Jekeseni wa infliximab

Zamkati

• Mankhwala opangira infliximab amagwiritsidwa ntchito kuthana ndi zovuta zamatenda amthupi (zomwe chitetezo cha mthupi chimayambitsa ziwalo zabwino za thupi ndikupangitsa kupweteka, kutupa, ndi kuwonongeka) kuphatikiza:
• Musanagwiritse ntchito jekeseni wa infliximab,
• Mankhwala opangira infliximab amatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Zizindikiro zotsatirazi sizachilendo, koma ngati mukukumana ndi zina mwazomwezi, kapena zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena magawo a MAWONEKEDWE OTHANDIZA, itanani dokotala wanu mwachangu:

Jekeseni wa infliximab, jekeseni wa infliximab-dyyb, ndi jakisoni wa infliximab-abda ndi mankhwala a biologic (mankhwala opangidwa kuchokera kuzinthu zamoyo). Jekeseni wa Biosimilar infliximab-dyyb ndi jekeseni ya infliximab-abda ndi ofanana kwambiri ndi jekeseni wa infliximab ndipo imagwira ntchito chimodzimodzi ndi jekeseni wa infliximab mthupi. Chifukwa chake, mawu akuti infliximab jekeseni wazogwiritsidwa ntchito kuyimira mankhwalawa pazokambirana izi.

Mankhwala opangira infliximab amachepetsa kuthekera kwanu kothana ndi matenda ndikuwonjezera chiopsezo choti mutenga matenda akulu, kuphatikiza matenda opatsirana a virus, bakiteriya, kapena mafangasi omwe amatha kufalikira mthupi lonse. Matendawa angafunike kuthandizidwa kuchipatala ndipo atha kupha. Uzani dokotala wanu ngati nthawi zambiri mumakhala ndi matenda aliwonse kapena ngati mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Izi zimaphatikizapo matenda ang'onoang'ono (monga mabala otseguka kapena zilonda), matenda omwe amabwera ndikadutsa (monga zilonda zozizira) ndi matenda opatsirana omwe samatha. Uzaninso dokotala wanu ngati muli ndi matenda ashuga kapena vuto lililonse lomwe limakhudza chitetezo chamthupi mwanu komanso ngati mumakhala kapena munakhalako m'malo monga zigwa za Ohio kapena Mississippi komwe matenda ofala a fungus amapezeka kwambiri. Funsani dokotala wanu ngati simukudziwa ngati matenda amapezeka kwambiri m'dera lanu. Muuzeni dokotala ngati mukumwa mankhwala omwe amachepetsa chitetezo cha mthupi monga abatacept (Orencia); anakinra (Kineret); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); ma steroids monga dexamethasone, methylprednisolone (Medrol), prednisolone (Orapred ODT, Pediapred, Prelone), kapena prednisone; kapena tocilizumab (Actemra).

Dokotala wanu adzakuyang'anirani ngati muli ndi matendawa nthawi yayitali komanso mutangomaliza kulandira chithandizo. Ngati muli ndi zizindikiro zotsatirazi musanayambe kumwa mankhwala kapena ngati mukukumana ndi zizindikiro zotsatirazi mukamalandira chithandizo kapena mutangochoka kumene, pitani kuchipatala nthawi yomweyo: kufooka; thukuta; kuvuta kupuma; chikhure; chifuwa; kutsokomola ntchofu zamagazi; malungo; kutopa kwambiri; zizindikiro ngati chimfine; khungu lofunda, lofiira, kapena lopweteka; kutsegula m'mimba; kupweteka m'mimba; kapena zizindikiro zina za matenda.

