Wachi Bosentan

Zamkati

• Musanatenge bosentan,
• Bosentan ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Zizindikiro zotsatirazi sizachilendo, koma ngati mungakumane ndi zina mwazomwe zalembedwa m'gawo la CHENJEZO, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Kwa odwala amuna ndi akazi:

Bosentan imatha kuwononga chiwindi. Uzani dokotala wanu ngati mwakhalapo kapena mukudwala matenda a chiwindi. Dokotala wanu adzaitanitsa mayeso a magazi kuti atsimikizire kuti chiwindi chanu chikugwira bwino ntchito musanayambe kumwa bosentan komanso mwezi uliwonse mukamalandira chithandizo. Sungani maimidwe onse ndi dokotala wanu ndi labotale. Bosentan itha kuwononga chiwindi isanayambitse zizindikiro. Kuyesa magazi pafupipafupi ndiyo njira yokhayo yopezera kuwonongeka kwa chiwindi isanakhale yokhazikika komanso yayikulu. Ngati mukukumana ndi izi, uzani dokotala nthawi yomweyo: nseru, kusanza, malungo, kupweteka m'mimba, chikasu cha khungu kapena maso, kapena kutopa kwambiri. Dokotala wanu akhoza kuchepetsa mlingo wanu, kapena kuimitsa kwakanthawi kapena kwamuyaya mankhwala anu ndi bosentan ngati mukumva zovuta kapena muli ndi zovuta zapa lab.

Kwa odwala achikazi:

Musatenge bosentan ngati muli ndi pakati kapena mukukonzekera kutenga pakati. Bosentan itha kuvulaza mwana wosabadwayo. Ngati mutha kutenga pakati, muyenera kuyezetsa asanayambe kulandira chithandizo, mwezi uliwonse mukamalandira chithandizo, komanso kwa mwezi umodzi mutalandira chithandizo kuti muwonetse kuti mulibe pakati. Dokotala wanu adzakulemberani mayeso oyembekezera. Muyenera kugwiritsa ntchito njira yodalirika yolerera popereka chithandizo komanso kwa mwezi umodzi mutalandira chithandizo. Njira zolerera za mahomoni (mapiritsi olera, zigamba, mphete, kuwombera, zopangira, ndi zida za intrauterine) sizingagwire bwino ntchito mukamagwiritsa ntchito bosentan ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yolerera. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Nthawi zambiri mudzafunika kugwiritsa ntchito njira ziwiri zakulera.

Itanani dokotala wanu nthawi yomweyo ngati mukugonana mosadziteteza, ganizirani kuti zakulera zalephera, kusowa nthawi kapena kuganiza kuti mutha kukhala ndi pakati mukamamwa bosentan. Musayembekezere mpaka nthawi yanu yotsatira kudzakambirana izi ndi dokotala wanu.

Ngati ndinu kholo kapena woyang'anira wodwala wamkazi yemwe anali asanakule msinkhu, yang'anani mwana wanu pafupipafupi kuti muwone ngati akukula chizindikiro chilichonse chokhudzana ndi kutha msinkhu (masamba a m'mawere, tsitsi labanja) ndipo muuzeni dokotala kuti adziwe zosintha zilizonse.

Chifukwa cha kuwonongeka kwa chiwindi komanso kupunduka kwa kubadwa, bosentan imapezeka pokhapokha pulogalamu yoletsedwa yotchedwa Tracleer Risk Evaluation and Mitigation Strategy Program (Tracleer REMS). Kuti mulandire bosentan inu ndi dokotala muyenera kulembetsa ndi Tracleer REMS, ndikutsatira zomwe zikufunika monga kamodzi pamwezi pakugwira chiwindi komanso kuyezetsa pakati. Dokotala wanu adzakulembetsani pulogalamuyi. Bosentan imangopezeka m'ma pharmacies ena omwe amalembetsa ku Tracleer REMS. Funsani dokotala wanu kapena wamankhwala ngati muli ndi mafunso okhudza momwe mungadzaze mankhwala anu.

Mukalandira pepala lazidziwitso za wodwala wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi bosentan ndipo nthawi iliyonse mukadzaza mankhwala. Werengani zambiri mosamala nthawi iliyonse ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kupeza Maupangiri a Medication kuchokera patsamba la FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Lankhulani ndi dokotala wanu za kuopsa kotenga bosentan.

Bosentan imagwiritsidwa ntchito pochizira matenda oopsa a m'mapapo mwanga (PAH, kuthamanga kwa magazi m'mitsempha yomwe imanyamula magazi kumapapu) mwa akulu ndi ana azaka zitatu kapena kupitilira apo. Bosentan atha kupititsa patsogolo luso lawo lochita masewera olimbitsa thupi ndikuchepetsa kuchepa kwa zizindikilo mwa odwala omwe ali ndi PAH. Bosentan ali mgulu la mankhwala otchedwa endothelin receptor antagonists. Zimagwira ntchito poletsa endothelin, mankhwala achilengedwe omwe amachititsa kuti mitsempha yamagazi ichepetse komanso kupewa magazi omwe amapezeka mwa anthu omwe ali ndi PAH.

