Lumacaftor ndi Ivacaftor

Zamkati

• Musanatenge lumacaftor ndi ivacaftor,
• Lumacaftor ndi ivacaftor zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo:

Lumacaftor ndi ivacaftor amagwiritsidwa ntchito pochizira mitundu ina ya cystic fibrosis (matenda obadwa nawo omwe amayambitsa mavuto kupuma, chimbudzi, ndi kubereka) mwa akulu ndi ana azaka 2 kapena kupitirira. Lumacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) okonza. Ivacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Mankhwala onsewa amagwira ntchito pokonzanso magwiridwe antchito a thupi m'thupi kuti muchepetse kuchuluka kwa ntchofu m'mapapu ndikuwongolera zina za cystic fibrosis.

Kuphatikiza kwa lumacaftor ndi ivacaftor kumabwera ngati piritsi komanso granules kuti mutenge pakamwa. Nthawi zambiri amatengedwa ndi zakudya zamafuta kawiri patsiku, kupatula maola 12. Tengani lumacaftor ndi ivacaftor mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani lumacaftor ndi ivacaftor ndendende monga mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Pofuna kukonzekera mlingo wa lumacaftor ndi ivacaftor granules, sakanizani paketi yonse ya granules mu supuni 1 (5 mL) ya chakudya chofewa kapena madzi (ozizira kapena kutentha) monga yogurt, maapulosi, pudding, mkaka, kapena madzi. Tengani chisakanizo chonse pasanathe ola limodzi posakaniza ma granules ndi chakudya kapena madzi.

Tengani lumacaftor ndi ivacaftor ndi zakudya zamafuta monga mazira, mapeyala, mtedza, batala, batala wa kirimba, pizza ya tchizi, mkaka wonse ndi zinthu zina zonse zamkaka monga tchizi ndi mafuta yogurt. Lankhulani ndi dokotala wanu za zakudya zina zamafuta zoti mudye ndi lumacaftor ndi ivacaftor.

Lumacaftor ndi ivacaftor amawongolera cystic fibrosis koma samachiritsa. Pitirizani kutenga lumacaftor ndi ivacaftor ngakhale mukumva bwino. Osasiya kumwa lumacaftor ndi ivacaftor osalankhula ndi dokotala.

Ngati simutenga lumacaftor ndi ivacaftor masiku 7 kapena kupitilira apo, musayambirenso kumwa popanda kulankhula ndi dokotala wanu. Dokotala wanu angafunike kusintha mlingo wa mankhwalawa kapena mankhwala ena omwe mukumwa.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge lumacaftor ndi ivacaftor,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi lumacaftor ndi ivacaftor, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa ndi lumacaftor ndi mapiritsi a ivacaftor kapena granules. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: ma antifungal ena monga itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), ndi voriconazole (Vfend); maantibayotiki ena monga clarithromycin (Biaxin, mu Prevpac), erythromycin (EES, Erythrocin, Eryped, ena), rifabutin (Mycobutin) ndi rifampin (Rifadin, Rifamate, Rifater, Rimactane); mankhwala ena a shuga monga chlorpropamide (Diabinese), glimepiride (Amaryl, ku Duetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, ku Glucovance), repaglinide (Prandin), tolazamide ndi tolbutamide; digoxin (Lanoxin); ibuprofen (Advil, Motrin, mu Vicoprofen); ma immunosuppressants ena monga cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) ndi tacrolimus (Astagraf, Prograf); masewera; montelukast (Singulair); methylprednisolone (Medrol); wolosera (Rayos); ma proton pump inhibitors (PPIs) monga esomeprazole (Nexium, ku Vimovo), lansoprazole (Prevacid, ku Prevpac), ndi omeprazole (Prilosec, ku Zegerid); ranitidine (Zantac); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, ndi phenytoin (Dilantin, Phenytek); ma serotonin reuptake inhibitors (SSRIs) monga citalopram (Celexa), escitalopram (Lexapro), ndi sertraline (Zoloft); katatu (Halcion); ndi warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi lumacaftor ndi ivacaftor, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. Dokotala wanu mwina angakuuzeni kuti musatenge wort ya St. John mukatenga lumacaftor ndi ivacaftor.
• auzeni adotolo ngati mwakhala mukudwalapo kupuma kapena vuto linalake, kumuika thupi, kapena chiwindi kapena matenda a impso.
• Muyenera kudziwa kuti lumacaftor ndi ivacaftor zitha kuchepetsa mphamvu yolerera yapa mahomoni (mapiritsi oletsa kubala, zigamba, mphete, jakisoni, zopangira, kapena zida za intrauterine). Lankhulani ndi dokotala wanu za njira zina zakulera zomwe zingakuthandizireni mukatenga lumacaftor ndi ivacaftor.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga lumacaftor ndi ivacaftor, itanani dokotala wanu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mukukumbukira mlingo womwe mwaphonya pasanathe maola 6 kuchokera nthawi yomwe munayenera kumwa, tengani mlingo womwe mwaphonya nthawi yomweyo. Komabe, ngati maola opitilira 6 adutsa kuchokera nthawi yomwe mumakonda kutenga lumacaftor ndi ivacaftor, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Lumacaftor ndi ivacaftor zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupuma movutikira
• kufinya pachifuwa kapena kupweteka
• mavuto opuma
• kutsegula m'mimba
• mpweya
• kutopa kwambiri
• zidzolo
• kusamba mosalekeza, kuphonya, zolemetsa kapena zopweteka, makamaka kwa amayi omwe amatenga njira zolerera za mahomoni
• kutuluka mphuno, kuyetsemula, kutsokomola, zilonda zapakhosi, kapena zizindikiro zonga chimfine
• chikhure
• yothina kapena yothamanga m'mphuno
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• nseru
• kusanza
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwam'mimba
• mkodzo wakuda
• chisokonezo
• chikasu cha khungu kapena maso

Lumacaftor ndi ivacaftor zimatha kuyambitsa matenda amiso (kutsekemera kwa mandala a diso omwe angayambitse mavuto a masomphenya) mwa ana ndi achinyamata. Ana ndi achinyamata omwe amatenga lumacaftor ndi ivacaftor ayenera kukaonana ndi dokotala wamaso asanafike komanso akamalandira chithandizo. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopatsa lumacaftor ndi ivacaftor kwa mwana wanu.

Lumacaftor ndi ivacaftor zimatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• mutu
• zidzolo

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso a labu musanayambe mankhwala anu kuti muwone ngati matenda anu atha kuchiritsidwa ndi lumacaftor ndi ivacaftor chifukwa ayenera kugwiritsidwa ntchito mwa anthu okhawo omwe ali ndi majini enaake. Dokotala wanu amalamula kuti mukayezetse maso ndi mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku lumacaftor ndi ivacaftor. Magazi anu ayenera kuyang'aniridwa pafupipafupi mukamamwa mankhwalawa.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Orkambi^®