Mlembi: William Ramirez
Tsiku La Chilengedwe: 20 Sepitembala 2021
Sinthani Tsiku: 13 Novembala 2024
Anonim
Selective Estrogen Receptor Modulators (SERMs) – Gynecology | Lecturio
Kanema: Selective Estrogen Receptor Modulators (SERMs) – Gynecology | Lecturio

Zamkati

Kutenga estrogen kumawonjezera chiopsezo kuti mudzadwala khansa ya endometrial (khansa ya m'chiberekero [chiberekero] panthawi yachipatala kapena mpaka zaka 15 mutalandira chithandizo, ngati simunalandire hysterectomy (opareshoni yochotsa chiberekero [m'mimba ]). Mukamadya estrogen, pamakhala chiopsezo chachikulu chotenga khansa ya endometrial. Kutenga bazedoxifene pamodzi ndi estrogen kungachepetse chiopsezo choti mungakhale ndi khansa ya endometrial. Musatenge mankhwala ena aliwonse omwe ali ndi estrogen mukamalandira chithandizo chifukwa izi zitha kuwonjezera chiopsezo chokhala ndi khansa ya endometrial. Musanayambe kumwa estrogen, uzani adotolo ngati mwadwalapo khansa kapena muli ndi magazi achilendo. Dokotala wanu angakuuzeni kuti musatenge estrogen ndi bazedoxifene ngati muli ndi magazi osadziwika bwino. Dokotala wanu adzakuyang'anirani mosamala chifukwa cha chiwopsezo choti mungakhale ndi khansa ya endometrial nthawi kapena mutalandira chithandizo. Itanani dokotala wanu nthawi yomweyo ngati muli ndi magazi achilendo kapena osazolowereka mukamalandira chithandizo ndi estrogen.


Amayi omwe amatenga estrogen akhoza kukhala pachiwopsezo chachikulu chotenga kapena kupha kapena kukhala ndi magazi m'mapapu kapena m'miyendo, khansa ya m'mawere, ndi matenda amisala (kutaya kuganiza, kuphunzira, ndi kumvetsetsa) kuposa azimayi omwe satenga estrogen. Uzani dokotala wanu ngati inu kapena wina aliyense m'banja mwanu adakhalapo ndi magazi kapena khansa ya m'mawere, ngati mwadwala matenda a mtima kapena sitiroko, kapena ngati muli ndi vuto lililonse lomwe lingapangitse kuti mukhale ndi magazi. Dokotala wanu angakuuzeni kuti musatenge estrogen ndi bazedoxifene. Komanso muuzeni dokotala ngati mumasuta kapena mumasuta fodya, ndipo ngati mwakhalapo ndi kuthamanga kwa magazi, kuchuluka kwama cholesterol kapena mafuta, matenda ashuga, matenda amtima, lupus (vuto lomwe thupi limakumana ndi ziwalo zake zomwe zimawononga ndi kutupa), ziphuphu za m'mawere, kapena mammogram yachilendo (x-ray ya m'mawere omwe amapeza khansa ya m'mawere).

Zizindikiro zotsatirazi zitha kukhala zizindikilo za zovuta zomwe zalembedwa pamwambapa. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi zizindikiro izi mukamamwa estrogen ndi bazedoxifene: mwadzidzidzi, mutu wopweteka kwambiri; mwadzidzidzi, kusanza kwambiri; mavuto a kulankhula; chizungulire kapena kukomoka; kutaya mwadzidzidzi kwathunthu kapena pang'ono masomphenya; masomphenya awiri; kufooka kapena kufooka kwa mkono kapena mwendo; kuphwanya kupweteka pachifuwa kapena kulemera pachifuwa; kutsokomola magazi; kupuma mwadzidzidzi; kuvuta kuganiza bwino, kukumbukira, kapena kuphunzira zinthu zatsopano; ziphuphu za m'mawere kapena kusintha kwa mawere ena; kumaliseche ku nsonga zamabele; kapena kupweteka, kukoma, kapena kufiira mwendo umodzi.


