Jekeseni wa Nivolumab

Zamkati

• Asanalandire jakisoni wa nivolumab,

Jekeseni ya Nivolumab imagwiritsidwa ntchito:

• payekha kapena kuphatikiza ipilimumab (Yervoy) kuchiza mitundu ina ya khansa ya khansa (mtundu wa khansa yapakhungu) yomwe yafalikira mbali zina za thupi kapena sangathe kuchotsedwa ndi opaleshoni,
• kuchiza ndi kupewa kubwereranso kwa mtundu winawake wa khansa ya khansa mutatha kuchitidwa opaleshoni kuti muwuchotse ndi matenda am'mimba ndi ma lymph node,
• kuphatikiza ndi ipilimumab (Yervoy) kuchiza mtundu wina wa khansa yamapapo (non-small cell cell cancer; NSCLC) yomwe yafalikira mbali zina za thupi,
• kuphatikiza ndi ipilimumab (Yervoy) ndi platinamu chemotherapy yochizira mtundu wina wa NSCLC womwe wabwerera kapena wafalikira mbali zina za thupi,
• ndekha yochizira mtundu wina wa NSCLC womwe wafalikira mbali zina za thupi ndipo wawonjezeka kwambiri panthawi kapena pambuyo pothandizidwa ndi mankhwala a platinamu chemotherapy,
• kuchiza mtundu wina wa khansa yamapapo (khansa yaying'ono yamapapo yam'mapapo, SCLC) yomwe yafalikira mbali zina za thupi zomwe zidakulirakulira atalandira chithandizo pambuyo pa platinum chemotherapy komanso mankhwala ena amodzi a chemotherapy,
• kuchiza matenda a renal cell carcinoma (RCC, mtundu wa khansa womwe umayambira m'maselo a impso) omwe adakulirakulira atalandira chithandizo ndi mankhwala ena a chemotherapy,
• kuphatikiza ndi ipilimumab (Yervoy) kuchiza ma RCC apamwamba mwa anthu omwe sanalandire mankhwala ena a chemotherapy,
• kuchiza Hodgkin's lymphoma (matenda a Hodgkin) mwa achikulire omwe adakulirakulira kapena osayankha pakulowetsa ma cell a autologous (njira yomwe ma cell amwazi amachotsedwa mthupi ndikubwerera m'thupi pambuyo pa chemotherapy ndi / kapena radiation radiation) ndi brentuximab vedotin (Adcetris) chithandizo kapena mitundu itatu yazithandizo kuphatikiza kuphatikizira ma cell a stem,
• kuchiza mtundu wina wa khansa yamutu ndi khosi yomwe imabwereranso kapena yomwe yafalikira mbali zina za thupi kapena kukulirakulira mukamalandira chithandizo kapena mankhwala ena a chemotherapy,
• kuchiza khansa ya m'mitsempha (khansara ya chikhodzodzo ndi ziwalo zina za mkodzo) yomwe yafalikira mbali zina za thupi ndipo yawonjezeka kwambiri mukamalandira mankhwala ena kapena chemotherapy
• ndekha kapena kuphatikiza ipilimumab kuchiza mtundu wina wa khansa yoyipa (khansa yomwe imayamba m'matumbo akulu) mwa akulu ndi ana azaka 12 kapena kupitilira zomwe zafalikira mbali zina za thupi ndipo zawonjezeka atalandira chithandizo ndi chemotherapy ina mankhwala,
• ndekha kapena kuphatikiza ipilimumab kuchiza hepatocellular carcinoma (HCC; mtundu wa khansa ya chiwindi) mwa anthu omwe kale amathandizidwa ndi sorafenib (Nexafar),
• kuchiza khansa yam'magazi yam'mimba (khansa ya chubu yolumikiza kukhosi kwanu ndi m'mimba mwanu) yomwe yafalikira mbali zina za thupi, yawonjezeka atalandira chithandizo ndi mankhwala ena a chemotherapy, kapena sangachiritsidwe ndi opaleshoni,
• komanso kuphatikiza ipilimumab kuchiza malignant pleural mesothelioma (mtundu wa khansa womwe umakhudza mkati mwa mapapo ndi chifuwa) mwa akulu omwe sangachotsedwe ndi opaleshoni.

Nivolumab ali mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito pothandiza chitetezo cha mthupi chanu kuti muchepetse kapena kuletsa kukula kwa maselo a khansa.

Nivolumab imabwera ngati madzi olowetsedwa mumtsinje kwa mphindi 30 ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Nivolumab ikaperekedwa yokha kuti ichiritse khansa ya khansa yapakhungu (NSCLC), Hodgkin lymphoma, khansa ya mutu ndi khosi, khansa ya urothelial, RCC yayikulu, khansa yoyipa, khansa ya m'mimba, kapena hepatocellular carcinoma, imaperekedwa kamodzi milungu iwiri kapena iwiri iliyonse kutengera mulingo wanu malinga ngati dokotala akuuzani kuti mulandire chithandizo. Nivolumab ikaperekedwa yokha kuti ichiritse khansa yaying'ono yamapapo yam'mapapo (SCLC), imaperekedwa kamodzi pamasabata awiri bola dokotala atakulimbikitsani kuti mulandire chithandizo. Nivolumab ikaperekedwa kuphatikiza ipilimumab kuchiza khansa ya khansa, hepatocellular carcinoma, khansa yoyipa, kapena RCC, imaperekedwa kamodzi pamasabata atatu pamiyeso 4 yokhala ndi ipilimumab, kenako kamodzi kamodzi pamasabata awiri kapena 4 kutengera mulingo wanu wa as bola dokotala atakulangizani kuti mulandire chithandizo. Nivolumab ikaperekedwa pamodzi ndi ipilimumab kuti ichiritse NSCLC, imaperekedwa kamodzi pamasabata awiri bola dokotala atakulimbikitsani kuti mulandire chithandizo. Nivolumab ikaperekedwa pamodzi ndi ipilimumab kuti ithetse vuto loyipa la mesothelioma, nthawi zambiri limaperekedwa kamodzi pamasabata atatu bola dokotala atakulimbikitsani kuti mulandire chithandizo. Nivolumab ikaperekedwa pamodzi ndi ipilimumab ndi platinum chemotherapy kuti ichiritse NSCLC, imaperekedwa kamodzi pamasabata atatu bola dokotala atakulimbikitsani kuti mulandire chithandizo.

