Simeprevir

Zamkati

• Musanatenge simeprevir,
• Simeprevir itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgawo LOFUNIKA CHENJEZO ndi CHENJEZO, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Simeprevir sikupezeka ku United States. Ngati mukumwa simeprevir, muyenera kuyimbira dokotala kuti akambirane zosinthira kuchipatala china.

Mutha kukhala ndi kachilombo ka hepatitis B (kachilombo kamene kamagwira chiwindi ndipo kakhoza kuwononga chiwindi kwambiri) koma osakhala ndi zisonyezo za matendawa. Poterepa, kumwa simeprevir kumatha kuwonjezera chiopsezo kuti matenda anu akhoza kukhala owopsa kapena owopseza moyo ndipo mudzakhala ndi zizindikilo. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi kachilombo ka hepatitis B. Dokotala wanu amalamula kuti ayesedwe magazi kuti awone ngati mwadwalapo matenda a hepatitis B. Dokotala wanu adzakuyang'anirani ngati muli ndi matenda a chiwindi cha B mkati ndi miyezi ingapo mutalandira chithandizo. Ngati ndi kotheka, dokotala wanu akhoza kukupatsani mankhwala ochizira matendawa musanachitike komanso mukamalandira chithandizo cha simeprevir. Ngati mukumane ndi zizindikiro izi mukamalandira chithandizo kapena mutalandira chithandizo, itanani dokotala wanu mwachangu: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako, kunyoza kapena kusanza, mipando yotuwa, kupweteka m'mimba, kapena mkodzo wakuda.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena musanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira simeprevir.

Lankhulani ndi dokotala wanu za chiopsezo chotenga simeprevir.

Simeprevir imagwiritsidwa ntchito limodzi ndi ribavirin (Copegus, Rebetol) ndi peginterferon alfa (Pegasys) kuchiza matenda a chiwindi a C (matenda opatsirana omwe amawononga chiwindi). Simeprevir ali mgulu la mankhwala otchedwa protease inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka hepatitis C (HCV) mthupi. Simeprevir mwina singaletse kufalikira kwa matenda a chiwindi a C kwa anthu ena.

Simeprevir imabwera ngati kapisozi woti umutenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya kamodzi patsiku. Tengani simeprevir mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani simeprevir ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Mutha kutenga simeprevir ndi peginterferon alfa ndi ribavirin kwa milungu 12. Kenako mudzasiya kumwa simeprevir ndipo mudzatenga peginterferon ndi ribavirin kwa masabata ena 12 kapena 36. Kutalika kwa chithandizo chanu kumadalira ngati mudalandira chithandizo choyambirira cha matenda a chiwindi a C, momwe mudayankhira kuchipatala, momwe mumayankhira mankhwalawo, komanso ngati mukukumana ndi zovuta zina. Pitirizani kumwa simeprevir, peginterferon alfa, ndi ribavirin malinga ngati akupatsani dokotala. Osasiya kumwa mankhwalawa osalankhula ndi dokotala ngakhale mukumva bwino.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge simeprevir,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi simeprevir, mankhwala a sulfa, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a simeprevir. Funsani wamankhwala wanu kapena onani zomwe wodwala akupanga kuti muwone mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: mankhwala ena oletsa mafungal monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), kapena voriconazole (Vfend); calcium blockers monga amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), kapena verapamil (Calan, Verelan, ena); mankhwala ena a cholesterol wambiri monga atorvastatin (Lipitor, ku Caduet), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), kapena simvastatin (Flolipid, Zocor, ku Vytorin); cisapride (Propulsid) (sikupezeka ku U.S.); clarithromycin (Biaxin, mu Prevpac); mankhwala okhala ndi cobicistat (Stribild); erythromycin (EES, Eryc, Ery-tab, ena), mankhwala ena a HIV monga atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), kapena tipranavir (Aptivus); mankhwala ena osagunda pamtima monga amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide (Tambocor), mexiletine, propafenone (Rythmol SR), kapena quinidine (ku Nuedexta); cyclosporine (Gengraf, Neoral, Sandimmune); dexamethasone; digoxin (Lanoxin); ledipasvir (Harvoni); midazolam yotengedwa pakamwa; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); rifapentine (Priftin); mankhwala ena ogwidwa monga carbamazepine (Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, kapena phenytoin (Dilantin, Phenytek); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); mankhwala (Rapamune); tacrolimus (Prograf); tadalafil (mtundu wa Adcirca wokha womwe umagwiritsidwa ntchito matenda am'mapapo); telithromycin (Ketek); triazolam (Halcion) yotengedwa pakamwa; vardenafil (Levitra, Staxyn), kapena warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi simeprevir, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka nthula yamkaka kapena wort ya St. Simuyenera kutenga nthula yamkaka kapena St. John's wort mukamalandira simeprevir.
• uzani adotolo ngati mwadulidwa chiwindi, ngati mukulandira phototherapy, ngati ndinu ochokera ku East Asia, komanso ngati mwakhalapo ndi matenda amtundu wa chiwindi kupatula hepatitis C.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mutha kutenga pakati. Ngati ndinu wamwamuna, auzeni dokotala ngati mnzanu ali ndi pakati, akukonzekera kutenga pakati, kapena atha kutenga pakati. Simeprevir iyenera kutengedwa ndi ribavirin yomwe imatha kuvulaza mwanayo. Muyenera kugwiritsa ntchito njira ziwiri zakulera kuti mupewe kutenga pakati panu kapena mnzanu mukamamwa mankhwalawa komanso kwa miyezi 6 mutalandira chithandizo. Lankhulani ndi dokotala wanu za njira zomwe muyenera kugwiritsa ntchito; Njira zolerera za mahomoni (mapiritsi oletsa kubereka, zigamba, ma implants, mphete, kapena jakisoni) sizingagwire bwino ntchito kwa amayi omwe akumwa mankhwalawa. Inu kapena mnzanu muyenera kuyesedwa ngati muli ndi pakati musanalandire chithandizo, mwezi uliwonse mukamalandira chithandizo, komanso kwa miyezi 6 mutalandira chithandizo. Ngati inu kapena mnzanu mumakhala ndi pakati mukamamwa mankhwalawa, itanani dokotala wanu mwachangu.
• Uzani dokotala wanu ngati mukuyamwitsa.
• konzani kupewa kupezeka kwa kuwala kwadzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zoteteza, magalasi ofunikira, chipewa, ndi zotchingira dzuwa mukamachiza simeprevir. Komanso pewani kugwiritsa ntchito kama, makina owala dzuwa, kapena mitundu ina ya mankhwala opepuka mukamalandira chithandizo. Simeprevir imatha kupangitsa khungu lanu kuzindikira kuwala kwa dzuwa. Itanani dokotala wanu nthawi yomweyo ngati mukupsa ndi dzuwa kapena kutentha, kufiira, kutupa, zotupa pakhungu lanu, kapena maso ofiira kapena otupa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo wosowa ndi chakudya mukangokumbukira. Komabe, ngati pasanathe maola 12 isanakwane nthawi yanu yotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Simeprevir itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuyabwa
• nseru
• kupweteka kwa minofu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgawo LOFUNIKA CHENJEZO ndi CHENJEZO, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kuvuta kupuma
• zidzolo
• zilonda mkamwa kapena zilonda
• maso ofiira kapena otupa ("diso la pinki")

Simeprevir itha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Olysio^®