Jekeseni wa Rituximab

Zamkati

• Asanalandire mankhwala opangira rituximab,
• Zida za jekeseni wa Rituximab zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

Jekeseni wa Rituximab, jekeseni wa rituximab-abbs, ndi jakisoni wa rituximab-pvvr ndi mankhwala a biologic (mankhwala opangidwa kuchokera kuzinthu zamoyo). Biosimilar rituximab-abbs jekeseni ndi jekeseni wa rituximab-pvvr ndi ofanana kwambiri ndi jekeseni wa rituximab ndipo imagwira ntchito chimodzimodzi ndi jekeseni wa rituximab mthupi. Chifukwa chake, mawu akuti rituximab mankhwala adzagwiritsidwa ntchito kuyimira mankhwalawa pazokambirana izi.

Mutha kukumana ndi vuto lalikulu mukalandira kapena pasanathe maola 24 mutalandira mankhwala opangira rituximab. Izi zimachitika nthawi yoyamba ya mankhwala opangira rituximab ndipo imatha kupha. Mudzalandira mlingo uliwonse wa mankhwala opangira jekeseni wa rituximab kuchipatala, ndipo dokotala kapena namwino adzakuyang'anirani mosamala mukalandira mankhwala. Mukalandira mankhwala ena othandizira kupewa zovuta zilizonse musanalandire mankhwala aliwonse a rituximab jakisoni. Uzani dokotala wanu ngati mwakhalapo ndi vuto la mankhwala a rituximab kapena ngati mwakhala mukumenya mtima mosasinthasintha, kupweteka pachifuwa, mavuto ena amtima, kapena mavuto am'mapapo. Ngati mukumane ndi izi, uzani dokotala wanu kapena wothandizira zaumoyo nthawi yomweyo: ming'oma; zidzolo; kuyabwa; kutupa kwa milomo, lilime, kapena pakhosi; kuvuta kupuma kapena kumeza; chizungulire; kukomoka; kupuma movutikira, kupuma; mutu; kugunda kapena kugunda kwamtima kosazolowereka; kuthamanga kapena kufooka kolimba; wotumbululuka kapena khungu labuluu; kupweteka pachifuwa komwe kumatha kufalikira mbali zina zakumtunda; kufooka; kapena thukuta lolemera.

Zida zopangira jekeseni wa Rituximab zabweretsa mavuto owopsa pakhungu ndi pakamwa. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: zilonda zopweteka pakhungu, milomo, kapena pakamwa; matuza; zidzolo; kapena khungu losenda.

Mutha kukhala ndi kachilombo ka hepatitis B (kachilombo kamene kamagwira chiwindi ndipo kakhoza kuwononga chiwindi kwambiri) koma osakhala ndi zisonyezo za matendawa. Poterepa, kulandira mankhwala opangira rituximab kumatha kuonjezera chiopsezo kuti matenda anu akhoza kukhala owopsa kapena owopseza moyo ndipo mudzakhala ndi zizindikilo. Uzani dokotala wanu ngati mwakhala mukudwala matenda opatsirana kwambiri, kuphatikizapo matenda a hepatitis B virus. Dokotala wanu amalamula kuti mukayezetse magazi kuti muwone ngati muli ndi matenda opatsirana a hepatitis B. Ngati ndi kotheka, dokotala wanu angakupatseni mankhwala kuti muchepetse matendawa musanachitike komanso mukamalandira mankhwala opangira rituximab. Dokotala wanu adzakuyang'anirani ngati muli ndi matenda a chiwindi cha B mkati ndi miyezi ingapo mutalandira chithandizo. Ngati mukumane ndi zizindikiro izi mukamalandira chithandizo kapena mutalandira chithandizo, itanani dokotala wanu mwachangu: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako, kunyoza kapena kusanza, kupweteka kwa minofu, kupweteka m'mimba, kapena mkodzo wakuda.

