Mlembi: Clyde Lopez
Tsiku La Chilengedwe: 21 Kulayi 2021
Sinthani Tsiku: 15 Novembala 2024
Anonim
Glucagon  - A Therapeutic Target
Kanema: Glucagon - A Therapeutic Target

Zamkati

Glucagon imagwiritsidwa ntchito limodzi ndi chithandizo chamankhwala chamwadzidzidzi kuti muchepetse shuga wotsika kwambiri wamagazi. Glucagon imagwiritsidwanso ntchito poyesa kuyesa m'mimba ndi ziwalo zina zam'mimba. Glucagon ili mgulu la mankhwala otchedwa glycogenolytic agents. Zimagwira ntchito ndikupangitsa chiwindi kutulutsa shuga wosungidwa kumwazi. Zimagwiranso ntchito pofewetsa minofu yosalala ya m'mimba ndi ziwalo zina zam'mimba kuti muzitha kuyesa.

Glucagon imabwera ngati yankho (madzi) mu syringe yoyikiratu komanso chida chodzipangira jekeseni mozungulira (pansi pa khungu). Zimabweranso ngati ufa wosakanikirana ndi madzi omwe amaperekedwa kuti alowemo subcutaneous, intramuscularly (mu minofu), kapena kudzera m'mitsempha (mumtsempha). Nthawi zambiri amabayidwa jekeseni momwe amafunikira pachizindikiro choyamba cha hypoglycemia. Pambuyo pa jakisoni, wodwalayo akuyenera kutembenuzidwira mbali yawo kuti asapume ngati akusanza. Gwiritsani ntchito jakisoni wa glucagon monga momwe mwalangizira; osabaya jekeseni pafupipafupi kapena kuibaya pang'ono kapena pang'ono kuposa momwe adanenera dokotala.


Funsani dokotala kapena wamankhwala kuti akuwonetseni, banja, kapena osamalira omwe angakhale akubayira mankhwala momwe mungagwiritsire ntchito ndikukonzekera jekeseni wa glucagon. Mnzanu kapena wachibale wanu asanagwiritse ntchito jakisoni wa glucagon kwa nthawi yoyamba, werengani zambiri zokhudza wodwalayo. Izi zimaphatikizaponso mayendedwe amomwe mungagwiritsire ntchito jakisoni. Onetsetsani kuti mufunse wamankhwala kapena dokotala ngati inu kapena omwe amakusamalirani mulibe mafunso okhudza kubayitsa mankhwalawa.

Kutsatira jakisoni wa glucagon, munthu wopanda chidziwitso yemwe ali ndi hypoglycemia (shuga wotsika magazi) amatha kudzuka mphindi 15. Glucagon ikaperekedwa, nthawi yomweyo kambiranani ndi dokotala ndikupeza chithandizo chamankhwala mwadzidzidzi. Ngati munthuyo sadzuka mkati mwa mphindi 15 kuchokera mu jakisoni, perekani mlingo umodzi wa glucagon. Dyetsani munthuyo kasupe wothamanga kwambiri wa shuga (mwachitsanzo, chakumwa chofewa nthawi zonse kapena msuzi wa zipatso) kenako gwero lachitetezo cha nthawi yayitali (mwachitsanzo, ma crackers, tchizi kapena sangweji yanyama) akangodzuka ndikutha kumeza .


Nthawi zonse yang'anani yankho la glucagon lisanabayidwe. Iyenera kukhala yoyera, yopanda utoto, komanso yopanda tinthu tating'onoting'ono. Musagwiritse ntchito jakisoni wa glucagon ngati kuli mitambo, ili ndi tinthu tating'onoting'ono, kapena ngati tsiku lomaliza latha. Funsani dokotala wanu kapena wamankhwala momwe mungatherere chidebe chosagwira mankhwala.

Glucagon itha kubayidwa ndi jakisoni woyikapo kapena autoinjector kumtunda, ntchafu, kapena m'mimba. Musamabaye jekeseni woyeserera wa glucagon kapena autoinjector mumtsempha kapena minofu.

Ndikofunikira kuti odwala onse azikhala ndi wachibale yemwe amadziwa zizindikiro za shuga wotsika magazi komanso momwe angaperekere glucagon. Ngati mumakhala ndi shuga wambiri wamagazi, pitirizani kulandira jakisoni wa glucagon nthawi zonse. Muyenera komanso wachibale kapena bwenzi kuti muzitha kuzindikira zina mwazizindikiro za shuga wotsika magazi (mwachitsanzo, kugwedezeka, chizungulire kapena mutu wopepuka, thukuta, chisokonezo, mantha kapena kukwiya, kusintha mwadzidzidzi pamakhalidwe kapena malingaliro, mutu, dzanzi kapena kulira mozungulira pakamwa, kufooka, khungu loyera, njala yadzidzidzi, kusokonekera kapena kusokonekera). Yesetsani kudya kapena kumwa chakudya kapena chakumwa chokhala ndi shuga, monga maswiti olimba kapena msuzi wa zipatso, musanapatse glucagon.


Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani wamankhwala kapena dokotala kuti afotokoze gawo lililonse lomwe inu kapena abale anu simukumvetsa. Gwiritsani ntchito glucagon monga momwe mwalangizira. Osamagwiritsa ntchito zocheperako kapena kuzigwiritsa ntchito pafupipafupi kuposa momwe adanenera dokotala.

Mankhwalawa nthawi zina amapatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito jakisoni wa glucagon,

  • uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la glucagon, lactose, mankhwala ena aliwonse, nyama ya ng'ombe kapena nyama ya nkhumba, kapena china chilichonse mu jakisoni wa glucagon. Funsani dokotala wanu kapena wamankhwala mndandanda wa zosakaniza.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: mankhwala a anticholinergic monga benztropine (Cogentin), dicyclomine (Bentyl), kapena diphenhydramine (Benadryl); zotchinga beta monga atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), ndi propranolol (Inderal, Innopran); mankhwala osokoneza bongo (Indocin); insulini; kapena warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
  • Uzani dokotala wanu ngati muli ndi pheochromocytoma (chotupa pa kansalu kakang'ono pafupi ndi impso) kapena insulinoma (zotupa za kapamba), Dokotala wanu angakuuzeni kuti musagwiritse ntchito jakisoni wa glucagon.
  • uzani dokotala wanu ngati munakhalapo ndi glucagonoma (chotupa cha kapamba), mavuto am'magazi a adrenal, kusowa kwa zakudya m'thupi kapena matenda amtima.
  • Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Glucagon ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • nseru
  • kusanza
  • ming'oma
  • jekeseni tsamba lotupa kapena kufiira
  • mutu
  • kugunda kwamtima mwachangu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, uzani dokotala nthawi yomweyo:

  • kuvuta kupuma
  • kutaya chidziwitso
  • zotupa ndi khungu, khungu lofiira loyera kumaso, kubuula, m'chiuno, kapena miyendo

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Osayiika m'firiji kapena kuiwunditsa.Chotsani mankhwala aliwonse owonongeka kapena omwe sayenera kugwiritsidwa ntchito ndipo onetsetsani kuti muli ndi othandizira.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale.

Musalole kuti wina aliyense agwiritse ntchito mankhwala anu. Ngati jekeseni wanu wa glucagon wagwiritsidwa ntchito, onetsetsani kuti mwalowa m'malo nthawi yomweyo. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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Idasinthidwa Komaliza - 11/15/2019

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