Vandetanib

Zamkati

• Musanatenge vandetanib,
• Vandetanib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Vandetanib itha kuyambitsa kutalikitsa kwa QT (mtima wosasintha wamtima womwe ungayambitse kukomoka, kutaya chidziwitso, kugwidwa, kapena kufa mwadzidzidzi). Uzani dokotala wanu ngati inu kapena wina aliyense m'banja mwanu adakhalapo kapena adakhalapo ndi matenda a QT (matenda obadwa nawo momwe munthu amakhala ndi kutalikirana kwa QT) kapena mwakhalapo ndi calcium, potaziyamu kapena magnesium ochepa magazi anu, kugunda kwamtima kosasinthasintha, kulephera kwa mtima, kapena matenda amtima. Uzani dokotala ndi wazamankhwala ngati mukumwa chloroquine (Aralen); clarithromycin (Biaxin, mu Prevpac); haloperidol (Haldol); mankhwala a kugunda kwamtima kosafanana monga amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, ndi sotalol (Betapace); mankhwala ena amiseru monga dolasetron (Anzemet) ndi granisetron (Sancuso); methadone (Dolophine, Methadose); moxifloxacin (Avelox); ndi pimozide (Orap). Ngati mukukumana ndi izi, siyani kumwa vandetanib ndikumuimbira foni nthawi yomweyo kapena kupeza chithandizo chamankhwala mwadzidzidzi: kusala pang'ono, kugunda, kapena kugunda kwamtima mosasinthasintha; kukomoka; mutu wopepuka; kapena kutaya chidziwitso. Vandetanib imatha kukhala mthupi lanu kwa miyezi ingapo mutasiya kumwa mankhwala, kuti mupitilizebe kukhala pachiwopsezo cha zovuta nthawi imeneyo.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena, monga kuyesa magazi ndi ma electrocardiograms (EKGs, mayeso omwe amalemba zamagetsi mumtima) musanachitike komanso pafupipafupi mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti mutenge vandetanib. Dokotala wanu amathanso kuyitanitsa mayesowa nthawi iliyonse yomwe mlingo wanu wa vandetanib wasinthidwa kapena mukayamba kumwa mankhwala atsopano.

Pulogalamu yotchedwa Caprelsa Risk Evaluation and Mitigation Strategy (REMS) yakhazikitsidwa kuti ithetse ngozi za mankhwalawa. Mutha kulandira vandetanib ngati dotolo amene akupatseni mankhwala anu adalembetsa nawo pulogalamuyi. Mutha kulandila mankhwalawo kuchokera ku pharmacy yomwe imatenga nawo gawo pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza kutenga nawo mbali pulogalamuyi kapena momwe mungapezere mankhwala anu.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira chithandizo ndi vandetanib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm)kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kotenga vandetanib.

Vandetanib amagwiritsidwa ntchito pochiza mtundu wina wa khansa ya chithokomiro yomwe singathe kuchiritsidwa ndi opaleshoni kapena yomwe yafalikira mbali zina za thupi. Vandetanib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Vandetanib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kamodzi patsiku. Tengani vandetanib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani vandetanib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Pewani mapiritsi athunthu ndi kapu yamadzi. Osagawanika, kutafuna, kapena kuwaphwanya. Ngati piritsi laphwanyidwa mwangozi, pewani kukhudzana ndi khungu lanu. Ngati pali kukhudzana kulikonse, sambani malo okhudzidwa bwino ndi madzi.

Ngati mukulephera kumeza mapiritsi athunthu, mutha kuwasungunula m'madzi. Ikani piritsi mugalasi lomwe mumakhala ma ouniga awiri amadzi akumwa opanda madzi. Musagwiritse ntchito madzi ena aliwonse kuti asungunule piritsi. Muziganiza osakaniza kwa mphindi 10 mpaka piritsi litakhala tizidutswa tating'ono kwambiri; phale silidzasungunuka kwathunthu. Imwani chisakanizo nthawi yomweyo. Muzimutsuka galasi ndi ma ouniki ena 4 a madzi osakhala ndi kaboni ndikumwa madzi otsuka kuti mutsimikizire kuti mumeza mankhwala onse.

Dokotala wanu akhoza kuchepetsa mlingo wa vandetanib kapena kukuuzani kuti musiye kumwa vandetanib kwakanthawi mukamamwa mankhwala. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kutenga vandetanib ngakhale mukumva bwino. Osasiya kumwa vandetanib osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge vandetanib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la vandetanib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a vandetanib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgawo la CHENJEZO CHENJEZO ndi zina mwa izi: carbamazepine (Tegretol, Carbatrol, Equetro), dexamethasone, phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, , rifapentin (Priftin), ndi mahomoni a chithokomiro monga levothyroxine (Synthroid). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi vandetanib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala omwe mumamwa, makamaka St. Johns Wort.
• auzeni adotolo ngati mwakhosomola kumene magazi kapena muli ndi vuto lina lililonse lakutuluka magazi ndipo ngati mwakhalapo ndi kuthamanga kwa magazi, matenda amtundu uliwonse, khunyu, kapena mapapo, impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga pakati mukamamwa vandetanib komanso kwa miyezi 4 mutalandira chithandizo. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukatenga vandetanib, itanani dokotala wanu mwachangu. Vandetanib atha kuvulaza mwana wosabadwayo.
• uzani dokotala wanu ngati mukuyamwitsa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani adotolo kapena dokotala kuti mukumwa vandetanib.
• Muyenera kudziwa kuti vandetanib imatha kukupangitsani kuti mukhale osinza, ofooka, kapena kuti muwoneke bwino. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.
• konzekerani kupeŵa kuwunika kwa dzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zoteteza, magalasi a dzuwa, ndi zoteteza ku dzuwa. Vandetanib imapangitsa khungu lanu kukhala lowala ndi dzuwa mukamalandira chithandizo komanso kwa miyezi 4 mutasiya mankhwala anu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mulingo wanu wotsatira ukukwana maola 12 kapena kupitilira apo, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mlingo wotsatira udzatengeke pasanathe maola 12, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Vandetanib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kutentha pa chifuwa
• kusowa chilakolako
• kuonda
• kupweteka m'mimba
• mphuno
• kutopa kwambiri
• kufooka
• kuvuta kugona kapena kugona
• kukhumudwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutsegula m'mimba
• zidzolo kapena ziphuphu
• khungu louma, losenda, kapena loyabwa
• matuza kapena zilonda pakhungu kapena pakamwa
• kufiira kwa nkhope, manja, kapena mapazi
• minofu kapena molumikizana mafupa
• malungo
• kupweteka pachifuwa (komwe kumatha kuwonjezeka ndikupuma kwambiri kapena kutsokomola)
• hiccups kapena kupuma mwachangu
• kupuma movutikira
• chifuwa chosatha
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• kunenepa mwadzidzidzi
• dzanzi kapena kufooka kwa nkhope, mkono, kapena mwendo, makamaka mbali imodzi ya thupi
• chisokonezo mwadzidzidzi
• kuvuta kuyankhula kapena kumvetsetsa
• vuto ladzidzidzi kuwona m'maso amodzi kapena onse awiri
• kuyenda mwadzidzidzi kapena kusinthasintha
• mutu wopweteka mwadzidzidzi
• kugwidwa
• kuvulaza kapena kutuluka mwachilendo

Vandetanib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti awone kuyankha kwa thupi lanu ku vandetanib. Dokotala wanu amayang'ananso kuthamanga kwa magazi kwanu nthawi zonse mukamachiza vandetanib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Mzinda wa Caprelsa^®