Anthu ena omwe adalandira mankhwala opangira jekeseni ya rituximab adayamba kukhala ndi leukoencephalopathy (PML; matenda opatsirana aubongo omwe sangachiritsidwe, kupewa, kapena kuchiritsidwa ndipo nthawi zambiri amayambitsa imfa kapena kulemala kwambiri) kapena atalandira chithandizo. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kusintha kwatsopano kapena mwadzidzidzi pakuganiza kapena kusokonezeka; kuvuta kulankhula kapena kuyenda; kutaya malire; kutaya mphamvu; kusintha kwatsopano kapena kwadzidzidzi m'masomphenya; kapena zizindikiro zina zachilendo zomwe zimachitika mwadzidzidzi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire ndi mankhwala opangira rituximab.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa rituximab ndipo nthawi iliyonse yomwe mumalandira mankhwala. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwala opangira rituximab.

Mankhwala opangira majekesiti a Rituximab amagwiritsidwa ntchito paokha kapena ndi mankhwala ena kuti athetse mitundu yosiyanasiyana ya non-Hodgkin's lymphoma (NHL; mtundu wa khansa womwe umayambira mumtundu wama cell oyera omwe nthawi zambiri amalimbana ndi matenda). Mankhwala opangidwa ndi jekeseni wa Rituximab amagwiritsidwanso ntchito ndi mankhwala ena kuti athetse khansa ya m'magazi (CLL; mtundu wa khansa yamagazi oyera). Jekeseni wa Rituximab (Rituxan) imagwiritsidwanso ntchito ndi methotrexate (Otrexup, Rasuvo, Xatmep, ena) kuti athetse matenda a nyamakazi (RA; momwe thupi limagwirira mafupa ake, kupweteketsa, kutupa, ndi kutaya ntchito) mwa akulu omwe adalandira kale mtundu wina wamankhwala wotchedwa chotupa chotchedwa necrosis factor (TNF) inhibitor. Jekeseni wa Rituximab (Rituxan, Ruxience) imagwiritsidwanso ntchito kwa achikulire ndi ana azaka ziwiri kapena kupitilira apo limodzi ndi mankhwala ena ochiza granulomatosis ndi polyangiitis (Wegener's Granulomatosis) ndi microscopic polyangiitis, yomwe ndi mikhalidwe yomwe thupi limagunda mitsempha yake ndi zina Mitsempha yamagazi, yomwe imawononga ziwalo, monga mtima ndi mapapo. Jekeseni wa Rituximab (Rituxan) amagwiritsidwa ntchito pochizira pemphigus vulgaris (vuto lomwe limayambitsa matuza opweteka pakhungu ndikulumikiza mkamwa, mphuno, pakhosi komanso kumaliseche). Zida za jekeseni wa Rituximab zili mgulu la mankhwala otchedwa monoclonal antibodies. Amachiza mitundu yosiyanasiyana ya NHL ndi CLL popha ma cell a khansa. Mankhwala ena a rituximab jekeseni amathandizanso nyamakazi ya nyamakazi, granulomatosis ndi polyangiitis, microscopic polyangiitis, ndi pemphigus vulgaris poletsa zochitika za chitetezo cha mthupi zomwe zingawononge ziwalo, mitsempha, ndi mitsempha ina yamagazi.

Zida za jekeseni wa Rituximab zimabwera ngati yankho (madzi) kuti alowetsedwe mumtsempha. Zida za jekeseni wa Rituximab zimaperekedwa ndi dokotala kapena namwino kuofesi yazachipatala kapena kulowetsedwa m'malo. Kukhazikika kwanu kudzadalira momwe muliri, mankhwala ena omwe mukugwiritsa ntchito, komanso momwe thupi lanu limayankhira kuchipatala.

Zinthu zopangira jekeseni wa Rituximab ziyenera kuperekedwa pang'onopang'ono mumtsempha. Zitha kutenga maola angapo kapena kupitilira apo kuti mulandire mankhwala anu oyamba a rituximab, chifukwa chake muyenera kukonzekera kukhala nthawi yayitali kuofesi ya zamankhwala kapena kulowetsedwa mkati. Mutatha kumwa mankhwala oyamba, mutha kulandira mankhwala opangira rituximab mwachangu , kutengera momwe mumayankhira mankhwala.

