Jekeseni wa Ocrelizumab

Zamkati

• Jekeseni wa Ocrelizumab imagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yosiyanasiyana ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) kuphatikizapo:
• Asanalandire jakisoni wa ocrelizumab,
• Ocrelizumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa m'gawo la HOW, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Jekeseni wa Ocrelizumab imagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yosiyanasiyana ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) kuphatikizapo:

• mitundu yoyambira-pang'onopang'ono (zizindikilo zimayamba kuchepa pakapita nthawi) za MS,
• matenda opatsirana (CIS; zizindikiro za mitsempha zomwe zimakhala pafupifupi maola 24),
• mitundu yobwezeretsanso (matenda omwe matenda amawonekera nthawi ndi nthawi), kapena
• mitundu yachiwiri yopita patsogolo (matenda omwe amabwereranso amapezeka pafupipafupi).

Ocrelizumab m'kalasi la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito poletsa maselo ena amthupi kuti asawonongeke.

Jakisoni wa Ocrelizumab amabwera ngati yankho (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino. Nthawi zambiri amaperekedwa kamodzi pamasabata awiri pamiyeso iwiri yoyambirira (sabata 0 ndi sabata 2), kenako amalowetsedwa kamodzi miyezi isanu ndi umodzi.

Jekeseni wa Ocrelizumab imatha kuyambitsa mavuto akulu pakulowetsedwa mpaka tsiku limodzi mutalandira kulowetsedwa. Mutha kupatsidwa mankhwala ena kuti muzitha kuchiza kapena kuthandizira kupewa kuchitapo kanthu pa ocrelizumab. Dokotala kapena namwino adzakuyang'anirani mosamala mukalandira kulowetsedwa komanso kwa ola limodzi pambuyo pake kuti akupatseni chithandizo pakagwa zovuta zina ndi mankhwala. Dokotala wanu akhoza kuyimitsa chithandizo chanu kwakanthawi kapena kosatha kapena kuchepetsa mlingo, ngati mukukumana ndi zovuta zina. Uzani dokotala kapena namwino wanu ngati mukukumana ndi izi kapena mkati mwa maola 24 mutalowetsedwa: kuyabwa; ming'oma; kufiira pamalo obayira; kuvuta kupuma kapena kumeza; chifuwa; kupuma; zidzolo; kumva kukomoka; kupweteka kwa mmero; kupweteka pakamwa kapena pakhosi; kupuma movutikira; kutupa kwa nkhope, maso, pakamwa, pakhosi, lilime, kapena milomo; kuthamanga; malungo; kutopa; kutopa; mutu; chizungulire; nseru; kapena kugunda kwamtima. Itanani dokotala wanu nthawi yomweyo kapena pitani kuchipatala mwadzidzidzi mukakumana ndi zina mwazizindikirozi mutachoka kuofesi yanu kapena kuchipatala.

Ocrelizumab itha kuthandizira kuthana ndi ziwalo zingapo koma sichichiza.Dokotala wanu amakuyang'anirani mosamala kuti muwone momwe ocrelizumab imagwirira ntchito kwa inu. Ndikofunika kuuza dokotala momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa ocrelizumab ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm)kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa ocrelizumab,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi ocrelizumab, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu jakisoni wa ocrelizumab. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe amaletsa chitetezo chanu chamthupi monga awa: corticosteroids kuphatikiza dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos); cyclosporine (Gengraf, Neoral, Sandimmune); daclizumab (Zinbryta); fingolimod (Gilenya); mitochantrone; natalizumab (Tysabri); tacrolimus (Astagraf, Prograf); kapena teriflunomide (Aubagio). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mudakhalapo ndi hepatitis B (HBV; kachilombo komwe kamayambitsa chiwindi ndipo kangayambitse chiwindi kapena khansa ya chiwindi). Dokotala wanu angakuuzeni kuti musalandire ocrelizumab.
• uzani dokotala wanu ngati muli ndi matenda amtundu uliwonse musanayambe mankhwala anu ndi jakisoni wa ocrelizumab.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Gwiritsani ntchito njira yolerera yothandiza panthawi yomwe mumalandira chithandizo cha ocrelizumab komanso kwa miyezi 6 mutalandira mankhwala omaliza. Mukakhala ndi pakati mukalandira ocrelizumab, itanani dokotala wanu. Ngati mulandira jekeseni wa ocrelizumab mukakhala ndi pakati, onetsetsani kuti mwalankhula ndi dokotala wa mwana wanu izi zitabadwa. Mwana wanu angafunikire kuchedwa kulandira katemera wina.
• Uzani dokotala wanu ngati mwalandira katemera waposachedwa kapena mukuyenera kulandira katemera uliwonse. Mungafunike kulandira mitundu ina ya katemera pafupifupi milungu inayi isanakwane komanso enanso milungu iwiri musanayambe mankhwala ndi jakisoni wa ocrelizumab. Musakhale ndi katemera musanalankhule ndi dokotala mukamalandira chithandizo.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi kuti mulandire ocrelizumab, itanani dokotala wanu posachedwa kuti musinthe nthawi yanu.

Ocrelizumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutupa kapena kupweteka m'manja, mikono, miyendo, kapena mapazi
• kutsegula m'mimba

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa m'gawo la HOW, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• malungo, kuzizira, kutsokomola kosalekeza, kapena zizindikilo zina za matenda
• zilonda mkamwa
• ziphuphu (ziphuphu zomwe zingachitike mwa anthu omwe adakhalapo ndi nkhuku m'mbuyomu)
• zilonda kuzungulira maliseche kapena zotuluka
• matenda akhungu
• kufooka mbali imodzi ya thupi; kuphwanya kwa manja ndi miyendo; masomphenya amasintha; kusintha kwa malingaliro, kukumbukira, ndi malingaliro; chisokonezo; kapena kusintha kwa umunthu

Ocrelizumab ikhoza kuonjezera chiopsezo cha khansa zina, kuphatikizapo khansa ya m'mawere. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Ocrelizumab ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jakisoni wa ocrelizumab.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza jekeseni wa ocrelizumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Ocrevus^®