Jekeseni wa Bevacizumab

Zamkati

• Mankhwala a Bevacizumab amagwiritsidwa ntchito
• Asanalandire mankhwala a bevacizumab,
• Mankhwala opangidwa ndi jekeseni wa Bevacizumab angayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Jekeseni wa Bevacizumab, jakisoni wa bevacizumab-awwb, ndi jakisoni wa bevacizumab-bvzr ndi mankhwala a biologic (mankhwala opangidwa kuchokera kuzinthu zamoyo). Biosimilar bevacizumab-awwb jekeseni ndi jekeseni ya bevacizumab-bvzr ndi ofanana kwambiri ndi jekeseni wa bevacizumab ndipo imagwira ntchito chimodzimodzi ndi jekeseni wa bevacizumab mthupi. Chifukwa chake, mawu akuti mankhwala a jekeseni wa bevacizumab adzagwiritsidwa ntchito kuyimira mankhwalawa pazokambirana izi.

Mankhwala a Bevacizumab amagwiritsidwa ntchito

• kuphatikiza ndi mankhwala ena a chemotherapy ochiza khansa ya m'matumbo (matumbo akulu) kapena rectum yomwe yafalikira mbali zina za thupi;
• kuphatikiza ndi mankhwala ena a chemotherapy othandizira mitundu ina ya khansa yamapapo yomwe yafalikira kumatumba oyandikira kapena ziwalo zina za thupi, zomwe sizingachotsedwe ndi opareshoni, kapena zabwerera mutalandira chithandizo ndi mankhwala ena a chemotherapy;
• kuchiza glioblastoma (mtundu wina wa khansa yotupa yaubongo) yomwe sinasinthe kapena yabwerera pambuyo pochiritsidwa ndi mankhwala ena;
• kuphatikiza ndi interferon alfa yochiza khansa ya m'mitsempha (RCC, mtundu wa khansa yomwe imayamba mu impso) yomwe yafalikira mbali zina za thupi;
• kuphatikiza ndi mankhwala ena a chemotherapy othandiza khansa ya pachibelekero (khansa yomwe imayamba potsegulira chiberekero [chiberekero] yomwe sinasinthe kapena yabwerera pambuyo pochiritsidwa ndi mankhwala ena kapena yafalikira mbali zina za thupi;
• kuphatikiza ndi mankhwala ena a chemotherapy othandizira mitundu ina yamchiberekero (ziwalo zoberekera zachikazi komwe mazira amapangidwira), chubu (chotengera chomwe chimatumiza mazira otulutsidwa ndi thumba losunga mazira kupita kuchiberekero), ndi peritoneal (wosanjikiza wa minofu yomwe imayala pamimba) khansa zomwe sizinasinthe kapena zabwerera pambuyo pothandizidwa ndi mankhwala ena; ndipo
• kuphatikiza ndi atezolizumab kuchiza hepatocellular carcinoma (HCC) yomwe yafalikira kapena singachotsedwe ndi opaleshoni mwa anthu omwe sanalandire chemotherapy m'mbuyomu.

Mankhwala a Bevacizumab ali mgulu la mankhwala otchedwa antiangiogenic agents. Amagwira ntchito poletsa mapangidwe amitsempha yamagazi yomwe imabweretsa mpweya wabwino ndi michere m'matumbo. Izi zitha kuchepetsa kukula ndi kufalikira kwa zotupa.

Mankhwala opangidwa ndi jekeseni wa Bevacizumab amabwera ngati yankho (madzi) operekera pang'onopang'ono mumtsempha. Mankhwala opangidwa ndi jekeseni wa Bevacizumab amaperekedwa ndi dokotala kapena namwino kuofesi yazachipatala, malo olowerera, kapena chipatala. Zida zopangira jekeseni wa Bevacizumab zimaperekedwa kamodzi pamasabata awiri kapena atatu. Kukhazikika kwanu kudzadalira momwe muliri, mankhwala ena omwe mukugwiritsa ntchito, komanso momwe thupi lanu limayankhira kuchipatala.

Iyenera kutenga mphindi 90 kuti mulandire mulingo wanu woyamba wa mankhwala a jekeseni wa bevacizumab. Dokotala kapena namwino adzakuyang'anirani kuti muwone momwe thupi lanu limachitira ndi bevacizumab. Ngati mulibe zovuta zilizonse mukalandira mankhwala anu oyamba a jekeseni wa bevacizumab, zimangotenga mphindi 30 mpaka 60 kuti mulandire mankhwala aliwonse omwe atsala.

Mankhwala opangidwa ndi jekeseni wa Bevacizumab amatha kuyambitsa mavuto ena pakulowetsedwa kwa mankhwalawo. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kuvutika kupuma kapena kupuma movutikira, kuzizira, kugwedezeka, kutuluka thukuta, kupweteka mutu, kupweteka pachifuwa, chizungulire, kumva kukomoka, kuthamanga, kuyabwa, zidzolo, kapena ming'oma. Dokotala wanu angafunike kuchepetsa kulowetsedwa kwanu, kapena kuchedwetsa kapena kuyimitsa chithandizo chanu mukakumana ndi izi kapena zovuta zina.

