Jekeseni wa Romidepsin

Zamkati

• Asanalandire jekeseni wa romidepsin,
• Jekeseni wa Romidepsin imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

Jekeseni ya Romidepsin imagwiritsidwa ntchito pochizira T-cell lymphoma (CTCL; gulu la khansa yama chitetezo amthupi yomwe imawonekera koyamba ngati zotupa pakhungu) mwa anthu omwe adalandira kale mankhwala ena amodzi. Jekeseni wa Romidepsin imagwiritsidwanso ntchito pochizira zotumphukira T-cell lymphoma (PTCL; mtundu wa non-Hodgkin's lymphoma) mwa anthu omwe adalandira kale mankhwala osachepera amodzi. Jekeseni ya Romidepsin ili mgulu la mankhwala otchedwa histone deacetylase (HDAC) inhibitors. Zimagwira pochepetsa kukula kwa maselo a khansa.

Jekeseni ya Romidepsin imabwera ngati ufa woti uzisakanikirana ndi madzi kuti alowe mu jakisoni (mumtsempha) kwa ola la 4 ndi dokotala kapena namwino. Nthawi zambiri amaperekedwa masiku 1, 8, ndi 15 masiku 28. Kuzungulira kumeneku kumatha kubwerezedwa malinga ngati mankhwalawa akupitilizabe kugwira ntchito ndipo sizimayambitsa zovuta zina.

Lankhulani ndi dokotala wanu za zovuta zilizonse zomwe mumakumana nazo mukamalandira jakisoni wa romidepsin. Ngati mukukumana ndi zovuta zina, dokotala akhoza kuyimitsa chithandizo chanu kwanthawi zonse kapena kwakanthawi ndipo / kapena amachepetsa mlingo wanu.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa romidepsin,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la jakisoni wa romidepsin, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jekeseni wa romidepsin. Funsani wamankhwala wanu kapena onani zambiri za wodwalayo kuti muwone mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maantibayotiki ena monga clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), ndi telithromycin (Ketek); maanticoagulants (owonda magazi) monga warfarin (Coumadin, Jantoven); antifungals monga itraconazole (Sporanox), ketoconazole (Nizoral), ndi voriconazole (Vfend); cisapride (Propulsid) (sikupezeka ku U.S.); dexamethasone; mankhwala a kachirombo ka HIV (monga HIV) monga atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (ku Kaletra, Norvir), ndi saquinavir (Invirase); mankhwala osagunda pamtima monga amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), ndi sotalol (Betapace, Betapace AF); mankhwala ena ogwidwa monga carbamazepine (Epitol, Equetro, Tegretol), phenobarbital, ndi phenytoin (Dilantin); nefazodone; pimozide (Orap); rifabutin (Mycobutin); rifampin (Rifadin, ku Rifamate, ku Rifater, Rimactane); rifapentine (Priftin); sparfloxacin (Zagam); kapena thioridazine (Mellaril). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi jakisoni wa romidepsin, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• Uzani dokotala wanu ngati muli ndi mseru, kusanza, kapena kutsegula m'mimba musanayambe mankhwala anu ndi jekeseni wa romidepsin. Komanso muuzeni dokotala ngati mwakhalapo ndi nthawi yayitali ya QT (vuto losawerengeka la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi), kugunda kwamtima mosasinthasintha kapena mwachangu, potaziyamu wochulukirapo kapena magnesium m'magazi anu , hepatitis B (HBV; kachilombo kamene kamayambitsa chiwindi ndipo kangayambitse chiwindi kapena khansa ya chiwindi), Epstein Barr virus (EBV; kachilombo ka herpes kamene kamayambitsa matenda opatsirana a mononucleosis ndipo amakhudzana ndi khansa zina), kapena chiwindi, impso, kapena matenda amtima.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Dokotala wanu amatha kuwona ngati muli ndi pakati musanayambe kumwa mankhwala. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa jakisoni wa romidepsin komanso kwa mwezi umodzi mutatha kumwa. Komabe, simuyenera kugwiritsa ntchito njira zakulera za mahomoni (estrogen) (mapiritsi oletsa kubala, zigamba, mphete, zopangira, kapena jakisoni) chifukwa jakisoni wa romidepsin angaimitse mankhwalawa kugwira ntchito momwe ayenera kukhalira. Ngati ndinu wamwamuna wokhala ndi mkazi yemwe angatenge mimba, onetsetsani kuti mukugwiritsa ntchito njira yolerera mukamalandira jakisoni wa romidepsin komanso kwa mwezi umodzi mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito. Mukakhala ndi pakati mukalandira jakisoni wa romidepsin, itanani dokotala wanu. Jekeseni ya Romidepsin itha kuvulaza mwana wosabadwayo. Simuyenera kuyamwa mukamamwa mankhwala a jekeseni wa romidepsin komanso osachepera sabata limodzi mutatha kumwa mankhwala omaliza.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani adotolo kapena dokotala kuti mukulandira jekeseni wa romidepsin.

Onetsetsani kuti mumamwa madzi ambiri kwa masiku atatu osatsata jakisoni wa romidepsin.

Lankhulani ndi dokotala wanu za kudya zipatso zamphesa ndi kumwa madzi amphesa pamene mukulandira mankhwalawa.

Jekeseni wa Romidepsin imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kupweteka m'mimba
• zilonda mkamwa
• mutu
• kusintha kwa kukoma
• kusowa chilakolako
• kuyabwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kutopa kapena kufooka
• khungu lotumbululuka
• kupuma movutikira
• kupweteka pachifuwa
• kugunda kwamtima kosasintha
• kumva chizungulire kapena kukomoka
• kuvulaza kosavuta kapena kutuluka magazi
• malungo, chifuwa, matenda onga chimfine, kupweteka kwa minofu, kutentha pokodza, kukulitsa mavuto akhungu, ndi zizindikilo zina za matenda (atha kutha masiku 30 mutalandira chithandizo)
• zidzolo
• khungu kapena khungu
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi

Jekeseni wa Romidepsin itha kubweretsa mavuto kubereka. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa ngati mukufuna kukhala ndi ana.

Jekeseni wa Romidepsin imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire jakisoni wa romidepsin.

Funsani wamankhwala wanu mafunso aliwonse omwe ali nawo okhudza jekeseni wa romidepsin.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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