Ravulizumab-cwvz jekeseni

Zamkati

• Musanalandire jakisoni wa ravulizumab-cwvz,
• Ravulizumab-cwvz ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena Momwe mungayankhire, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Kulandila jekeseni wa ravulizumab-cwvz kungapangitse kuti mukhale ndi chiopsezo chotenga matenda a meningococcal (matenda omwe angakhudze chophimba cha ubongo ndi msana wam'mimba komanso / kapena kufalikira kudzera m'magazi) mukamalandira chithandizo kapena kwakanthawi pambuyo pake. Matenda a meningococcal amatha kuyambitsa imfa munthawi yochepa. Muyenera kulandira katemera wa meningococcal osachepera milungu iwiri musanayambe mankhwala anu ndi jakisoni wa ravulizumab-cwvz kuti muchepetse chiopsezo chotenga matendawa. Ngati munalandirapo katemerayu m'mbuyomu, mungafunike kulandira mankhwala owonjezera musanayambe kumwa mankhwala. Ngati dokotala akuwona kuti muyenera kuyamba kulandira chithandizo ndi jekeseni wa ravulizumab-cwvz nthawi yomweyo, mudzalandira katemera wanu wa meningococcal posachedwa ndikumwa maantibayotiki kwa milungu iwiri.

Ngakhale mutalandira katemera wa meningococcal, pali chiopsezo kuti mutha kudwala matenda a meningococcal nthawi kapena mutalandira chithandizo chamankhwala a ravulizumab-cwvz. Ngati mukukumana ndi izi, pitani kuchipatala msanga kapena mulandire chithandizo chamankhwala mwadzidzidzi: kupweteka mutu komwe kumabwera ndi nseru kapena kusanza, malungo, khosi lolimba, kapena msana wolimba; malungo; zidzolo ndi malungo; chisokonezo; kupweteka kwa minofu ndi zina monga chimfine; kapena ngati maso anu ali ndi chidwi ndi kuwala.

Uzani dokotala wanu ngati muli ndi malungo kapena zizindikiro zina za matenda musanayambe mankhwala anu ndi jekeseni wa ravulizumab-cwvz. Dokotala wanu sangakupatseni jekeseni wa ravulizumab-cwvz ngati muli ndi matenda a meningococcal.

Dokotala wanu adzakupatsani khadi yachitetezo cha wodwala yokhudzana ndi chiopsezo chokhala ndi matenda a meningococcal nthawi yayitali kapena kwakanthawi mukamalandira chithandizo. Nyamulani khadi ili nthawi zonse mukamalandira chithandizo komanso kwa miyezi 8 mutalandira chithandizo. Onetsani khadi kwa onse othandizira zaumoyo omwe amakuthandizani kuti adziwe za chiopsezo chanu.

Pulogalamu yotchedwa Ultomiris REMS yakhazikitsidwa kuti ichepetse kuopsa kolandila jekeseni wa ravulizumab-cwvz. Mutha kulandira jekeseni wa ravulizumab-cwvz kuchokera kwa dokotala yemwe walembetsa nawo pulogalamuyi, walankhula nanu za kuopsa kwa matenda a meningococcal, wakupatsani khadi yachitetezo cha wodwala, ndikuwonetsetsa kuti mwalandira katemera wa meningococcal.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi ravulizumab-cwvz ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kolandira jakisoni wa ravulizumab-cwvz.

Jakisoni wa Ravulizumab-cwvz amagwiritsidwa ntchito kwa achikulire pochiza paroxysmal nocturnal hemoglobinuria (PNH: mtundu wa kuchepa magazi m'thupi momwe maselo ofiira ambiri agwera mthupi, motero palibe maselo athanzi okwanira kubweretsa mpweya kumadera onse a thupi ). Jakisoni wa Ravulizumab-cwvz amagwiritsidwanso ntchito kwa achikulire ndi ana a 1 mwezi wazaka kapena kupitilira kuti athetse matenda am'mapapo a hemolytic uremic (aHUS; mkhalidwe wobadwa nawo womwe timagazi tating'onoting'ono tomwe timapanga m'thupi ndipo titha kuwononga mitsempha yamagazi, maselo amwazi, impso, ndi ziwalo zina za thupi). Ravulizumab-cwvz ali mgulu la mankhwala otchedwa ma monoclonal antibodies. Zimagwira ntchito poletsa zochitika za gawo la chitetezo cha mthupi zomwe zitha kuwononga maselo amwazi mwa anthu omwe ali ndi PNH ndipo zimayambitsa kuundana mwa anthu omwe ali ndi aHUS.

