Jekeseni wa Alemtuzumab (Multiple Sclerosis)

Zamkati

• Jakisoni wa Alemtuzumab amagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yosiyanasiyana ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) omwe sanachite bwino ndi mankhwala osachepera awiri kapena kupitilira apo kuphatikiza:
• Asanalandire jakisoni wa alemtuzumab,
• Jakisoni wa Alemtuzumab angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Jakisoni wa Alemtuzumab ungayambitse matenda oopsa oyimitsa chitetezo cha mthupi (mikhalidwe momwe chitetezo chamthupi chimagwirira mbali zathanzi za thupi ndikupangitsa kupweteka, kutupa, ndi kuwonongeka), kuphatikiza thrombocytopenia (kuchuluka kwamagazi othandiza magazi kuundana [mtundu wa khungu lamagazi wofunikira kutseka magazi]) ndi mavuto a impso. Uzani dokotala wanu ngati muli ndi vuto lakukha magazi kapena matenda a impso. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: kutuluka magazi mosazolowereka, kutupa kwa miyendo kapena mapazi anu, kutsokomola magazi, kutuluka magazi kuchokera pakadula kovutirapo kuti asiye, kutaya magazi nthawi yayitali kapena kusamba, mawanga pakhungu lanu omwe ali chofiira, pinki, kapena chibakuwa, kutuluka m'magazi kapena mphuno, magazi mumkodzo, kupweteka pachifuwa, kuchepa kwa mkodzo, komanso kutopa.

Mutha kukhala ndi vuto lakulowetsedwa kapena kuwopseza moyo mukalandila jakisoni wa alemtuzumab kapena mpaka masiku atatu pambuyo pake. Mudzalandira mlingo uliwonse wa mankhwala kuchipatala, ndipo dokotala wanu adzakuyang'anirani mosamala mukamulowetsedwa komanso mukalandira mankhwalawo. Ndikofunikira kuti mukakhale pakulowetsedwa kwa maola osachepera 2 mutamalizidwa kulowetsedwa. Ngati mukumane ndi zizindikiro zotsatirazi nthawi yanu itatha kapena mutalowetsedwa, uzani dokotala nthawi yomweyo: malungo; kuzizira; nseru; mutu; kusanza; ming'oma; zidzolo; kuyabwa; kuthamanga; kutentha pa chifuwa; chizungulire; kupuma movutikira; kuvuta kupuma kapena kumeza; kupuma pang'ono; kukhwimitsa pakhosi; kutupa kwa maso, nkhope, pakamwa, milomo, lilime kapena mmero; ukali; chizungulire; mutu wopepuka; kukomoka; kuthamanga kapena kusakhazikika kwamtima; kapena kupweteka pachifuwa.

Jekeseni wa Alemtuzumab ungayambitse sitiroko kapena misozi m'mitsempha yanu yomwe imapereka magazi kuubongo wanu, makamaka m'masiku atatu oyamba mutalandira chithandizo. Ngati mukumane ndi izi mwazizindikiro mukamulowetsedwa kapena muuzeni, uzani dokotala nthawi yomweyo: mukugwa mbali imodzi kumaso, kupweteka mutu, kupweteka m'khosi, kufooka mwadzidzidzi kapena kufooka kwa mkono kapena mwendo, makamaka mbali imodzi ya thupi , kapena kuvutika kuyankhula, kapena kumvetsetsa.

Jakisoni wa Alemtuzumab ungakulitse chiopsezo chokhala ndi khansa, kuphatikiza khansa ya chithokomiro, khansa ya khansa (mtundu wa khansa yapakhungu), ndi mitundu ina ya khansa yamagazi. Muyenera kuyezetsa khungu lanu ndi dokotala ngati ali ndi khansa musanayambe kumwa mankhwala komanso chaka chilichonse pambuyo pake. Itanani dokotala wanu ngati muli ndi zizindikiro zotsatirazi zomwe zingakhale chizindikiro cha khansa ya chithokomiro: chotupa chatsopano kapena kutupa m'khosi mwanu; kupweteka pamaso pa khosi; kuwonda kosadziwika; kupweteka kwa mafupa kapena mafupa; zotupa kapena zotupa pakhungu lanu, khosi, mutu, kubuula kapena m'mimba; kusintha kwa mawonekedwe a mole, kukula, kapena mtundu kapena magazi; chotupa chochepa chokhala ndi malire osakhazikika ndi magawo omwe amawoneka ofiira, oyera, abuluu kapena akuda buluu; hoarseness kapena mawu ena amasintha omwe samachoka; zovuta kumeza kapena kupuma; kapena chifuwa.

