Avelumab jekeseni

Zamkati

• Asanalandire jekeseni wa avelumab,
• Avelumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa m'gawo la HOW, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Jekeseni wa Avelumab imagwiritsidwa ntchito pochizira Merkel cell carcinoma (MCC; mtundu wa khansa yapakhungu) yomwe yafalikira mbali zina za thupi mwa akulu ndi ana azaka 12 kapena kupitirira. Jekeseni wa Avelumab imagwiritsidwanso ntchito pochiza khansa ya m'mitsempha (khansa ya chikho cha chikhodzodzo ndi mbali zina zam'mimba) yomwe yafalikira kumatenda oyandikira kapena ziwalo zina za thupi mwa anthu omwe khansa idakulirakulira mkati kapena mkati mwa miyezi 12 itatha amathandizidwa ndi mankhwala a platinamu chemotherapy. Amagwiritsidwanso ntchito ngati mankhwala opitilira khansa ya muubongo yomwe yafalikira kumatenda oyandikira kapena ziwalo zina za thupi kuti athandizire kuyankha mankhwala a platinamu. Jakisoni wa Avelumab umagwiritsidwanso ntchito limodzi ndi axitinib (Inlyta) ngati mankhwala oyamba a renal cell carcinoma (RCC; khansa yomwe imayamba mu impso) yomwe yafalikira kapena sangathe kuchotsedwa ndi opaleshoni. Jekeseni ya Avelumab ili mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito pothandiza thupi kuchepetsa kapena kuletsa kukula kwa maselo a khansa.

Jakisoni wa Avelumab umadza ngati yankho (madzi) ojambulidwa kudzera mumitsempha (mumtsempha) kwa mphindi 60 ndi dokotala kapena namwino kuchipatala kapena malo olowererapo. Nthawi zambiri amaperekedwa kamodzi pamasabata awiri. Dokotala wanu adzasankha kuti mulandire avelumab kangati kutengera momwe thupi lanu likuyankhira mankhwalawa.

Jekeseni wa Avelumab imatha kuyambitsa mavuto akulu pakulowetsedwa kwa mankhwala. Mutha kupatsidwa mankhwala ena othandizira kapena kuthandizira kupewa mayankho ku avelumab. Dokotala kapena namwino adzakuyang'anirani mosamala mukalandira mankhwala. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mukukumana ndi izi mwa kulowetsedwa: kuzizira kapena kugwedeza, ming'oma, malungo, kuthamanga, kupweteka kwa msana, kupuma movutikira, kupuma, kapena kupweteka m'mimba. Dokotala wanu angafunike kuchepetsa kulowetsedwa kwanu kapena kuchedwetsa kapena kuimitsa mankhwala anu mukakumana ndi zotsatirazi.

Dokotala wanu amathanso kuchotseratu chithandizo chanu, kapena angakupatseni mankhwala ena ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo ndi jakisoni wa avelumab.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa avelumab ndipo nthawi iliyonse yomwe mumalandira mankhwala. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa avelumab,

• uzani dokotala ndi wamankhwala ngati muli ndi vuto la avelumab, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jekeseni wa avelumab. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• Uzani dokotala wanu ngati mwakhalapo ndi matenda ashuga, matenda a Crohn (matenda omwe thupi limagwiritsa ntchito gawo la m'mimba, kumayambitsa kupweteka, kutsegula m'mimba, kuchepa thupi, ndi malungo), ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda mkatikati mwa kholingo [matumbo akulu] ndi thumbo), kumuika thupi, kapena chiwindi, mapapo, kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Gwiritsani ntchito njira yodalirika yolerera popewa kutenga mimba mukamachiza komanso kwa mwezi umodzi mutatha kumwa mankhwala avelumab. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukalandira avelumab, itanani dokotala wanu mwachangu. Avelumab ikhoza kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukalandira avelumab komanso kwa mwezi umodzi mutatha kumwa mankhwala omaliza.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yoti mulandire avelumab, itanani dokotala wanu posachedwa.

Avelumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupweteka kwa minofu, fupa, kapena molumikizana
• mutu
• kudzimbidwa
• kutsegula m'mimba
• kupweteka m'mimba
• nseru
• kusanza
• kusowa chilakolako
• kuonda
• kutopa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa m'gawo la HOW, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• chifuwa chatsopano kapena chowonjezeka; kupuma movutikira; kapena kupweteka pachifuwa
• nseru; kusanza; kupweteka kumanja kwa mimba; mkodzo wakuda (tiyi); kutopa kwambiri; kuvulala kwachilendo kapena kutuluka magazi
• kugunda kwamtima mwachangu; kudzimbidwa; kuchuluka thukuta; mawu amasintha; kusintha kwa kulemera; kumva ludzu kuposa masiku onse; chizungulire kapena kukomoka; kutayika tsitsi; nseru; kusanza; kusintha kwa malingaliro; kupweteka m'mimba; kapena kumva kuzizira
• kupweteka kumtunda chakumanja kwam'mimba; chikasu cha khungu kapena maso; nseru; kusanza, kapena kutaya mwazi mosavuta kapena kuvulala
• kutsegula m'mimba; magazi m'mipando; mdima, kudikira, ndowe zomata; kapena kupweteka kwa m'mimba kapena kufatsa
• kufooka kwa minofu
• Kusinza
• kumva chizungulire kapena kukomoka
• kutupa kwa mapazi ndi miyendo
• kupweteka pachifuwa ndi kulimba
• malungo kapena zizindikiro zina zonga chimfine
• masomphenya amasintha
• kugunda kwa mtima kumasintha
• zotupa, zotupa kapena khungu
• kuvuta kupuma kapena kumeza
• kuchepa pokodza; magazi mkodzo; kutupa m'mapazi; kapena kusowa kwa njala
• kutuluka mwachilendo kapena kuphwanya
• kukodza pafupipafupi, kupweteka, kapena mwachangu

Jekeseni wa Avelumab ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira avelumab.

Funsani wamankhwala anu mafunso aliwonse omwe muli nawo okhudza jekeseni wa avelumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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