Jakisoni wa Ravulizumab-cwvz umadza ngati yankho (madzi) oti alowe mu jakisoni (mu mtsempha) kwa maola pafupifupi 2-4 ndi dokotala kapena namwino mu ofesi ya zamankhwala. Nthawi zambiri amaperekedwa milungu isanu ndi itatu iliyonse kuyambira milungu iwiri mutangomwa kumene. Ana amatha kulandira jakisoni wa ravulizumab-cwvz pakatha milungu inayi kapena isanu ndi itatu, kutengera kulemera kwa thupi lawo, kuyambira milungu iwiri mutalandira mankhwala oyamba.

Jakisoni wa Ravulizumab-cwvz angayambitse zovuta zina. Dokotala wanu amakuyang'anirani mosamala mukalandira jakisoni wa ravulizumab-cwvz komanso kwa ola limodzi mutalandira mankhwala. Dokotala wanu amatha kuchepetsa kapena kuyimitsa kulowetsedwa kwanu ngati mukumana ndi vuto linalake. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka pachifuwa; kuvuta kupuma; kupuma movutikira; kutupa kwa nkhope yanu, lilime, kapena mmero; kupweteka kwa msana; ululu ndi kulowetsedwa; kapena kumva kukomoka.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanalandire jakisoni wa ravulizumab-cwvz,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi ravulizumab-cwvz, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jekeseni wa ravulizumab-cwvz. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda ena aliwonse.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukalandira jakisoni wa ravulizumab-cwvz, itanani dokotala wanu.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukalandira ravulizumab-cwvz komanso kwa miyezi 8 mutalandira mankhwala anu omaliza.
• ngati mukulandira PNH, muyenera kudziwa kuti matenda anu atha kupangitsa kuti maselo ofiira ochulukirapo awonongeke mukasiya kulandira jakisoni wa ravulizumab-cwvz. Dokotala wanu adzakuyang'anirani mosamala ndipo atha kuyitanitsa mayeso a labotale kwa milungu ingapo 16 mutamaliza mankhwala anu. Itanani dokotala wanu nthawi yomweyo ngati mungakhale ndi izi: kutopa kwambiri; magazi mkodzo; kupweteka m'mimba; zovuta kumeza; Kulephera kupeza kapena kusunga erection; kupuma movutikira; kupweteka, kutupa, kutentha, kufiira, kapena kukoma mwendo umodzi wokha; mawu odekha kapena ovuta; kufooka kapena kufooka kwa mkono kapena mwendo; kapena zizindikiro zina zachilendo.
• ngati mukulandira aHUS, muyenera kudziwa kuti vuto lanu lingayambitse magazi kuundana mutasiya kulandira jakisoni wa ravulizumab-cwvz. Dokotala wanu adzakuyang'anirani mosamala ndipo atha kuyitanitsa mayeso a labotore kwa miyezi 12 mutamaliza mankhwala anu. Itanani dokotala wanu nthawi yomweyo ngati mungakhale ndi izi: mwadzidzidzi vuto loyankhula kapena kumvetsetsa mawu, kusokonezeka, kufooka mwadzidzidzi kapena kufooka kwa mkono kapena mwendo (makamaka mbali imodzi ya thupi) kapena nkhope, kuyenda mwadzidzidzi, chizungulire, kusakhazikika bwino kapena kulumikizana, kukomoka, kukomoka, kupweteka pachifuwa, kupuma movutikira, kapena zizindikilo zina zachilendo.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Mukaphonya nthawi kuti mulandire jakisoni wa ravulizumab-cwvz, itanani dokotala wanu nthawi yomweyo.

Ravulizumab-cwvz ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• nseru
• kusanza
• kudzimbidwa
• mutu
• kupweteka kwa minofu kapena molumikizana
• kupweteka kwa mikono kapena miyendo
• mphuno
• kupweteka kapena kutupa m'mphuno kapena pakhosi
• chifuwa
• chizungulire
• pokodza kowawa kapena kovuta
• kutayika tsitsi
• khungu lowuma
• kuchepa kudya
• kutopa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena Momwe mungayankhire, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• malungo kapena zizindikiro zina za matenda
• kupweteka m'mimba

Ravulizumab-cwvz ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira jakisoni wa ravulizumab-cwvz.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo za jekeseni wa ravulizumab-cwvz.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Ultomiris^®