Chifukwa cha kuopsa kwa mankhwalawa, jakisoni wa alemtuzumab amapezeka pokhapokha pulogalamu yoletsa yogawa. Pulogalamu yotchedwa Pulogalamu yotchedwa Lemtrada Risk Evaluation and Mitigation Strategy (REMS) Program. Funsani dokotala wanu ngati muli ndi mafunso okhudza momwe mudzalandire mankhwala anu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu lingayankhire jekeseni wa alemtuzumab musanachitike komanso mukamalandira chithandizo chanu komanso kwa zaka 4 mutalandira mankhwala anu omaliza.

Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa alemtuzumab.

Jakisoni wa Alemtuzumab amagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yosiyanasiyana ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) omwe sanachite bwino ndi mankhwala osachepera awiri kapena kupitilira apo kuphatikiza:

• mitundu yobwezeretsanso (matenda omwe matenda amayamba kuwonekera nthawi ndi nthawi) kapena
• mitundu yachiwiri yopita patsogolo (matenda omwe amabwereranso amapezeka pafupipafupi).

Alemtuzumab ili mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

Alemtuzumab imapezekanso ngati jakisoni (Campath) yomwe imagwiritsidwa ntchito pochiza khansa ya m'magazi (khansa yomwe ikukula pang'onopang'ono) momwe mitundu yambiri yamagazi oyera imakhalira mthupi). Izi zimangopereka chidziwitso chokhudza jakisoni wa alemtuzumab (Lemtrada) wa multiple sclerosis. Ngati mukulandira alemtuzumab ya matenda amitsempha yamagazi, werengani buku lotchedwa Alemtuzumab Injection (Chronic Lymphocytic Leukemia).

Jakisoni wa Alemtuzumab umadza ngati yankho (madzi) kuti alowe jakisoni (mumtsempha) kupitilira maola 4 ndi dokotala kapena namwino kuchipatala kapena kuofesi yazachipatala. Kawirikawiri amaperekedwa kamodzi tsiku lililonse kwa masiku 5 pa nthawi yoyamba ya mankhwala. Njira yachiwiri yothandizira imaperekedwa kamodzi tsiku lililonse kwa masiku atatu, miyezi 12 kuchokera nthawi yoyamba yamankhwala. Dokotala wanu akhoza kukupatsani mankhwala owonjezera kwa masiku atatu osachepera miyezi 12 mutalandira chithandizo choyambirira.

Jakisoni wa Alemtuzumab amathandizira kuwongolera ziwalo zambiri, koma samachiritsa.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa alemtuzumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la alemtuzumab, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu jakisoni wa alemtuzumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchula izi: alemtuzumab (Campath; dzina la mankhwala omwe amagwiritsidwa ntchito pochiza khansa ya m'magazi); mankhwala a khansa; kapena mankhwala opatsirana pogonana monga cyclosporine (Gengraf, Neoral, Sandimmune), mycophenolate (Cellcept), prednisone, ndi tacrolimus (Astagraf, Envarsus, Prograf). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• Uzani dokotala wanu ngati muli ndi kachilombo ka HIV kapena kachilombo ka HIV. Dokotala wanu angakuuzeni kuti musalandire jakisoni wa alemtuzumab.
• auzeni adotolo ngati mwakhalapo ndi chifuwa chachikulu (TB; matenda akulu omwe amakhudza mapapo ndipo nthawi zina mbali zina za thupi), herpes zoster (ming'alu; zotupa zomwe zimatha kuchitika kwa anthu omwe adakhalapo ndi nthomba m'mbuyomu) , maliseche (matenda opatsirana a herpes omwe amayambitsa zilonda kuzungulira ziwalo zoberekera ndi zotuluka nthawi ndi nthawi), varicella (nkhuku), matenda a chiwindi kuphatikiza hepatitis B kapena hepatitis C, kapena chithokomiro, mtima, mapapo, kapena ndulu.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa miyezi 4 mutalandira mankhwala. Lankhulani ndi dokotala wanu za mitundu yoletsa yomwe mungagwiritse ntchito popewera kutenga mimba nthawi imeneyi. Mukakhala ndi pakati mukalandira jakisoni wa alemtuzumab, itanani dokotala wanu mwachangu. Alemtuzumab itha kuvulaza mwana wosabadwayo.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera aliyense musanalandire alemtuzumab. Uzani dokotala wanu ngati mwalandira katemera m'masabata 6 apitawa. Musakhale ndi katemera musanalankhule ndi dokotala mukamalandira chithandizo.

