyamwitsa. Mankhwala a Cannabidiol atha kuipitsidwa ndi zinthu zina zomwe zitha kuvulaza mwana wosabadwa kapena khanda. Khalani otetezeka ndikupewa kugwiritsa ntchito.

Ana: Mankhwala a cannabidiol product (Epidiolex) ndi WOTSATIRA BWINO mukamamwa pakamwa muyezo mpaka 25 mg / kg tsiku lililonse. Izi zimavomerezedwa kuti zizigwiritsidwa ntchito kwa ana ena azaka 1 kapena kupitirira.

Matenda a chiwindi: Anthu omwe ali ndi matenda a chiwindi angafunikire kugwiritsa ntchito mankhwala ochepa a cannabidiol poyerekeza ndi odwala athanzi.

Matenda a Parkinson: Kafukufuku woyambirira akuwonetsa kuti kumwa kwambiri cannabidiol kumatha kupangitsa kuti kusuntha kwa minofu ndi kunjenjemera kukhale koyipa mwa anthu ena omwe ali ndi matenda a Parkinson.

Wamkati

Samalani ndi kuphatikiza uku.

Brivaracetam (Briviact)

Brivaracetam imasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera brivaracetam mwachangu. Izi zitha kuwonjezera kuchuluka kwa brivaracetam mthupi.

Carbamazepine (Tegretol)

Carbamazepine amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera carbamazepine mwachangu. Izi zitha kuwonjezera kuchuluka kwa carbamazepine mthupi ndikuwonjezera zovuta zake.

Clobazam (Onfi)

Clobazam imasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimagwera mwachangu clobazam. Izi zitha kukulitsa zovuta ndi zovuta za clobazam.

Eslicarbazepine (Aptiom)

Eslicarbazepine amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera eslicarbazepine mwachangu. Izi zitha kukulitsa eslicarbazepine mthupi pang'ono.

Everolimus (Zostress)

Everolimus amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera pansi nthawi zonse. Izi zitha kuwonjezera kuchuluka kwa ma everolimus mthupi.

Lifiyamu

Kutenga kuchuluka kwa cannabidiol kumatha kuwonjezera kuchuluka kwa lithiamu. Izi zitha kuwonjezera chiopsezo cha lithiamu kawopsedwe.

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 1A1 (CYP1A1))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi monga chlorzoxazone (Lorzone) ndi theophylline (Theo-Dur, ena).

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 1A2 (CYP1A2))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, ena), verapamil (Calan, Isoptin, ena), ndi ena.

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 1B1 (CYP1B1))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi theophylline (Theo-Dur, ena), omeprazole (Prilosec, Omesec), clozapine (Clozaril, FazaClo), progesterone (Prometrium, ena), lansoprazole (Prevacid), flutamide (Eulexin), oxaliplatin (Eloxatin ), erlotinib (Tarceva), ndi caffeine.

Mankhwala asinthidwa ndi chiwindi (magawo a Cytochrome P450 2A6 (CYP2A6))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi chikonga, chlormethiazole (Heminevrin), coumarin, methoxyflurane (Penthrox), halothane (Fluothane), valproic acid (Depacon), disulfiram (Antabuse), ndi ena.

Mankhwala asinthidwa ndi chiwindi (magawo a Cytochrome P450 2B6 (CYP2B6))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), ndi dexamethasone (Decadron).

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 2C19 (CYP2C19))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi ma proton pump inhibitors kuphatikiza omeprazole (Prilosec), lansoprazole (Prevacid), ndi pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); ndi ena.

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 2C8 (CYP2C8))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.
Mankhwala ena omwe amasinthidwa ndi chiwindi ndi amiodarone (Cordarone), carbamazepine (Tegretol), chloroquine (Aralen), diclofenac (Voltaren), paclitaxel (Taxol), repaglinide (Prandin) ndi ena.

Mankhwala asinthidwa ndi chiwindi (magawo a Cytochrome P450 2C9 (CYP2C9))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol limodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi amaphatikizapo mankhwala osagwiritsa ntchito zotupa (NSAIDs) monga diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), ndi celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); ndi ena.

Mankhwala osinthidwa ndi ziwindi (cytochrome P450 2D6 (CYP2D6) magawo)

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol pamodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil) ), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), ndi ena.

Mankhwala osinthidwa ndi ziwindi (magawo a Cytochrome P450 3A4 (CYP3A4))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol pamodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine, fexofenadine (Halcion), verapamil (Calan, Isoptin) ndi ena ambiri.

Mankhwala osinthidwa ndi chiwindi (magawo a Cytochrome P450 3A5 (CYP3A5))

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Mwachidziwitso, kugwiritsa ntchito cannabidiol pamodzi ndi mankhwala ena omwe awonongeka ndi chiwindi kumatha kukulitsa zovuta ndi zovuta zina za mankhwala ena. Musanagwiritse ntchito cannabidiol, lankhulani ndi omwe amakuthandizani ngati mutamwa mankhwala omwe amasinthidwa ndi chiwindi.

