Burosumab-twza jekeseni

Zamkati

• Musanagwiritse ntchito jakisoni wa burosumab-twza,
• Jekeseni wa Burosumab-twza ingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu:

Jekeseni wa Burosumab-twza imagwiritsidwa ntchito pochizira X-yolumikizidwa ndi hypophosphatemia (XLH; matenda obadwa nawo pomwe thupi silisunga phosphorous ndipo limabweretsa mafupa ofooka) mwa akulu ndi ana azaka 6 zakubadwa kapena kupitilira apo. Amagwiritsidwanso ntchito pochiza osteomalacia yotupa yotupa (chotupa chomwe chimayambitsa kutayika kwa phosphorous m'thupi lomwe limafikitsa mafupa ofooka) omwe sangachotsedwe opaleshoni kwa akulu ndi ana azaka 2 kapena kupitirira, jekeseni wa Burosumab-twza uli mkati gulu la mankhwala otchedwa fibroblast grow factor 23 (FGF23) omwe amateteza ma antibodies. Zimagwira ntchito poletsa kuchitapo kanthu kwa zinthu zina zachilengedwe m'thupi zomwe zimayambitsa zizindikiro za XLH.

Jekeseni wa Burosumab-twza imabwera ngati yankho (madzi) kuti alandire jakisoni (pansi pa khungu) ndi dokotala kapena namwino. Pochiza hypophosphatemia yolumikizidwa ndi X, nthawi zambiri amabayidwa kamodzi milungu iwiri iliyonse kwa ana a miyezi 6 mpaka 17, komanso kamodzi pamilungu inayi kwa akulu. Pochiza osteomalacia yotupa yotupa, mwa ana azaka ziwiri mpaka 17, nthawi zambiri amabayidwa kamodzi milungu iwiri iliyonse. Pochiza osteomalacia yotupa yotupa mwa akulu, nthawi zambiri amabayidwa masabata anayi aliwonse ndipo mlingowu ukachulukitsidwa amatha kubayidwa milungu iwiri iliyonse. Dokotala wanu kapena namwino adzakupatsani mankhwala m'manja anu apamwamba, ntchafu, matako, kapena m'mimba, ndikugwiritsa ntchito jakisoni wosiyanasiyana nthawi iliyonse.

Uzani dokotala wanu ngati mukumwa mankhwala aliwonse a phosphate kapena mavitamini D ena monga calcitriol (Rocaltrol) kapena paricalcitol (Zemplar). Muyenera kusiya kumwa sabata limodzi ili musanayambe kumwa mankhwala.

Dokotala wanu akhoza kukulitsa mlingo wanu (osapitilira kamodzi pakatha milungu inayi), kapena akhoza kudumpha mlingo, kutengera zotsatira za mayeso anu a labu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito jakisoni wa burosumab-twza,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la burosumab-twza, mankhwala ena aliwonse, kapena zina zilizonse mu jakisoni wa burosumab-twza. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati muli ndi matenda a impso. Dokotala wanu angakuuzeni kuti musagwiritse ntchito jakisoni wa burosumab-twza.
• auzeni adotolo ngati mwadwala kapena simunakhalepo ndi matenda amiyendo (RLS; vuto lomwe limapangitsa kuti miyendo isavutike komanso chidwi chofuna kusuntha miyendo, makamaka usiku komanso mukakhala pansi kapena mutagona).
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukalandira jakisoni ya burosumab-twza, itanani dokotala wanu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yoti mudzalandire mlingo, pangani msonkhano wina posachedwa.

Jekeseni wa Burosumab-twza ingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kusanza
• malungo
• kupweteka m'manja, miyendo, kapena kumbuyo
• kupweteka kwa minofu
• kudzimbidwa
• chizungulire

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu:

• kufiira, zidzolo, ming'oma, kuyabwa, kutupa, kupweteka, kapena mabala pafupi kapena pomwe mankhwala adalowetsedwa
• zidzolo kapena ming'oma
• kusapeza bwino mu miyendo; chilimbikitso champhamvu chosuntha miyendo, makamaka usiku komanso pokhala kapena kugona pansi

Jekeseni wa Burosumab-twza ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu lingayankhire jekeseni wa burosumab-twza.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Crysvita^®