Jekeseni wa Bevacizumab (Avastin) nthawi zina amagwiritsidwanso ntchito kuthana ndi kuchepa kwamankhwala okhudzana ndi zaka (AMD; matenda opitilira diso omwe amachititsa kuti asamaoneke kutsogolo ndipo zitha kupangitsa kuti zikhale zovuta kuwerenga, kuyendetsa, kapena kuchita zina Zochita za tsiku ndi tsiku). Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito bevacizumab kuchiza matenda anu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire mankhwala a bevacizumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la bevacizumab, bevacizumab-awwb, bevacizumab-bvzr, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa ndi mankhwala a jekeseni wa bevacizumab.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula ma anticoagulants (oponda magazi) monga warfarin (Coumadin, Jantoven); ndi sunitinib (Sutent). Komanso muuzeni dokotala ngati mukumwa kapena ngati mudalandirapo anthracycline (mtundu wa chemotherapy womwe umagwiritsidwa ntchito pa khansa ya m'mawere ndi mitundu ina ya leukemia) monga daunorubicin (Cerubidine), doxorubicin, epirubicin (Ellence), kapena idarubicin (Idamycin) . Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala ngati mwalandira mankhwala a radiation kumanzere kwa chifuwa kapena m'chiuno; ndipo ngati mwakhalapo ndi kuthamanga kwa magazi, kulephera kwa mtima, kapena vuto lililonse lomwe limakhudza mtima wanu kapena mitsempha yamagazi (machubu omwe amasuntha magazi pakati pamtima ndi ziwalo zina za thupi). Komanso, uzani dokotala wanu ngati mwangoyamba kumene kukhetsa magazi.
• Muyenera kudziwa kuti mankhwala a jekeseni wa bevacizumab atha kubweretsa kusabereka mwa amayi (kuvutika kukhala ndi pakati); komabe, simuyenera kuganiza kuti simungakhale ndi pakati. Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse kutenga pakati mukamamwa mankhwala a jekeseni wa bevacizumab komanso kwa miyezi isanu ndi umodzi mutatha kumwa.Mukakhala ndi pakati mukamagwiritsa ntchito jekeseni wa bevacizumab, itanani dokotala wanu. Bevacizumab itha kuvulaza mwana wosabadwayo ndikuwonjezera chiopsezo chotaya mimba.
• Uzani dokotala wanu ngati mukuyamwitsa. Musamayamwitse mukamamwa mankhwala a jekeseni wa bevacizumab komanso kwa miyezi isanu ndi umodzi mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa atha kuyambitsa ovarian. Lankhulani ndi dokotala wanu za kuopsa kwa kusabereka kwa amayi chifukwa cha bevacizumab. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwala a bevacizumab mankhwala.
• uzani dokotala wanu ngati mwachitidwa opaleshoni posachedwapa kapena ngati mukufuna kuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano. Ngati mukuyenera kuchitidwa opaleshoni, dokotala wanu adzaimitsa chithandizo chanu ndi mankhwala opangira bevacizumab masiku 28 asanafike opaleshoni. Ngati mwachitidwa opaleshoni posachedwa, simuyenera kulandira mankhwala opangira bevacizumab mpaka masiku osachepera 28 atadutsa ndipo mpaka malowo atachira.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi kuti mulandire mankhwala a bevacizumab, itanani dokotala wanu posachedwa.

Mankhwala opangidwa ndi jekeseni wa Bevacizumab angayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chizungulire
• kusowa chilakolako
• kutentha pa chifuwa
• kusintha kwa kulawa chakudya
• kutsegula m'mimba
• kuonda
• zilonda pakhungu kapena pakamwa
• mawu amasintha
• kuwonjezera kapena kuchepa misozi
• yothina kapena yothamanga m'mphuno
• kupweteka kwa minofu kapena molumikizana
• kuvuta kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kutuluka magazi m'kamwa mwanu; kutsokomola kapena kusanza magazi kapena zinthu zomwe zimawoneka ngati malo a khofi; kutuluka mwachilendo kapena kuvulala; kuchuluka kusamba kapena magazi kumaliseche; pinki, wofiira, kapena mkodzo wakuda; ofiira kapena ofiyira matumbo akuda; kapena kupweteka mutu, chizungulire, kapena kufooka
• zovuta kumeza
• mawu odekha kapena ovuta
• kukomoka
• kufooka kapena kufooka kwa mkono kapena mwendo
• kupweteka pachifuwa
• kupweteka kwa mikono, khosi, nsagwada, m'mimba, kapena kumtunda kwakumbuyo
• kupuma pang'ono kapena kupuma
• kugwidwa
• kutopa kwambiri
• chisokonezo
• kusintha masomphenya kapena kutayika kwa masomphenya
• zilonda zapakhosi, malungo, kuzizira, ndi zizindikiro zina za matenda
• kutupa kwa nkhope, maso, mimba, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kunenepa kopanda tanthauzo
• mkodzo wa thovu
• ululu, kukoma, kutentha, kufiira, kapena kutupa mwendo umodzi wokha
• kufiira, kuyabwa, kapena kukula kwa khungu
• kupweteka m'mimba, kudzimbidwa, nseru, kusanza, kunjenjemera, kapena malungo

Mankhwala opangidwa ndi jekeseni wa Bevacizumab angayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu. Dokotala wanu amayang'ana kuthamanga kwa magazi ndikuyesa mkodzo wanu pafupipafupi mukamalandira chithandizo cha jakisoni wa bevacizumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Avastin^® (bevacizumab)
• Mvasi^® (bevacizumab-awwb)
• Zirabev^® (bevacizumab-bvzr)