Mankhwala ena omwe amasinthidwa ndi chiwindi ndi testosterone, progesterone (Endometrin, Prometrium), nifedipine (Adalat CC, Procardia XL), cyclosporine (Sandimmune), ndi ena.

Mankhwala osinthidwa ndi chiwindi (Glucuronidated drug)

Mankhwala ena amasinthidwa ndikuwonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira mankhwala ena mwachangu. Kutenga cannabidiol pamodzi ndi mankhwala ena omwe awonongeka ndi chiwindi atha kukulitsa zovuta ndi zoyipa za mankhwalawa.
Ena mwa mankhwala omwe asinthidwa ndi chiwindi ndi acetaminophen (Tylenol, ena) ndi oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), ndi ena.

Mankhwala omwe amachepetsa kuwonongeka kwa mankhwala ena ndi chiwindi (Cytochrome P450 2C19 (CYP2C19) inhibitors)

Cannabidiol yawonongeka ndi chiwindi. Mankhwala ena amachepetsa momwe chiwindi chimaphwanyira msanga cannabidiol. Kutenga cannabidiol limodzi ndi mankhwalawa kumatha kukulitsa zovuta ndi zoyipa za cannabidiol.
Mankhwala ena omwe angachepetse kuwonongeka kwa cannabidiol m'chiwindi ndi cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), ndi ena.

Mankhwala omwe amachepetsa kuwonongeka kwa mankhwala ena m'chiwindi (Cytochrome P450 3A4 (CYP3A4) inhibitors)

Cannabidiol yawonongeka ndi chiwindi. Mankhwala ena amachepetsa momwe chiwindi chimaphwanyira msanga cannabidiol. Kutenga cannabidiol limodzi ndi mankhwalawa kumatha kukulitsa zovuta ndi zoyipa za cannabidiol.
Mankhwala ena omwe angachepetse momwe chiwindi chimatha msanga cannabidiol ndi amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase) , Invirase), ndi ena ambiri.

Mankhwala omwe amachulukitsa kuwonongeka kwa mankhwala ena ndi chiwindi (Cytochrome P450 3A4 (CYP3A4) inducers)

Cannabidiol yawonongeka ndi chiwindi. Mankhwala ena amatha kuwonjezera momwe chiwindi chimaphwanyira msanga cannabidiol. Kutenga cannabidiol limodzi ndi mankhwalawa kumatha kuchepetsa zotsatira za cannabidiol.
Ena mwa mankhwalawa ndi carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), ndi ena.

Mankhwala omwe amachulukitsa kuwonongeka kwa mankhwala ena ndi chiwindi (Cytochrome P450 2C19 (CYP2C19) inducers)

Cannabidiol yawonongeka ndi chiwindi. Mankhwala ena amatha kuwonjezera momwe chiwindi chimaphwanyira msanga cannabidiol. Kutenga cannabidiol limodzi ndi mankhwalawa kumatha kuchepetsa zotsatira za cannabidiol.
Mankhwala ena omwe angapangitse kuwonongeka kwa cannabidiol m'chiwindi ndi carbamazepine (Tegretol), prednisone (Deltasone), ndi rifampin (Rifadin, Rimactane).

Methadone (Dolophine)

Methadone yawonongeka ndi chiwindi. Cannabidiol ikhoza kuchepa momwe chiwindi chimaphwanyira methadone mwachangu. Kutenga cannabidiol pamodzi ndi methadone kumatha kukulitsa zovuta ndi zoyipa za methadone.

Rufinamide (Banzel)

Rufinamide amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera rufinamide mwachangu. Izi zitha kukulitsa kuchuluka kwa rufinamide mthupi pang'ono.

Mankhwala osokoneza bongo (CNS depressants)

Cannabidiol ikhoza kuyambitsa tulo ndi kugona. Mankhwala omwe amachititsa kuti anthu azigona tulo amatchedwa mankhwala ogonetsa. Kutenga cannabidiol pamodzi ndi mankhwala osokoneza bongo kungayambitse kugona kwambiri.

Mankhwala ena otopetsa ndi benzodiazepines, pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), ndi ena.

Sirolimus (Rapamune)

Sirolimus amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera msana sirolimus. Izi zitha kuwonjezera kuchuluka kwa sirolimus mthupi.

Stiripentol (Diacomit)

Stiripentol amasinthidwa ndikuphwanya thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera msanga stiripentol. Izi zitha kuwonjezera kuchuluka kwa mankhwala otakasuka m'thupi ndikuwonjezera zovuta zake.

Zamatsenga (Prograf)

Tacrolimus amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera tacrolimus mwachangu. Izi zitha kuwonjezera kuchuluka kwa tacrolimus mthupi.

Topiramate (Tompamax)

Topiramate imasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera topiramate mwachangu. Izi zitha kukulitsa kuchuluka kwa topiramate mthupi pang'ono.