Mutha kukhala ndi kachilombo ka TB (TB, matenda opatsirana m'mapapo) kapena hepatitis B (kachilombo kamene kamakhudza chiwindi) koma mulibe zizindikiro zilizonse za matendawa. Poterepa, zopangira jekeseni za infliximab zitha kuwonjezera chiopsezo kuti matenda anu adzakula kwambiri ndipo mudzakhala ndi zizindikiro. Dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi kachilombo ka TB kosagwira ntchito ndipo atha kuyitanitsa kuyesa magazi kuti muwone ngati muli ndi matenda a hepatitis B osagwira ntchito. Ngati ndi kotheka, dokotala wanu adzakupatsani mankhwala ochizira matendawa musanayambe kugwiritsa ntchito mankhwala opangira infliximab. Uzani dokotala ngati mwadwalapo kapena munakhalapo ndi TB, ngati munakhalako kapena munapitako malo amene TB imafala, kapena ngati munakhalapo ndi munthu amene ali ndi TB. Ngati muli ndi zizindikiro zotsatirazi za chifuwa chachikulu cha TB, kapena ngati muli ndi zina mwazizindikiro mukamalandira chithandizo, pitani kuchipatala mwachangu: chifuwa, kuchepa thupi, kuchepa kwa minofu, malungo, kapena thukuta usiku. Komanso itanani dokotala wanu nthawi yomweyo ngati muli ndi zina mwazizindikiro za matenda a chiwindi a B kapena ngati muli ndi zina mwazizindikiro mukalandira kapena mutalandira chithandizo: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako chambiri, nseru kapena kusanza, kupweteka kwa minofu, mkodzo wamdima, matumbo ofiira dongo, malungo, kuzizira, kupweteka m'mimba, kapena zotupa.

Ana ena, achinyamata, komanso achikulire omwe adalandira mankhwala opangira infliximab kapena mankhwala ofanana nawo adayamba khansa yowopsa kapena yowopsa kuphatikizapo lymphoma (khansa yomwe imayambira m'maselo omwe amalimbana ndi matenda). Achinyamata ena achikulire omwe amatenga mankhwala a infliximab kapena mankhwala ofanana nawo adayamba ndi hepatosplenic T-cell lymphoma (HSTCL), khansa yoopsa kwambiri yomwe nthawi zambiri imapha munthu patangopita nthawi yochepa.Ambiri mwa anthu omwe adapanga HSTCL anali kuchiritsidwa ndi matenda a Crohn (matenda omwe thupi limagwiritsa ntchito gawo logaya chakudya, kumayambitsa kupweteka, kutsegula m'mimba, kuchepa thupi, ndi malungo) kapena ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda. m'mbali mwa kholingo [matumbo akulu] ndi thumbo) wokhala ndi mankhwala opangira infliximab kapena mankhwala ofanana ndi omwewo azathioprine (Azasan, Imuran) kapena 6-mercaptopurine (Purinethol, Purixan). Uzani dokotala wa mwana wanu ngati mwana wanu adakhalapo ndi khansa yamtundu uliwonse. Mwana wanu akayamba kudwala matendawa, itanani dokotala wake mwachangu: kuonda kosadziwika; zotupa zotupa pakhosi, pansi, kapena kubuula; kapena kuvulaza kosavuta kapena kutuluka magazi. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopatsa mankhwala opangira infliximab kwa mwana wanu.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi mankhwala opangira infliximab ndipo nthawi iliyonse yomwe mumalandira mankhwalawo. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwala opangira infliximab.

Mankhwala opangira infliximab amagwiritsidwa ntchito kuthana ndi zovuta zamatenda amthupi (zomwe chitetezo cha mthupi chimayambitsa ziwalo zabwino za thupi ndikupangitsa kupweteka, kutupa, ndi kuwonongeka) kuphatikiza:

• nyamakazi ya nyamakazi (momwe thupi limagwirira ziwalo zake, zimapweteka, kutupa, komanso kutayika kwa ntchito) yomwe imathandizidwanso ndi methotrexate (Rheumatrex, Trexall),
• Matenda a Crohn (matenda omwe thupi limagwiritsa ntchito gawo la m'mimba, kupweteka, kutsegula m'mimba, kuchepa thupi, ndi malungo) kwa akulu ndi ana azaka 6 kapena kupitilira apo zomwe sizinasinthe mukamalandira mankhwala ena,
• ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda mkatikati mwa matumbo akulu) mwa akulu ndi ana azaka 6 kapena kupitilira zomwe sizinasinthe mukamalandira mankhwala ena,
• ankylosing spondylitis (momwe thupi limagwirira malo olumikizirana mafupa a msana ndi madera ena omwe amayambitsa kupweteka komanso kuwonongeka kwamagulu),
• plaque psoriasis (matenda apakhungu momwe zigamba zofiira, zotupa zimapangika m'malo ena amthupi) mwa akulu pomwe mankhwala ena ndiosayenera,
• ndi psoriatic nyamakazi (vuto lomwe limayambitsa kupweteka kwamagulu ndi kutupa ndi masikelo pakhungu).

Mankhwala opangira infliximab ali mgulu la mankhwala otchedwa tumor necrosis factor-alpha (TNF-alpha) inhibitors. Amagwira ntchito potseka zochita za TNF-alpha, chinthu m'thupi chomwe chimayambitsa kutupa.

