Mlembi: Clyde Lopez
Tsiku La Chilengedwe: 24 Kulayi 2021
Sinthani Tsiku: 1 Epulo 2025
Anonim
How does Niacin (B3) Work? (+ Pharmacology)
Kanema: How does Niacin (B3) Work? (+ Pharmacology)

Zamkati

Niacin ndi mtundu wa vitamini B3. Amapezeka mu zakudya monga yisiti, nyama, nsomba, mkaka, mazira, masamba obiriwira, ndi mbewu monga chimanga. Niacin amapangidwanso m'thupi kuchokera ku tryptophan, yomwe imapezeka mu chakudya chokhala ndi mapuloteni. Mukatengedwa ngati chowonjezera, niacin nthawi zambiri imapezeka kuphatikiza ndi mavitamini ena a B.

Osasokoneza niacin ndi NADH, niacinamide, inositol nicotinate, IP-6, kapena tryptophan. Onani mindandanda yapaderadera pamitu iyi.

Mitundu yolembera ya niacin imavomerezedwa ndi US Food and Drug Administration (FDA) kuti ichepetse cholesterol komanso kuti iwonjezere kuchuluka kwa cholesterol, yotchedwa HDL. Mankhwala opatsirana a Niacin ndi mankhwala amathandizanso pakamwa popewa kuchepa kwa vitamini B3 ndi zovuta zina monga pellagra.

Mankhwala Achilengedwe Pazonse mitengo yogwira ntchito potengera umboni wasayansi molingana ndi muyeso wotsatirawu: Wogwira Mtima, Wogwira Mtima, Mwinanso Wogwira Ntchito, Mwinanso Wosagwira Ntchito, Mwinanso Wosagwira Ntchito, Wosagwira Ntchito, Ndi Umboni Wosakwanira Wowerengera.

Kuchita bwino kwa NIACIN ndi awa:


Zothandiza ...

  • Mavuto osadziwika a cholesterol kapena mafuta amwazi (dyslipidemia). Zida zina za niacin zimavomerezedwa ndi US Food and Drug Administration (FDA) ngati mankhwala omwe amachiza mafuta achilendo. Mankhwalawa ndiacin omwe amakhala ndi mphamvu zokwanira 500 mg kapena kupitilira apo. Mitundu yowonjezera ya niacin nthawi zambiri imabwera ndi mphamvu ya 250 mg kapena yocheperako. Popeza kuchuluka kwambiri kwa niacin kumafunikira kuti muchepetse mafuta a cholesterol, zakudya zowonjezera niacin nthawi zambiri sizoyenera. Niacin itha kuphatikizidwa ndi mankhwala ena ochepetsa mafuta m'thupi pamene mankhwala ndi mankhwala amodzi osakwanira. Niacin amakulitsa mafuta m'thupi, koma samakulitsa zotsatira za mtima ndi mtima.
  • Matenda omwe amadza chifukwa cha kusowa kwa niacin (pellagra). Niacin imavomerezedwa ndi US Food and Drug Administration (FDA) kuti agwiritse ntchito. Komabe, niacin imatha kuyambitsa "kuthamanga" (kufiira, kuyabwa, ndi kumva kulira). Chifukwa chake chinthu china, chotchedwa niacinamide, nthawi zina chimakondedwa chifukwa sichimayambitsa zotsatirazi.

Mwina zothandiza ...

  • Mafuta achilendo amtundu wa anthu omwe ali ndi HIV / AIDS. Kutenga niacin kumawoneka kuti kumakulitsa cholesterol ndi mafuta amwazi omwe amatchedwa triglycerides mwa odwala omwe ali ndi vutoli.
  • Gulu lazizindikiro zomwe zimawonjezera chiopsezo cha matenda ashuga, matenda amtima, ndi sitiroko (metabolic syndrome). Kutenga niacin kumawoneka kuti kumawonjezera kuchuluka kwa mafuta okhala ndi lipoprotein (HDL kapena "zabwino") cholesterol ndikuchepetsa mafuta amwazi omwe amatchedwa triglycerides mwa anthu omwe ali ndi matenda amadzimadzi. Kutenga niacin limodzi ndi mankhwala omega-3 fatty acid akuwoneka kuti akugwiranso ntchito bwino.

Zosathandiza pa ...