Valproate

Valproic acid imatha kuvulaza chiwindi. Kutenga cannabidiol ndi valproic acid kungapangitse mwayi wovulala chiwindi. Cannabidiol ndi / kapena valproic acid angafunikire kuyimitsidwa, kapena mulingo ungafunike kuchepetsedwa.

Warfarin

Cannabidiol itha kukulitsa warfarin, yomwe imatha kuwonjezera ngozi yakutaya magazi. Cannabidiol ndi / kapena warfarin angafunike kuyimitsidwa, kapena mulingo ungafunike kuchepetsedwa.

Zonisamide

Zonisamide amasinthidwa ndikuphwanyidwa ndi thupi. Cannabidiol ikhoza kuchepa momwe thupi limagwetsera mwachangu zonisamide. Izi zitha kukulitsa magawo a zonisamide mthupi pang'ono.

Zitsamba ndi zowonjezera zowonjezera

Cannabidiol imatha kuyambitsa tulo kapena kugona. Kuigwiritsa ntchito limodzi ndi zitsamba zina ndi zowonjezera zomwe zimakhala ndi vuto lomwelo zimatha kugona kwambiri. Zina mwa zitsamba ndi zowonjezera zimaphatikizapo calamus, California poppy, catnip, hop, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, wort St. John's, sassafras, skullcap, ndi ena.

Mowa (Mowa)

Kutenga cannabidiol ndi mowa kumawonjezera kuchuluka kwa cannabidiol yomwe imayamwa ndi thupi. Izi zitha kukulitsa zovuta ndi zoyipa za cannabidiol.

Mafuta ndi zakudya zokhala ndi mafuta

Kutenga cannabidiol ndi chakudya chokhala ndi mafuta ambiri kapena osachepera muli mafuta, kumawonjezera kuchuluka kwa cannabidiol komwe kumayamwa ndi thupi. Izi zitha kukulitsa zovuta ndi zoyipa za cannabidiol.

Mkaka

Kutenga cannabidiol ndi mkaka kumawonjezera kuchuluka kwa cannabidiol yomwe imayamwa ndi thupi. Izi zitha kukulitsa zovuta ndi zoyipa za cannabidiol.

Mlingo wotsatira udaphunziridwa pakufufuza kwasayansi:

ACHIKULU

NDI PAKAMWA:

• Kwa khunyu: Mankhwala a cannabidiol product (Epidiolex) agwiritsidwa ntchito. Mlingo woyambira wa Lennox-Gastaut syndrome ndi Dravet syndrome ndi 2.5 mg / kg kawiri tsiku lililonse (5 mg / kg / tsiku). Pakatha sabata limodzi mlingowo umatha kukwezedwa mpaka 5 mg / kg kawiri tsiku lililonse (10 mg / kg / tsiku). Ngati munthuyo samayankha pamlingowu, zomwe zimalimbikitsidwa ndi 10 mg / kg kawiri tsiku lililonse (20 mg / kg / tsiku). Mlingo woyambira woyambira wa tuberous sclerosis complex ndi 2.5 mg / kg kawiri tsiku lililonse (5 mg / kg / tsiku). Izi zitha kuwonjezeka pakadutsa sabata ngati kuli kofunikira, mpaka kufika pa 12.5 mg / kg kawiri patsiku (25 mg / kg / tsiku). Palibe umboni wamphamvu wosonyeza kuti mankhwala osagwiritsidwa ntchito polembedwa a cannabidiol ndi othandiza khunyu.

ANA

NDI PAKAMWA:

• Kwa khunyu: Mankhwala a cannabidiol product (Epidiolex) agwiritsidwa ntchito. Mlingo woyambira wa Lennox-Gastaut syndrome ndi Dravet syndrome ndi 2.5 mg / kg kawiri tsiku lililonse (5 mg / kg / tsiku). Pakatha sabata limodzi mlingowo umatha kukwezedwa mpaka 5 mg / kg kawiri tsiku lililonse (10 mg / kg / tsiku). Ngati munthuyo samayankha pamlingowu, zomwe zimalimbikitsidwa ndi 10 mg / kg kawiri tsiku lililonse (20 mg / kg / tsiku). Mlingo woyambira woyambira wa tuberous sclerosis complex ndi 2.5 mg / kg kawiri tsiku lililonse (5 mg / kg / tsiku). Izi zitha kuwonjezeka pakadutsa sabata ngati kuli kofunikira, mpaka kufika pa 12.5 mg / kg kawiri patsiku (25 mg / kg / tsiku). Palibe umboni wamphamvu wosonyeza kuti mankhwala osagwiritsidwa ntchito polembedwa a cannabidiol ndi othandiza khunyu.

2 - [(1R, 6R) -3-Methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl] -5-pentylbenzene-1,3-diol, CBD.

Kuti mudziwe zambiri za momwe nkhaniyi idalembedwera, chonde onani Mankhwala Achilengedwe Pazonse njira.

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