Gilteritinib

Zamkati

• Musanatenge gilteritinib,
• Gilteritinib itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mu gawo la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Gilteritinib imatha kuyambitsa matenda owopsa kapena owopsa omwe amatchedwa kusiyanitsa. Dokotala wanu amayang'anitsitsa mosamala kuti awone ngati mukukula matendawa. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: malungo, chifuwa, zidzolo, kunenepa mwadzidzidzi, chizungulire, kuchepa pokodza, kutupa kwa mikono kapena miyendo, kupuma movutikira, kupuma movutikira, kupweteka pachifuwa, kapena kupweteka kwa mafupa. Zizindikirozi zimatha kutha miyezi itatu mutayamba mankhwala ndi gilteritinib. Pachizindikiro choyamba kuti mukuyamba kusiyanitsa, dokotala wanu adzakupatsani mankhwala ochizira matendawa, ndipo angakuuzeni kuti musiye kumwa gilteritinib kwakanthawi.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi gilteritinib ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso.Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Gilteritinib amagwiritsidwa ntchito pochiza mtundu winawake wa myeloid leukemia (AML) womwe waipiraipira kapena kubwereranso pambuyo pothandizidwa ndi mankhwala ena a chemotherapy. Gilteritinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa kuchitapo kanthu mwachilengedwe komwe kumafunikira kuti maselo a khansa achulukane.

Gilteritinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse popanda kapena chakudya kwa miyezi yosachepera 6. Tengani gilteritinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani gilteritinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi athunthu ndi madzi; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu amatha kusintha mlingo wanu kapena kuimitsa kwakanthawi kwakanthawi kapena kosatha kutengera momwe mankhwalawo amakuthandizirani komanso ngati mungakhale ndi zovuta zina. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kumwa gilteritinib ngakhale mutakhala bwino. Osasiya kumwa gilteritinib osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge gilteritinib,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la gilteritinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a gilteritinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal ena monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ndi ketoconazole; clarithromycin (Biaxin, mu PrevPac); escitalopram (Lexapro); fluoxetine (Prozac); mankhwala ena opatsirana pogonana (HIV) kapena matenda opatsirana m'thupi (AIDS) monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); nefazodone; pioglitazone (Actos); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); ndi sertraline (Zoloft). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi gilteritinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mwakhalapo ndi kutalika kwa nthawi ya QT (mtima wosakhazikika womwe ungayambitse kukomoka, kutayika, kukomoka, kapena kufa mwadzidzidzi); kugunda kwapang'onopang'ono, kwachangu, kapena kosasintha; kapena potaziyamu kapena magnesium wambiri m'magazi anu.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Inu kapena mnzanu simuyenera kutenga pakati mukamamwa gilteritinib. Ngati ndinu wamkazi, muyenera kuyezetsa pakati pa masiku osachepera asanu ndi awiri musanayambe mankhwala, ndipo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa miyezi 6 mutalandira mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi 4 mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mumakhala ndi pakati mukatenga gilteritinib, itanani dokotala wanu. Gilteritinib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala a gilteritinib komanso kwa miyezi iwiri mutalandira mankhwala omaliza.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati pasanathe maola 12 isanakwane mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Gilteritinib itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kulumikizana kapena kupweteka kwa minofu
• kutopa kwambiri
• nseru
• kusanza
• kutsegula m'mimba
• zilonda mkamwa
• kusintha pakutha kulawa chakudya
• mutu
• kusowa chilakolako
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mu gawo la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kugwidwa; mutu; kuchepa kukhala tcheru; chisokonezo; kapena masomphenya amasintha
• kuthamanga, kugunda, kapena kugunda kwamtima kosasinthasintha; kukomoka; kutaya chidziwitso; kapena kugwidwa
• kupweteka kosalekeza komwe kumayambira m'mimba koma kumafalikira kumbuyo komwe kumatha kuchitika popanda mseru komanso kusanza

Gilteritinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi gilteritinib. Dokotala wanu adzaitanitsanso mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira gilteritinib. Dokotala wanu amathanso kuyitanitsa electrocardiogram (ECG; kuyesa komwe kumayesa magetsi mumtima) musanachitike komanso mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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