Mutha kukhala ndi zizindikilo monga kutentha thupi, kuzizira, kutopa, kupweteka mutu, kapena mseru mukalandira mankhwala a rituximab, makamaka mlingo woyamba. Uzani dokotala wanu kapena wothandizira zaumoyo ngati mukukumana ndi izi mukalandira mankhwala anu. Dokotala wanu akhoza kukupatsani mankhwala ena othandizira kupewa kapena kuthetsa izi. Dokotala wanu angakuuzeni kumwa mankhwalawa musanalandire mankhwala aliwonse a rituximab.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire mankhwala opangira rituximab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la rituximab, rituximab-abbs, rituximab-pvvr, mankhwala ena aliwonse, kapena chilichonse mwazinthu zopangira jekeseni wa rituximab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: adalimumab (Humira); certolizumab (Cimzia); etanercept (Enbrel); golimumab (Simponi); infliximab (Remicade); mankhwala ena a nyamakazi; ndi mankhwala omwe amapondereza chitetezo cha mthupi monga azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune, Torisel), ndi tacrolimus (Envarsus, Prograf). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani adotolo ngati muli ndi zina mwazomwe zatchulidwa mgawo la CHENJEZO LOFUNIKA ndipo ngati mwakhalapo ndi hepatitis C kapena ma virus ena monga nkhuku, herpes (kachilombo kamene kangayambitse zilonda zoziziritsa kapena kuphulika kwa matuza kumaliseche dera), ma shingles, kachilombo ka West Nile (kachilombo kamene kamafalikira kudzera mu udzudzu ndipo kumatha kuyambitsa matenda akulu), parvovirus B19 (matenda achisanu; kachilombo kofala mwa ana komwe kumangobweretsa mavuto akulu mwa anthu ena achikulire), kapena cytomegalovirus (a kachilombo koyambitsa matendawa kamene kamangoyambitsa matenda aakulu mwa anthu omwe afooketsa chitetezo cha mthupi kapena omwe ali ndi kachilombo pobadwa), kapena matenda a impso.Komanso uzani dokotala wanu ngati muli ndi matenda aliwonse pano kapena ngati muli ndi matenda omwe sangachoke kapena matenda omwe amabwera ndikutha.
• uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse kutenga pakati mukamamwa mankhwala opangira rituximab komanso kwa miyezi 12 mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za mitundu yoletsa yomwe ingakuthandizeni. Mukakhala ndi pakati mukamagwiritsa ntchito jakisoni wa rituximab, itanani dokotala wanu. Rituximab itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala a rituximab jakisoni komanso kwa miyezi 6 mutapatsidwa mlingo womaliza.
• Funsani dokotala ngati mukufuna kulandira katemera musanayambe mankhwala anu ndi mankhwala a rituximab. Musakhale ndi katemera uliwonse mukamalandira chithandizo popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi kuti mulandire mankhwala a rituximab, pitani kuchipatala nthawi yomweyo.

Zida za jekeseni wa Rituximab zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kupweteka kumbuyo kapena kumalumikizana
• kuchapa
• thukuta usiku
• kumva kuda nkhawa kapena kuda nkhawa modabwitsa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kuvulaza kapena kutuluka mwachilendo
• zilonda zapakhosi, mphuno, chifuwa, malungo, kuzizira, kapena zizindikilo zina za matenda
• khutu
• pokodza kwambiri
• kufiira, kukoma mtima, kutupa kapena kutentha kwa khungu
• kufinya pachifuwa

Zida za jekeseni wa Rituximab zitha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Chikhalidwe^® (rituximab)
• Kukhulupirika^® (rituximab-pvvr)
• Truxima^® (rituximab-abbs)