  • Matenda a mtima. Kafukufuku wapamwamba kwambiri akuwonetsa kuti niacin siyimatchinjiriza mtima kapena kupwetekedwa kwa anthu omwe amatenga niacin kupewa kapena kuchiza matenda amtima. Niacin sanawonetsedwe kuti amachepetsa chiopsezo cha imfa. Niacin sayenera kumwedwa kuchiza kapena kuteteza matenda amtima.

Umboni wosakwanira woti ungagwire bwino ntchito ...

  • Kuuma kwa mitsempha (atherosclerosis). Kutenga niacin pakamwa pamodzi ndi mankhwala otchedwa bile acid sequestrants kungachepetse kuuma kwa mitsempha mwa amuna omwe ali ndi vutoli. Zikuwoneka kuti zimagwira ntchito bwino mwa amuna omwe ali ndi mafuta ambiri m'magazi otchedwa triglycerides. Koma kutenga niacin sikuwoneka kuti kumachepetsa kuuma kwa mitsempha kwa odwala omwe ali ndi vuto lotchedwa peripheral arterial disease (PAD). Komanso, niacin siyimateteza zochitika zamtima monga matenda amtima kapena sitiroko.
  • Matenda a Alzheimer. Anthu omwe amadya kwambiri niacin kuchokera pachakudya ndi ma multivitamini akuwoneka kuti ali pachiwopsezo chochepa chotenga matenda a Alzheimer kuposa anthu omwe amadya niacin yochepa. Koma palibe umboni kuti kumwa mankhwala a niacin kumathandiza kupewa matenda a Alzheimer's.
  • Kupunduka. Anthu omwe amadya kwambiri niacin atha kukhala ndi mwayi wocheperako wokhala ndi ng'ala ya nyukiliya. Matenda a nyukiliya ndi omwe amapezeka kwambiri. Zotsatira zakumwa mankhwala a niacin sizikudziwika.
  • Matenda am'matumbo omwe amayambitsa kutsegula m'mimba (kolera). Kutenga niacin pakamwa kumawoneka ngati kumachepetsa kutsegula m'mimba mwa anthu omwe ali ndi kolera.
  • Kulephera kwa Erectile (ED). Kutenga niacin womasulidwa nthawi yogona kwa masabata a 12 kumawoneka kuti kumathandiza amuna omwe ali ndi ED komanso omwe ali ndi milomo yambiri amakhala ndi erection panthawi yogonana.
  • Mlingo waukulu wa phosphate m'magazi (hyperphosphatemia). Anthu omwe ali ndi vuto la impso akhoza kukhala ndi magazi ambiri a phosphate. Kafukufuku woyambirira akuwonetsa kuti kumwa niacin kumatha kuchepetsa kuchuluka kwa magazi a phosphate mwa anthu omwe ali ndi matenda a impso otsiriza komanso kuchuluka kwa magazi a phosphate. Koma kafukufuku wina akuwonetsa kuti kumwa niacin sikuchepetsa ma phosphate m'magazi mwa anthu omwe akumwako mankhwala omwe amagwiritsira ntchito kutsitsa magazi a phosphate.
  • Kutsekeka kwa mtsempha m'maso (mitsempha yotsekera m'mitsempha): Kafukufuku woyambirira akuwonetsa kuti kumwa niacin kumatha kupangitsa kuti anthu omwe ali ndi vutoli aziona bwino.
  • Matenda a khungu: Kafukufuku woyambirira akuwonetsa kuti kumwa niacin sikuthandizira kuchuluka kwamafuta amwazi mwa anthu omwe ali ndi matenda a zenga.
  • Ziphuphu.
  • Kusokonezeka kwa mowa.
  • Kuchita masewera.
  • Matenda a chidwi-kuchepa kwa matenda (ADHD).
  • Matenda okhumudwa.
  • Chizungulire.
  • Zizolowezi zomwe zimadza chifukwa cha mankhwala osokoneza bongo.
  • Migraine.
  • Matenda oyenda.
  • Matenda achizungu.
  • Zochitika zina.
Umboni wina umafunikira kuti muyese niacin pazogwiritsidwa ntchito izi.

Niacin imayamwa ndi thupi ikasungunuka m'madzi ndikumwa. Amatembenuzidwa kukhala niacinamide ngati atengedwa mochuluka kuposa zomwe thupi limafunikira.

Niacin imafunika kuti mafuta ndi shuga azigwira bwino ntchito mthupi komanso kuti akhale ndi maselo athanzi. Mlingo waukulu, niacin imatha kuthandiza anthu omwe ali ndi matenda amtima chifukwa chazomwe zimapangitsa pakumangika. Zitha kupangitsanso mafuta amtundu wina otchedwa triglycerides m'magazi.

