Tolvaptan (matenda a impso)

Zamkati

• Musanatenge tolvaptan (Jynarque),
• Tolvaptan (Jynarque) imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo:

Tolvaptan (Jynarque) imatha kuwononga chiwindi, nthawi zina imakhala yovuta kwambiri kufuna kupatsirana chiwindi kapena kupha. Uzani dokotala wanu ngati mwakhalapo ndi vuto la chiwindi, kuphatikizapo matenda a chiwindi. Dokotala wanu angakuuzeni kuti musatenge tolvaptan (Jynarque). Dokotala wanu amalamula mayeso a labotale nthawi zonse musanadye komanso mukamalandira chithandizo kuti muwone ngati tolvaptan (Jynarque) ikukhudza chiwindi chanu. Dokotala wanu angakuuzeni kuti simuyenera kulandira mankhwalawa ngati mayeso awonetsa kuti muli ndi vuto la chiwindi. Ngati mukumane ndi izi, itanani dokotala wanu msanga: nseru, kusanza, kutopa kwambiri, kutuluka mwazi kapena kuvulaza, kusowa mphamvu, kusowa kwa njala, kupweteka kumtunda kwakumimba, chikaso cha khungu kapena maso , mkodzo wakuda, zidzolo, kuyabwa, kapena zizindikiro zonga chimfine.

Chifukwa cha kuopsa kwa mankhwalawa, tolvaptan (Jynarque) imangopezeka pokhapokha pulogalamu yoletsa yogawa. Pulogalamu yotchedwa Jynarque Risk Evaluation and Mitigation Strategies (REMS) yakhazikitsidwa kuti ichepetse chiwopsezo chotenga tolvaptan (Jynarque). Dokotala wanu komanso wamankhwala anu ayenera kulembetsa nawo pulogalamu ya Jynarque REMS. Funsani dokotala wanu kuti mumve zambiri za pulogalamuyi komanso momwe mungalandire mankhwala anu. Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira tolvaptan (Jynarque).

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira chithandizo ndi tolvaptan (Jynarque) ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za chiopsezo chotenga tolvaptan (Jynarque).

Tolvaptan (Jynarque) amagwiritsidwa ntchito pochepetsa kukula kwa impso mwa odwala ena omwe ali ndi matenda a impso a autosomal (ADPKD; mtundu wina wamatenda obadwa nawo a impso). Tolvaptan (Jynarque) ali mgulu la mankhwala otchedwa vasopressin V₂ otsutsana nawo. Zimagwira ntchito pakuwonjezera kuchuluka kwa madzi otulutsidwa m'thupi ngati mkodzo ndikuchepetsa kukula kwa zotupa mu impso. Kuchotsa madzi m'thupi ndikuchepetsa kukula kwa zotupa kumathandizira kuchepetsa kukula kwa ntchito ya impso.

Tolvaptan imapezekanso ngati piritsi (Samsca) yochizira m'magazi otsika a sodium mwa anthu omwe ali ndi vuto la mtima kapena zina. Izi zimangopereka chidziwitso cha mapiritsi a tolvaptan (Jynarque) kuti achepetse kuwonjezeka kwa impso kwa odwala omwe ali ndi ADPKD. Ngati mukugwiritsa ntchito mankhwalawa kuti muchepetse sodium yochulukirapo m'magazi, werengani monograph yotchedwa tolvaptan (low sodium sodium).

Tolvaptan (Jynarque) imabwera ngati piritsi kuti itenge pakamwa. Amamwa kawiri patsiku, piritsi limodzi m'mawa ndi piritsi limodzi patadutsa maola 8, kapena wopanda chakudya. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani tolvaptan (Jynarque) ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Dokotala wanu mwina angakuyambitseni pamlingo wochepa wa tolvaptan (Jynarque) ndipo pang'onopang'ono muwonjezere mlingo wanu.

Dokotala wanu angafunikire kuchepetsa mlingo wanu ngati mukukumana ndi zovuta zina. Ndikofunika kuti muuze dokotala momwe mukumvera mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge tolvaptan (Jynarque),

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi tolvaptan (Jynarque, Samsca), mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a tolvaptan. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• uzani dokotala ngati mukumwa mankhwala enaake ophera fungal monga ketoconazole (Nizoral) kapena itraconazole (Sporanox); clarithromycin (Biaxin); kapena mankhwala ena a HIV monga indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), kapena saquinavir (Invirase); conivaptan (Vaprisol); kapena nefazodone. Dokotala wanu angakuuzeni kuti musamwe tolvaptan (Jynarque) ngati mukumwa mankhwala amodzi kapena angapo.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: atorvastatin (Lipitor, ku Caduet), bosentan (Tracleer), desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin), fluconazole (Diflucan); furosemide (Lasix), glyburide (Diabeta, Glynase), lovastatin (Altoprev), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), nateglinide (Starlix), pravastatin (Pravachol), repaglinide (Prandin), rifampin (Rifadin, Rifadin ), rosuvastatin (Crestor), ndi simvastatin (Zocor, ku Vytorin). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi tolvaptan (Jynarque), onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati muli ndi zina mwazomwe zatchulidwa mgawo la CHENJEZO LOFUNIKA, ngati mwakhalapo ndi sodium wochuluka m'magazi anu, ngati mukuvutika kukodza kapena mukulephera kukodza, ngati mwasanza kwambiri kapena kutsegula m'mimba kapena kuganiza kuti mutha kuchepa madzi m'thupi, kapena ngati simukuzindikira kuti muli ndi ludzu. Dokotala wanu angakuuzeni kuti musatenge tolvaptan (Jynarque).
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga tolvaptan (Jynarque), itanani dokotala wanu. Simuyenera kuyamwa mukamamwa tolvaptan (Jynarque).

Muyenera kumwa madzi okwanira mukamamwa tolvaptan (Jynarque) kuti musamve ludzu kapena kusowa madzi m'thupi.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Tolvaptan (Jynarque) imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• ludzu
• pakamwa pouma
• pafupipafupi, pokodza kwambiri
• kutentha pa chifuwa
• kuchepa kudya

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kutsegula m'mimba
• Kulephera kumwa bwinobwino
• chizungulire
• kukomoka
• kuchepa pokodza
• kufooka
• Kusinza
• chisokonezo
• kuonda
• kuthamanga kapena kugunda kwamtima
• kutupa kwa nkhope, mmero, lilime, milomo, maso, manja, mapazi, akakolo, kapena miyendo yakumunsi
• ukali
• ming'oma

Tolvaptan (Jynarque) imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• kukodza kwambiri
• ludzu lokwanira
• chizungulire
• kukomoka

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu akhoza kuyitanitsa mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira tolvaptan (Jynarque).

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®