Mlembi: Virginia Floyd
Tsiku La Chilengedwe: 5 Ogasiti 2021
Sinthani Tsiku: 22 Jayuwale 2025
Anonim
Dextromethorphan-Quinidine for Agitation in Patients With Alzheimer Disease
Kanema: Dextromethorphan-Quinidine for Agitation in Patients With Alzheimer Disease

Zamkati

Kuphatikiza kwa dextromethorphan ndi quinidine kumagwiritsidwa ntchito pochiza pseudobulbar (PBA; vuto lakulira mwadzidzidzi, kulira kapena kuseka komwe sikungalamuliridwe) mwa anthu omwe ali ndi zovuta zina monga amyotrophic lateral sclerosis (ALS, matenda a Lou Gehrig; momwe mitsempha yomwe imalamulira kuyenda kwa minofu imamwalira pang'onopang'ono, kupangitsa kuti minofu ifooke ndikufooka) kapena multiple sclerosis (matenda omwe mitsempha sigwira ntchito bwino ndipo odwala amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu ndi mavuto ndi masomphenya, mawu, ndi chikhodzodzo). Dextromethorphan ali mgulu la mankhwala otchedwa central system system agents. Momwe imagwirira ntchito muubongo kuchitira PBA sikudziwika. Quinidine ali mgulu la mankhwala otchedwa antiarrhythmics. Mukaphatikizidwa ndi dextromethorphan, quinidine imagwira ndikuwonjezera kuchuluka kwa dextromethorphan mthupi.

Kuphatikiza kwa dextromethorphan ndi quinidine kumabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kamodzi patsiku kwa masiku 7. Pambuyo masiku 7, amatengedwa maola 12 aliwonse. Musatenge kuchuluka kopitilira 2 munthawi yamaola 24. Onetsetsani kuti mulola pafupifupi maola 12 pakati pa mlingo uliwonse. Tengani dextromethorphan ndi quinidine mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani kuphatikiza kwa dextromethorphan ndi quinidine chimodzimodzi monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.


Dokotala wanu amatha kuwunika nthawi ndi nthawi kuti awone ngati mankhwalawa akufunikirabe kuthana ndi matenda anu. Tsatirani malangizowa mosamala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge dextromethorphan ndi quinidine,

  • uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la dextromethorphan, quinidine (Quinidex), quinine (Qualaquin), mefloquine (Lariam), mankhwala ena aliwonse, kapena chilichonse chophatikizira kuphatikiza makapisozi a dextromethorphan ndi quinidine. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
  • uzani dokotala ngati mukumwa mefloquine (Lariam), pimozide (Orap), quinine (Qualaquin) thioridazine, kapena chinthu china chokhala ndi quinidine (Quinidex). Dokotala wanu angakuuzeni kuti musatenge dextromethorphan ndi quinidine ngati mukumwa mankhwala amodzi kapena angapo.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: antidepressants kuphatikiza clomipramine (Anafranil), desipramine (Doxepin, Sinequan), fluoxetine (Prozac, Sarafem), nefazodone, ndi paroxetine (Paxil, Pexeva); Aprepitant (Emend); clarithromycin (Biaxin, Prevpac); chifuwa ndi mankhwala ozizira okhala ndi dextromethorphan; cisapride; digoxin (Lanoxin, Digitek); erythromycin (EES E-Mycin, Erythrocin); fluconazole (Diflucan); itraconazole (Sporanox); ketoconazole (Nizoral); mankhwala ena a kachirombo ka HIV (HIV) monga atazanavir (Reyataz), amprenavir (Agenerase), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala a mtima wosasinthasintha monga amiodarone (Cordarone), diltiazem (Cardizem, Cartia, Tiazac, ena), disopyramide (Norpace), dofetilide (Tikosyn), procainamide (Procanbid, Pronestyl), sotalol (Betapace), ndi verapamil (Calan, Covera, Isoptin, Verelan, ku Tarka); mankhwala opweteka monga codeine, hydrocodone (mu Hydrogesic, Lorcet, Lortab, Vicodin, Zydone, ena), ndi methadone; moxifloxacin (Avelox); sparfloxacin (Zagam); ndi teliththromycin (Ketek). Komanso uzani dokotala wanu kapena wamankhwala ngati mukumwa mankhwalawa kapena mwasiya kuwamwa m'masabata awiri apitawa: Mao inhibitors kuphatikiza isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl ), ndi tranylcypromine (Parnate). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi dextromethorphan ndi quinidine, onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
  • Uzani dokotala wanu ngati mwakhalapo ndi izi kapena mukukhala ndi zinthu zotsatirazi mukatenga quinidine, quinine, kapena mefloquine: muchepetse kuchuluka kwa maselo amwazi m'mafupa anu, lupus (momwe thupi limagwirira matupi ake omwe amawononga komanso kutupa ), kapena hepatitis (kutupa kwa chiwindi). Komanso muuzeni dokotala ngati mwakhalapo ndi vuto linalake kapena mtima wosalimba. Dokotala wanu mwina angakuuzeni kuti musatengextromethorphan ndi quinidine.
  • Uzani dokotala wanu ngati mwakhalapo ndi myasthenia gravis (matenda amanjenje omwe amachititsa kufooka kwa minofu), mbiri yogwiritsa ntchito mankhwala osokoneza bongo kapena kugwiritsa ntchito mankhwala osokoneza bongo, kuthamanga kwa magazi, sitiroko, potaziyamu kapena magnesium magazi anu, kapena mtima, impso, kapena matenda a chiwindi.
  • uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga kuphatikiza kwa dextromethorphan ndi quinidine, itanani dokotala wanu.
  • ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa dextromethorphan ndi quinidine.
  • muyenera kudziwa kuti dextromethorphan ndi quinidine zimatha kukupangitsani kukhala ozunguzika. Ndikofunika kusamala kuti mupewe kugwa mukamamwa mankhwalawa.
  • Funsani dokotala wanu za zakumwa zoledzeretsa pamene mukumwa dextromethorphan ndi quinidine. Mowa ungapangitse mavuto obwera chifukwa cha mankhwalawa kukulirakulira.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.


Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Pitani muyezo womwe mwaphonya ndikumwa mlingo wotsatira nthawi yanthawi zonse. Musatenge mlingo wawiri kuti mupange omwe mwaphonya. Onetsetsani kuti mulola maola 12 pakati pa mlingo.

Kuphatikiza kwa dextromethorphan ndi quinidine kumatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • kutsegula m'mimba
  • kusanza
  • mpweya
  • kupweteka m'mimba
  • chifuwa
  • maso ouma kapena pakamwa
  • kufooka
  • kutuluka kwa minofu
  • kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
  • kukodza pafupipafupi, kupweteka, kapena kuvuta
  • mitambo kapena mkodzo wonunkha kwambiri

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

  • malungo
  • kutuluka mwachilendo kapena kuphwanya
  • kupweteka kwa minofu kapena molumikizana
  • zidzolo
  • kutupa kwa nkhope, mmero, lilime, kapena milomo
  • zotupa zam'mimba zotupa
  • ukali
  • kuvuta kupuma
  • wamisala
  • kukomoka
  • kuthamanga kwa mtima

Kuphatikiza kwa dextromethorphan ndi quinidine kumatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.


Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, ndipo ana ndi ziweto sangathe kuzipeza. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

  • nseru
  • kusanza
  • kutsegula m'mimba
  • chizungulire
  • mutu
  • kulira m'makutu
  • kusawona bwino kapena masomphenya awiri
  • chisokonezo
  • kusintha kwa kugunda kwa mtima
  • kuvuta kupuma
  • kutaya chidziwitso
  • kugwidwa
  • kusintha kwa kusintha kwa minofu
  • kutayika kwa mgwirizano
  • chisangalalo chachilendo
  • kuganiza kopanda tanthauzo

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu akhoza kuyitanitsa mayeso ena a labu kuti aone momwe thupi lanu likuyankhira ku dextromethorphan ndi quinidine. Dokotala wanu amathanso kuyitanitsa electrocardiogram (ECG; kuyesa komwe kumayesa magetsi mumtima) musanachitike komanso mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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