Kulephera kwa Niacin kumatha kuyambitsa matenda otchedwa pellagra, omwe amayambitsa khungu, kutsekula m'mimba, komanso matenda amisala. Pellagra inali yofala kumayambiriro kwa zaka za makumi awiri ndi makumi awiri, koma siyodziwika kwambiri pakadali pano, popeza zakudya zina zomwe zimakhala ndi ufa tsopano zalimbikitsidwa ndi niacin. Pellagra yatha pafupifupi chikhalidwe chakumadzulo.

Anthu omwe ali ndi vuto losadya bwino, uchidakwa, ndi mitundu ina ya zotupa zomwe zimakula pang'onopang'ono zomwe zimadziwika kuti zotupa za carcinoid atha kukhala pachiwopsezo cha kusowa kwa niacin. Mukamamwa: Niacin ndi WABWINO WABWINO kwa anthu ambiri akatengedwa moyenera. Zolemba zamankhwala zomwe zili ndi niacin ndizotetezeka mukamamwa moyenera. Zakudya zomwe zili ndi Niacin kapena zowonjezera ma niacin ndizotetezeka mukamamwa mankhwala ochepera 35 mcg tsiku lililonse.

Zotsatira zoyipa za niacin ndizomwe zimachitika. Izi zitha kupangitsa kuti kutentha, kuyabwa, kuyabwa, ndi kufiira nkhope, mikono, chifuwa, komanso kupweteka mutu. Kuyambira ndi mankhwala ochepa a niacin ndi kumwa 325 mg wa aspirin musanafike mlingo uliwonse wa niacin kumathandiza kuchepetsa kuthamanga. Kawirikawiri, izi zimapangitsa kuti thupi lizolowere mankhwala. Mowa umatha kupangitsa kuti madziwo aziziririka. Pewani mowa wambiri mukamamwa niacin.

Zotsatira zina zazing'ono za niacin ndikumva m'mimba, mpweya wam'mimba, chizungulire, kupweteka mkamwa, ndi mavuto ena.

Mlingo wa magalamu opitilira 3 patsiku la niacin ukutengedwa, zovuta zoyipa zimatha kuchitika. Izi zimaphatikizapo mavuto a chiwindi, gout, zilonda zam'mimba, kusowa kwa masomphenya, shuga wambiri wamagazi, kugunda kwamtima mosasinthasintha, ndi mavuto ena akulu.

Chenjezo lapadera & machenjezo:

Mimba ndi kuyamwitsa: Niacin ndi WABWINO WABWINO kwa amayi apakati ndi oyamwitsa akamwedwa pakamwa muyezo woyenera. Kuchuluka kwakukulu kwa niacin kwa amayi apakati kapena oyamwitsa ndi 30 mg patsiku kwa azaka zosakwana zaka 18, ndi 35 mg azimayi opitilira 18.

Ana: Niacin ndi WABWINO WABWINO akamwedwa pakamwa pamlingo woyenera wa gulu lililonse. Koma ana ayenera kupewa kumwa miyezo ya niacin pamwamba pamiyeso yayikulu tsiku lililonse, yomwe ndi 10 mg ya ana azaka zapakati pa 1-3, 15 mg ya ana azaka 4-8, 20 mg ya ana azaka 9-13, komanso 30 mg wa ana azaka 14-18.

Nthendayi: Niacin imatha kukulitsa chifuwa poyambitsa histamine, mankhwala omwe amachititsa ziwengo, kuti amasulidwe.

Matenda a mtima / angina wosakhazikika: Zambiri za niacin zitha kuonjezera chiwopsezo cha kugunda kwamtima mosasinthasintha. Gwiritsani ntchito mosamala.

Matenda a Crohn: Anthu omwe ali ndi matenda a Crohn atha kukhala ndi misinkhu yotsika ya niacin ndipo amafunika kuthandizidwa pakuwuka.

Matenda a shuga: Niacin imatha kuwonjezera shuga m'magazi. Anthu omwe ali ndi matenda a shuga omwe amatenga niacin ayenera kuwunika shuga wawo mosamala.

Matenda a gallbladder: Niacin imatha kukulitsa matenda a ndulu.

Gout: Zambiri za niacin zitha kubweretsa gout.