Muyenera kuyesa mabere anu mwezi uliwonse ndikukhala ndi mammogram ndi kuyesa mawere kochitidwa ndi dokotala chaka chilichonse kuti muthandize kuzindikira khansa ya m'mawere mwachangu. Dokotala wanu angakuuzeni momwe mungayang'anire mawere anu moyenera komanso ngati mukuyenera kuyesedwa kangapo kamodzi pachaka chifukwa cha mbiri yanu yazachipatala kapena yabanja.

Uzani dokotala wanu ngati mukuchitidwa opaleshoni kapena mugona pa bedi. Dokotala wanu angakuuzeni kuti musiye kumwa estrogen ndi bazedoxifene milungu 4 mpaka 6 asanachite opareshoni kapena kupumula kwa bedi kuti muchepetse chiopsezo chokhala ndi magazi. Ngati mukuyenda, onetsetsani kuti mudzuke ndikuyenda nthawi ndi nthawi chifukwa kukhala chete kwa nthawi yayitali kungapangitse kuti mukhale ndi magazi.

Mutha kuchitapo kanthu kuti muchepetse chiopsezo choti mungakhale ndi vuto lalikulu laumoyo mukamamwa estrogen. Estrogen ndi bazedoxifene sayenera kugwiritsidwa ntchito popewa matenda amtima, matenda amtima, stroko, kapena dementia. Kutenga mlingo wotsika kwambiri wa estrogen womwe umawongolera zizindikiritso zanu ndikungotenga estrogen bola ngati pakufunika kungathandize kuchepetsa ngozizi. Lankhulani ndi dokotala wanu nthawi ndi nthawi kuti musankhe ngati mungamwe mankhwala ochepa a estrogen kapena muyenera kusiya kumwa mankhwalawo.


Lankhulani ndi dokotala wanu pafupipafupi za kuopsa kotenga estrogen ndi bazedoxifene.

Mapiritsi a Estrogen ndi bazedoxifene amagwiritsidwa ntchito kuthana ndi kutentha (kutentha kwadzidzidzi, makamaka kumaso, khosi, ndi chifuwa) mwa amayi omwe akukumana ndi msambo (gawo la moyo nthawi yakusamba sicheperachepera ndipo amasiya ndipo azimayi amatha kukhala ndi zizindikilo zina ndi kusintha kwa thupi). Mapiritsi a Estrogen ndi bazedoxifene amagwiritsidwanso ntchito popewera kufooka kwa mafupa (momwe mafupa amafewera ndi kufowoka ndikuphwanya mosavuta) mwa azimayi omwe apita kumapeto. Estrogen ali mgulu la mankhwala otchedwa mahormone ndipo bazedoxifene ali mgulu la mankhwala otchedwa estrogen agonist-antagonists. Estrogen imagwira ntchito m'malo mwa estrogen yomwe nthawi zambiri imapangidwa ndi thupi. Bazedoxifene imagwiritsidwa ntchito kutsekereza zochita za estrogen pazovala za chiberekero, zomwe zimachepetsa chiopsezo chokulirapo chomwe chingayambitse khansa.

Kuphatikizana kwa Estrogen ndi bazedoxifene kumabwera ngati piritsi kuti mutenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kamodzi patsiku. Tengani estrogen ndi bazedoxifene mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani estrogen ndi bazedoxifene ndendende monga mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza piritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Estrogen ndi bazedoxifene zingathandize kuchepetsa zizindikilo zanu pokhapokha mutapitiliza kumwa mankhwalawo. Osasiya kumwa estrogen ndi bazedoxifene osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge estrogen ndi bazedoxifene,

  • uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la estrogen (m'mankhwala ambiri obwezeretsa mahomoni ndi mankhwala oletsa kubereka), bazedoxifene, mankhwala ena aliwonse, kapena chilichonse chosakaniza m'mapiritsi a estrogen ndi bazedoxifene. Funsani wamankhwala wanu kapena onani zambiri za wopanga kuti adziwe mndandanda wa zosakaniza.
  • Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, ndi zowonjezera zakudya, zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo mankhwala omwe atchulidwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: maantibayotiki ena kuphatikiza clarithromycin (Biaxin) ndi erythromycin (E.E.S, E-Mycin); mankhwala ena oletsa mafungal kuphatikiza itraconazole (Sporanox) ndi ketoconazole (Nizoral); ndi mankhwala ena okomoka kuphatikiza carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, ndi phenytoin (Dilantin); mankhwala a chithokomiro m'malo mwake; rifampin (Rifadin, Rimactane, ku Rifamate), ndi ritonavir (Norvir, ku Kaletra). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
  • uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St John's wort.
  • uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda a chiwindi. Dokotala wanu angakuuzeni kuti musatenge estrogen ndi bazedoxifene.
  • uzani dokotala wanu ngati muli ndi zaka zopitilira 75 ndipo ngati mudakhalapo ndi jaundice (matenda omwe amachititsa khungu kapena maso kukhala achikaso) mukakhala ndi pakati kapena mukamamwa mankhwala a estrogen. Komanso muuzeni dokotala ngati mwakhalapo ndi mphumu, matenda ashuga, khunyu, mutu waching'alang'ala porphyria (momwe zinthu zosazolowereka zimakhalira m'magazi zimayambitsa mavuto ndi khungu kapena dongosolo lamanjenje), cholowa cholowa angioedema (mkhalidwe wobadwa nawo womwe umayambitsa magawo Kutupa m'manja, kumapazi, kumaso, panjira, kapena m'matumbo), hypoparathyroidism (momwe thupi silimatulutsa timadzi tomwe timayambitsa matendawa), kapena matenda a impso.
  • uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga estrogen ndi bazedoxifene, itanani dokotala wanu mwachangu. Estrogen ndi bazedoxifene zitha kuvulaza mwana wosabadwayo.
  • ngati mukumwa estrogen kuti mupewe kufooka kwa mafupa, lankhulani ndi dokotala wanu za njira zina zopewera matendawa monga kuchita masewera olimbitsa thupi komanso kumwa vitamini D ndi / kapena calcium zowonjezera.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Estrogen ndi bazedoxifene zingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • nseru
  • kutentha pa chifuwa
  • kupweteka m'mimba
  • kutsegula m'mimba
  • kulimba kwa minofu
  • kupweteka kwa khosi
  • chikhure
  • chizungulire

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

  • maso otupa
  • kutupa kwa maso, nkhope, pakamwa, lilime, kapena pakhosi
  • ukali
  • kuvuta kupuma kapena kumeza

Kutenga estrogen ndi bazedoxifene kungapangitse chiopsezo kuti muthe kudwala khansa ya thumba losunga mazira kapena ndulu matenda ayenera kuchitidwa opaleshoni. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Estrogen ndi bazedoxifene zingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwalawa mu thumba lojambulalo ndi chithuza paketi yomwe idalowamo, yotsekedwa mwamphamvu, komanso yosafikirika ndi ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Ngati mulandira thumba la zojambulapo zingapo, musatsegule thumba lachiwirilo mpaka mutagwiritsa ntchito mankhwala onse m'thumba loyamba. Lembani tsiku lomwe mungatsegule thumba lojambulapo ndikutaya mankhwala aliwonse osagwiritsidwa ntchito mthumba patatha masiku 60 mutatsegula. Musachotse mapiritsi kuchokera mu chithuza mpaka mutakonzeka. Osasunga mapiritsi mu bokosi lamapiritsi kapena lokonzekera mapiritsi.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

  • nseru
  • kusanza
  • chikondi cha m'mawere
  • chizungulire
  • kupweteka m'mimba
  • kutopa
  • magazi ukazi

Sungani maimidwe onse ndi dokotala wanu.

Musanayezetsedwe kwa labotale, auzeni dokotala ndi ogwira nawo ntchito kuti mukumwa estrogen ndi bazedoxifene.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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