17-Hydroxyprogesterone

Zamkati

• Kodi kuyesa kwa 17-hydroxyprogesterone (17-OHP) ndi chiyani?
• Amagwiritsidwa ntchito yanji?
• Chifukwa chiyani ndikufuna mayeso a 17-OHP?
• Kodi chimachitika ndi chiyani poyesa 17-OHP?
• Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?
• Kodi pali zoopsa zilizonse pamayeso?
• Kodi zotsatirazi zikutanthauza chiyani?
• Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a 17-OHP?
• Zolemba

Kodi kuyesa kwa 17-hydroxyprogesterone (17-OHP) ndi chiyani?

Kuyesaku kumayeza kuchuluka kwa 17-hydroxyprogesterone (17-OHP) m'magazi. 17-OHP ndi mahomoni opangidwa ndi adrenal glands, ma gland awiri omwe ali pamwamba pa impso. Matenda a adrenal amapanga mahomoni angapo, kuphatikiza cortisol. Cortisol ndikofunikira pakusungitsa kuthamanga kwa magazi, shuga wamagazi, ndi zina zoteteza chitetezo cha mthupi. 17-OHP imapangidwa ngati gawo limodzi la ntchito yopanga cortisol.

Kuyesa kwa 17-OHP kumathandizira kupeza matenda osowa amtundu wotchedwa congenital adrenal hyperplasia (CAH). Ku CAH, kusintha kwa majini, komwe kumatchedwa kusintha, kumalepheretsa adrenal gland kupanga kotekisi yokwanira. Momwe ma adrenal gland amagwirira ntchito molimbika kuti apange cortisol yambiri, amatulutsa 17-OHP yowonjezera, komanso mahomoni ena achimuna.

CAH itha kuyambitsa kukula kosazolowereka kwa ziwalo zogonana komanso zikhalidwe zakugonana. Zizindikiro za matendawa zimayamba kuchokera pofatsa mpaka zovuta. Ngati sanalandire chithandizo, mitundu yoopsa kwambiri ya CAH imatha kubweretsa zovuta zazikulu, kuphatikizapo kuchepa kwa madzi m'thupi, kuthamanga kwa magazi, komanso kugunda kwamtima (arrhythmia).

Mayina ena: 17-OH progesterone, 17-OHP

Amagwiritsidwa ntchito yanji?

Mayeso a 17-OHP amagwiritsidwa ntchito kwambiri pofufuza CAH mwa ana obadwa kumene. Itha kugwiritsidwanso ntchito ku:

• Dziwani za CAH mwa ana okalamba komanso achikulire omwe atha kukhala ndi vuto lowopsa. Mu CAH yovuta, zizindikiro zimatha kuwonekera pambuyo pake m'moyo, kapena nthawi zina ayi.
• Onetsetsani chithandizo cha CAH

Chifukwa chiyani ndikufuna mayeso a 17-OHP?

Mwana wanu adzafunika mayeso a 17-OHP, nthawi zambiri mkati mwa masiku 1-2 atabadwa. Kuyesa kwa 17-OHP kwa CAH pakufunika malinga ndi lamulo ngati gawo la kuwunika kumene wakhanda. Kuwunika kumene kumangobadwa kumene ndikuyesa magazi kosavuta komwe kumafufuza matenda osiyanasiyana.

Ana okalamba ndi akulu amafunikanso kuyezetsa ngati ali ndi zizindikiro za CAH. Zizindikiro zimakhala zosiyana kutengera kukula kwa matendawa, msinkhu wazizindikiro, komanso ngati ndinu wamwamuna kapena wamkazi.

Zizindikiro za matendawa nthawi zambiri zimawoneka mkati mwa masabata 2-3 mutabadwa.

Ngati mwana wanu anabadwira kunja kwa United States ndipo sanayese kubadwa kumene, angafunike kuyesedwa ngati ali ndi chimodzi kapena zingapo mwa izi:

• Ziwalo zoberekera zomwe sizodziwika bwino kuti ndi amuna kapena akazi (maliseche ovuta)
• Kutaya madzi m'thupi
• Kusanza ndi mavuto ena odyetsa
• Nyimbo zosazolowereka (arrhythmia)

Ana okulirapo sangakhale ndi zizindikilo mpaka kutha msinkhu. Kwa atsikana, zizindikiro za CAH ndizo:

• Msambo wosasamba, kapena kusakhala ndi nthawi konse
• Kuwonekera koyambirira kwa pubic ndi / kapena tsitsi lamanja
• Tsitsi lokwanira pankhope ndi thupi
• Mawu akuya
• Clitoris yowonjezera

Kwa anyamata, zizindikiro zimaphatikizapo:

• Kukula kwa mbolo
• Kutha msinkhu (kutha msinkhu)

Mwa amuna ndi akazi achikulire, zizindikiro zimaphatikizapo:

• Kusabereka (kulephera kutenga pakati kapena kutenga mnzake pakati)
• Ziphuphu zazikulu

Kodi chimachitika ndi chiyani poyesa 17-OHP?

Pakuwunika kumene wakhanda, katswiri wazachipatala amayeretsa chidendene cha mwana wanu ndi mowa ndikumulanda chidendene ndi singano yaying'ono. Woperekayo amatolera magazi pang'ono ndikuyika bandeji pamalowo.

Mukayezetsa magazi ana okalamba komanso achikulire, katswiri wazachipatala amatenga magazi kuchokera mumtsuko wamkono mwanu, pogwiritsa ntchito singano yaying'ono. Singanoyo italowetsedwa, magazi ang'onoang'ono amatengedwa mu chubu choyesera. Mutha kumva kuluma pang'ono singano ikamalowa kapena kutuluka. Izi nthawi zambiri zimatenga mphindi zosakwana zisanu.

Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?

Palibe zokonzekera mwapadera zofunikira pakuyesa kwa 17-OHP.

Kodi pali zoopsa zilizonse pamayeso?

Palibe chiopsezo chachikulu kwa inu kapena mwana wanu yemwe ali ndi mayeso a 17-OHP. Mutha kukhala ndi ululu pang'ono kapena kuvulala pamalo pomwe singano idayikidwapo, koma zizindikiro zambiri zimatha msanga. Mwana wanu amatha kumverera pang'ono pamene chidendene chimakokedwa, ndipo mikwingwirima ingapangidwe pamalowo. Izi zikuyenera kuchoka mwachangu.

Kodi zotsatirazi zikutanthauza chiyani?

Ngati zotsatira zikuwonetsa kuchuluka kwa 17-OHP, ndiye kuti mwina inu kapena mwana wanu muli ndi CAH. Nthawi zambiri, kukwera kwambiri kumatanthauza mawonekedwe ovuta kwambiri, pomwe kuchuluka pang'ono nthawi zambiri kumatanthauza mawonekedwe ofatsa.

Ngati inu kapena mwana wanu mukulandira CAH, magawo 17-OHP angatanthauze kuti mankhwalawa akugwira ntchito. Chithandizo chake chingaphatikizepo mankhwala obwezeretsa cortisol yomwe ikusowa. Nthawi zina amachitidwa opaleshoni kuti asinthe mawonekedwe ndi maliseche.

Ngati muli ndi mafunso okhudza zotsatira zanu kapena zotsatira za mwana wanu, lankhulani ndi omwe amakuthandizani.

Dziwani zambiri zamayeso a labotale, magawo owerengera, ndi zotsatira zakumvetsetsa.

Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a 17-OHP?

Ngati inu kapena mwana wanu mwapezeka kuti muli ndi CAH, mungafune kukaonana ndi mlangizi wa majini, katswiri wodziwa bwino za majini. CAH ndimatenda amtundu momwe makolo onse ayenera kukhala ndi kusintha komwe kumayambitsa CAH. Kholo limatha kukhala chonyamulira cha jini, zomwe zikutanthauza kuti ali ndi jini koma nthawi zambiri alibe zizindikilo za matenda. Ngati makolo onse ali onyamula, mwana aliyense ali ndi mwayi 25% wokhala ndi vutoli.

Zolemba

1. Cares Foundation [intaneti]. Mgwirizano (NJ): Cares Foundation; c2012. Kodi Congenital Adrenal Hyperplasia (CAH) ndi chiyani ?; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.caresfoundation.org/what-is-cah
2. Eunice Kennedy Shriver National Institute of Child Health and Human Development [Intaneti]. Rockville (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Kobadwa nako Adrenal Hyperplasia (CAH): Chikhalidwe Chidziwitso; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.nichd.nih.gov/health/topics/cah/conditioninfo
3. Hormone Health Network [Intaneti]. Bungwe la Endocrine; c2019. Kobadwa nako Adrenal Hyperplasia; [yasinthidwa 2018 Sep; yatchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://www.hormone.org/diseases-and-conditions/congenital-adrenal-hyperplasia
4. Ana Health kuchokera ku Nemours [Internet]. Jacksonville (FL): Nemours Foundation; c1995–2019. Kobadwa nako Adrenal Hyperplasia; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://kidshealth.org/en/parents/congenital-adrenal-hyperplasia.html
5. Ana Health kuchokera ku Nemours [Internet]. Jacksonville (FL): Nemours Foundation; c1995–2019. Kuyesedwa Kwatsopano Kwa Ana Obadwa; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://kidshealth.org/en/parents/newborn-screening-tests.html
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7. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC; American Association for Chipatala Chemistry; c2001–2019. Kusabereka; [yasinthidwa 2017 Nov 27; yatchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/conditions/infertility
8. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. NCI Dictionary Yokhudza Khansa: mlangizi wamtundu; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/794108
9. National Center for Advancing Translational Sciences: Matenda Achibadwa ndi Osowa Information Center [Internet]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Kusowa kwa 21-hydroxolase; [yasinthidwa 2019 Apr 11; yatchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://rarediseases.info.nih.gov/diseases/5757/21-hydroxylase-deficiency
10. Magic Foundation [Intaneti]. Warrenville (IL): Magic Foundation; c1989–2019. Kobadwa nako Adrenal Hyperplasia; [yotchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.magicfoundation.org/Growth-Disorders/Congenital-Adrenal-Hyperplasia
11. Marichi wa Dimes [Intaneti]. Arlington (VA): Marichi wa Dimes; c2020. Kuyesedwa Kwatsopano Kobadwa Kwa Mwana Wanu; [adatchula 2020 Aug 8]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.marchofdimes.org/baby/newborn-screening-tests-for-your-baby.aspx
12. UF Health: University of Florida Health [Intaneti]. Gainesville (FL): Yunivesite ya Florida Health; c2019. 17-OH progesterone: Mwachidule; [yasinthidwa 2019 Aug 17; yatchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://ufhealth.org/17-oh-progesterone
13. UF Health: University of Florida Health [Intaneti]. Gainesville (FL): Yunivesite ya Florida Health; c2019. Kobadwa nako adrenal hyperplasia: mwachidule; [yasinthidwa 2019 Aug 17; yatchulidwa 2019 Aug 17]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://ufhealth.org/congenital-adrenal-hyperplasia

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