Mankhwala opangira jekeseni a infliximab amabwera ngati ufa woti azisakanikirana ndi madzi osabala ndikuwatumizira m'mitsempha (mumtsempha) ndi dokotala kapena namwino. Nthawi zambiri amaperekedwa ku ofesi ya dokotala kamodzi pa milungu iwiri kapena isanu ndi itatu iliyonse, nthawi zambiri kumayambiriro kwa chithandizo chanu ndipo nthawi zambiri chithandizo chanu chikapitirira. Zitenga pafupifupi maola awiri kuti mulandire mlingo wanu wonse wa infliximab, mankhwala opangira jekeseni.

Mankhwala opangidwa ndi jekeseni wa infliximab amatha kuyambitsa mavuto akulu, kuphatikiza zomwe zimachitika pakulowetsedwa komanso kwa maola awiri pambuyo pake. Dokotala kapena namwino adzakuwunikirani panthawiyi kuti awonetsetse kuti simukukhudzidwa ndi mankhwalawo. Mutha kupatsidwa mankhwala ena kuti muzitha kuchiritsa kapena kupewa kuyanjana ndi mankhwala opangira infliximab. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mukukumana ndi izi mwa izi kapena mutangomulowetsedwa: ming'oma; zidzolo; kuyabwa; kutupa kwa nkhope, maso, pakamwa, pakhosi, lilime, milomo, manja, mapazi, akakolo, kapena miyendo yakumunsi; kuvuta kupuma kapena kumeza; kuthamanga; chizungulire; kukomoka; malungo; kuzizira; kugwidwa; kutayika kwa masomphenya; ndi kupweteka pachifuwa.

Mankhwala opangira infliximab atha kuthandizira kuwongolera zizindikilo zanu, koma sangakuchiritseni. Dokotala wanu adzakuyang'anirani mosamala kuti muwone momwe mankhwala opangira infliximab amakuthandizirani. Ngati muli ndi nyamakazi kapena matenda a Crohn, dokotala wanu akhoza kukulitsa kuchuluka kwa mankhwala omwe mumalandira, ngati angafunike. Ngati muli ndi matenda a Crohn ndipo matenda anu sanasinthe pambuyo pa masabata a 14, dokotala wanu akhoza kusiya kukuchitirani mankhwala opangira infliximab. Ndikofunika kuuza dokotala momwe mukumvera mukamalandira chithandizo.

Mankhwala opangira infliximab amagwiritsidwanso ntchito pochiza matenda a Behcet's (zilonda zam'kamwa komanso kumaliseche ndi kutupa kwa ziwalo zosiyanasiyana za thupi). Lankhulani ndi dokotala wanu za kuopsa kokugwiritsa ntchito mankhwalawa.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito jekeseni wa infliximab,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la infliximab, infliximab-axxq, infliximab-dyyb, infliximab-abda, mankhwala aliwonse omwe amapangidwa kuchokera ku mapuloteni a murine (mbewa), mankhwala ena aliwonse, kapena chilichonse chosakaniza mu infliximab, infliximab-dyyb, kapena jekeseni wa infliximab-abda. Funsani dokotala wanu kapena wamankhwala ngati simukudziwa ngati mankhwala omwe simukugwirizana nawo amachokera ku mapuloteni a murine. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: maanticoagulants (owonda magazi) monga warfarin (Coumadin), cyclosporine (Gengraf, Neoral, Sandimmune), ndi theophylline (Elixophyllin, Theo-24, Theochron) . Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati munakhalapo ndi vuto la mtima kapena munakhalapo ndi vuto la mtima (momwe mtima sungapangire magazi okwanira mbali zina za thupi). Dokotala wanu angakuuzeni kuti musagwiritse ntchito jekeseni wa infliximab.
• Uzani dokotala ngati munalandirapo mankhwala a phototherapy (chithandizo cha psoriasis chomwe chimaphatikizapo kuwulula khungu ku kuwala kwa ultraviolet) ndipo ngati mwakhala mukudwala kapena munakhalapo ndi matenda omwe amakhudza dongosolo lanu lamanjenje, monga multiple sclerosis (MS; kutaya kulumikizana, kufooka, komanso kufooka chifukwa cha kuwonongeka kwa mitsempha), matenda a Guillain-Barre (kufooka, kumva kulira, komanso ziwalo zotheka chifukwa cha kuwonongeka kwamitsempha mwadzidzidzi) kapena optic neuritis (kutupa kwa mitsempha yomwe imatumiza mauthenga kuchokera kumaso kupita kuubongo); dzanzi, kutentha kapena kumva kulasalasa m'mbali iliyonse ya thupi lanu; kugwidwa; Matenda osokoneza bongo (COPD; gulu la matenda omwe amakhudza mapapu ndi njira zowuluka); khansa yamtundu uliwonse; Kutaya magazi kapena matenda omwe amakhudza magazi anu; kapena matenda amtima.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukamagwiritsa ntchito jakisoni wa infliximab, itanani dokotala wanu. Ngati mumagwiritsa ntchito jekeseni wa infliximab panthawi yomwe muli ndi pakati, onetsetsani kuti mwalankhula ndi dokotala wa mwana wanu izi zitabadwa. Mwana wanu angafunikire kulandira katemera wina mochedwa kuposa nthawi zonse.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukugwiritsa ntchito mankhwala opangira infliximab.
• uzani dokotala wanu ngati mwalandira katemera posachedwa. Komanso funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera popanda kulankhula ndi dokotala. Ndikofunika kuti akulu ndi ana alandire katemera woyenera zaka zonse asanayambe chithandizo ndi infliximab.
• muyenera kudziwa kuti mwina mutha kuchepa thupi pakadutsa masiku 3 kapena 12 mutalandira mankhwala opangira infliximab. Uzani dokotala wanu ngati mukukumana ndi izi zotsatirazi masiku angapo kapena kupitilira mankhwala anu: kupweteka kwa minofu kapena molumikizana; malungo; zidzolo; ming'oma; kuyabwa; kutupa kwa manja, nkhope, kapena milomo; zovuta kumeza; chikhure; ndi mutu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Mankhwala opangira infliximab amatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kutentha pa chifuwa
• mutu
• mphuno
• zigamba zoyera pakamwa
• kuyabwa kumaliseche, kutentha, ndi kupweteka, kapena zizindikilo zina za matenda yisiti
• kuchapa

