Avapritinib

Zamkati

• Musanatenge avapritinib,
• Avapritinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi, siyani kumwa avapritinib ndikuimbira foni mwachangu kapena pitani kuchipatala mwadzidzidzi:

Avapritinib amagwiritsidwa ntchito pochiza mtundu wina wa chotupa cham'mimba (GIST; mtundu wa chotupa chomwe chimamera pakhoma la m'mimba, matumbo [matumbo], kapena kholingo [chubu cholumikizira pakhosi ndi m'mimba] mwa achikulire omwe ali ndi kufalikira ku ziwalo zina za thupi kapena zomwe sizingachotsedwe ndi opaleshoni. Avapritinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Avapritinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse osadya kanthu, ola limodzi musanadye komanso maola awiri mutadya. Tengani avapritinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani avapritinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati musanza mutatenga avapritinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu wa avapritinib kapena kuimitsa chithandizo chanu kutengera momwe mankhwalawo amakuthandizirani komanso ngati mungakhale ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha avapritinib. Osasiya kumwa avapritinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge avapritinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la avapritinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a avapritinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchula izi: aprepitant (Emend); mankhwala ena oletsa mafungal monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), kapena ketoconazole; clarithromycin (Biaxin, mu Prevpac); diltiazem (Cardizem, Tiazac, ena); erythromycin (EES, Erythrocin, ena); mankhwala ena a HIV monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra, ena), kapena saquinavir (Invirase); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, ku Actoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, mu Rifater); ndi verapamil (Calan). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.Mankhwala ena ambiri amathanso kulumikizana ndi avapritinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mwadwalapo chiwindi kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa milungu isanu ndi umodzi mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa milungu 6 mutalandira mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga avapritinib, itanani dokotala wanu mwachangu. Avapritinib itha kuvulaza mwana wosabadwayo.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mukamamwa avapritinib komanso kwa milungu iwiri musanamwe mankhwala.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kotenga avapritinib.
• muyenera kudziwa kuti avapritinib imatha kukupangitsani kukhala ozunguzika, kugona kapena kusokoneza. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mulingo wotsatira ukukwanira munthawi yochepera maola 8, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Avapritinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupweteka m'mimba
• kusanza
• nseru
• kutsegula m'mimba
• kutentha pa chifuwa
• mutu
• kutopa
• kuvuta kugona kapena kugona
• kutayika tsitsi
• tsitsi limasintha
• kuonda
• maso misozi
• kusintha kwa kukoma

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi, siyani kumwa avapritinib ndikuimbira foni mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutupa kwa nkhope, maso, pakamwa, kapena pakhosi
• kutupa kwa manja, akakolo, kapena mapazi
• kusanza magazi kapena zinthu zomwe zimawoneka ngati malo a khofi kapena zofiira zofiira kapena zochedwa
• mutu wopweteka kwambiri, mavuto a masomphenya, kugona, kutopa kwambiri, kapena kufooka mbali imodzi ya thupi lanu
• kuyiwala, kusokonezeka, kugona, chizungulire, kuvutika kugona, kulephera kuyankhula, kuyerekezera zinthu m'maganizo, kapena kusintha maganizo kapena khalidwe
• zidzolo
• kupuma movutikira
• malungo kapena zizindikiro zina za matenda

Avapritinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kutentha kowonjezera ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso a labu musanayambe kumwa mankhwala kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi avapritinib. Dokotala wanu amatha kuyitanitsa mayeso ena a labu kuti aone momwe thupi lanu likuyankhira kwa avapritinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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