Matenda a impso: Niacin imatha kudziunjikira mwa anthu omwe ali ndi matenda a impso. Izi zitha kuvulaza.

Matenda a chiwindi: Niacin itha kukulitsa kuwonongeka kwa chiwindi. Musagwiritse ntchito ndalama zambiri ngati muli ndi matenda a chiwindi.

Zilonda zam'mimba kapena m'mimba: Niacin imatha kukulitsa zilonda. Musagwiritse ntchito ndalama zambiri ngati muli ndi zilonda.

Kuthamanga kwambiri kwa magazi: Niacin imatha kutsitsa kuthamanga kwa magazi ndikuwonjezera vutoli.

Opaleshoni: Niacin imatha kusokoneza kuwongolera shuga wamagazi nthawi komanso pambuyo pochita opaleshoni. Lekani kumwa niacin osachepera masabata awiri musanachite opareshoni.

Mafuta amaika mozungulira ma tendon (tendon xanthomas): Niacin itha kukulitsa chiopsezo chotenga matenda m'matenda a xanthomas.

Matenda a chithokomiro: Thyroxine ndi mahomoni opangidwa ndi chithokomiro. Niacin ikhoza kutsitsa magazi a thyroxine. Izi zitha kukulitsa zizindikilo za zovuta zina za chithokomiro.

Wamkati
Samalani ndi kuphatikiza uku.
Mowa (Mowa)
Niacin imatha kuyambitsa kuthamanga komanso kuyabwa. Kumwa mowa pamodzi ndi niacin kungapangitse kuthamanga ndi kuyabwa kukulirakulira. Palinso nkhawa ina kuti kumwa mowa ndi niacin kungapangitse mwayi wokhala ndi chiwindi.
Allopurinol (Zyloprim)
Allopurinol (Zyloprim) amagwiritsidwa ntchito pochizira gout. Kutenga mankhwala akulu a niacin kumatha kukulitsa gout ndikuchepetsa mphamvu ya allopurinol (Zyloprim).
Clonidine (Catapres)
Clonidine ndi niacin onse amachepetsa kuthamanga kwa magazi. Kutenga niacin ndi clonidine kungayambitse kuthamanga kwa magazi kutsika kwambiri.
Gemfibrozil (Lopid)
Kutenga niacin limodzi ndi gemfibrozil kumatha kuwononga minofu kwa anthu ena. Gwiritsani ntchito mosamala.
Mankhwala a shuga (Mankhwala oletsa matenda a shuga)
Kugwiritsa ntchito mlingo waukulu wa niacin (pafupifupi magalamu 3-4 tsiku lililonse) kumatha kuwonjezera shuga m'magazi. Powonjezera shuga m'magazi, niacin imatha kuchepetsa mphamvu ya mankhwala ashuga. Onetsetsani shuga lanu lamagazi mwatcheru. Mlingo wa mankhwala anu ashuga angafunike kusinthidwa.

Mankhwala ena omwe amagwiritsidwa ntchito ndi matenda a shuga ndi glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), chlorpropamide Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), ndi ena.
Mankhwala a kuthamanga kwa magazi (Mankhwala oletsa kuthamanga kwa magazi)
Kugwiritsa ntchito niacin ndi mankhwala omwe amachepetsa kuthamanga kwa magazi kumatha kukulitsa zovuta za mankhwalawa ndipo kumatha kutsitsa kuthamanga kwambiri kwa magazi.

Mankhwala ena othamanga magazi ndi monga captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), ndi ena ambiri .
Mankhwala omwe angawononge chiwindi (Hepatotoxic drug)
Niacin ikhoza kuwononga chiwindi. Kukonzekera kwa niacin kosasunthika kumawoneka kuti kuli pachiwopsezo chachikulu. Kutenga niacin pamodzi ndi mankhwala omwe amathanso kuwononga chiwindi kumatha kuonjezera chiwopsezo cha chiwindi. Musamamwe niacin ngati mukumwa mankhwala omwe angawononge chiwindi.

Mankhwala ena omwe angawononge chiwindi ndi monga acetaminophen (Tylenol ndi ena), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporaconazole) erythromycin (Erythrocin, Ilosone, ena), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), ndi ena ambiri.
Mankhwala omwe amachepetsa kugwetsa magazi (Anticoagulant / Antiplatelet drug)
Niacin imatha kuchepa magazi. Kutenga niacin pamodzi ndi mankhwala omwe amachepetsa kutseka magazi kumatha kuwonjezera mwayi wovulala ndi magazi.