Zotsatira zina zoyipa zingakhale zazikulu. Zizindikiro zotsatirazi sizachilendo, koma ngati mukukumana ndi zina mwazomwezi, kapena zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena magawo a MAWONEKEDWE OTHANDIZA, itanani dokotala wanu mwachangu:

• zotupa zamtundu uliwonse, kuphatikiza ndi zotupa m'masaya kapena mikono zomwe zimaipiraipira padzuwa
• kupweteka pachifuwa
• kugunda kwamtima kosasintha
• kupweteka kwa mikono, kumbuyo, khosi, kapena nsagwada
• kupweteka m'mimba
• kutupa kwa mapazi, akakolo, m'mimba, kapena miyendo yakumunsi
• kunenepa mwadzidzidzi
• kupuma movutikira
• kusawona bwino kapena masomphenya amasintha
• kufooka mwadzidzidzi kwa mkono kapena mwendo (makamaka mbali imodzi ya thupi) kapena nkhope
• kupweteka kwa minofu kapena molumikizana
• dzanzi kapena kumva kulasalasa mbali iliyonse ya thupi
• kusokonezeka mwadzidzidzi, kuyankhula movutikira, kapena kuvuta kumvetsetsa
• kuyenda mwadzidzidzi
• chizungulire kapena kukomoka
• kutayika bwino kapena kulumikizana
• mwadzidzidzi, mutu wopweteka kwambiri
• kugwidwa
• chikasu cha khungu kapena maso
• mkodzo wachikuda
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwam'mimba
• kuvulaza kapena kutuluka mwachilendo
• magazi mu chopondapo
• khungu lotumbululuka
• ofiira, amikanda kapena ziphuphu pakhungu

Jekeseni wa infliximab imatha kuwonjezera chiopsezo chanu chokhala ndi lymphoma (khansa yomwe imayamba m'maselo omwe amalimbana ndi matenda) ndi mitundu ina ya khansa. Lankhulani ndi dokotala wanu za kuopsa kolandila mankhwala a infliximab.

Mankhwala opangira infliximab amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Dokotala wanu azisunga mankhwalawo muofesi yake.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labotale kuti aone momwe thupi lanu lingayankhire ndi mankhwala opangira infliximab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Avsola^® (Zowonjezera)
• Zosokoneza^® (Infliximab-dyyb)
• Chotsani^® (Infliximab)
• Renflexis^® (Chidwi-abda)

• Anti-chotupa Necrosis Factor-alpha
• Anti-TNF alpha
• cA2