Ripretinib

Zamkati

• Musanatenge ripretinib,
• Ripretinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Ripretinib imagwiritsidwa ntchito pochiza zotupa zam'mimba (GIST; mtundu wa chotupa chomwe chimakula m'mimba, m'matumbo [matumbo], kapena kum'mero ​​[chubu chomwe chimalumikiza pakhosi ndi m'mimba] mwa achikulire omwe adalandirapo mankhwala ena, kuphatikiza imatinib (Gleevec). Ripretinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Ripretinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse kapena wopanda chakudya. Tengani ripretinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ripretinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga ripretinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angafunikire kuyimitsa chithandizo chanu kwakanthawi kapena kosatha kapena kuchepetsa mlingo wanu wa ripretinib mukamamwa mankhwala. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira mankhwala a ripretinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ripretinib,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la ripretinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a ripretinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungals monga itraconazole (Onmel, Sporanox) ndi ketoconazole; carbamazepine (Carbatrol, Tegretol, Equetro, ena); clarithromycin (Biaxin, mu Prevpac); mankhwala ena a kachirombo ka HIV (HIV) kapena matenda a immunodeficiency (AIDS) kuphatikiza efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase) ; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); rifabutin (Mycobutin); ndi rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi ripretinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni dokotala ngati mwakhalapo kapena mudakhalapo ndi matenda othamanga magazi kapena matenda amtima.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Simuyenera kutenga pakati mukamamwa ripretinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala a ripretinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamamwa mankhwala a ripretinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Ngati inu kapena mnzanu muli ndi pakati mukatenga ripretinib, itanani dokotala wanu mwachangu. Ripretinib imatha kupweteketsa mwana.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa ripretinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kotenga ripretinib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa ripretinib. Dokotala wanu angakuuzeni kuti musatenge ripretinib 1 sabata musanachite opaleshoni kapena njira yanu ndipo angakuuzeni nthawi yomwe muyenera kuyambiranso kumwa mankhwalawo.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 8 a mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ripretinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupweteka kwa minofu kapena molumikizana
• kutayika tsitsi
• khungu louma kapena loyabwa
• kufooka
• nseru
• kupweteka m'mimba
• kudzimbidwa
• kutsegula m'mimba
• zilonda mkamwa kapena zilonda
• mutu
• kuonda
• kusowa chilakolako
• kutuluka kwa minofu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kufiira, kupweteka, matuza, magazi, kapena kutupa pamanja kapena pamapazi; kapena totupa
• chida chatsopano
• kusintha kwa khungu
• zilonda pakhungu kapena chifuwa chofiira chomwe chimatuluka magazi kapena sichichira
• kusintha kukula kapena mtundu wa mole
• kutopa; kutupa kwa m'mimba, miyendo, kapena akakolo; kupuma movutikira; kapena mitsempha ya khosi kutuluka

Ripretinib itha kuonjezera chiopsezo kuti mungakhale ndi khansa yapakhungu. Lankhulani ndi dokotala wanu za chiopsezo ichi.

Ripretinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa). Musachotse desiccant (paketi yaying'ono yophatikizidwa ndi mapiritsi oyamwa chinyezi) kuchokera mu botolo lanu.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu ndikuwunika kuthamanga kwa magazi kwanu kuti muwone momwe thupi lanu likuyankhira ripretinib. Dokotala wanu adzawonanso khungu lanu ngati lingasinthe musanachitike komanso mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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