Ribociclib

Zamkati

• Musanatenge ribociclib,
• Ribociclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

Ribociclib imagwiritsidwa ntchito limodzi ndi mankhwala ena kuti athetse mtundu wina wa hormone receptor-positive (zimadalira mahomoni monga estrogen kukula) khansa ya m'mawere yomwe yapita patsogolo kapena yomwe yafalikira mbali zina za thupi mwa amayi omwe sanakumane ndi kusintha kwa thupi (kusintha za moyo; kutha kwa msambo wamwezi uliwonse) komanso mwa iwo omwe ali pafupi kapena omwe adayamba kale kusamba. Ribociclib imagwiritsidwanso ntchito limodzi ndi fulvestrant (Faslodex) pofuna kuchiza mtundu wina wa khansa ya m'mawere yotenga mahomoni yolandila kapena yomwe yafalikira mbali zina za thupi ngati chithandizo choyambirira kapena mwa anthu omwe sanalandire chithandizo chokwanira ndi mankhwala ena mwa amayi omwe adayamba kale kusamba. Ribociclib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Ribociclib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa wopanda chakudya kamodzi tsiku lililonse m'mawa kwa masiku 21 oyambira masiku 28. Tengani ribociclib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ribociclib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya. Osamwa mapiritsi osweka kapena osweka.

Ngati musanza mutatenga ribociclib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu wa ribociclib kapena kuimitsa kwamuyaya kapena kwakanthawi. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira ribociclib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ribociclib,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ribociclib, mankhwala ena aliwonse, kapena zina zilizonse zomwe zimaphatikizidwa ndi mapiritsi a ribociclib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone); maantibayotiki ena monga clarithromycin (Biaxin, mu Prevpac), erythromycin (EES, Ery-tab, Eryped), ndi moxifloxacin (Avelox); mankhwala ena oletsa mafungal monga itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); bepridil (sakupezeka ku U.S.); boceprevir (Victrelis, sakupezeka ku U.S.); chloroquine (Aralen); conivaptan; cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (DHH 45, Migranal); disopyramide (Norpace); ergotamine (Ergomar, ku Cafergot, ku Migergot); everolimus (Wothandizira, Zortress); fentanyl (Abstral, Actiq, Fentora, Onsolis); halofantrine (Halfan; sakupezeka ku U.S.); haloperidol (Haldol); Mankhwala ena a kachirombo ka HIV (efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), lopinavir (ku Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Equetro, Teril, ena) ndi phenytoin (Dilantin, Phenytek); methadone (Dolophine, Methadose); nefazodone; ondansetron (kudzera m'mitsempha); pimozide (Orap); kupeza; quinidine (mu Nuedexta); rifampin (Rimactane, Rifadin, ku Rifamate, ku Rifater); mankhwala (Rapamune); sotalol (Betapace, Sotylize); tacrolimus (Envarsus XR, Prograf), ndi tamoxifen (Soltamox). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.Mankhwala ena ambiri amathanso kulumikizana ndi ribociclib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• uzani dokotala ngati mwadwalapo mtima posachedwa; kapena mwakhala mukugunda pang'onopang'ono; nthawi yayitali ya QT (vuto losowa la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi); kuchuluka kwa potaziyamu, calcium, phosphorous, kapena magnesium m'magazi anu; mtima kulephera; kapena chiwindi, impso, kapena matenda amtima.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kukayezetsa mimba musanayambe kumwa mankhwala. Gwiritsani ntchito njira yodalirika yolerera popewa kutenga pakati mukamalandira chithandizo komanso masabata atatu mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga ribociclib, itanani dokotala wanu mwachangu. Ribociclib itha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa ribociclib komanso kwa milungu itatu mutatha kumwa mankhwala.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kotenga ribociclib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa ribociclib.

Musadye zipatso zamphesa kapena kumwa chipatso champhesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ribociclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• kupweteka m'mimba
• mutu
• kutayika tsitsi
• kupweteka kwa msana
• kuyabwa
• zilonda mkamwa
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• zidzolo
• kuphulika kapena khungu
• kutentha kapena kuphulika kwa milomo, maso, kapena pakamwa
• kugunda kwamtima msanga, kosasinthasintha, kapena kwamphamvu
• kuvuta kupuma kapena kupuma movutikira; kutsokomola kapena wopanda ntchofu; kapena kupweteka pachifuwa
• chizungulire
• kukomoka
• chikasu cha khungu kapena maso
• mkodzo wakuda kapena wabulauni (wa tiyi)
• kutopa
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwa m'mimba
• nseru
• kusanza
• Kutuluka magazi kapena kuphwanya mosavuta kuposa zachilendo

Ribociclib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku ribociclib. Dokotala wanu amathanso kuyitanitsa electrocardiogram (ECG; kuyesa komwe kumayesa magetsi mumtima) musanachitike komanso mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Kisqali^®

• Kisqali^® Femera^® (monga chinthu chophatikiza chophatikiza Letrazole ndi Ribociclib)