Mankhwala ena omwe amachepetsa kugwetsa magazi ndi monga aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), ndi ena.
Mankhwala ogwiritsira ntchito kutsitsa cholesterol (Bile acid sequestrants)
Mankhwala ena ochepetsa cholesterol omwe amatchedwa bile acid sequestrants amatha kuchepetsa kuchuluka kwa mankhwala omwe thupi limayamwa. Izi zitha kuchepetsa mphamvu ya niacin. Tengani niacin ndi mankhwala osachepera maola 4-6 popanda.

Zina mwa mankhwala omwe amagwiritsidwa ntchito pochepetsa cholesterol ndi monga cholestyramine (Questran) ndi colestipol (Colestid).
Mankhwala ogwiritsira ntchito kutsitsa cholesterol (Statins)
Niacin imatha kusokoneza minofu. Mankhwala ena omwe amagwiritsidwa ntchito pochepetsa cholesterol wotchedwa statins amathanso kukhudza minofu. Kutenga niacin limodzi ndi mankhwalawa kumatha kuwonjezera ngozi yamatenda.

Ena mwa mankhwala omwe amagwiritsidwa ntchito pa cholesterol yochuluka ndi monga rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol), ndi simvastatin (Zocor).
Ma probenecid (Benemid)
Probenecid imagwiritsidwa ntchito pochizira gout. Kutenga mankhwala akulu a niacin kumatha kukulitsa gout ndikuchepetsa mphamvu ya probenecid.
Sulfinpyrazone (Anturane) Chithandizo
Sulfinpyrazone (Anturane) amagwiritsidwa ntchito pochizira gout. Kutenga mankhwala akulu a niacin kumatha kukulitsa gout ndikuchepetsa mphamvu ya sulfinpyrazone (Anturane).
Mahomoni a chithokomiro
Thupi mwachilengedwe limapanga mahomoni a chithokomiro. Niacin ikhoza kuchepetsa kuchuluka kwa mahomoni a chithokomiro. Kutenga niacin ndi mapiritsi a mahomoni a chithokomiro kumatha kuchepetsa zovuta ndi zoyipa za mahomoni a chithokomiro.
Zing'onozing'ono
Khalani maso ndi kuphatikiza uku.
Asipilini
Aspirin nthawi zambiri amagwiritsidwa ntchito ndi niacin kuti achepetse kutsuka komwe kumayambitsidwa ndi niacin. Kutenga aspirin wocheperako kumachepetsa momwe thupi limachotsera niacin mwachangu. Izi zitha kuyambitsa kuchuluka kwa niacin mthupi ndipo mwina kumabweretsa zotsatirapo. Komabe, kuchuluka kwa ma aspirin omwe amagwiritsidwa ntchito kwambiri kupukutira zokhudzana ndi niacin sikuwoneka ngati vuto.
Chikopa cha Nicotine (Nicoderm)
Niacin nthawi zina imatha kuyambitsa ziwengo ndi chizungulire. Chigamba cha chikonga chimayambitsanso kuthamanga ndi chizungulire. Kutenga niacin kapena niacinamide ndikugwiritsa ntchito chikonga cha nicotine kumatha kukulitsa mwayi wokhala wamadzi komanso wamisala.
Beta-carotene
Kuphatikiza kwa niacin ndi mankhwala omwe mumalandira simvastatin (Zocor) amakweza HDL (high density lipoprotein) cholesterol ("cholesterol yabwino") mwa anthu omwe ali ndi matenda amtima komanso otsika a HDL. Komabe, kutenga niacin limodzi ndi ma antioxidants, kuphatikiza beta-carotene, zikuwoneka kuti zikuwononga kukwera kwa HDL. Sizikudziwika ngati izi zimachitika mwa anthu omwe alibe matenda amtima.
Chromium
Kutenga niacin ndi chromium palimodzi kungachepetse shuga m'magazi. Ngati muli ndi matenda ashuga ndipo mutenge mankhwala a chromium ndi niacin palimodzi, yang'anani shuga wanu wamagazi kuti muwone ngati satsika kwambiri.
Zitsamba ndi zowonjezera zomwe zingawononge chiwindi