Bosentan imabwera ngati piritsi komanso piritsi lomwe lingathe kufalikira (piritsi lomwe limatha kusungunuka m'madzi) kuti mulimwetse. Nthawi zambiri amatengedwa kapena wopanda chakudya kawiri patsiku m'mawa ndi madzulo. Kukuthandizani kukumbukira kukumbukira kutenga bosentan, tengani mozungulira nthawi imodzimodzi tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani bosentan ndendende monga momwe mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati mukumwa phale lomwe lingathe kufalikira, ikani piritsiyo pang'ono pang'ono musanamwe. Ngati dokotala wakuwuzani kuti mutenge piritsi theka, dulani piritsi lomwe limafalikira mosamala pamzere. Tengani theka la piritsi monga momwe adanenera, ndipo theka linalo mubwezeretse chithuza mu phukusi. Gwiritsani ntchito piritsi lina theka pasanathe masiku asanu ndi awiri. Osang'ambika phale lomwe limatha kufalikira.

Dokotala wanu mwina angakuyambitseni pamlingo wochepa wa bosentan ndikuwonjezera mlingo wanu pakatha milungu inayi.

Bosentan amayang'anira zizindikiro za PAH koma samachiritsa. Zitha kutenga 1 mpaka 2 miyezi kapena kupitilira apo kuti mumve bwino za bosentan. Pitilizani kutenga bosentan ngakhale mukumva bwino. Osasiya kumwa bosentan osalankhula ndi dokotala. Ngati mwasiya mwadzidzidzi kutenga bosentan, matenda anu akhoza kukulirakulira. Dokotala wanu akhoza kuchepetsa mlingo wanu pang'onopang'ono.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge bosentan,

• uzani dokotala ndi wamankhwala ngati muli ndi vuto la bosentan, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a bosentan kapena mapiritsi omwe angathe kufalikira.
• musatenge cyclosporine (Gengraf, Neoral, Sandimmune) kapena glyburide (DiaBeta, Glynase) mukamamwa bosentan.
• uzani dokotala ndi wamankhwala mankhwala ena akuchipatala ndi osapereka, mavitamini, zowonjezera zakudya, ndi mankhwala omwe mumamwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet), lovastatin (Altoprev), ndi simvastatin (Flolopid, Zocor, ku Vytorin); diltiazem (Cardizem, Cartia, Diltzac, ena); erythromycin (EES, Eryc, PCE); fluconazole (Diflucan); gemfibrozil (Lopid); itraconazole (Onmel, Sporanox); ketoconazole; rifampin (Rifadin, Rimactane, ku Rifater, Rifamate); ritonavir (Norvir, ku Kaletra, Viekira Pak, Technivie); voriconazole (Vfend); ndi warfarin (Coumadin, Jantoven). Mankhwala ena ambiri amathanso kulumikizana ndi bosentan, onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwalephera kapena munakhalapo ndi vuto la mtima (momwe mtima sungathe kupopera magazi okwanira mbali zina za thupi).
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Dokotala wanu angakuuzeni kuti musamayamwa mukamamwa bosentan.
• ngati muli ndi phenylketonuria (PKU, mkhalidwe wobadwa nawo momwe muyenera kudya chakudya chapadera kuti muchepetse kuchepa kwamaganizidwe), muyenera kudziwa kuti mapiritsi omwe amatha kufalikira amatsekemera ndi aspartame, gwero la phenylalanine.

Lankhulani ndi dokotala wanu za kumwa zakumwa zamadzimadzi mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Bosentan ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kuchapa
• chimfine, pakhosi, ndi zizindikiro zina zozizira
• kupweteka pamodzi

Zotsatira zina zoyipa zingakhale zazikulu. Zizindikiro zotsatirazi sizachilendo, koma ngati mungakumane ndi zina mwazomwe zalembedwa m'gawo la CHENJEZO, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• ming'oma; zidzolo; kuyabwa; kuvuta kupuma kapena kumeza; kutupa kwa nkhope, mmero, lilime, milomo, ndi maso; ukali; malungo; zotupa zaminyewa zotupa; kutopa
• kutupa kwa mapazi, akakolo, kapena miyendo yakumunsi, kunenepa modzidzimutsa, mavuto ambiri ndikupuma kuposa zachilendo
• kupuma kwatsopano kapena kukulira; chifuwa chatsopano kapena chowonjezeka kapena popanda magazi; kupweteka pachifuwa; kusala kudya, kugunda, kapena kugunda kwamtima kosazolowereka
• kukomoka
• chizungulire; khungu lotumbululuka; kupuma movutikira; kufooka; kusala kudya, kugunda, kapena kugunda kwamtima kosazolowereka

Zinyama zanthabwala zamwamuna zomwe zimapatsidwa mankhwala ofanana ndi bosentan zidayamba kukhala ndi mavuto machende awo ndikupanga umuna wocheperako (maselo oberekera achimuna) kuposa zachilendo. Sizikudziwika ngati bosentan itha kuwononga machende kapena kuchepetsa kuchuluka kwa umuna wopangidwa mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kotenga bosentan ngati mukufuna kudzakhala ndi ana mtsogolo.

Bosentan ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• mutu
• nseru
• kusanza
• kugunda kwamtima mwachangu
• kukomoka
• thukuta
• chizungulire
• kusawona bwino

Musalole kuti aliyense azimwa mankhwala anu. Funsani dokotala mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Wopondereza^®