Pewani zakudya zotsatirazi zomwe zingayambitse matenda osachepera mwezi umodzi musanalandire alemtuzumab komanso mukamalandira chithandizo: nyama yoperekera zakudya, mkaka wopangidwa ndi mkaka wosasamalidwa, tchizi wofewa, kapena nyama yosaphika, nsomba, kapena nkhuku.

Jakisoni wa Alemtuzumab angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuvuta kugona kapena kugona
• kupweteka kwa miyendo, mikono, zala, ndi manja
• kupweteka kumbuyo, olowa, kapena khosi
• kumva kulasalasa, kumenya, kuzizira, kutentha, kapena kumva khungu pakhungu
• khungu lofiira, loyabwa, kapena lansalu
• kutentha pa chifuwa
• kutupa kwa mphuno ndi kukhosi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kupuma pang'ono, kupweteka pachifuwa kapena kukanika, kutsokomola, kutsokomola magazi, kapena kupuma
• malungo, kuzizira, kutsegula m'mimba, nseru, kusanza, kupweteka mutu, kupweteka kwa mafupa kapena minofu, kuuma kwa khosi, kuyenda movutikira, kapena kusintha kwamaganizidwe
• kuvulaza kapena kutuluka magazi mosavuta, magazi mumkodzo kapena chopondapo, kutuluka magazi m'mphuno, masanzi amwazi, kapena zopweteka komanso / kapena zotupa
• thukuta kwambiri, kutupa kwa diso, kuonda, mantha, kapena kugunda kwamtima
• kunenepa kosadziwika, kutopa, kumva kuzizira, kapena kudzimbidwa
• kukhumudwa
• kuganiza zodzipweteka kapena kudzipha kapena kukonzekera kapena kuyesa kutero
• zilonda zoberekera, kumva zikhomo ndi singano, kapena zotupa pa mbolo kapena kumaliseche
• zilonda zozizira kapena zotupa za malungo pakamwa kapena mozungulira pakamwa
• zotupa zopweteka mbali imodzi ya nkhope kapena thupi, zokhala ndi zotupa, kupweteka, kuyabwa, kapena kumva kuwawa m'malo am'magazi
• (mwa akazi) kununkhira kwa ukazi, kumaliseche koyera kapena koterako (kumatha kukhala kotupa kapena kuwoneka ngati kanyumba kanyumba), kapena kuyabwa kumaliseche
• zotupa zoyera lilime kapena masaya amkati
• kupweteka m'mimba kapena kufatsa, malungo, nseru, kapena kusanza
• nseru, kusanza, kupweteka m'mimba, kutopa kwambiri, kusowa chilakolako, maso achikasu kapena khungu, kutopa kwambiri, mkodzo wamdima, kapena kutuluka magazi kapena kuvulaza mosavuta kuposa zachilendo
• kufooka mbali imodzi ya thupi kuti worsens pa nthawi; kuphwanya kwa manja kapena miyendo; Kusintha kalingaliridwe kanu, kukumbukira, kuyenda, kulinganiza, kulankhula, maso, kapena nyonga zomwe zimakhala masiku angapo; mutu; kugwidwa; chisokonezo; kapena kusintha kwa umunthu
• malungo, zotupa zotupa, zotupa, kugwa, kusintha kwa kuganiza kapena kukhala tcheru, kapena kwatsopano kapena kukulitsa kusakhazikika kapena kuyenda movutikira

Jakisoni wa Alemtuzumab angayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

• mutu
• zidzolo
• chizungulire

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza jakisoni wa alemtuzumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Lemtrada^®