Mlembi: Virginia Floyd
Tsiku La Chilengedwe: 5 Ogasiti 2021
Sinthani Tsiku: 15 Novembala 2024
Anonim
Inactivation of ANGPTL3 and Cardiovascular Disease
Kanema: Inactivation of ANGPTL3 and Cardiovascular Disease

Zamkati

Evinacumab-dgnb imagwiritsidwa ntchito limodzi ndi mankhwala ena kuti achepetse kuchuluka kwa mafuta otsika kwambiri a lipoprotein (LDL) cholesterol ('cholesterol yoyipa') ndi zinthu zina zamafuta m'magazi mwa akulu ndi ana azaka 12 kapena kupitirira omwe ali ndi homozygous banja hypercholesterolemia (HoFH; mkhalidwe wobadwa nawo momwe cholesterol sichingachotsedwe m'thupi nthawi zonse). Evinacumab-dgnb ali mgulu la mankhwala otchedwa angiopoietin-like protein 3 (ANGPTL3) inhibitor monoclonal antibodies. Zimagwira ntchito pochepetsa kupanga cholesterol ya LDL ndikuwonjezera kuwonongeka kwa cholesterol cha LDL ndi mafuta ena m'thupi.

Kuwonjezeka kwa cholesterol ndi mafuta m'mbali mwa mitsempha yanu (njira yotchedwa atherosclerosis) imachepetsa kutuluka kwa magazi, chifukwa chake, mpweya umapatsa mtima wanu, ubongo, ndi ziwalo zina za thupi lanu. Kutsitsa magazi anu wama cholesterol ndi mafuta kumatha kuthandizira kupewa matenda amtima, angina (kupweteka pachifuwa), stroko, komanso matenda amtima.

Evinacumab-dgnb imabwera ngati yankho (madzi) kuti isakanikidwe ndi madzi ndikubayidwa pang'onopang'ono mumtsinje kwa mphindi 60 ndi dokotala kapena namwino. Nthawi zambiri amaperekedwa kamodzi pamasabata anayi.


Jakisoni wa Evinacumab-dgnb amatha kuyambitsa mavuto ena pakulowetsedwa kwa mankhwala. Dokotala kapena namwino adzakuyang'anirani mosamala mukalandira mankhwala. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mukumane ndi izi mwa izi kapena mukamulowetsedwa: kupuma movutikira; kupuma; zidzolo; ming'oma; kuyabwa; chizungulire; kufooka kwa minofu; malungo; nseru; kuchulukana kwa mphuno; kapena kutupa kwa nkhope, mmero, lilime, milomo, kapena maso.

Dokotala wanu angafunikire kuchepetsa kulowetsedwa kwanu kapena kusiya chithandizo chanu mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha evinacumab-dgnb.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanalandire evinacumab-dgnb,

  • Uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi evinacumab-dgnb, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jekeseni wa evinacumab-dgnb. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa.
  • Uzani dokotala wanu ngati muli ndi pakati, kapena konzekerani kutenga pakati. Mungafunike kukayezetsa mimba musanayambe chithandizo ndi evinacumab-dgnb. Simuyenera kutenga pakati mukamalandira jakisoni wa evinacumab-dgnb. Muyenera kugwiritsa ntchito njira yolerera yothandiza kupewa mimba mukamamwa mankhwala a jekeseni wa evinacumab-dgnb komanso kwa miyezi 5 mutatha kumwa mankhwala. Mukakhala ndi pakati mukalandira evinacumab-dgnb, itanani dokotala wanu mwachangu.
  • Uzani dokotala wanu ngati mukuyamwitsa.

Idyani chakudya chochepa cha mafuta, cholesterol. Onetsetsani kuti mukutsatira zolimbitsa thupi komanso malingaliro azakudya zomwe adokotala anu kapena odyetsa. Mutha kuchezanso tsamba la National Cholesterol Education Program (NCEP) kuti mumve zambiri za zakudya pa: http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.


Itanani dokotala wanu nthawi yomweyo ngati simungathe kusungitsa nthawi yokumana kuti mulandire jakisoni wa evinacumab-dgnb.

Evinacumab-dgnb ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • mphuno
  • Kuchuluka kwa mphuno
  • chikhure
  • zizindikiro ngati chimfine
  • chikhure
  • chizungulire
  • nseru
  • kupweteka kwa miyendo kapena mikono
  • kuchepa mphamvu

Evinacumab-dgnb ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.


Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira evinacumab-dgnb.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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