Tisagenlecleucel jekeseni

Zamkati

• Asanalandire jekeseni wa tisagenlecleucel,
• Jekeseni wa Tisagenlecleucel ungayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Jakisoni wa Tisagenlecleucel amatha kuyambitsa matenda oopsa kapena owopsa omwe amatchedwa cytokine release syndrome (CRS). Dokotala kapena namwino adzakuyang'anirani mosamala mukamalowetsedwa komanso kwa milungu ingapo pambuyo pake. Uzani dokotala wanu ngati muli ndi vuto lotupa kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Mupatsidwa mankhwala kwa mphindi 30 mpaka 60 musanalowetsedwe kuti muthandizire kupewa zomwe mungachite tisagenlecleucel. Ngati mukumane ndi zizindikiro izi mukamakulowetsani, uzani dokotala nthawi yomweyo: malungo, kuzizira, kugwedezeka, kutsokomola, kusowa chilakolako, kutsekula m'mimba, kupweteka kwa minofu kapena mafupa, kutopa, kupuma movutikira, kupuma movutikira, chisokonezo, nseru , kusanza, chizungulire, kapena mutu wopepuka.

Jakisoni wa Tisagenlecleucel amatha kuyambitsa machitidwe amanjenje kapena owopsa. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka mutu, kusakhazikika, kusokonezeka, nkhawa, kuvutika kugona kapena kugona, kugwedezeka kosalamulirika kwa gawo lina la thupi, kutaya chidziwitso, kusokonezeka, kukhumudwa, kugwidwa, kupweteka kapena dzanzi m'manja kapena mwendo, kulephera kuchita bwino, kumvetsetsa zovuta, kapena kulephera kuyankhula.

Jekeseni wa Tisagenlecleucel umapezeka pokhapokha pulogalamu yapadera yogawa yogawa. Pulogalamu yotchedwa Kymriah REMS (Risk Evaluation and Mitigation Strategy) yakhazikitsidwa chifukwa cha kuwopsa kwa CRS ndi poizoni wamitsempha. Mutha kulandila mankhwala kuchokera kwa adotolo ndi malo azaumoyo omwe amatenga nawo mbali pulogalamuyi.Funsani dokotala wanu ngati muli ndi mafunso okhudza pulogalamuyi.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi tisagenlecleucel. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Jakisoni wa Tisagenlecleucel amagwiritsidwa ntchito pochiza khansa ina ya m'magazi (YONSE; yomwe imadziwikanso kuti khansa ya m'magazi ndi acute lymphatic leukemia; mtundu wa khansa yomwe imayamba m'maselo oyera a magazi) mwa anthu azaka 25 kapena kupitilira apo omwe abwerera kapena osamvera mankhwala ena. Amagwiritsidwanso ntchito pochiza mtundu wina wa non-Hodgkin's lymphoma (mtundu wa khansa womwe umayambira mumtundu wama cell oyera omwe nthawi zambiri amalimbana ndi matenda) mwa akulu omwe abwerera kapena osamvera atalandira chithandizo ndi mankhwala osachepera awiri. Jakisoni wa Tisagenlecleucel ali m'kalasi la mankhwala otchedwa autologous cellular immunotherapy, mtundu wa mankhwala omwe amakonzedwa pogwiritsa ntchito maselo am'magazi a wodwalayo. Zimagwira ntchito poyambitsa chitetezo cha mthupi (gulu la maselo, zotupa, ndi ziwalo zomwe zimateteza thupi kuti lisagwidwe ndi mabakiteriya, mavairasi, ma cell a khansa, ndi zinthu zina zomwe zimayambitsa matenda) kulimbana ndi ma cell a khansa.

Jekeseni wa Tisagenlecleucel umabwera ngati kuyimitsidwa (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino kuofesi ya udokotala kapena malo olowererapo. Kawirikawiri amaperekedwa kwa mphindi 60 ngati gawo limodzi. Musanalandire mlingo wanu tisagenlecleucel, dokotala kapena namwino wanu adzakupatsani mankhwala ena a chemotherapy kuti akonzekeretse thupi lanu kuti tisalelecleucel.