Nivolumab imatha kuyambitsa mavuto akulu kapena owopsa panjira yolowetsedwa. Dokotala kapena namwino adzakuyang'anirani mosamala mukamakulowetsedwako ndipo posakhalitsa kulowetsedwa kuti awonetsetse kuti simukuyankha bwino mankhwalawo. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mungakhale ndi izi:

Dokotala wanu angachedwetse kulowetsedwa kwanu, kuchedwetsa, kapena kuyimitsa chithandizo chanu ndi jakisoni wa nivolumab, kapena kukupatsirani mankhwala owonjezera kutengera kuyankha kwanu kwa mankhwala ndi zovuta zina zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa nivolumab. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa nivolumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la nivolumab, mankhwala ena aliwonse, kapena zina zilizonse zopangira jakisoni wa nivolumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mudadulidwapo. Muuzeni dokotala wanu ngati mwakhalapo ndi matenda omwe amadzichotsera okha (momwe chitetezo cha mthupi chimagwirira gawo labwino la thupi) monga matenda a Crohn's (momwe chitetezo cha mthupi chimagwirira ntchito m'mimba momwe zimapwetekera, Kutsekula m'mimba, kuchepa thupi, ndi malungo), ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda m'mbali mwa kholingo [matumbo akulu] ndi rectum), kapena lupus (momwe chitetezo cha mthupi chimagwilira ziphuphu ndi ziwalo zambiri kuphatikiza khungu, mafupa, magazi, ndi impso); mtundu uliwonse wamatenda am'mapapo kapena kupuma; kapena matenda a chithokomiro, impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyesa mayeso musanalandire nivolumab. Simuyenera kutenga pakati pomwe mukulandira jakisoni wa nivolumab. Muyenera kugwiritsa ntchito njira yolerera yothandiza kupewa mimba mukamalandira jakisoni wa nivolumab komanso kwa miyezi yosachepera 5 mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukalandira jakisoni wa nivolumab, itanani dokotala wanu mwachangu. Jekeseni wa Nivolumab itha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukalandira jakisoni wa nivolumab komanso kwa miyezi 5 mutatha kumwa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Mukaphonya nthawi kuti mulandire jakisoni wa nivolumab, itanani dokotala wanu posachedwa.

Jekeseni wa Nivolumab itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kulumikizana, msana, nsagwada, kapena kupweteka kwa mafupa
• kupweteka kwa minofu kapena kufooka
• khungu louma, losweka, lakuthwa
• kufiira, kutupa, kapena kupweteka m'manja mwanu kapena pansi pa mapazi anu
• zilonda mkamwa
• maso ouma kapena pakamwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa mgulu la HOW, uzani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• kupuma movutikira
• chifuwa chatsopano kapena chowonjezeka
• kutsokomola magazi
• kupweteka pachifuwa
• kutsegula m'mimba
• m'mimba kupweteka kapena kukoma
• chimbudzi chakuda, chodikira, chomata, kapena chokhala ndi magazi
• kutopa kapena kufooka
• kumva kuzizira
• kuzama kwa mawu kapena kukodola
• kusintha kwa kulemera (kupindula kapena kutaya)
• kusintha kwamakhalidwe kapena machitidwe (kutsika kwa kugonana, kukwiya, kapena kuyiwala)
• kuuma khosi
• kupweteka, kuwotcha, kumva kulasalasa, kapena dzanzi m'manja kapena m'mapazi
• kupweteka kwa mutu, kuphatikiza zomwe sizachilendo kapena sizidzatha
• kuyerekezera zinthu m'maganizo (kuwona zinthu kapena kumva mawu omwe kulibe)
• kugwidwa
• chisokonezo
• malungo
• kutayika tsitsi
• kuyabwa, zidzolo, ming'oma, kapena matuza pakhungu lanu
• kudzimbidwa
• nseru
• kusanza
• Kusinza
• chizungulire kapena kukomoka
• chikasu cha khungu kapena maso, mkodzo wamdima, kutuluka magazi kapena kuvulaza mosavuta kuposa zachilendo, kusowa kwa njala, kuchepa mphamvu, kapena kupweteka kumanja kwa m'mimba
• ludzu lowonjezeka
• kuchepa kapena kuwonjezera kukodza
• kutupa kwa nkhope, mikono, miyendo, mapazi kapena akakolo
• magazi mkodzo
• kusintha kwa masomphenya
• mpweya womwe umanunkhira zipatso

Jekeseni wa Nivolumab ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire jakisoni wa nivolumab. Nthawi zina, dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi nivolumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Opdivo^®