Ivosidenib

Zamkati

• Musanatenge ivosidenib,
• Ivosidenib ikhoza kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Ivosidenib ingayambitse matenda owopsa kapena owopsa omwe amatchedwa kusiyanitsa. Dokotala wanu amayang'anitsitsa mosamala kuti awone ngati mukukula matendawa. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: malungo, chifuwa, zidzolo, kunenepa mwadzidzidzi, kuchepa pokodza, kutupa kwa mikono kapena miyendo, chizungulire kapena mutu wopepuka, kupuma movutikira, kapena kupuma movutikira. Zizindikirozi zimatha kutha miyezi itatu mutayamba kulandira chithandizo ndi ivosidenib. Pachizindikiro choyamba kuti mukuyamba kusiyanitsa, dokotala wanu adzakupatsani mankhwala ochizira matendawa, ndipo angakuuzeni kuti musiye kumwa ivosidenib kwakanthawi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ivosidenib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi ivosidenib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kuti mupeze Chithandizo cha Mankhwala.

Ivosidenib imagwiritsidwa ntchito pochiza mtundu winawake wa myeloid leukemia (AML; mtundu wa khansa womwe umayambira m'maselo oyera a magazi) omwe abwerera kapena omwe sanasinthe atalandira chithandizo cham'mbuyomu. Ivosidenib imagwiritsidwanso ntchito pochizira mtundu wina wa AML mwa achikulire ena azaka zopitilira 75 ngati chithandizo choyamba. Ivosidenib ali mgulu la mankhwala a cad IDH1 inhibitors. Zimagwira pochepetsa kapena kuletsa kukula kwa maselo a khansa.

Ivosidenib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Chitani ayi imwani ndi chakudya chamafuta ambiri (monga zakudya zokazinga kapena chakudya chofulumira). Tengani ivosidenib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ivosidenib ndendende monga mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga ivosidenib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena amaletsa kwakanthawi mankhwala anu ndi ivosidenib kutengera yankho lanu kuchipatala kapena zovuta zina zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ivosidenib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ivosidenib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a ivosidenib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone), carbamazepine (Equetro, Tegretol, Teril, ena), clarithromycin, diltiazem (Cardizem, Cartia, Diltzac, Tiazac, ena), efavirenz (Sustiva, ku Atripla, in Symfi), erythromycin (Eryc), fluconazole (Diflucan), indinavir (Crixivan), itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, njira zakulera zam'kamwa monga zina ('mapiritsi oletsa kubereka'), zigamba, ndi mphete za amayi, nefazodone , nelfinavir (Viracept), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos), procainamide, quinidine (mu Nuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin, Rifadin. (Norvir, ku Kaletra, ku Viekira), saquinavir (Fortovase, Invirase), telithromycin (Ketek), ndi verapamil (Calan, Verelan, ku Tarka). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi ivosidenib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• auzeni adotolo ngati inu kapena aliyense m'banja mwanu mwakhalapo kapena mwakhalapo ndi nthawi yayitali ya QT (zomwe zimawonjezera chiopsezo chokhala ndi kugunda kwamtima kosafunikira komwe kumatha kukomoka kapena kufa mwadzidzidzi); ngati mwakhala mukugunda pang'onopang'ono kapena mosasinthasintha kapena mavuto ena amtima; magazi ochepa a sodium, potaziyamu, kapena magnesium; mavuto amanjenje; matenda a chiwindi, kuphatikizapo matenda enaake; kapena ngati mukulandira chithandizo cha dialysis kapena ngati mwakhalapo ndi matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati, kapena mukuyamwitsa. Muyenera kudziwa kuti ivosidenib imachepetsa mphamvu yolera yakumapiritsi (mapiritsi oletsa kubala, zigamba, mphete, kapena jakisoni) mukamamwa mankhwalawa. Lankhulani ndi dokotala wanu za kugwiritsa ntchito njira ina yolerera. Mukakhala ndi pakati mukatenga ivosidenib, itanani dokotala wanu mwachangu. Ivosidenib itha kuvulaza mwana.
• uzani dokotala wanu ngati mukuyamwitsa. Musamwe mkaka mukamamwa mankhwala ndi ivosidenib komanso kwa mwezi umodzi mutatha kumwa.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Onetsetsani kuti mumamwa madzi ambiri kapena madzi ena tsiku lililonse mukamamwa ivosidenib.

Ngati mulingo wanu wotsatira ukukwana maola 12 kapena kupitilira apo, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mlingo wotsatira udzatengeke pasanathe maola 12, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ivosidenib ikhoza kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kutopa
• kulumikizana kapena kupweteka kwa minofu
• kutsegula m'mimba
• kudzimbidwa
• kusanza
• nseru
• kusowa chilakolako
• kupweteka mkamwa ndi zilonda
• kupweteka m'mimba

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• chizungulire, mutu wopepuka, kapena kukomoka
• kufooka kapena kumva kulira kwamiyendo, mikono, kapena thupi lakumtunda; dzanzi ndi kupweteka mbali imodzi kapena mbali zonse ziwiri za thupi; kusintha pakutha kwanu kuwona, kukhudza, kumva, kapena kulawa; kutentha kapena kumenyedwa; kapena kupuma movutikira
• kupweteka pachifuwa

Ivosidenib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Dokotala wanu adzakonzekeretsani labu musanayambe kumwa mankhwala kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi ivosidenib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Tibsovo^®