Pafupifupi milungu itatu kapena inayi asanalandire jekeseni wanu wa tisagenlecleucel, mayeso am'magazi anu oyera adzatengedwa kumalo osungira maselo pogwiritsa ntchito leukapheresis (njira yomwe imachotsa maselo oyera amthupi). Njirayi imatenga pafupifupi 3 mpaka 6 maola ndipo imafunika kuibwereza. Chifukwa mankhwalawa amapangidwa kuchokera m'maselo anu, ayenera kuperekedwa kwa inu nokha. Ndikofunika kukhala munthawi yake komanso kuti musaphonye nthawi yomwe mumakonzekera kusonkhanitsidwa kwama cell kapena kulandira mankhwala anu. Muyenera kukonzekera kukhala mkati mwa maola awiri kuchokera komwe mudalandira chithandizo chanu cha tisagenlecleucel kwa milungu yosachepera 4 mutamwa mankhwala. Wothandizira zaumoyo wanu adzawona ngati chithandizo chanu chikugwira ntchito ndikukuyang'anirani zotsatira zoyipa zilizonse. Lankhulani ndi dokotala wanu za momwe mungakonzekerere leukapheresis ndi zomwe muyenera kuyembekezera mukamachita izi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa tisagenlecleucel,

• uzani dokotala ndi wamankhwala kuti ngati muli ndi vuto la tisagenlecleucel, mankhwala ena aliwonse, dimethyl sulfoxide (DMSO), dextran 40, kapena china chilichonse mu jekeseni wa tisagenlecleucel. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma steroids monga dexamethasone, methylprednisolone (Medrol), prednisolone, ndi prednisone (Rayos). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala ngati mwakhalapo ndi zotulukapo zamankhwala am'mbuyomu monga kupuma kapena kugunda kwamtima mosasinthasintha. Komanso, uzani dokotala wanu ngati mwakhalapo ndi matenda am'mapapo, impso, mtima, kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kuyezetsa asanayambe kulandira chithandizo cha tisagenlecleucel. Mukakhala ndi pakati mukalandira jekeseni wa tisagenlecleucel, itanani dokotala wanu mwachangu. Jekeseni wa Tisagenlecleucel ungayambitse vuto la mwana.
• muyenera kudziwa kuti jekeseni ya tisagenlecleucel imatha kukupangitsani kugona komanso kuyambitsa chisokonezo, kufooka, chizungulire, ndi khunyu. Osayendetsa galimoto kapena kugwiritsa ntchito makina kwa masabata osachepera 8 mutadwala mlingo wa tisagenlecleucel.
• musapereke magazi, ziwalo, ziwalo, kapena maselo kuti mumupatse mukalandira jekeseni wa tisagenlecleucel.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera musanalankhule ndi dokotala kwa milungu iwiri musanayambe chemotherapy, mukamamwa tisagenlecleucel, mpaka dokotala atakuwuzani kuti chitetezo chamthupi chanu chayamba.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yosankhidwa kuti mudzatenge maselo anu, muyenera kuyimbira dokotala wanu ndi malo osonkhanitsira nthawi yomweyo. Ngati mwaphonya nthawi yakusankhidwa kuti mulandire mlingo wanu tisagenlecleucel, muyenera kuyimbira dokotala nthawi yomweyo.

Jekeseni wa Tisagenlecleucel ungayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kupweteka m'mimba
• kupweteka kwa msana

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutuluka mwachilendo kapena kuphwanya
• magazi mkodzo
• amachepetsa kukodza pafupipafupi kapena kuchuluka
• kutupa kwa maso, nkhope, milomo, lilime, mmero, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• zovuta kumeza
• zidzolo
• ming'oma
• kuyabwa

Jekeseni wa Tisagenlecleucel ungakulitse chiopsezo chanu chokhala ndi khansa. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Jekeseni wa Tisagenlecleucel ungayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani nthawi yonse yokumana ndi dokotala wanu, malo osungira maselo, ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu lingayankhire jekeseni wa tisagenlecleucel.

Musanayezetsedwe kwa labotale, auzeni adotolo ndi ogwira nawo ntchito kuti mukulandira jekeseni la 9. Mankhwalawa angakhudze zotsatira za mayeso ena a labotale.

Funsani wamankhwala wanu mafunso aliwonse omwe ali nawo okhudza tisagenlecleucel jekeseni.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Wolemba nyimbo^®