Niacin, makamaka muyezo waukulu ungayambitse chiwindi. Kutenga niacin pamodzi ndi zitsamba zina kapena zowonjezera zomwe zingawononge chiwindi zitha kuwonjezera ngozi. Zina mwazinthu izi ndi androstenedione, tsamba la borage, chaparral, comfrey, dehydroepiandrosterone (DHEA), germander, kava, mafuta a pennyroyal, yisiti wofiira, ndi ena.
Zitsamba ndi zowonjezera zomwe zingachepetse kuthamanga kwa magazi
Niacin amachepetsa kuthamanga kwa magazi. Kutenga niacin ndi zitsamba zina ndi zowonjezera zomwe zimachepetsanso kuthamanga kwa magazi kumatha kuyambitsa kuthamanga kwa magazi kutsika kwambiri. Zitsamba zina ndi zowonjezera zomwe zimachepetsa kuthamanga kwa magazi zimaphatikizapo andrographis, casein peptides, claw's cat, coenzyme Q10, L-arginine, lycium, neting nettle, theanine, ndi ena.
Zitsamba ndi zowonjezera zomwe zingachedwetse magazi kugunda
Niacin imatha kuchepa magazi. Kugwiritsa ntchito niacin pamodzi ndi zitsamba zina ndi zowonjezerazo zomwe zimachedwetsa magazi kugundana kumatha kuwonjezera ngozi yakutaya magazi mwa anthu ena. Zitsamba zina zamtunduwu ndi Angelica, clove, danshen, adyo, ginger, Panax ginseng, ndi ena.
Kombucha tiyi
Pali nkhawa ina kuti tiyi ya kombucha ikhoza kuchepa kuyamwa kwa niacin. Komabe, izi ziyenera kuphunziridwa mochulukira.
Selenium
Kuphatikiza kwa niacin ndi mankhwala omwe mumalandira simvastatin (Zocor) amakweza HDL (high density lipoprotein) cholesterol ("cholesterol yabwino") mwa anthu omwe ali ndi matenda amtima komanso otsika a HDL. Komabe, kumwa niacin limodzi ndi ma antioxidants, kuphatikiza selenium, zikuwoneka kuti kukuwonjezera kukwera kwa HDL. Sizikudziwika ngati izi zimachitika mwa anthu omwe alibe matenda amtima.
Yesani
Ena tryptophan ochokera ku zakudya amatha kusandulika niacin mthupi. Kutenga niacin ndi tryptophan palimodzi kumatha kukulitsa magawo komanso zoyipa za niacin.
Vitamini C
Kuphatikiza kwa niacin ndi mankhwala omwe mumalandira simvastatin (Zocor) amakweza HDL (high density lipoprotein) cholesterol ("cholesterol yabwino") mwa anthu omwe ali ndi matenda amtima komanso otsika a HDL. Komabe, kumwa niacin limodzi ndi ma antioxidants, kuphatikiza vitamini C, zikuwoneka kuti zikuwononga kukwera kwa HDL. Sizikudziwika ngati izi zimachitika mwa anthu omwe alibe matenda amtima.
Vitamini E
Kuphatikiza kwa niacin ndi mankhwala omwe mumalandira simvastatin (Zocor) amakweza HDL (high density lipoprotein) cholesterol ("cholesterol yabwino") mwa anthu omwe ali ndi matenda amtima komanso otsika a HDL. Komabe, kumwa niacin limodzi ndi ma antioxidants, kuphatikiza vitamini E, zikuwoneka kuti kukuwonjeza kukwera kwa HDL. Sizikudziwika ngati izi zimachitika mwa anthu omwe alibe matenda amtima.
Nthaka
Thupi limatha kupanga niacin. Anthu omwe alibe chakudya chokwanira komanso ali ndi vuto la niacin, monga zidakwa, amapanga niacin wowonjezera ngati atenga zinc. Pakhoza kukhala chiopsezo chowonjezeka cha zovuta zina zokhudzana ndi niacin monga kutsuka ndi kuyabwa ngati niacin ndi zinc atengedwa palimodzi.
Zakumwa zotentha
Niacin imatha kuyambitsa kuthamanga ndi kuyabwa. Zotsatirazi zitha kuwonjezeka ngati niacin amatengedwa ndi chakumwa chotentha.
Mlingo wotsatira udaphunziridwa pakufufuza kwasayansi:

ACHIKULU

NDI PAKAMWA:
  • Zonse: Zina mwazinthu zowonjezera zowonjezera zimatulutsa mndandanda wa niacin womwe uli pachizindikiro cha niacin equivalents (NE). 1 mg wa niacin ndi wofanana ndi 1 mg NE. Niacin ikalembedwa pamtundu wa NE, itha kuphatikizanso mitundu ina ya niacin, kuphatikiza niacinamide, inositol nicotinate, ndi tryptophan. Ndalama zolandilidwa tsiku ndi tsiku (RDAs) za niacin mwa akulu ndi 16 mg NE ya amuna, 14 mg NE ya azimayi, 18 mg NE ya azimayi apakati, ndi 17 mg NE ya azimayi oyamwitsa.
  • Kwa cholesterol chambiri: Zotsatira za niacin zimadalira mlingo. Mlingo wa niacin mpaka 50 mg ndipo mpaka magalamu 12 tsiku lililonse agwiritsidwa ntchito. Komabe, kuwonjezeka kwakukulu kwa HDL ndikuchepa kwa triglycerides kumachitika pa 1200 mpaka 1500 mg / tsiku. Zotsatira zazikulu za Niacin pa LDL zimachitika pa 2000 mpaka 3000 mg / tsiku. Niacin nthawi zambiri amagwiritsidwa ntchito ndi mankhwala ena othandizira kuchepetsa mafuta m'thupi.
  • Popewa ndikuthandizira kusowa kwa vitamini B3 ndi zovuta zina monga pellagra: 300-1000 mg tsiku ndi tsiku m'magulu ogawanika.
  • Pofuna kuthandizira kuuma kwa mitsempha: Mlingo wa niacin wakwera mpaka magalamu 12 tsiku lililonse. Komabe, pafupifupi 1 mpaka 4 magalamu a niacin tsiku lililonse, okha kapena limodzi ndi ma statins kapena bile acid sequestrants (mankhwala ochepetsa mafuta m'thupi), akhala akugwiritsidwa ntchito kwa zaka 6.2.
  • Pochepetsa kuchepa kwamadzimadzi kochokera ku poizoni wa kolera: 2 magalamu tsiku lililonse akhala akugwiritsidwa ntchito.
  • Pamafuta osadziwika amwazi wamagazi chifukwa chothandizidwa ndi HIV / AIDS: Mpaka magalamu awiri tsiku lililonse akhala akugwiritsidwa ntchito.
  • Kwa matenda amadzimadzi: 2 magalamu a niacin amatengedwa tsiku lililonse kwa milungu 16. Nthawi zina, niacin 2 magalamu tsiku lililonse, payekha kapena pamlingo uwu, amatengedwa limodzi ndi magalamu 4 amtundu wa omega-3 ethyl esters (Lovaza, GlaxoSmithKline Pharmaceuticals).
Wolemba IV:
  • Popewa ndikuthandizira kusowa kwa vitamini B3 ndi zovuta zina monga pellagra: 60 mg ya niacin yagwiritsidwa ntchito.
Monga kuwombera:
  • Popewa ndikuthandizira kusowa kwa vitamini B3 ndi zovuta zina monga pellagra: 60 mg ya niacin yagwiritsidwa ntchito.
ANA

NDI PAKAMWA:
  • Zonse: Malipiro azakudya tsiku lililonse (RDAs) a niacin mwa ana ndi 2 mg NE ya makanda azaka 0-6, 4 mg NE ya makanda a miyezi 7-12, 6 mg NE ya ana azaka 1-3, 8 mg NE ya ana azaka 4-8, 12 mg NE ya ana azaka 9-13, 16 mg NE ya anyamata azaka 14-18, ndi 14 mg NE ya atsikana azaka 14-18.
  • Popewa ndikuthandizira kusowa kwa vitamini B3 ndi zovuta zina monga pellagra: 100-300 mg pa tsiku la niacin, wopatsidwa magawo ogawanika.
3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complexe de Vitamines B, Facteur Anti-Pellagre, Niacina, Niacine, Nicosedine, Nicotinra Aciding, Phunziro la Nicotinra Vitamini B3, Vitamini PP, Vitamina B3, Vitamini B3, Vitamini PP.

Kuti mudziwe zambiri za momwe nkhaniyi idalembedwera, chonde onani Mankhwala Achilengedwe Pazonse njira.


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Mankhwala

Zolemba

Chovalacho ndi chotupa chodzaza madzi pakhungu.Chovalacho ndi chaching'ono. Itha kukhala yaying'ono ngati pamwamba pa pini kapena mpaka 5 millimeter mulifupi. Chithuza chachikulu amatchedwa bu...